公开(公告)号：US07178378B2

公开(公告)日：2007-02-20

申请号：US10651338

申请日：2003-08-28

申请人： Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

发明人： Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

IPC分类号： G01N23/036

CPC分类号： G01N29/036 ,  B81B3/0089 ,  B81B2201/0214 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01L1/10 ,  G01N2291/0257 ,  G01N2291/0427

摘要： The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.

摘要翻译： 所公开的传感器芯片包括衬底和耦合到衬底并被设置为相对于衬底移动的移动构件。 移动构件响应于衬底的移动而在第一方向和第二方向上相对于衬底移动。 第一方向与第二方向不同。 移动构件包括多个受体。 受体被配置为选择性地结合第一被测量。

公开(公告)号：US07167831B2

公开(公告)日：2007-01-23

申请号：US10067696

申请日：2002-02-04

申请人： Stephen Russell Falcon ,  Clement Chun Pong Yip ,  David Michael Miller ,  Dan Banay

发明人： Stephen Russell Falcon ,  Clement Chun Pong Yip ,  David Michael Miller ,  Dan Banay

IPC分类号： G10L21/00

CPC分类号： G10L15/30 ,  G10L2015/228

摘要： Systems and methods are described for a speech system that manages multiple grammars from one or more speech-enabled applications. The speech system includes a speech server that supports different grammars and different types of grammars by exposing several methods to the speech-enabled applications. The speech server supports static grammars that do not change and dynamic grammars that may change after a commit. The speech server provides persistence by supporting persistent grammars that enable a user to issue a command to an application even when the application is not loaded. In such a circumstance, the application is automatically launched and the command is processed. The speech server may enable or disable a grammar in order to limit confusion between grammars. Global and yielding grammars are also supported by the speech server. Global grammars are always active (e.g., “call 9-1-1”) while yielding grammars may be deactivated when an interaction whose grammar requires priority is active.

摘要翻译： 对于管理来自一个或多个支持语音的应用的多个语法的语音系统描述了系统和方法。 语音系统包括通过将几种方法暴露给支持语音的应用来支持不同语法和不同类型的语法的语音服务器。 语音服务器支持不改变的静态语法和提交后可能更改的动态语法。 语音服务器通过支持持久性语法来提供持久性，使得用户即使在未加载应用程序时也向应用程序发出命令。 在这种情况下，应用程序会自动启动并处理命令。 语音服务器可以启用或禁用语法，以限制语法之间的混淆。 语音服务器还支持全局和产生语法。 全局语法总是处于活动状态（例如，“调用9-1-1”），同时当语法需要优先级的交互活动时，可能会停用语法。

公开(公告)号：US20060286685A1

公开(公告)日：2006-12-21

申请号：US11183484

申请日：2005-07-18

申请人： Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

发明人： Michael Miller ,  Brett Masters ,  Mark Lundstrom ,  Eric Fitch

IPC分类号： G01N33/553 ,  C12M1/34

CPC分类号： G01N33/54313 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/0681 ,  B01L2300/1822 ,  B01L2400/043 ,  B01L2400/0487 ,  B82Y15/00 ,  B82Y30/00 ,  G01N29/022 ,  G01N29/036 ,  G01N29/4418 ,  G01N33/56911 ,  G01N2291/0256 ,  G01N2291/02836 ,  G01N2291/0422 ,  G01N2291/0423 ,  G01N2291/0426 ,  G01N2291/0427 ,  G01N2800/324 ,  Y02A50/52 ,  Y02A50/57

摘要： A system for detecting an analyte in a sample includes a resonant sensor that has a sensor surface coated with the capture agent. A plurality of magnetic particles, each of which is coated with a capture agent having an affinity for the analyte, is combined with the sample to form a plurality of analyte-particle complexes. The system also includes a transport arrangement for transporting the sample to the sensor surface, and a magnetic field inducing structure constructed and arranged to establish a magnetic field at and adjacent to the sensor surface. The resonant sensor produces a signal corresponding to an amount of analyte-particle complexes that are bound to the sensor surface.

摘要翻译： 用于检测样品中的分析物的系统包括具有涂覆有捕获剂的传感器表面的共振传感器。 将多个磁性颗粒（其中每一个都涂覆有对分析物具有亲和力的捕获剂）与样品组合以形成多个分析物 - 颗粒复合物。 该系统还包括用于将样品传送到传感器表面的传送装置，以及构造和布置成在传感器表面处和邻近传感器表面建立磁场的磁场诱导结构。 谐振传感器产生对应于结合到传感器表面的分析物 - 颗粒复合物的量的信号。

