公开(公告)号：US20060089782A1

公开(公告)日：2006-04-27

申请号：US10535729

申请日：2003-10-01

申请人： Frederic Galtier ,  Hong Zhang

发明人： Frederic Galtier ,  Hong Zhang

IPC分类号： G01M15/11

CPC分类号： G01M15/11 ,  F02D41/1498 ,  F02D41/2451 ,  F02D2200/1012 ,  F02D2200/1015

摘要： According to methods known in prior art, a parameter which depends on the acceleration of the internal combustion engine is determined by means of a monitoring and analyzing system and is compared with a threshold value. According to the inventive method, the spread of said acceleration-dependent parameter is used for adjusting the threshold value to changes in the smoothness of running of the internal combustion engine.

摘要翻译： 根据现有技术中已知的方法，通过监视和分析系统确定取决于内燃机的加速度的参数，并将其与阈值进行比较。 根据本发明的方法，所述加速度相关参数的扩展用于调节阈值以改变内燃机的运行平稳度。

公开(公告)号：US20050272254A1

公开(公告)日：2005-12-08

申请号：US11184404

申请日：2005-07-18

申请人： Peijun Ding ,  Zheng Xu ,  Hong Zhang ,  Xianmin Tang ,  Praburam Gopalraja ,  Suraj Rengarajan ,  John Forster ,  Jianming Fu ,  Tony Chiang ,  Gongda Yao ,  Fusen Chen ,  Barry Chin ,  Gene Kohara

发明人： Peijun Ding ,  Zheng Xu ,  Hong Zhang ,  Xianmin Tang ,  Praburam Gopalraja ,  Suraj Rengarajan ,  John Forster ,  Jianming Fu ,  Tony Chiang ,  Gongda Yao ,  Fusen Chen ,  Barry Chin ,  Gene Kohara

IPC分类号： C23C14/06 ,  C23C14/16 ,  C23C14/32 ,  H01L21/285 ,  H01L21/44 ,  H01L21/4763 ,  H01L21/768

CPC分类号： H01L21/02183 ,  C23C14/0641 ,  C23C14/165 ,  C23C14/541 ,  C23C14/5806 ,  H01L21/02266 ,  H01L21/2855 ,  H01L21/318 ,  H01L21/76846 ,  H01L21/76856 ,  H01L21/76862 ,  H01L21/76876

摘要： We have discovered a method of providing a thin approximately from about 2 Å to about 100 Å thick TaN seed layer, which can be used to induce the formation of alpha tantalum when tantalum is deposited over the TaN seed layer. Further, the TaN seed layer exhibits low resistivity, in the range of 30 μΩ cm and can be used as a low resistivity barrier layer in the absence of an alpha tantalum layer. In one embodiment of the method, a TaN film is altered on its surface form the TaN seed layer. In another embodiment of the method, a Ta film is altered on its surface to form the TaN seed layer.

摘要翻译： 我们已经发现了一种提供大约约2埃至大约100埃的Ta N种子层的薄膜的方法，当钽沉积在Ta上时可用于诱导形成α钽， SUB> N 种子层。 此外，Ta N N种子层在30μΩ·cm的范围内显示低电阻率，并且可以在不存在α钽层的情况下用作低电阻率阻挡层。 在该方法的一个实施方案中，TaN膜在其表面上形成Ta N N种子层。 在该方法的另一个实施方案中，在其表面上改变Ta膜以形成Ta N N种子层。

公开(公告)号：US20050227938A1

公开(公告)日：2005-10-13

申请号：US11015193

申请日：2004-12-17

申请人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

发明人： C. Bennett ,  Brenda Baker ,  Nicholas Dean ,  Brett Monia ,  Susan Freier ,  James Karras ,  Hong Zhang ,  Susan Murray ,  Madeline Butler ,  Erich Koller ,  Thomas Condon ,  William Gaarde ,  Andrew Watt ,  Mark Graham ,  Jacqueline Wyatt ,  Lex Cowsert ,  Kenneth Dobie ,  Mark Roach

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07H21/02 ,  C12N15/113

CPC分类号： C12N15/1138 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/335 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3521 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of TFAP2C. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding TFAP2C. Methods of using these compounds for modulation of TFAP2C expression and for treatment of diseases associated with expression of TFAP2C are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节TFAP2C的表达。 组合物包含靶向编码TFAP2C的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节TFAP2C表达和治疗与TFAP2C表达相关的疾病的方法。

公开(公告)号：US20050214774A1

公开(公告)日：2005-09-29

申请号：US10809816

申请日：2004-03-26

申请人： Shyr-Jiann Li ,  James Clark ,  Hong Zhang

发明人： Shyr-Jiann Li ,  James Clark ,  Hong Zhang

IPC分类号： C07H21/04 ,  C12N5/06 ,  C12N9/64 ,  C12N15/09 ,  C12Q1/68

CPC分类号： C12N9/6472

摘要： The present invention provides isolated monkey Cathepsin S proteins and isolated nucleic acid molecules such as cDNA molecules that encode these monkey Cathepsin S proteins. The present invention specifically provides, for example, isolated monkey Cathepsin S proteins and encoding nucleic acid molecules, methods of producing the monkey Cathepsin S proteins, methods of identifying and screening modulators of the monkey Cathepsin S proteins, and methods of using these modulators to treat a human disease or disorders associated with an orthologous human Cathepsin S protein.

