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公开(公告)号：US20090131319A1
公开(公告)日：2009-05-21
申请号：US12235837
申请日：2008-09-23
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N15/09 , C12N5/00 , C12P21/06 , C07K14/00 , C07K16/00
CPC分类号： C07K14/7151
摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。
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公开(公告)号：US20090081727A1
公开(公告)日：2009-03-26
申请号：US12020205
申请日：2008-01-25
申请人： Jian Ni , Reiner L. Gentz , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Craig A. Rosen
CPC分类号： C07K14/70596
摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.
摘要翻译： 本发明涉及一种新型的CD33样蛋白。 特别地，提供编码CD33样蛋白质的分离的核酸分子。 重组载体和宿主细胞也提供重组CD33样多肽。 本发明还提供了在针对表达CD33样多肽的细胞的肿瘤或炎性疾病诊断或预后和治疗性治疗期间有用的方法。
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公开(公告)号：US07452538B2
公开(公告)日：2008-11-18
申请号：US10648786
申请日：2003-08-27
申请人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
发明人： Jian Ni , Craig A. Rosen , James G. Pan , Reiner L. Gentz , Vishva M. Dixit
IPC分类号： A61K39/395 , A61K38/18 , A61K38/19 , C07K16/30
CPC分类号： C07K16/2878 , A61K38/00 , A61K39/39541 , C07K14/70578 , C07K14/7151 , C07K2319/30 , C12N2799/026 , Y02A50/412 , A61K2300/00
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity and methods for using DR4 polynucleotides and polypeptides. The invention also relates to the treatment of diseases associated with reduced or increased levels of apoptosis using antibodies specific for DR4, which may be agonists and/or antagonists of DR4 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法以及使用DR4多核苷酸和多肽的方法。 本发明还涉及使用DR4特异性抗体（其可以是DR4活性的激动剂和/或拮抗剂）的减少或增加的细胞凋亡相关疾病的治疗。
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公开(公告)号：US20080227110A1
公开(公告)日：2008-09-18
申请号：US12036846
申请日：2008-02-25
申请人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
发明人： Paul A. Moore , Reiner L. Gentz , Henry Hongjun Ji , Jian Ni , Jing-Shan Hu , Craig A. Rosen
摘要： Human polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptides for therapeutic purposes. Antagonists against such polypeptides and their use as a therapeutic are also disclosed. Also disclosed are diagnostic methods for detecting disease which utilize the sequences and polypeptides.
摘要翻译： 公开了编码这种多肽的人多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了将这些多肽用于治疗目的的方法。 还公开了抗这些多肽的拮抗剂及其作为治疗剂的用途。 还公开了用于检测利用序列和多肽的疾病的诊断方法。
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公开(公告)号：US07374764B2
公开(公告)日：2008-05-20
申请号：US10413518
申请日：2003-04-15
申请人： Jian Ni , Reiner L. Gentz , Craig A. Rosen
发明人： Jian Ni , Reiner L. Gentz , Craig A. Rosen
CPC分类号： C07K14/70596
摘要： The present invention concerns a novel CD33-like protein. In particular, isolated nucleic acid molecules are provided encoding the CD33-like protein. Recombinant CD33-like polypeptides are also provided as are recombinant vectors and host cells. The invention further provides methods useful during tumor or inflammatory disease diagnosis or prognosis and therapeutic treatments targeting cells expressing CD33-like polypeptides.
摘要翻译： 本发明涉及一种新型的CD33样蛋白。 特别地，提供编码CD33样蛋白质的分离的核酸分子。 重组载体和宿主细胞也提供重组CD33样多肽。 本发明还提供了在针对表达CD33样多肽的细胞的肿瘤或炎性疾病诊断或预后和治疗性治疗期间有用的方法。
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公开(公告)号：US07232667B2
公开(公告)日：2007-06-19
申请号：US10733311
申请日：2003-12-12
申请人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
发明人： Steven M. Ruben , Joachim R. Gruber , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Patrick J. Dillon , Reiner L. Gentz , Pablo Jimenez
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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公开(公告)号：US07199225B2
公开(公告)日：2007-04-03
申请号：US10435392
申请日：2003-05-12
申请人： Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
发明人： Jian Ni , Ping Feng , Patrick J. Dillon , Reiner L. Gentz , Joseph Merregaert , Patrick Smits
IPC分类号： C07K16/28
CPC分类号： C12Q1/6883 , A61K38/00 , A61K48/00 , A61K2039/51 , C07K14/47 , C07K14/51 , C12N2799/026 , C12Q2600/156 , Y10T436/143333
摘要： A human ECM-1 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating the differentiation in growth of osteoblasts and osteoclasts, which may be used to promote the healing of bone fractures and de novo bone formation, for osteoporosis, for and to promote angiogenesis. Antagonists to the polypeptide of the present invention are also disclosed which may be utilized to treat osteodystrophy, osteohypertrophy, osteoma, osteoblastoma and cancers. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention.
摘要翻译： 公开了编码这种多肽的人ECM-1多肽和DNA（RNA），以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽刺激成骨细胞和破骨细胞生长分化的方法，其可用于促进骨折愈合和从头骨形成，用于骨质疏松症，促进血管生成。 还公开了本发明多肽的拮抗剂，其可用于治疗骨营养不良，骨质肥大，骨瘤，成骨细胞瘤和癌症。 用于鉴定编码本发明多肽的核酸序列中的突变的诊断测定。
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公开(公告)号：US07060272B2
公开(公告)日：2006-06-13
申请号：US10226318
申请日：2002-08-23
申请人： Jian Ni , Craig A Rosen , James G Pan , Reiner L Gentz , Vishva M Dixit
发明人： Jian Ni , Craig A Rosen , James G Pan , Reiner L Gentz , Vishva M Dixit
IPC分类号： A61K39/395 , A61K51/10 , C07K16/30
CPC分类号： C07K14/70578
摘要： The present invention relates to novel Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor (TNF) receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity.
摘要翻译： 本发明涉及作为肿瘤坏死因子（TNF）受体家族成员的新的含有死亡域的受体-4（DR4）蛋白。 特别地，提供编码人DR4蛋白的分离的核酸分子。 还提供了DR4多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定DR4活性的激动剂和拮抗剂的筛选方法。
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89.发明授权I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 失效I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡公开(公告)号：US06680171B1
公开(公告)日：2004-01-20
申请号：US09489155
申请日：2000-01-21
申请人： Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
发明人： Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
IPC分类号： C07H2104
CPC分类号： C12N9/6475 , A61K38/00
摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of INFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是INFR-1和CD-95诱导的凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。
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90.发明授权I-flice, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis 失效I-flice，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡公开(公告)号：US06623938B2
公开(公告)日：2003-09-23
申请号：US09009893
申请日：1998-01-21
申请人： Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
发明人： Jian Ni , Craig A. Rosen , Vishva M. Dixit , Reiner L. Gentz , Joseph J. Kenny
IPC分类号： C12P2106
CPC分类号： C12N9/6475 , A61K38/00
摘要： The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
摘要翻译： 本发明涉及一种新型的I-FLICE-1或I-FLICE-2蛋白，其是TNFR-1和CD-95诱导的细胞凋亡的新型抑制剂。 特别地，提供编码人I-FLICE-1或I-FLICE-2蛋白的分离的核酸分子。 还提供I-FLICE-1或I-FLICE-2多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及用于鉴定I-FLICE-1或I-FLICE-2活性的激动剂和拮抗剂的筛选方法。 还提供了用于治疗与凋亡相关的疾病和病症的治疗方法。
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