公开(公告)号：US11517538B2

公开(公告)日：2022-12-06

申请号：US17342368

申请日：2021-06-08

Applicant: Massachusetts Institute of Technology

Inventor： Eric A. Appel ,  Mark W. Tibbitt ,  Robert S. Langer

IPC: A61K9/51 ,  A61K9/06 ,  A61K47/36 ,  A61K47/38 ,  A61K47/30 ,  A61K47/34

Abstract: Network materials which exhibit both shear thinning and self-healing properties are disclosed. The networks contain particles and gel-forming compounds. The networks are useful for a variety of biomedical uses, including drug delivery.

公开(公告)号：US11458158B2

公开(公告)日：2022-10-04

申请号：US16867291

申请日：2020-05-05

Applicant: Massachusetts Institute of Technology

Inventor： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC: A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

Abstract: Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US20220280435A1

公开(公告)日：2022-09-08

申请号：US17694852

申请日：2022-03-15

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital Inc.

Inventor： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

IPC: A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M5/142 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61M5/158

Abstract: Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component (e.g., having a relatively high API loading).

公开(公告)号：US11369607B2

公开(公告)日：2022-06-28

申请号：US16752256

申请日：2020-01-24

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Jeffrey M. Karp ,  Robert S. Langer ,  Xiaolei Yin ,  Nitin Joshi

IPC: A61K31/506 ,  C12N5/0793 ,  A61K35/36 ,  A61K9/00 ,  A61K31/167 ,  A61K31/19 ,  A61K31/422 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/5517 ,  A61K33/00 ,  C12N5/071

Abstract: Method and compositions for inducing the self-renewal of stem/progenitor supporting cells comprised by a cochlear cell population, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells.

公开(公告)号：US11337930B2

公开(公告)日：2022-05-24

申请号：US17080355

申请日：2020-10-26

Applicant: Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

Inventor： Arturo J. Vegas ,  Minglin Ma ,  Kaitlin M. Bratlie ,  Daniel G. Anderson ,  Robert S. Langer

IPC: A61K9/50 ,  A61K9/00 ,  C08B37/00 ,  A61K35/39 ,  A61K45/06 ,  A61K9/51

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.

公开(公告)号：US11318293B2

公开(公告)日：2022-05-03

申请号：US16696233

申请日：2019-11-26

Applicant: Massachusetts Institute of Technology

Inventor： Michael S. Williams ,  Jason Siu Wei Li ,  Jacob Coffey ,  Christoph Winfried Johannes Steiger ,  Miguel Jimenez ,  Robert S. Langer ,  Ester Caffarel Salvador ,  Alex Abramson ,  Carlo Giovanni Traverso

IPC: A61M37/00 ,  A01K11/00

Abstract: A platform technology has been designed to provide a means for controlled delivery of single or multiple doses of therapeutic, prophylactic, diagnostic or identifying agents to livestock. The delivery system is based on a livestock ear tag that releases therapeutic and/or prophylactic agent when applied to the ear or other desired anatomical target of the animal. The agent to be delivered is encapsulated in or on microneedles and or microparticles and or nanoparticles or combination thereof on a surface thereon of the male or female part of the tag, which is pressed into the skin so that the microneedles penetrate into the epidermis and dermis layers of the skin. The agent is then released into the animal from the microneedles and or microparticles and or nanoparticles or combination thereof at the site of contact into the epidermis and dermis layers of the skin.

公开(公告)号：US20220054719A1

公开(公告)日：2022-02-24

申请号：US17520891

申请日：2021-11-08

Applicant: Massachusetts Institute of Technology ,  The General Hospital Corporation

Inventor： Laura Indolfi ,  Elazer R. Edelman ,  Robert S. Langer ,  Jeffrey W. Clark ,  David T. Ting ,  Cristina Rosa Annamaria Ferrone ,  Matteo Ligorio

IPC: A61L31/10 ,  A61K9/70 ,  A61K31/337 ,  A61K47/34 ,  A61K9/00 ,  A61L31/16 ,  A61L31/14

Abstract: Drug-eluting devices and methods for the treatment of tumors of the pancreas, biliary system, gallbladder, liver, small bowel, or colon, are provided. Methods include deploying a drug-eluting device having a film which includes a mixture of a degradable polymer and a chemotherapeutic drug, wherein the film has a thickness from about 2 μm to about 1000 μm, into a tissue site and releasing a therapeutically effective amount of the chemotherapeutic drug from the film to treat the tumor, wherein the release of the therapeutically effective amount of the drug from the film is controlled by in vivo degradation of the polymer at the tissue site.

公开(公告)号：US11254781B2

公开(公告)日：2022-02-22

申请号：US17185528

申请日：2021-02-25

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc. ,  Biocant-Center of Innovation and Biotechnology

Inventor： Robert S. Langer ,  Jeffrey M. Karp ,  Maria Jose Maio Nunes-Pereira ,  Ben Ouyang ,  Lino da Silva Ferreira ,  Debanjan Sarkar

IPC: C08G18/42 ,  C08G18/08 ,  A61K9/70

Abstract: Among other things, the present disclosure provides compositions and methods for an elastomeric cross-linked polyester material. Such an elastomeric cross-linked polyester material, in some embodiments, comprises a plurality of polymeric units of the general formula (-A-B-)p, wherein p is an integer greater than 1; and a plurality of urethane cross-links each of which covalently links two polymeric units to one another, which two linked polymeric unit each had at least one free hydroxyl or amino group prior to formation of the crosslink.

公开(公告)号：US20220031913A1

公开(公告)日：2022-02-03

申请号：US17377124

申请日：2021-07-15

Applicant: Massachusetts Institute of Technology ,  The Children's Medical Center Corporation

Inventor： Arturo Vegas ,  Joshua C. Doloff ,  Omid Veiseh ,  Minglin Ma ,  Robert S. Langer ,  Daniel G. Anderson

IPC: A61L29/08 ,  A61K47/36 ,  A61K9/48 ,  A61K35/39 ,  C08B37/00 ,  A61K9/00 ,  A61K9/50 ,  A61L31/10 ,  A61L33/08 ,  C07D487/04 ,  C12N5/00 ,  C12N5/071

Abstract: Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for coating of any material where reduced fibrosis is desired, such as encapsulated cells for transplantation and medical devices implanted or used in the body.

公开(公告)号：US20220023602A1

公开(公告)日：2022-01-27

申请号：US17293804

申请日：2019-11-15

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Sahab Babaee ,  Simo Pajovic ,  Ester Caffarel Salvador

IPC: A61M31/00

Abstract: Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.