摘要翻译： 本发明提供了分离的猴组织蛋白酶S蛋白和分离的核酸分子，例如编码这些猴组织蛋白酶S蛋白的cDNA分子。 本发明特别提供了例如分离的猴组织蛋白酶S蛋白和编码核酸分子，产生猴组织蛋白酶S蛋白的方法，鉴定和筛选猴组织蛋白酶S蛋白的调节剂的方法，以及使用这些调节剂治疗的方法 与直向同源人组织蛋白酶S蛋白相关的人类疾病或病症。

公开(公告)号：US20050101555A1

公开(公告)日：2005-05-12

申请号：US10663451

申请日：2003-09-16

申请人： Hong Zhang ,  Andrew Watt

发明人： Hong Zhang ,  Andrew Watt

IPC分类号： A61K38/00 ,  A61K48/00 ,  C12N15/113 ,  C07H21/04

CPC分类号： C12N15/1137 ,  A61K38/00 ,  A61K48/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12Y304/2206 ,  Y02P20/582 ,  C12N2310/3525

摘要： Antisense compounds, compositions and methods are provided for modulating the expression of caspase 7. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding caspase 7. Methods of using these compounds for modulation of caspase 7 expression and for treatment of diseases associated with expression of caspase 7 are provided.

摘要翻译： 提供反义化合物，组合物和方法用于调节半胱天冬酶7的表达。组合物包含靶向编码半胱天冬酶7的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节半胱天冬酶7表达和治疗疾病的方法 提供与胱天蛋白酶7的表达相关的。

公开(公告)号：US20050090526A1

公开(公告)日：2005-04-28

申请号：US10989057

申请日：2004-11-16

申请人： Sui Cai ,  Hong Zhang ,  William Kemnitzer ,  Songchun Jiang ,  John Drewe ,  Richard Storer

发明人： Sui Cai ,  Hong Zhang ,  William Kemnitzer ,  Songchun Jiang ,  John Drewe ,  Richard Storer

IPC分类号： A61K31/35 ,  A61K31/385 ,  A61K31/47 ,  C07D215/54 ,  C07D221/10 ,  C07D311/16 ,  C07D311/58 ,  C07D335/06 ,  C07D409/04 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  A61K31/366 ,  A61K31/382

CPC分类号： C07D335/06 ,  A61K31/35 ,  A61K31/385 ,  A61K31/47 ,  C07D215/54 ,  C07D221/10 ,  C07D311/16 ,  C07D311/58 ,  C07D409/04 ,  C07D471/04 ,  C07D491/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04

摘要： The present invention is directed to substituted coumarins and quinolines and analogs thereof, represented by the general Formula I: wherein A, B, X, Y, and Z are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

摘要翻译： 本发明涉及由通式I表示的取代香豆素和喹啉及其类似物：其中A，B，X，Y和Z如本文所定义。 本发明还涉及发现具有式I的化合物是胱天蛋白酶的活化剂和凋亡诱导剂。 因此，本发明的胱天蛋白酶和细胞凋亡诱导剂的激活剂可用于诱导异常细胞发生不受控制的生长和扩散的各种临床病症中的细胞死亡。

公开(公告)号：US06877354B2

公开(公告)日：2005-04-12

申请号：US10327275

申请日：2002-12-20

申请人： Klaus Bayerle ,  Frank Hacker ,  Hong Zhang

发明人： Klaus Bayerle ,  Frank Hacker ,  Hong Zhang

IPC分类号： F01N11/00 ,  F01P11/00 ,  G01N33/00 ,  G01N27/00 ,  G01M15/00

CPC分类号： F01N11/00 ,  F01N2550/02 ,  F01P11/00 ,  F01P2025/00 ,  G01N33/0006 ,  G01N33/0039 ,  Y02A50/247 ,  Y02T10/47

摘要： To balance ozone sensors for the onboard diagnosis of a catalytic element which is arranged in a vehicle and is exposed to an ambient airstream, for breaking down ozone, predetermined enable conditions allowing the sensor balancing to be carried out are checked, and if the enable conditions are fulfilled the values of the output signals from the ozone sensors are recorded and compared with one another. This comparison gives a deviation value which is characteristic of the deviation between the two values, and the deviation value is used to decide whether sensor balancing is required and indeed possible. If sensor balancing is required and possible, the values of the output signals from the ozone sensors are compared with a threshold value and depending on the result of this comparison either an additive or a multiplicative correction of the values of the output signals is performed.

