公开(公告)号：US20190117843A1

公开(公告)日：2019-04-25

申请号：US16127872

申请日：2018-09-11

Applicant: Muffin Incorporated ,  Cook Biotech Incorporated

Inventor： Michael C. Hiles ,  Chad E. Johnson ,  Neal E. Fearnot ,  Thomas Payne ,  Ronald Jankowski

IPC: A61L27/50 ,  C12N5/00 ,  C12M3/00 ,  A61L27/38 ,  A61L27/36 ,  C12M1/12 ,  A61L27/24 ,  C12M1/00

Abstract: Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.

公开(公告)号：US10231703B2

公开(公告)日：2019-03-19

申请号：US14719367

申请日：2015-05-22

Applicant: Muffin Incorporated

Inventor： Neal E. Fearnot ,  Peter S. McKinnis ,  Sarah Robbins ,  Yun Zhou

IPC: A61B8/00 ,  A61B8/12 ,  G01S15/89 ,  B06B1/06 ,  G10K11/00 ,  G10K11/35 ,  A61B8/08

Abstract: There are disclosed embodiments of devices and methods for ultrasound imaging, for example of the inside of a body part such as a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a second motor operating a shaft or a filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.

公开(公告)号：US10004475B2

公开(公告)日：2018-06-26

申请号：US14199028

申请日：2014-03-06

Applicant: Muffin Incorporated

Inventor： Benjaman B. Quearry

IPC: B29C59/04 ,  A61B8/00 ,  A61B8/08 ,  A61B17/34 ,  A61B90/00 ,  A61B8/12 ,  A61B17/00

CPC classification number: A61B8/4455 ,  A61B8/0841 ,  A61B8/4483 ,  A61B8/58 ,  A61B17/3421 ,  A61B90/39 ,  A61B2017/00526 ,  A61B2017/00725 ,  A61B2017/3413 ,  A61B2090/3925

Abstract: Disclosed are embodiments of methods and devices for providing enhanced echogenicity to medical devices. The method includes rolling an impression roller having a plurality of protrusions and an outer surface against a medical device. The protrusions create depressions in the surface of the medical device. A guide roller forms a ridge of the depression into the depression to create a lobe. The lobe forms a pocket between a bottom surface of the depression and the lobe.

公开(公告)号：US09993580B2

公开(公告)日：2018-06-12

申请号：US15058329

申请日：2016-03-02

Applicant: Muffin Incorporated

Inventor： Shelley Lynn Scoville ,  Amanda F. Taylor ,  Steven Charlebois ,  Christine M. Steinhart ,  Neal E. Fearnot

IPC: C07K9/00 ,  A61L27/36 ,  A61L27/54 ,  A61L27/12

CPC classification number: A61L27/3633 ,  A61L27/12 ,  A61L27/54 ,  A61L2300/414 ,  A61L2400/06 ,  A61L2430/02

Abstract: Osteogenic compositions include a decellularized extracellular matrix tissue and bone morphogenic protein, preferably BMP-2. The compositions make beneficial use of the BMP, which can be used at relatively low doses and can bind to native components (e.g., native sulfated glycosaminoglycans such as heparin and/or heparan sulfate) remaining in the decellularized extracellular matrix tissue. Methods for preparation and use of such compositions are also described. The compositions and related methods can be used in the treatment of diseased or damaged bone tissue.

公开(公告)号：US09987194B2

公开(公告)日：2018-06-05

申请号：US14835757

申请日：2015-08-26

Applicant: Muffin Incorporated

Inventor： William J. Havel ,  Neal E. Fearnot ,  Peter S. McKinnis ,  Richard B. Sisken ,  Charles Leland Baxter

IPC: B65D75/42 ,  B65D75/44 ,  B31B70/00 ,  A61J1/14 ,  A61J1/10 ,  A61J1/20 ,  B65B51/26 ,  B29C65/00 ,  B29C65/02 ,  B65D77/00 ,  B65D75/58 ,  B29C65/08 ,  B29C65/10 ,  B29C65/14 ,  B29C65/16 ,  B29C65/48 ,  B29C65/04 ,  B29L31/00

CPC classification number: A61J1/1406 ,  A61J1/10 ,  A61J1/1468 ,  A61J1/2093 ,  B29C65/02 ,  B29C65/04 ,  B29C65/08 ,  B29C65/10 ,  B29C65/14 ,  B29C65/16 ,  B29C65/48 ,  B29C65/4895 ,  B29C66/1122 ,  B29C66/344 ,  B29C66/3452 ,  B29C66/43121 ,  B29C66/71 ,  B29C66/7212 ,  B29C66/73921 ,  B29C66/8266 ,  B29C66/8322 ,  B29L2031/7148 ,  B31B70/00 ,  B65B51/26 ,  B65D75/42 ,  B65D75/44 ,  B65D75/5883 ,  B29K2023/083 ,  B29K2307/04 ,  B29K2023/06 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2075/00

Abstract: Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.

