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81.发明授权
公开(公告)号：US4768507A
公开(公告)日：1988-09-06
申请号：US93110
申请日：1987-08-31
CPC分类号： A61F2/958 , A61F2/82 , A61F2/88 , A61F2/95 , A61L31/084 , A61L31/10 , A61F2/0077 , A61F2002/9665 , A61F2210/0076
摘要： This invention is in the field of percutaneous insertion catheters that are used for placing a coil spring stent into a vessel of a living body for the purposes of enhancing luminal dilation, preventing arterial restenosis and preventing vessel blockage resulting from intimal dissection following balloon and other methods of angioplasty. The stent can also be used for the maintaining patency of many different ducts or vessels within a living body.
摘要翻译： 本发明涉及经皮插入导管领域，其用于将螺旋弹簧支架放置在生物体的容器中，目的是增加腔内扩张，防止动脉再狭窄，并防止气囊和其他方法后的内膜解剖引起的血管阻塞 的血管成形术。 支架还可用于维持生物体内许多不同导管或血管的通畅。
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公开(公告)号：US07494458B2
公开(公告)日：2009-02-24
申请号：US11974712
申请日：2007-10-15
IPC分类号： A61N2/04
CPC分类号： A61N2/02
摘要： Disclosed is a system and method for treating headaches. The system employs a self-contained, battery operated, readily portable and easy-to-operate head-mounted magnetic depolarizer to generate a transient or time-varying high-intensity magnetic field into and around the user's head or neck. The magnetic depolarizer system can be used to depolarize the neurons of the brain and/or the trigeminal nerve. This type of neuronal depolarization has the capability for terminating migraine or other types of headaches.
摘要翻译： 公开了一种治疗头痛的系统和方法。 该系统采用独立的电池供电，易于携带和易于操作的头戴磁性去极化器，以在用户的头部或颈部内和周围产生瞬时或时变的高强度磁场。 磁去极化系统可用于去极化脑和/或三叉神经的神经元。 这种类型的神经元去极化具有终止偏头痛或其他类型头痛的能力。
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公开(公告)号：US06427086B1
公开(公告)日：2002-07-30
申请号：US09557168
申请日：2000-04-21
申请人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
发明人： Robert E. Fischell , David R. Fischell , Adrian R. M. Upton , Dennis R. Potts , Benjamin D. Pless
IPC分类号： A61N136
CPC分类号： A61B5/6814 , A61B5/0476 , A61B5/4094 , A61N1/36017 , A61N1/36025 , A61N1/3605 , A61N1/36064 , A61N1/37235
摘要： Disclosed is a means and method for placing an implantable neurostimulator control module into a place in the cranium where cranial bone has been removed. The method for accomplishing this cranial implantation is by first removing a patient's hair over the site of the implant, then cutting the scalp at that site and pulling it back to expose the cranium. A neurosurgeon would then remove a portion of the cranial bone to accept a control module to be implanted within that hole. The control module would then be placed into that hole. It is also conceived that the control module would be fixed in place by the use of one or more attachment devices such as a multiplicity of bone screws placed through holes in one or more flanges that extend over the cranium beyond the control module. The implantation could also include a fairing placed around the control module to provide a smooth contour under the patient's scalp. Also described is a spacer shim placed under the flange(s) to adjust the position of the control module so that its bottom surface does not put pressure on the dura mater lying directly over the brain tissue at the bottom of the hole. It is also envisioned that a resorbable disk could be placed under the bottom surface of the control module to further protect the brain and/or to elute an anti-biotic or anti-inflammatory substance to reduce the possibility of infection and/or inflammation.
摘要翻译： 公开了一种用于将可植入的神经刺激器控制模块放置在颅骨已被移除的头颅中的位置的手段和方法。 完成这种颅骨植入的方法是首先将患者的头发去除植入物的部位，然后在该部位切割头皮并将其拉回以暴露颅骨。 然后，神经外科医生将去除颅骨的一部分以接受待植入该孔内的控制模块。 然后将控制模块放入该孔中。 还可以想到，控制模块将通过使用一个或多个附接装置固定在适当的位置，例如通过一个或多个凸缘中的孔布置的多个骨螺钉，所述多个骨螺钉在颅骨上延伸超过控制模块。 植入还可以包括放置在控制模块周围的整流罩，以在患者的头皮下面提供平滑的轮廓。 还描述了放置在凸缘下方的间隔垫片，以调节控制模块的位置，使得其底部表面不对直接位于孔底部的脑组织的硬脑膜施加压力。 还可以设想，可再吸收的盘可以放置在控制模块的底表面下方以进一步保护大脑和/或洗脱抗生素或抗炎物质以减少感染和/或炎症的可能性。
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84.发明授权EEG d-c voltage shift as a means for detecting the onset of a neurological event 失效EEG d-c电压偏移作为检测神经系统事件发作的手段
公开(公告)号：US6061593A
公开(公告)日：2000-05-09
申请号：US65739
申请日：1998-04-24
IPC分类号： A61N1/36 , A61D5/0476
CPC分类号： A61B5/0476 , A61B5/4094 , A61B5/6814 , A61N1/3605 , A61N1/36025 , A61N1/36082 , A61N1/37211
摘要： Disclosed herein is a multiple electrode, closed-loop system for the treatment of certain neurological disorders such as epilepsy, migraine headaches and Parkinson's disease. Specifically, the present invention combines a multi-electrode array with sophisticated signal processing techniques to achieve reliable detection of the onset of a neurological event (such as an epileptic seizure or migraine headache) typically originating from a focus of limited spatial extent within the brain. It is highly desirable to detect an epileptic seizure at least 5 seconds before the onset of clinical symptoms. Since there is often a d-c shift in the EEG voltage more than 5 seconds before the seizure, disclosed herein is a means for utilizing the d-c shift of the EEG for early detection of the seizure.
