摘要:
The present invention includes and relates generally to compounds which modulate apoptosis in cells. The present invention also provides pharmaceutical compositions containing these compounds, methods of making these compounds, and methods of using these compounds and pharmaceutical compositions for treatment of diseases associated with irregular apoptosis in cells.
摘要:
The present invention relates to a method for identifying compounds that modulate the activity of p300/CBP. Compounds of the invention are identified by designing or screening for a compound which binds to at least one amino acid residue of the newly identified lysine-CoA inhibitor binding site, L1 loop, electronegative pocket, or electronegative groove of the HAT domain of p300/CBP and testing the compound for its ability to modulate the activity of p300/CBP. Compositions and methods for preventing or treating diseases or disorders associated with p300/CBP are also provided as is a method for producing a semi-synthetic HAT domain.
摘要:
The present invention relates to selection of sites of a communication system for measurement units that are for measuring a feature of wireless signals so that the location of a wireless station may be determined based on the measurement. Each measurement unit provides a measurement coverage. In the method a first set of information is defined, said first set relating to sites that are possible locations for the location measurement units and to the coverage provided by the site if it is provided with a measurement unit. A second set of information is defined that relates to signalling environment within the sites. Based on the defined first and second sets of information, a third set of information is defined, said third set associating each site with access entities of the communication system. Based on the third set of information, appropriate sites can be selected for the location measurement units.
摘要:
A recombinant fusion protein comprising a human erythropoietin peptide portion linked to an immunoglobulin peptide portion is described. The fusion protein has a prolonged half-life in vivo in comparison to naturally occurring or recombinant native human erythropoietin. In one embodiment of the invention, the protein has a half-life in vivo at least three fold higher than native human erythropoietin. The fusion protein also exhibits enhanced erythropoietic bioactivity in comparison to native human erythropoietin. In one embodiment, the fusion protein comprises the complete peptide sequence of a human erythropoietin (EPO) molecule and the peptide sequence of an Fc fragment of human immunoglobulin IgG1. The Fc fragment in the fusion protein includes the hinge region, CH2 and CH3 domains of human immunoglobulin IgG1. The EPO molecule may be linked directly to the Fc fragment to avoid extraneous peptide linkers and lessen the risk of an immunogenic response when administered in vivo. In one embodiment the hinge region is a human Fc fragment variant having a non-cysteine residue at amino acid 6. The invention also relates to nucleic acid and amino acid sequences encoding the fusion protein and transfected cell lines and methods for producing the fusion protein. The invention further includes pharmaceutical compositions comprising the fusion protein and methods of using the fusion protein and/or the pharmaceutical compositions, for example to stimulate erythropoiesis in subjects in need of therapy.
摘要:
A method is disclosed for conducting a query to transform data in a pre-existing database, the method comprising: collecting database information from the pre-existing database, the database information including inconsistent dimensional tables and fact tables; running an entity discovery process on the inconsistent dimensional tables and the fact tables to produce entity mapping tables; using the entity mapping tables to resolve the inconsistent dimensional tables into resolved dimensional tables; and running the query on a resolved database to obtain a query result, the resolved database including the resolved dimensional table.
摘要:
A lighting control system network and method of providing same including a remote control unit having a RF signal transmitter and a RF receiver and a number of lighting control units, each of the lighting control units having a RF signal transmitter, a RF receiver, and a lighting unit associated therewith. The remote control unit and the lighting control units are configured in a master-slave oriented network. One of the lighting control units is configured as a master in the network and the remaining lighting control units and the remote control unit are configured as slaves in the network. The lighting control units and the remote control units communicate bi-directionally with each other over RF wireless links. The network may include sensors for detecting an environmental or system parameter. Multiple instances of the lighting control network may be interfaced together to form a building-wide network.
摘要:
The present invention presents techniques useful in methods for gene expression monitoring, and other nucleic acid hybridization assays, that utilize microelectronic arrays to drive the transport and hybridization of nucleic acids. Particularly, methods for normalizing the signals of individual microlocations by the use of an internal control sequence probe are provided. These methods are particularly useful for hybridization assays in which a quantitative comparison of the hybridization of several different sequences at a plurality of microlocations is desired, such as in gene expression analyses.
摘要:
Methods are provided for the analysis and determination of the nature of single nucleic acid polymorphisms (SNPs) in a genetic target. In one method of this invention, the nature of the SNPs in the genetic target is determined by the steps of providing a plurality of hybridization complexes arrayed on a plurality of test sites on an electronically bioactive microchip, where the hybridization complex includes at least a nucleic acid target containing a SNP, a stabilizer probe having a sequence complementary to the target sequence and/or reporter probe, and a reporter probe having a selected sequence complementary to either the stabilizer or the same target sequence strand wherein a selected sequence of the reporter includes either a wild type nucleotide or a nucleotide corresponding to the SNP of the target. In accordance with the invention, the stabilizer, reporter and target amplicons are hybridized using electronic assistance of the microchip system such that base-stacking energies are utilized in discerning among other identifying indicators, the presence of wild type or polymorphism sequence. Applications include disease diagnostics, such as for the identification of polymorphisms in structural genes, regulatory regions, antibiotic or chemotherapeutic resistance conferring regions, or for SNPs associated with speciation or used for determination of genetic linkage.
摘要:
An air bearing slider has an air bearing surface with two rails separated by a cavity. The rails are nonsymmetrical about the longitudinal axis. Instead, the width of the active rail is greater at the trailing end than at the leading end, such as by having a hook portion 64 which extends inward at a sharp angle to the longitudinal axis of the slider. The wider hook portion 64 causes an increased flying height sensitivity to underlying disc/wind speed. The nonactive rail has a greater width than the non-hook portion of the active rail, so the slider exhibits slight negative roll. A vibration sensor is attached to the air bearing slider, and the air bearing slider is used in glide testing of discs.
摘要:
A method and receiver for determining the speed of a terminal equipment in a radio system using a time division multiple access method in which a signal is transmitted in a succession of time slots each of a given duration and the signal is received and sampled, the received sampled signal having a signal envelope with a mean strength, in which the speed determination is made by measuring the man strength of the signal envelope of the received sampled signal within a given time window. The given time window has a duration that is at most half of the duration of a time slot, a parameter proportional to the mean strength of the signal envelope is formed during each time window, in each received time slot the parameter is measured by using at least two time windows, and a variation of the envelope is calculated by time slots on the basis of the parameter, to form a derived variation value, the derived variation value is averaged over several time slots to form an averaged variation value, and the averaged variation value is compared with a calculated reference value, which comparison indicates the speed of the equipment.