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公开(公告)号：US20130184573A1
公开(公告)日：2013-07-18
申请号：US13725039
申请日：2012-12-21
Applicant: California Institute of Technology
Inventor： Niema Pahlevan , Peyman Tavallali , Thomas Yizhao Hou , Morteza Gharib
CPC classification number: A61B5/02416 , A61B5/0004 , A61B5/0013 , A61B5/0077 , A61B5/02028 , A61B5/02405 , A61B5/02438 , A61B5/0507 , A61B5/7235 , A61B5/7278 , A61B5/7282 , A61B5/746 , A61B8/02 , A61B8/06 , A61B8/5223 , A61B8/565
Abstract: Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the Dicrotic Notch. The intrinsic frequencies provide metrics/measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/or is diagnosis. Exemplary uses include identifying (diagnosing) the presence of arrhythmia, heat failure, atrial fibrillation, aneurysms, vessel stenosis or aortic valve dysfunction and the necessity for valve replacement and/or monitoring congestive heart failure progression, together with identifying the acute need for hospitalization in connection with daily testing for any such condition.
Abstract translation: 描述了用于心脏健康测量的硬件和软件方法。 分析针对受试者各种获得的血流动力学波形，以计算或近似跨越Dicrotic Notch的两个域中的两个域中的固有频率。 固有频率提供与受试者的心脏健康相关的度量/措施。 该系统可用于监测病症和/或诊断。 示例性用途包括识别（诊断）心律不齐，热衰竭，心房颤动，动脉瘤，血管狭窄或主动脉瓣功能障碍的存在以及瓣膜置换和/或监测充血性心力衰竭进展的必要性，以及确定急性住院需要 与任何此类状况的日常测试连接。
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公开(公告)号：US20230050058A1
公开(公告)日：2023-02-16
申请号：US17886374
申请日：2022-08-11
Applicant: California Institute of Technology
Inventor： Alessio Tamborini , Morteza Gharib
Abstract: Systems and methods are provided for a non-invasive high resolution pressure pulse waveform measurement system. The system may include a blood pressure cuff, an air pump to inflate the blood pressure cuff to specific pressure levels, high resolution pressure sensors configured to perform high sensitivity signal acquisition at a specified pressure level, high range pressure sensors configured to measure an absolute reference for the signal and to calibrate the signal, pneumatic tubing connecting the air pump and sensors with the cuff, and a hydrodynamic filter configured as an input to a reference port of the high resolution pressure sensor. The hydrodynamic filter may be configured to transmit only mean pressure by attenuating a selected frequency range of the signal.
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83.发明申请公开(公告)号：US20220123356A1
公开(公告)日：2022-04-21
申请号：US17361993
申请日：2021-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Isabelle M. Darolles , Azin Fahimi , Cong Wang , Adrianus I. Aria , Luciana Cendon , Morteza Gharib
IPC: H01M10/0525 , H01M4/13 , H01M4/38 , H01M4/66 , H01M10/0565 , H01M10/0585
Abstract: Features for rechargeable lithium ion batteries, the batteries optionally employing vertically aligned carbon nanotube scaffolding, are described. Methods of manufacture and a solid polymer electrolyte are described for 3-dimensional battery architectures using the vertically aligned carbon nanotubes. Poly(ethylene)oxide bis(azide) and graphene poly(lactic acid) composite coatings are also described for use in such batteries or others.
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公开(公告)号：US11072421B2
公开(公告)日：2021-07-27
申请号：US16150183
申请日：2018-10-02
Applicant: California Institute of Technology
Inventor： Xichen Shi , Marcel Veismann , Christopher J. Dougherty , Stephanie Rider , Soon-Jo Chung , Morteza Gharib , Kyunam Kim , Salar Rahili
IPC: B64C27/26 , B64C11/00 , B64C11/02 , B64C39/02 , B64C27/52 , B64C29/02 , B64C3/56 , B64C27/20 , B64C29/00 , B64C27/56 , B64C15/02 , B64C23/00
Abstract: An automated flying transport vehicle that capitalizes on the strengths and complexities of a fixed and rotary winged aircraft. The air transport vehicle comprises a body aerodynamically designed to generate lift and a plurality of rotors that can generate lift as well as forward thrust from which a fixed wing portion of the air transport vehicle will begin to generate additional lift allowing for a sustained flight.
