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366 条记录 (耗时 0.034 秒)

    THERMALLY CONTROLLED RECONFIGURABLE MEDICAL DEVICES
    86.
    发明申请
    THERMALLY CONTROLLED RECONFIGURABLE MEDICAL DEVICES 有权

    公开(公告)号：US20220023602A1

    公开(公告)日：2022-01-27

    申请号：US17293804

    申请日：2019-11-15

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Sahab Babaee ,  Simo Pajovic ,  Ester Caffarel Salvador

    IPC分类号： A61M31/00

    摘要： Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.

    MILLINEEDLE SYSTEMS FOR ESOPHAGEAL DRUG DELIVERY
    87.
    发明申请
    MILLINEEDLE SYSTEMS FOR ESOPHAGEAL DRUG DELIVERY 有权

    公开(公告)号：US20220008701A1

    公开(公告)日：2022-01-13

    申请号：US17293799

    申请日：2019-11-15

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Robert S. Langer ,  Carlo Giovanni Traverso ,  Ester Caffarel Salvador ,  Sahab Babaee ,  Simo Pajovic

    IPC分类号： A61M31/00 ,  A61M37/00

    摘要： Systems and methods related to reconfigurable medical devices are described. In some embodiments, a reconfigurable medical device may include a central core and a plurality of arms. The arms may be rotatably coupled to the central core such that the plurality of arms may rotate outwards away from the central core to selectively reconfigure the reconfigurable device between a retracted configuration and an expanded configuration. In an initial state, the arms may be biased outwards away from the central core into the expanded configuration. When the reconfigurable device is exposed to a temperature greater than a threshold temperature, the arms may be biased towards the central core into the retracted configuration. In some embodiments, a reconfigurable medical device may include therapeutic compound-loaded needles coupled to distal portions of the arms.

    Self-righting articles
    88.
    发明授权
    Self-righting articles 有权

    公开(公告)号：US11179341B2

    公开(公告)日：2021-11-23

    申请号：US16614083

    申请日：2018-05-17

    申请人： Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

    发明人： Carlo Giovanni Traverso ,  Alex G. Abramson ,  Ester Caffarel Salvador ,  Niclas Roxhed ,  Minsoo Khang ,  Taylor Bensel ,  Robert S. Langer

    IPC分类号： A61M5/142 ,  A61M5/158 ,  A61K9/48 ,  A61J3/07 ,  A61K9/00 ,  A61B5/145 ,  A61B10/02 ,  A61M37/00 ,  A61N1/32 ,  A61N1/36 ,  A61M5/20 ,  A61M5/32 ,  A61M31/00 ,  A61K38/28 ,  A61N1/05

    摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

    Gene editing through microfluidic delivery
    90.
    发明授权
    Gene editing through microfluidic delivery 有权

    公开(公告)号：US11125739B2

    公开(公告)日：2021-09-21

    申请号：US15542892

    申请日：2016-01-12

    申请人： Massachusetts Institute of Technology ,  President and Fellows of Harvard College

    发明人： Armon R. Sharei ,  Marc Lajoie ,  Klavs F. Jensen ,  Robert S. Langer

    IPC分类号： C12N15/87 ,  G01N33/50 ,  G01N33/487 ,  C12Q1/00

    摘要： Gene editing can be performed by introducing gene-editing components into a cell by mechanical cell disruption. Related apparatus, systems, techniques, and articles are also described. The methods and systems of the invention solve the problem of intracellular delivery of gene editing components and gene editing complexes to target cells. The results described herein indicate that delivery of gene editing components, e.g., protein, ribonucleic acid (RNA), and deoxyribonucleic acid (DNA), by mechanical disruption of cell membranes leads to successful gene editing. Because intracellular delivery of gene editing materials is a current challenge, the methods provide a robust mechanism to engineer target cells without the use of potentially harmful viral vectors or electric fields.