公开(公告)号：US09604037B2

公开(公告)日：2017-03-28

申请号：US13910693

申请日：2013-06-05

Applicant: Cook Medical Technologies LLC ,  Muffin Incorporated

Inventor： Frank J. Fischer, Jr. ,  James R. Randolph ,  Neal E. Fearnot ,  Jimmy L. Taylor, Jr. ,  Gary Bradford Shirley

IPC: A61M31/00 ,  A61M25/10 ,  A61M25/00 ,  A61M37/00

CPC classification number: A61M25/1011 ,  A61B34/20 ,  A61M25/0026 ,  A61M25/0041 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/10 ,  A61M37/0092 ,  A61M2025/0003 ,  A61M2025/0004 ,  A61M2025/0042 ,  A61M2025/1015 ,  A61M2025/1052 ,  A61M2025/1061 ,  A61M2025/1093

Abstract: Described in one aspect is a multi-pressure monitoring system for cell or other therapy includes a first catheter having a first lumen for accepting a treatment device, a second lumen for inflating a balloon, a pressure sensor for monitoring fluid pressure within the first lumen, and a flow restrictor such as a hemostasis valve for limiting the exchange of fluids into and out of the first lumen while treatment devices are present or exchanged in the first lumen. Also disclosed is a method of using the first catheter with a first pressure monitor coupled to the first pressure sensor along with a second catheter attached to a second pressure sensor coupled to a second pressure monitor. The second catheter is positioned within the first lumen of the first catheter during treatment operations and the first and second pressure monitors are used to verify proper pressures throughout the procedure. Described also are novel methods, systems, and catheters for delivering flowable therapeutic substances, such as viable cellular preparations, to patients.

公开(公告)号：US20170065401A1

公开(公告)日：2017-03-09

申请号：US15355167

申请日：2016-11-18

Applicant: Muffin Incorporated

Inventor： Neal E. Fearnot ,  Palle Munk Hansen

IPC: A61F2/07 ,  A61B17/12

CPC classification number: A61F2/07 ,  A61B17/12118 ,  A61B17/12177 ,  A61B90/08 ,  A61B2017/00455 ,  A61B2017/00526 ,  A61B2017/1205 ,  A61B2017/22038 ,  A61B2090/0811 ,  A61F2/856 ,  A61F2/86 ,  A61F2/90 ,  A61F2/966 ,  A61F2/97 ,  A61F2002/075 ,  A61F2002/077 ,  A61F2002/823 ,  A61F2002/9665 ,  A61F2230/0023 ,  A61F2230/0026 ,  A61F2230/0058 ,  A61F2230/0078 ,  A61F2240/001

Abstract: Intravascular devices and systems useful for blocking the opening of an aneurysm or a vessel branch are disclosed. In some aspects, the disclosure provides arrangements that align a covering material of a stent graft with an opening in the vessel wall before, during, and/or after expansion of the stent graft within the vasculature of a patient. In some instances, systems and devices include a sheath with a side aperture arranged to align a portion of the sheath and/or a portion of a stent graft contained within the sheath with the mouth of an aneurysm. Similarly, the present disclosure also provides embodiments in which the stent graft comprises an aligning member arranged to align the stent graft and/or a sheath with the mouth of an aneurysm. Other embodiments are disclosed.

Abstract translation: 公开了用于阻断动脉瘤或血管分支开放的血管内装置和系统。 在一些方面，本公开提供了在支架移植物在患者的脉管系统内扩张之前，期间和/或之后使支架移植物的覆盖材料与容器壁中的开口对齐的布置。 在一些情况下，系统和装置包括具有侧孔的护套，该侧孔设置成将护套的一部分和/或包含在护套内的支架移植物的一部分与动脉瘤的口对准。 类似地，本公开还提供了实施例，其中支架移植物包括布置成使支架移植物和/或鞘与动脉瘤的口对准的对准构件。 公开了其他实施例。