公开(公告)号：USD533920S1

公开(公告)日：2006-12-19

申请号：US29230911

申请日：2005-05-27

申请人： Noah Dingler ,  Dominic Daunter ,  Michael Miller ,  Kristen Swope

设计人： Noah Dingler ,  Dominic Daunter ,  Michael Miller ,  Kristen Swope

公开(公告)号：US20060270841A1

公开(公告)日：2006-11-30

申请号：US10504446

申请日：2003-02-25

申请人： Amy Espeseth ,  Marc Ferrer ,  Osvaldo Flores ,  Daria Hazuda ,  James Inglese ,  Michael Miller ,  Bruce Register ,  Xiao-Ping Shi ,  Adam Simon ,  Paul Zuck

发明人： Amy Espeseth ,  Marc Ferrer ,  Osvaldo Flores ,  Daria Hazuda ,  James Inglese ,  Michael Miller ,  Bruce Register ,  Xiao-Ping Shi ,  Adam Simon ,  Paul Zuck

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C12N9/64

CPC分类号： C07K14/47 ,  C07K14/4702 ,  C07K14/4711 ,  C07K2319/00 ,  C07K2319/50 ,  G01N2500/10

摘要： The present invention provides DNA constructs, genetically engineered host cells, and methods for identifying inhibitors of amyloid precursor protein (APP) processing. The methods provide for the convenient identification, in a single assay, of inhibitors of β-secretase and γ-secretase as well as other forms of APP processing. The methods rely on fusion proteins of APP and transcription factors in which APP processing releases the transcription factors, allowing the transcription factors to activate transcription of a reporter gene. Inhibitors are identified as substances that block or diminish transcription factor release from the fusion protein, thereby causing a diminution of reporter gene readout.

摘要翻译： 本发明提供了DNA构建体，遗传工程化宿主细胞和用于鉴定淀粉样前体蛋白（APP）处理抑制剂的方法。 该方法提供了在单次测定中方便地鉴定β-分泌酶和γ-分泌酶抑制剂以及其它形式的APP处理。 该方法依赖于APP和转录因子的融合蛋白，其中APP处理释放转录因子，允许转录因子激活报告基因的转录。 抑制剂被鉴定为阻断或减少转录因子从融合蛋白释放的物质，从​​而导致报告基因读出的减少。

公开(公告)号：US20060261732A1

公开(公告)日：2006-11-23

申请号：US11135310

申请日：2005-05-23

申请人： Michael Miller ,  Andrew Arnold

发明人： Michael Miller ,  Andrew Arnold

IPC分类号： H05B33/00 ,  H05B33/02

CPC分类号： H01L27/3216 ,  H01L27/3213

摘要： An improved OLED color display device is disclosed, in which a display pixel has a plurality of light-emitting elements of different colors, wherein the areas of the light-emitting elements are different based on the emission efficiency of the light-emitting elements and the luminance stability over time of the light-emitting elements, thereby protecting the light-emitting elements whose emission efficiency or luminance stability is low from prematurely deteriorating, wherein the improvement comprises: the relative areas of the light-emitting elements being further based on a display usage profile including probabilities of different colors to be produced on the display during its lifetime, thereby further extending the useful lifetime of the display.

摘要翻译： 公开了一种改进的OLED彩色显示装置，其中显示像素具有多个不同颜色的发光元件，其中发光元件的面积基于发光元件的发射效率而不同，并且 发光元件的亮度稳定度随着发光元件的发光效率或亮度稳定度低而保护发光元件的过度劣化，其特征在于：发光元件的相对面积进一步基于显示器 使用简档包括在其寿命期间在显示器上产生的不同颜色的概率，从而进一步延长了显示器的使用寿命。

公开(公告)号：US20060223856A1

公开(公告)日：2006-10-05

申请号：US11358248

申请日：2006-02-21

申请人： Tze-Ming Chan ,  Kathleen Cox ,  Wenqing Feng ,  Michael Miller ,  Daniel Weston ,  Stuart McCombie

发明人： Tze-Ming Chan ,  Kathleen Cox ,  Wenqing Feng ,  Michael Miller ,  Daniel Weston ,  Stuart McCombie

IPC分类号： A61K31/4545 ,  C07D403/14

CPC分类号： C07D401/14

摘要： In its many embodiments, the present invention provides a novel class of compounds of structural formula IA or IB where R1-R8 are as disclosed herein as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

摘要翻译： 在其许多实施方案中，本发明提供了一类新颖结构式IA或IB的化合物，其中R 1至R 8如本文所公开的CCR5受体的抑制剂 制备这些化合物的方法，含有一种或多种这样的化合物的药物组合物，制备包含一种或多种这类化合物的药物制剂的方法，以及使用这种化合物治疗，预防，抑制或改善与CCR5相关的一种或多种疾病的方法 或药物组合物。 本发明还涉及本发明化合物与一种或多种可用于治疗人类免疫缺陷病毒（HIV）的抗病毒剂或其它药剂的组合的用途。 本发明还涉及本发明化合物单独或与另一种药剂组合用于治疗实体器官移植排斥，移植物抗宿主病，关节炎，类风湿性关节炎，炎症性肠病，特应性皮炎，牛皮癣 ，哮喘，过敏或多发性硬化。

