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403 条记录 (耗时 0.192 秒)

    Prostate specific secreted protein
    81.
    发明授权
    Prostate specific secreted protein 失效
    前列腺特异性分泌蛋白

    公开(公告)号：US06365369B1

    公开(公告)日：2002-04-02

    申请号：US09280839

    申请日：1999-03-30

    申请人： Gregory A. Endress ,  Craig A. Rosen

    发明人： Gregory A. Endress ,  Craig A. Rosen

    IPC分类号： C12P2106

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K2319/00 ,  Y02A50/475

    摘要： The present invention relates to a novel human protein called Prostate Specific Secreted Protein, and isolated polynucleotides encoding this protein. Also provided are vectors, host cells, antibodies, and recombinant methods for producing this human protein. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to this novel human protein.

    摘要翻译： 本发明涉及一种称为前列腺特异性分泌蛋白的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 还提供了用于产生该人蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白相关的疾病的诊断和治疗方法。

    Neutrokine-alpha polypeptides
    82.
    发明授权
    Neutrokine-alpha polypeptides 有权
    中枢神经素α多肽

    公开(公告)号：US06812327B1

    公开(公告)日：2004-11-02

    申请号：US09507968

    申请日：2000-02-22

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： A61K3816

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地提供编码人Neutrokine-α和/或Neutrokine-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 Neutrokine-α和/或Neutrokine-αSV激动剂和Neutrokine-α和/或Neutrokine-αSV活性的拮抗剂。 也生产相同。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Monoclonal antibodies to membrane neutrokine-&agr;
    83.
    发明授权
    Monoclonal antibodies to membrane neutrokine-&agr; 有权
    膜中性粒细胞α的单克隆抗体

    公开(公告)号：US06635482B1

    公开(公告)日：2003-10-21

    申请号：US09589286

    申请日：2000-06-08

    申请人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    发明人： Guo-Liang Yu ,  Reinhard Ebner ,  Jian Ni ,  Craig A. Rosen

    IPC分类号： C12N506

    CPC分类号： C07K16/24 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07H21/04 ,  C07K14/52 ,  C07K14/715 ,  C07K16/2875 ,  C07K2317/34 ,  C07K2317/622 ,  C07K2317/76 ,  G01N33/564 ,  G01N33/6863 ,  G01N2333/52 ,  G01N2500/00 ,  G01N2500/02 ,  G01N2800/245 ,  Y02A50/473

    摘要： The present invention relates to a novel Neutrokine-alpha, and a splice variant thereof designated Neutrokine-alphaSV, polynucleotides and polypeptides which are members of the TNF family. In particular, isolated nucleic acid molecules are provided encoding the human Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides, including soluble forms of the extracellular domain. Neutrokine-alpha and/or Neutrokine-alphaSV polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of Neutrokine-alpha and/or Neutrokine-alphaSV activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

    摘要翻译： 本发明涉及一种新的Neutrokine-α及其剪接变体，其命名为Neutrokine-αSV，作为TNF家族成员的多核苷酸和多肽。 特别地，提供编码人Neutrokine-α和/或中枢神经素-αSV多肽的分离的核酸分子，包括细胞外结构域的可溶形式。 还提供了中和型α和/或中枢神经素αSV多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明进一步涉及用于鉴定中和性α和/或中枢神经素αSV活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。

    Method of inhibiting human G-protein chemokine receptor (CCR5) HDGNR10
    86.
    发明授权
    Method of inhibiting human G-protein chemokine receptor (CCR5) HDGNR10 有权
    抑制人G蛋白趋化因子受体（CCR5）HDGNR10的方法

    公开(公告)号：US07862818B2

    公开(公告)日：2011-01-04

    申请号：US11626244

    申请日：2007-01-23

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： A61K39/395 ,  A61K31/00

    CPC分类号： C07K14/7158 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/505 ,  C07K16/24 ,  C07K16/2866 ,  C07K2319/00 ,  C12N2799/026

    摘要： The present invention relates to a novel human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this novel human protein and these novel human antibodies.

    摘要翻译： 本发明涉及一种称为人G蛋白趋化因子受体（CCR5）HDGNR10的新型人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该新型人蛋白质和这些新型人抗体相关的疾病，病症和/或病症的诊断和治疗方法。

    Albumin fusion proteins
    89.
    发明授权
    Albumin fusion proteins 有权
    白蛋白融合蛋白

    公开(公告)号：US07569384B2

    公开(公告)日：2009-08-04

    申请号：US11500508

    申请日：2006-08-08

    申请人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben

    发明人： Craig A. Rosen ,  William A. Haseltine ,  Steven M. Ruben

    IPC分类号： C12N15/62 ,  C12N15/70 ,  C12N15/79 ,  C12N15/81 ,  C12N15/85

    CPC分类号： C07K14/765 ,  A61K38/00 ,  C07K2319/31 ,  C07K2319/35 ,  C12N15/62

    摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.

    摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

    Human G-protein chemokine receptor (CCR5) HDGNR10
    90.
    发明授权
    Human G-protein chemokine receptor (CCR5) HDGNR10 有权
    人类G蛋白趋化因子受体（CCR5）HDGNR10

    公开(公告)号：US07501123B2

    公开(公告)日：2009-03-10

    申请号：US11518949

    申请日：2006-09-12

    申请人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    发明人： Viktor Roschke ,  Craig A. Rosen ,  Steven M. Ruben

    IPC分类号： C07K16/28 ,  C07K14/705

    CPC分类号： C07K16/2866 ,  C07K14/7158 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/30 ,  G01N2333/715

    摘要： The present invention relates to a human protein called Human G-protein Chemokine Receptor (CCR5) HDGNR10, and isolated polynucleotides encoding this protein. The invention is also directed to human antibodies that bind Human G-protein Chemokine Receptor (CCR5) HDGNR10 and to polynucleotides encoding those antibodies. Also provided are vectors, host cells, antibodies, and recombinant methods for producing Human G-protein Chemokine Receptor (CCR5) HDGNR10 and human anti-Human G-protein Chemokine Receptor (CCR5) HDGNR10 antibodies. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to this human protein and these human antibodies.

    摘要翻译： 本发明涉及称为人G蛋白趋化因子受体（CCR5）HDGNR10的人类蛋白质，以及编码该蛋白质的分离的多核苷酸。 本发明还涉及结合人G蛋白趋化因子受体（CCR5）HDGNR10的人抗体和编码那些抗体的多核苷酸。 还提供了用于产生人G蛋白趋化因子受体（CCR5）HDGNR10和人抗人G蛋白趋化因子受体（CCR5）HDGNR10抗体的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与该人类蛋白质和这些人抗体相关的疾病，病症和/或病症的诊断和治疗方法。