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公开(公告)号：US20080171363A1
公开(公告)日：2008-07-17
申请号：US11838730
申请日：2007-08-14
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Adelbert Grossmann , Friederike Hesse , Andreas Schaubmar , Roberto Falkenstein , Hans Koll , Markus Dembowski
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US06946296B2
公开(公告)日：2005-09-20
申请号：US09954692
申请日：2001-09-12
IPC分类号： C12N15/09 , A61K38/45 , A61K48/00 , C07K14/435 , C07K14/47 , C07K14/545 , C07K14/56 , C07K16/00 , C12N7/00 , C12N9/02 , C12N9/10 , C12N9/12 , C12N9/38 , C12N9/86 , C12N15/10 , C12N15/52 , C12N15/64 , C12P21/02 , C12Q1/68 , C40B40/02 , G01N33/68 , C12N15/00 , C07H21/02 , C07H21/04
CPC分类号： C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
摘要： Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
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公开(公告)号：US06413745B1
公开(公告)日：2002-07-02
申请号：US09723520
申请日：2000-11-27
IPC分类号： C12P2106
CPC分类号： C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
摘要翻译： 调节，调节和改进用于核酸洗牌过程的分子的杂交性质和重组性质的方法涉及重组混合物，并且提供调节，调节，改进和进化的RNA和蛋白质剪接的方法。
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公开(公告)号：US06365377B1
公开(公告)日：2002-04-02
申请号：US09517933
申请日：2000-03-03
IPC分类号： C12P1934
CPC分类号： C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
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公开(公告)号：US06358740B1
公开(公告)日：2002-03-19
申请号：US09723473
申请日：2000-11-27
IPC分类号： C12N1500
CPC分类号： C12N15/8274 , C12N15/10 , C12N15/1027 , C12N15/8216 , C12N15/8289 , Y10T436/143333
摘要： Methods of modulating, tuning and improving hybridization properties and recombination properties of molecules for use in nucleic acid shuffling procedures, relates recombination mixtures and methods of modulating, tuning, improving and evolving splicing of RNAs and proteins are provided.
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公开(公告)号：US20110053781A1
公开(公告)日：2011-03-03
申请号：US12557983
申请日：2009-09-11
IPC分类号： C40B10/00
CPC分类号： C12N15/1031 , A61K38/45 , A61K48/00 , C07K14/43595 , C07K14/545 , C07K14/56 , C07K16/00 , C07K2317/565 , C07K2317/622 , C12N7/00 , C12N9/0069 , C12N9/1007 , C12N9/16 , C12N9/86 , C12N15/10 , C12N15/1027 , C12N15/1034 , C12N15/1037 , C12N15/1058 , C12N15/52 , C12N15/64 , C12N15/67 , C12N2795/14043 , C12N2795/14143 , C12Q1/6811 , C12Q1/6853 , C12Q1/686 , C40B40/02 , C40B40/08 , C40B50/06 , G01N33/68 , G01N33/6845
摘要： Methods are provided for the evolution of proteins of industrial and pharmaceutical interest, including methods for effecting recombination and selection. Compositions produced by these methods are also disclosed.
摘要翻译： 提供了用于工业和医药兴趣蛋白质进化的方法，包括进行重组和选择的方法。 还公开了通过这些方法制备的组合物。
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公开(公告)号：US07531324B2
公开(公告)日：2009-05-12
申请号：US11531557
申请日：2006-09-13
申请人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Roberto Falkenstein
发明人： Phillip A. Patten , Sridhar Viswanathan , Torben Lauesgaard Nissen , Anne Vogt , Harald Kropshofer , Ralf Schumacher , Stephan Fischer , Stefan Seeber , Andreas Schaubmar , Roberto Falkenstein
CPC分类号： A61K38/212 , A61K47/60 , C07K14/56 , Y02A50/463
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US07498152B1
公开(公告)日：2009-03-03
申请号：US11554557
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20090042252A1
公开(公告)日：2009-02-12
申请号：US11554557
申请日：2006-10-30
CPC分类号： C07K14/56 , A61K9/0019 , A61K38/212 , A61K47/60
摘要： The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
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公开(公告)号：US20080207459A1
公开(公告)日：2008-08-28
申请号：US12026412
申请日：2008-02-05
申请人： Erik Karrer , Steven H. Bass , Robert Whalen , Phillip A. Patten
发明人： Erik Karrer , Steven H. Bass , Robert Whalen , Phillip A. Patten
IPC分类号： C40B10/00 , C40B50/00 , C40B30/00 , C40B30/02 , C40B30/04 , C07K1/00 , C40B40/08 , C12N5/06 , C12N15/00
CPC分类号： C07K16/1271 , C07K16/00 , C07K16/1275 , C07K2317/24
摘要： Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
摘要翻译： 提供了通过多种DNA多样化和选择程序改进抗体的方法。 改善包括亲和力的增加，特异性和效应子功能的改变，以及降低的抗原性，例如。 人性化。 提供重组抗体序列的文库，以及表达这些文库成员的细胞。 提供了新的噬菌体展示载体。 提供了抗体及其同源抗原共转化方法。 共转化用于发展具有增加的抗原性的HIV包膜蛋白和与之相互作用的广泛中和抗体。 提供了改进用于检测生物战剂的抗体的方法。
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