摘要翻译： 本文公开了用于治疗某些神经障碍如癫痫，偏头痛和帕金森病的多电极闭环系统。 具体地，本发明将多电极阵列与复杂的信号处理技术相结合，以实现通常来自脑内有限空间范围内的焦点的神经系统事件（例如癫痫发作或偏头痛头痛）的发作的可靠检测。 在临床症状发作前至少5秒检测癫痫发作是非常需要的。 由于在癫痫发作前超过5秒脑电图经常发生d-c偏移，所以这里公开了利用脑电图的d-c位移来早期检测癫痫发作的手段。
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公开(公告)号：US5938689A
公开(公告)日：1999-08-17
申请号：US70974
申请日：1998-05-01
CPC分类号： A61N1/0529 , A61N1/0534 , A61N1/36185 , A61N1/36064 , A61N1/36075
摘要： Disclosed herein are several unique configurations of electrodes for stimulation of brain tissue. Specifically, a configuration of electrodes is disclosed that has at least one electrode on the brain's surface and at least one additional electrode located deep within the tissue of the brain. It is envisioned that all such electrodes would be located in close proximity to a particular region of the brain such as an epileptic focus. It is further envisioned that several brain surface electrodes would be used in conjunction with several deep brain electrodes. Specifically, it is envisioned that all surface electrodes would be electrically joined together and all deep electrodes would be electrically joined together. In this way, when a source of electrical current is connected to those electrodes, a particular region of the brain could be surrounded by a "curtain" of electrical current that can be used to depolarize neurons at the perimeter of the region so as to prevent any electrical signal originating in that region from being transmitted beyond that region to the rest of the brain. Sub-surface electrodes placed between 1 and 10 mm below the brain's surface could also be used with either brain surface electrodes or deep brain electrodes.
摘要翻译： 本文公开了用于刺激脑组织的电极的几种独特配置。 具体地，公开了在脑的表面上具有至少一个电极和位于脑的组织内的至少一个另外的电极的电极的构造。 可以设想，所有这样的电极将位于紧邻脑的特定区域，例如癫痫焦点。 进一步设想，几个脑表面电极将与几个深层脑电极结合使用。 具体地，可以想象所有的表面电极将被电连接在一起，并且所有的深电极将被电连接在一起。 以这种方式，当电流源连接到那些电极时，脑的特定区域可以被电流的“窗帘”所包围，可以用于在该区域的周边去极化神经元，以防止 源自该区域的任何电信号都不会传播到超出该区域的大脑的其余部分。 放置在脑表面下方1至10毫米之间的子表面电极也可用于脑表面电极或深脑电极。
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公开(公告)号：US08454677B2
公开(公告)日：2013-06-04
申请号：US12007289
申请日：2008-01-09
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2002/91525 , A61F2002/91541 , A61F2002/91558 , A61F2002/91583 , A61F2210/0076 , A61F2230/0013 , A61F2250/0032 , A61F2250/0036 , A61F2250/0098
摘要： A stent in the form of a thin-walled, multi-cellular tubular structure is provided. The tubular structure has a longitudinal axis and the stent includes a plurality of circumferential sets of strut members. Each set of the strut members is longitudinally displaced from each other and connected to each other by longitudinally extending links. Each set of the strut members forms a closed and cylindrical portion of the stent. Further, each set of the strut members includes a plurality of connected curve sections and diagonal sections. The sets of the strut members further include end sets of strut members located at each end of the stent and central sets of strut members located between the end sets of the strut members. The diagonal sections of the end sets of the strut members have a center portion and two ends.