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85.发明授权公开(公告)号：US11000369B2
公开(公告)日：2021-05-11
申请号：US16215376
申请日：2018-12-10
Applicant: FOLDAX, INC. , CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Manuel Bedrossian , Stephanie Rider , Jason G. Beith
IPC: A61F2/24
Abstract: Improved prosthetic heart valves, their methods of manufacture, and systems and devices for manufacturing the valves are described. The prosthetic heart valves can be configured for transcatheter implantation. The prosthetic heart valves can have artificial leaflets. The prosthetic heart valves can be manufactured in numerous ways, such as by polymeric dipping processes.
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Patent Agency Ranking
86.发明申请公开(公告)号：US20200328404A1
公开(公告)日：2020-10-15
申请号：US16915553
申请日：2020-06-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Adrianus I. Aria , Morteza Gharib
IPC: H01M4/36 , H01M4/38 , H01M10/0525 , H01M10/058 , H01M4/13 , H01M4/62
Abstract: Provided herein are electrochemical systems and related methods of making and using electrochemical systems. Electrochemical systems of the invention implement novel cell geometries and composite carbon nanomaterials based design strategies useful for achieving enhanced electrical power source performance, particularly high specific energies, useful discharge rate capabilities and good cycle life. Electrochemical systems of the invention are versatile and include secondary lithium ion cells, useful for a range of important applications including use in portable electronic devices.
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公开(公告)号：US20190174117A1
公开(公告)日：2019-06-06
申请号：US16209089
申请日：2018-12-04
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Morteza Gharib , Alexei Harvard , Scott Hsieh , Jian Lu
IPC: H04N13/207 , H04N13/214 , G06T7/70 , G06T7/593
Abstract: Hardware and software configurations, optionally, for performing profilometry of an object are disclosed. An advantageous imaging device is described. An advantageous approach to determining imager position is also described. Each aspect described may be used independently of the other. Moreover, the teaching may find use in other fields including velocimetry, etc.
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公开(公告)号：US20190167131A1
公开(公告)日：2019-06-06
申请号：US16272750
申请日：2019-02-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Derek Rinderknecht , Morteza Gharib , Niema Pahlevan , Peyman Tavallali
Abstract: Devices, systems, and methods are described for acquiring heart sound timing content to enhance pulse waveform analysis.
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89.发明申请公开(公告)号：US20190015604A1
公开(公告)日：2019-01-17
申请号：US16134136
申请日：2018-09-18
Applicant: California Institute of Technology
Inventor： Morteza Gharib , Daegyoum Kim
Abstract: A method and apparatus that enables the production of micron-scale free-standing bubbles made of liquids containing surfactants are provided. The method and apparatus of the invention overcomes the limitations of conventional bubble forming techniques by using a controlled cavitation process in a liquid media.
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公开(公告)号：US20180256922A1
公开(公告)日：2018-09-13
申请号：US15912359
申请日：2018-03-05
Applicant: California Institute of Technology
Inventor： David Reza Mittelstein , Morteza Gharib , Stefanie Heyden , Michael Ortiz , Mikhail G. Shapiro
CPC classification number: A61N7/00 , A61B5/055 , A61B8/485 , A61B8/5261 , A61B17/3205 , A61B2017/00154 , A61B2018/00642 , A61B2018/0066 , A61B2018/00732 , A61B2090/374 , A61B2090/378 , A61M37/0092
Abstract: Systems and methods for targeting specific cell types by selective application of ultrasonic harmonic excitation at their resonance frequency (“oncotripsy”) are presented. The systems and methods result in the permeabilization, lysis, and/or death of targeted cell types by using ultrasonic harmonic excitations that have their frequency and pulse duration specifically tuned to disrupt the nuclear membrane of the targeted cells types by inducing a destructive vibrational response therein while leaving non-targeted cell types intact. Target cells may be neoplastic.
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