公开(公告)号：US20170042505A1

公开(公告)日：2017-02-16

申请号：US15235217

申请日：2016-08-12

Applicant: Muffin Incorporated

Inventor： William J. Havel ,  Peter S. McKinnis

IPC: A61B8/12 ,  A61B8/08 ,  A61B8/00

Abstract: Devices and methods for obtaining a real-time, three-dimensional image of a body part, particularly a blood vessel. A catheter has a chamber in its tip. The chamber contains an ultrasound transducer and reflector which generally face each other and rotate about a common axis. The transducer element on the transducer and the reflective face on the reflector are both tilted off-axis. The difference in angular velocity generally creates a phase shift between the transducer and the reflective face. The phase shift allows the transducer and the reflective face to actively scan a three-dimensional volume that is generally bounded interiorly by a hyperboloid and exteriorly by the effective range of the ultrasound beam. The transducer and reflector may rotate at constant speeds or nonconstant speeds as well in the same direction or in opposite directions.

Abstract translation: 用于获得身体部位，特别是血管的实时三维图像的装置和方法。 导管在其尖端具有腔室。 该腔室包含一个超声换能器和反射器，它们通常彼此相对并围绕公共轴线旋转。 传感器上的传感器元件和反射器上的反射面都偏离轴。 角速度的差异通常在换能器和反射面之间产生相移。 相移允许换能器和反射面主动地扫描通常由双曲面内部界定的三维体积，并且外部超过超声波束的有效范围。 换能器和反射器可以在相同方向或相反方向上以恒定速度或非恒定速度旋转。

公开(公告)号：US20150320979A1

公开(公告)日：2015-11-12

申请号：US14704236

申请日：2015-05-05

Applicant: Muffin Incorporated

Inventor： Neal E. Fearnot ,  Peter S. McKinnis ,  Kem Hawkins

IPC: A61M25/09 ,  A61B8/12 ,  A61B8/00 ,  A61B8/08

CPC classification number: A61M25/09 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/445 ,  A61B8/483 ,  A61M25/0108 ,  A61M2025/0177 ,  A61M2025/09133 ,  A61M2025/09166

Abstract: Described are guidewires having at least one echolucent segment, and associated apparatuses and methods. The guidewires can be combined with devices equipped with intravascular ultrasound probes and used to effectively image regions during procedures underway in the vascular environment. The echolucent segment can have one or more echogenic markers to enable detection of the segment and/or relative movement of the segment using intravascular ultrasound.

Abstract translation: 描述了具有至少一个回波段的导线以及相关的装置和方法。 导线可以与装有血管内超声探头的装置组合，并用于在血管环境中正在进行的手术期间有效地对区域进行成像。 回声部分可以具有一个或多个回声标记，以使得能够使用血管内超声检测片段和/或片段的相对运动。

公开(公告)号：US20150250451A1

公开(公告)日：2015-09-10

申请号：US14719367

申请日：2015-05-22

Applicant: Muffin Incorporated

Inventor： Neal E. Fearnot ,  Peter S. McKinnis ,  Sarah Robbins ,  Yun Zhou

IPC: A61B8/00 ,  A61B8/12

CPC classification number: A61B8/4466 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/445 ,  A61B8/4461 ,  A61B8/4483 ,  A61B8/483 ,  B06B1/06 ,  G01S15/8918 ,  G01S15/894 ,  G01S15/8943 ,  G10K11/004 ,  G10K11/352

Abstract: There are disclosed embodiments of devices and methods for ultrasound imaging, for example of the inside of a body part such as a blood vessel. In particular embodiments, a catheter has a tip chamber, within which is an ultrasound transducer mounted on a pivot mechanism, a motor for turning the transducer, and an implement for pivoting the transducer. Examples of such an implement are a second motor operating a shaft or a filament, and the pivot mechanism may be biased to return to a base position when the implement is not pivoting the transducer. In other embodiments, a mirror reflecting ultrasound signals from the transducer may be rotated and/or pivoted, using similar mechanisms.

Abstract translation: 公开了用于超声成像的装置和方法的实施例，例如诸如血管的身体部分的内部。 在特定实施例中，导管具有尖端腔室，其中安装有枢转机构的超声换能器，用于转动换能器的马达以及用于枢转换能器的器具。 这种工具的示例是操作轴或细丝的第二马达，并且当工具不枢转换能器时，枢转机构可被偏置以返回到基座位置。 在其他实施例中，使用类似的机构可以使来自换能器的反射超声信号的镜子旋转和/或枢转。