摘要翻译： 提供了薄壁多孔管状结构形式的支架。 管状结构具有纵向轴线，并且支架包括多个圆周组的支柱构件。 每组支柱构件彼此纵向移位并通过纵向延伸的连杆相互连接。 每组支柱构件形成支架的闭合和圆柱形部分。 此外，每组支柱构件包括多个连接的曲线部分和对角线部分。 支柱构件的组还包括位于支架的每个端部处的支柱构件的端组和位于支柱构件的端部组之间的支柱构件的中心组。 支柱构件的端部组的对角部分具有中心部分和两端。
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公开(公告)号：US08244338B2
公开(公告)日：2012-08-14
申请号：US12320948
申请日：2009-02-10
IPC分类号： A61B5/0402
CPC分类号： A61B5/0472 , A61B5/0006 , A61B5/0031 , A61B5/02405 , A61B5/02455 , A61B5/04012 , A61B5/042 , A61B5/0432 , A61B5/044 , A61B5/0452 , A61B5/413 , A61B5/686 , A61B5/746 , A61N1/025 , A61N1/37211 , A61N1/37247
摘要： A system for cardiac event detection over varying time scales includes implanted electrical leads forming a portion of an implanted cardiotracker and external equipment including external alarm mechanisms and a physicians programmer. The cardiac event detection system monitors the degradation of a patient's cardiovascular condition from one or more causes. A processor computes the electrical signals of a heart signal parameter's average value over a time period for a multiplicity of heart rate ranges. The electrical signals are stored and information transmitted to external equipment.
摘要翻译： 用于在不同时间尺度上进行心脏事件检测的系统包括形成植入式心脏呼吸器的一部分的植入电引线和包括外部警报机构和医生程序员的外部设备。 心脏事件检测系统从一个或多个原因监测患者心血管疾病的恶化。 处理器在多个心率范围内计算心脏信号参数在一段时间内的平均值的电信号。 电信号被存储，信息传输到外部设备。
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公开(公告)号：US20120158116A1
公开(公告)日：2012-06-21
申请号：US12969134
申请日：2010-12-15
CPC分类号： A61F2/958 , A61F2/915 , A61F2/962 , A61F2002/91575 , A61F2002/9522 , A61F2002/9583 , A61L31/02 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/416 , Y10T29/49826 , Y10T29/49888 , Y10T29/49913
摘要： A balloon disposed near a distal end of the catheter tubing and moving between deflated and inflated states, and proximal and distal stent retention bands concentrically arranged around respective proximal and distal end portions of the balloon. The proximal stent retention band has a distal end located within 2 mm of the proximal end of a stent coaxially received by the balloon and the distal stent retention band has a largest diameter within 2 mm of the distal end of the stent received by the balloon.
摘要翻译： 设置在导管管的远端附近并在放气和膨胀状态之间移动的气囊，以及同心地布置在气囊的相应近端部分和远端部分的近端和远端支架保持带。 近端支架保持带的远端位于由球囊同轴接收的支架的近端的2mm内，并且远侧支架保持带具有由球囊接收的支架远端的2mm内的最大直径。
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公开(公告)号：US08080052B2
公开(公告)日：2011-12-20
申请号：US10185250
申请日：2002-06-28
申请人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
发明人： Robert Burgermeister , David C. Majercak , David R. Fischell , Hikmat Hojeibane , Robert E. Fischell
IPC分类号： A61F2/82
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2230/0013
摘要： The present invention envisions an improved flexible connecting link used in conjunction with in-phase and half-phase circumferential sets of strut members. By increasing the total length and diagonality of the undulating connecting links, the present invention is a stent that provides increased flexibility during delivery and enhanced conformability to the shape of a curved artery when the stent is deployed into a curved vessel such as a tortuous coronary artery.
摘要翻译： 本发明设想了一种改进的柔性连接链节，其与支柱构件的同相和半相周向组合一起使用。 通过增加起伏的连接链节的总长度和对角线，本发明是一种支架，其在输送期间提供增加的灵活性，并且当支架部署到诸如曲折冠状动脉的弯曲容器时对弯曲动脉的形状具有增强的适应性 。
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公开(公告)号：US08024028B2
公开(公告)日：2011-09-20
申请号：US12379627
申请日：2009-02-26
IPC分类号： A61B5/04
CPC分类号： A61N1/37235 , A61B5/0031 , A61B5/0452 , A61B5/0472 , A61B5/413 , A61N1/025 , A61N1/37247
摘要： Disclosed is a “tracker system” that includes implanted electrical leads which are part of an implanted cardiotracker plus external equipment that includes external alarm means and a physician's programmer. The tracker system is designed to monitor the degradation of a patient's cardiovascular condition from one or more causes. These causes include the rejection of a transplanted heart and/or the progression of a stenosis in a coronary artery. As one or more stenoses in a coronary artery become progressively more narrow thereby causing reduced blood flow to the heart muscle coronary circulation, the tracker system can alert the patient by either or both internal and/or external alarm means to take the appropriate medical action. The physician's programmer can be used to display histograms of key heart signal parameters that are indicative of the patient's cardiovascular condition.
摘要翻译： 公开了一种“跟踪器系统”，其包括植入的电引线，其是植入式心脏病治疗仪的一部分以及包括外部警报装置和医师程序员的外部设备。 跟踪器系统被设计成从一个或多个原因监测患者的心血管疾病的恶化。 这些原因包括移植心脏的排斥和/或冠状动脉狭窄进展。 由于冠状动脉中的一个或多个狭窄变得越来越窄，从而导致血液流向心脏肌肉冠状动脉循环的减少，所以跟踪器系统可以通过内部和/或外部报警装置中的一个或两个来警告患者以采取适当的医疗行动。 医师的程序员可用于显示指示患者心血管疾病的关键心脏信号参数的直方图。
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