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155 条记录 (耗时 0.047 秒)

    Drug-eluting stent cover and method of use
    81.
    发明申请
    Drug-eluting stent cover and method of use 有权
    药物洗脱支架盖及使用方法

    公开(公告)号：US20060271165A1

    公开(公告)日：2006-11-30

    申请号：US11497652

    申请日：2006-08-01

    申请人： Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

    发明人： Philip Yip ,  James Jacobs ,  Syed Hossainy ,  Jon Becker ,  Timothy Limon

    IPC分类号： A61F2/90

    CPC分类号： A61F2/91 ,  A61F2/90 ,  A61F2/915 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2250/0036 ,  A61F2250/0067 ,  A61F2250/0071 ,  Y10S623/903

    摘要： An intravascular stent includes an eluting sheath fabricated from a mesh for controlled release of therapeutic drugs and for delivery of the therapeutic drugs in localized drug therapy in a blood vessel. The eluting sheath is attached to at least a portion of an outside surface area of the stent structure and is fabricated from a mesh designed to neck down in response to a radially outward directed force resulting in the uniform expansion of the stent. The eluting sheath can be loaded with at least one therapeutic drug for the release thereof at a treatment site to facilitate repair of a damaged vessel. The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial strength sufficient to hold open an artery or other body lumen.

    摘要翻译： 血管内支架包括由用于控制释放治疗药物的网格和用于在血管中局部药物治疗中递送治疗药物的筛网制成的洗脱鞘。 洗脱鞘附着到支架结构的外表面区域的至少一部分上，并且由设计成颈部向下的网眼制成，以响应径向向外的力而导致支架的均匀膨胀。 洗脱鞘可以装载至少一种用于在治疗部位释放的治疗药物，以便于修复受损血管。 支架在纵向具有高度的柔性，但具有足够的容器壁覆盖和径向强度足以保持打开动脉或其他体腔。

    Concentration gradient profiles for control of agent release rates from polymer matrices
    82.
    发明申请
    Concentration gradient profiles for control of agent release rates from polymer matrices 审中-公开
    用于控制聚合物基质的试剂释放速率的浓度梯度曲线

    公开(公告)号：US20060246109A1

    公开(公告)日：2006-11-02

    申请号：US11119020

    申请日：2005-04-29

    申请人： Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

    发明人： Syed Hossainy ,  Fuh-Wei Tang ,  Andrew McNiven ,  Joseph Eppert ,  Gregory Kevorkian

    IPC分类号： A61F2/00

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/604 ,  A61L2300/606

    摘要： The present invention generally encompasses the control of the release rate of agents from a polymeric matrix. This control over the release rate of agents provides for control over, inter alia, the therapeutic, prophylactic, diagnostic, and ameliorative effects that are realized by a patient in need of such treatment. In addition, the control of the release rate of agents also has an effect upon the mechanical integrity of the polymeric matrix, as well as a relationship to a subject's absorption rate of the absorbable polymers.

    摘要翻译： 本发明通常包括对来自聚合物基质的试剂的释放速率的控制。 这种对药剂释放速率的控制提供了对需要这种治疗的患者实现的治疗，预防，诊断和改善效果的控制。 此外，试剂的释放速率的控制也对聚合物基质的机械完整性以及与受试者吸收聚合物的吸收速率的关系有影响。