公开(公告)号：US20060184063A1

公开(公告)日：2006-08-17

申请号：US11058128

申请日：2005-02-15

申请人： Michael Miller

发明人： Michael Miller

IPC分类号： A61B10/00

CPC分类号： A61B10/0266 ,  A61B2010/0208 ,  A61B2017/00398 ,  A61B2017/00539

摘要： A tissue removal apparatus having a cutting element mounted to a handpiece. The cutting element includes an outer cannula defining a tissue-receiving opening and an inner cannula concentrically disposed within the outer cannula. The outer cannula has a trocar tip at its distal end and a cutting board snugly disposed within the outer cannula. The inner cannula defines an inner lumen that extends the length of the inner cannula, and which provides an avenue for aspiration. The inner cannula terminates in an inwardly beveled, razor-sharp cutting edge and is driven by a single motor that causes both rotary and reciprocating movement of the inner cannula.

摘要翻译： 一种具有安装到手持件的切割元件的组织去除装置。 切割元件包括限定组织接收开口的外套管和同心地设置在外套管内的内套管。 外套管在其远端具有套针针头，并且紧贴地设置在外插管内的切割板。 内套管限定内腔，其延伸内套管的长度，并且其提供用于抽吸的通道。 内套管终止于向内倾斜的剃刀锋利的切割边缘，并且由单个马达驱动，其引起内套管的旋转和往复运动。

公开(公告)号：US20060173296A1

公开(公告)日：2006-08-03

申请号：US11242334

申请日：2005-10-03

申请人： Michael Miller ,  Michael Hoffa ,  Joseph Mark

发明人： Michael Miller ,  Michael Hoffa ,  Joseph Mark

IPC分类号： A61B6/00

CPC分类号： A61B90/39 ,  A61B10/02 ,  A61B2017/00004 ,  A61B2017/00867 ,  A61B2090/3908 ,  A61B2090/3925 ,  A61B2090/3995

摘要： A site marker is provided that includes a generally hollow body defining a cavity. At least one marker element is captured within the cavity but is able to move within the cavity. The capturing prevents migration of the marker within a body. The site marker is formed into a predeployment configuration whereby the site marker is compressed into a predetermined size and shape to as to be readily positionable within a deployment device. The site marker expands from the predeployment position to a post deployment configuration upon insertion into the body.

摘要翻译： 提供了一种位置标记，其包括限定空腔的大体中空的主体。 至少一个标记元件被捕获在空腔内，但是能够在空腔内移动。 捕获可防止标记在体内迁移。 站点标记形成为部署前配置，由此站点标记被压缩成预定尺寸和形状以便容易地定位在展开装置内。 插入身体后，站点标记将从部署前位置展开为后部署配置。

公开(公告)号：US20060170712A1

公开(公告)日：2006-08-03

申请号：US11048385

申请日：2005-02-01

申请人： Michael Miller ,  Paul Kane ,  Michael Murdoch ,  Dustin Winters

发明人： Michael Miller ,  Paul Kane ,  Michael Murdoch ,  Dustin Winters

IPC分类号： G09G5/02

CPC分类号： H01L27/3211 ,  G09G3/3208 ,  G09G2300/0452 ,  H01L27/3216 ,  H01L27/3218

摘要： A color display device is disclosed, comprising: an array of subpixels of three different colors, including subpixels of a relatively high luminance first color and subpixels of relatively lower luminance second and third colors, wherein the subpixels are arranged into rows or columns to form a repeating pattern of alternating lower luminance and high luminance color subpixels in each row or column, with the sequential order of the two lower luminance color subpixels being alternated within each row or column, and wherein the alignment of subpixels of the same colors in adjacent rows or columns is such that the high luminance color subpixels are aligned more closely to perpendicular than are each of the lower luminance color subpixels relative to the direction of the rows or columns in which the subpixels are arranged in a repeating pattern.

摘要翻译： 公开了一种彩色显示装置，包括：三种不同颜色的子像素阵列，包括相对高亮度第一颜色的子像素和相对较低亮度的第二和第三颜色的子像素，其中子像素被布置成行或列以形成 每行或列中的交替的低亮度和高亮度彩色子像素的重复图案，其中两个低亮度彩色子像素的顺序在每行或列内交替，并且其中相邻行中的相同颜色的子像素的对准或 列相对于子像素以重复图案排列的行或列的方向，高亮度彩色子像素比垂直于更低亮度的彩色子像素的垂直方向更接近。