摘要翻译： 为了平衡臭氧传感器用于在车辆上布置的并暴露于环境空气流中的催化元件的机载诊断，用于分解臭氧，检查允许执行传感器平衡的预定使能条件，并且如果使能条件 满足来自臭氧传感器的输出信号的值被彼此记录和比较。 该比较给出了两个值之间的偏差的特征的偏差值，并且偏差值用于确定传感器平衡是否需要并且确实可能​​。 如果需要传感器平衡并且可能，将来自臭氧传感器的输出信号的值与阈值进行比较，并且根据该比较的结果，执行输出信号的值的加法或乘法校正。

公开(公告)号：US20050022508A1

公开(公告)日：2005-02-03

申请号：US10890391

申请日：2004-07-14

申请人： Gerd Rosel ,  Hong Zhang

发明人： Gerd Rosel ,  Hong Zhang

IPC分类号： F01N3/08 ,  F01N11/00 ,  F01N13/02 ,  F02D41/02 ,  F02D41/14 ,  F01N3/00 ,  F01N7/00

CPC分类号： F02D41/1495 ,  F01N3/0814 ,  F01N3/0842 ,  F01N11/00 ,  F01N13/009 ,  F01N2550/02 ,  F01N2560/02 ,  F01N2560/026 ,  F01N2570/14 ,  F01N2570/16 ,  F02D41/1441 ,  F02D41/1456 ,  F02D41/146 ,  F02D41/1461 ,  F02D41/1463 ,  F02D2041/1468 ,  F02D2250/36 ,  Y02A50/2344 ,  Y02T10/47

摘要： A method for checking an exhaust gas cleaning plant connected to an internal combustion engine in an exhaust gas tract that includes a catalytic converter having oxygen storage characteristics as well as a NOx sensor positioned downstream in the exhaust gas tract that emits a sensor signal depending on the NOx and the NH3 concentration in the exhaust gas in which case the internal-combustion engine is operated with a periodic air/fuel ratio oscillating around the value lambda=1 and that the average of the sensor signal is formed over one period or several periods and if the threshold value of the average is exceeded, damage to the monolith of the catalytic converter is detected.

摘要翻译： 一种检查排气净化装置的方法，该废气净化装置与排气管内的内燃机连接，该废气管道包括具有储氧特性的催化转化器，以及位于排气道下游的NOx传感器，该NOx传感器根据 NOx和废气中的NH 3浓度，在这种情况下，内燃机以围绕值λ= 1摆动的周期性空气/燃料比运行，并且传感器信号的平均值在一个周期或数个周期内形成， 如果超过了平均值的阈值，则检测到催化转化器的整体的损坏。

公开(公告)号：US06769412B2

公开(公告)日：2004-08-03

申请号：US10181604

申请日：2002-07-16

申请人： Klaus Bayerle ,  Harry Schuele ,  Hong Zhang

发明人： Klaus Bayerle ,  Harry Schuele ,  Hong Zhang

IPC分类号： F02M5100

CPC分类号： F02D41/009 ,  F02D41/047 ,  F02D41/062 ,  F02D2041/0092 ,  F02D2200/0402

摘要： During the starting of an internal combustion engine with fuel injection, so-called preliminary injections (I) are dispensed according to a certain preliminary injection strategy in order to build up a wall film in the cylinders and simultaneously provide an ignitable mixture for the initial combustion. To avoid a situation where the preliminary charges during the starting phase are too rich or too lean, different quantities of fuel are chosen for the preliminary injections (I), depending on the charges to be expected in the relevant cylinders.

摘要翻译： 在具有燃料喷射的内燃机启动期间，根据特定的预喷射策略分配所谓的预喷射（I），以便在气缸中建立壁膜并且同时提供用于初始燃烧的可燃混合物 。 为了避免起始阶段的初步费用太丰富或太瘦的情况，根据相关气瓶预期的费用，可以选择不同数量的燃料进行初步注射（I）。

公开(公告)号：US06571550B2

公开(公告)日：2003-06-03

申请号：US10084132

申请日：2002-02-27

申请人： Gerd Rösel ,  Hong Zhang

发明人： Gerd Rösel ,  Hong Zhang

IPC分类号： F01N300

CPC分类号： F01N3/101 ,  F01N13/009 ,  F01N13/0093 ,  F02D41/0295 ,  F02D41/1441 ,  F02D41/1456 ,  F02D41/187 ,  F02D2200/0814 ,  Y02T10/22

摘要： For a three-way catalytic converter system with a preliminary catalytic converter, a main catalytic converter and an oxygen sensor with a constant characteristic curve disposed between the two catalytic converters, a method for resetting the oxygen concentration in the preliminary catalytic converter and the main catalytic converter in the event of a transition from lean-burn operation to stoichiometric operation includes exposing both catalytic converters to a rich mix until the desired oxygen concentrations have been reached. In the process, the constant measurement signal from the oxygen sensor and the measurement signal from an air mass flow meter are used to calculate the quantity of oxygen that is released to the exhaust gas from the main catalytic converter, in order to end rich-burn operation when a predetermined desired value is reached.