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    Depot formulations
    82.
    发明授权
    Depot formulations 失效
    储备制剂

    公开(公告)号：US5629287A

    公开(公告)日：1997-05-13

    申请号：US424582

    申请日：1995-04-17

    申请人： Robert Brown ,  Gordon Blun

    发明人： Robert Brown ,  Gordon Blun

    IPC分类号： A61K38/18 ,  A61L26/00 ,  A61K38/16

    CPC分类号： A61L26/0066 ,  A61K38/18 ,  A61K38/39 ,  A61L26/0042 ,  A61L26/0047 ,  A61L26/0052 ,  A61L2300/414

    摘要： A depot formulation comprising fibronectin or a fragment thereof, a growth factor binding agent linked thereto and growth factor bound to the binding agent is used to promote wound healing in combination with macroscopically oriented cell adhesion proteins, the depot formulations allow the healing process to be directed to afford stronger or more cosmetically acceptable results.

    摘要翻译： 包含纤维连接蛋白或其片段，与其连接的生长因子结合剂和与结合剂结合的生长因子的贮库制剂用于与宏观取向的细胞粘附蛋白结合促进伤口愈合，所述贮库制剂允许愈合过程被引导 提供更强或更美观的结果。

    Gel forming system for use as wound dressings
    83.
    发明授权
    Gel forming system for use as wound dressings 失效
    凝胶成型系统，用作伤口敷料

    公开(公告)号：US5578661A

    公开(公告)日：1996-11-26

    申请号：US221159

    申请日：1994-03-31

    申请人： Adrian S. Fox ,  Amy E. Allen

    发明人： Adrian S. Fox ,  Amy E. Allen

    IPC分类号： A61L15/22 ,  A61L15/60 ,  A61L26/00 ,  C08L71/02 ,  C08L5/00 ,  C08L39/06

    CPC分类号： A61L26/008 ,  A61L15/225 ,  A61L15/60 ,  A61L26/0052 ,  C08L71/02 ,  Y10S514/944

    摘要： A gel forming system comprising an aqueous mixture of a first component of at least one water-soluble polymer in an amount sufficient to increase the initial viscosity of the mixture and impart adhesivity properties thereto; a second component of a acid-containing polymer; a third component of an amino-containing polymer; and water. This system has a pH in the range of between about 5.5 and 8.5 and the second and third components are each present in sufficient amounts which, in combination, increase the cohesiveness of the mixture over time, such that the mixture can be initially combined in a relatively fluid state and subsequently forms a cohesive gel structure. This system is useful as a wound dressing for deep wound cavities because the gel protects the wound and permits healing, does not interfere with new tissue growth or development, is capable of absorbing significant amounts of wound exudate, and has sufficient cohesive strength for subsequent removal from the cavity as an integral plug without interrupting the healing process.

    摘要翻译： 一种凝胶形成系统，其包含至少一种水溶性聚合物的第一组分的水混合物，其量足以增加混合物的初始粘度并赋予其粘合性; 含酸聚合物的第二组分; 含氨基聚合物的第三组分; 和水。 该系统的pH值在约5.5至8.5之间，第二和第三组分各自以足够的量存在，其组合可以增加混合物随时间的凝聚性，使得混合物可以最初组合成 相对流体状态，随后形成凝聚凝胶结构。 该系统可用作深伤口腔的创伤敷料，因为凝胶保护伤口并允许愈合，不干扰新组织生长或发育，能够吸收大量的伤口渗出物，并具有足够的内聚强度用于随后的去除 从腔中作为整体插头，而不会中断愈合过程。

    Cross-linked hydrogels and their use as wound dressings
    85.
    发明授权
    Cross-linked hydrogels and their use as wound dressings 失效
    交联水凝胶及其作为伤口敷料的用途

    公开(公告)号：US5336501A

    公开(公告)日：1994-08-09

    申请号：US875488

    申请日：1992-04-29

    申请人： Zbigniew Czech ,  Kurt Seeger

    发明人： Zbigniew Czech ,  Kurt Seeger

    IPC分类号： A61L15/16 ,  A61K9/70 ,  A61L15/00 ,  A61L15/24 ,  A61L15/28 ,  A61L15/32 ,  A61L26/00 ,  A61K9/10 ,  A61F13/02 ,  A61K47/10

    CPC分类号： A61L26/008 ,  A61L26/0052 ,  Y10S514/801

    摘要： The invention relates to a wound secretion absorbing hydrogel of the following composition:______________________________________ a) 20 to 70%-wt of at least one multivalent alcohol b) 10 to 35%-wt of at least one natural thickener (biopolymer) c) 0.05 to 12%-wt of at least one uncross-linked copolymer of one or more vinylcar- boxylic acids and their salts (syn- thetic polymer) d) 0.05 to 10%-wt of a cross-linking agent e) 0 to 50%-wt of a water or physiological saline ______________________________________ as well as to the use of this hydrogel as wound dressing.

    摘要翻译： 本发明涉及以下组合物的伤口分泌物吸收水凝胶：-a）20至70重量％的至少一种多价醇-b）10至35重量％的至少一种天然增稠剂 - （生物聚合物）-c ）0.05至12重量％的至少一种一种或多种乙烯基羧酸与其盐的交联共聚物（合成聚合物）-d）0.05至10重量％的交联剂 -e）0至50重量％的水或生理盐水，以及使用该水凝胶作为伤口敷料。

    Method of making a hydrogel-forming wound dressing or skin coating material
    86.
    发明授权
    Method of making a hydrogel-forming wound dressing or skin coating material 失效
    制造水凝胶形成伤口敷料或皮肤涂层材料的方法

    公开(公告)号：US5013769A

    公开(公告)日：1991-05-07

    申请号：US475884

    申请日：1990-02-06

    申请人： Douglas G. Murray ,  Dennis C. Smith ,  James E. Guillet

    发明人： Douglas G. Murray ,  Dennis C. Smith ,  James E. Guillet

    IPC分类号： A61L26/00 ,  C08L39/06 ,  C08L71/02 ,  C08L89/06 ,  C09D133/02

    CPC分类号： A61L26/008 ,  A61L26/0052 ,  C09D133/02 ,  C08L39/06 ,  C08L71/02 ,  C08L89/06

    摘要： The invention disclosed is a hydrogel-forming wound dressing or skin coating material suitable for household and veterinary use, consisting substantially entirely of wound-compatible and skin-compatible ingredients and comprising a first hydrophilic polymer, selected from polymers or copolymers of acrylic acid, polymers or copolymers of methacrylic acid, polymers or copolymers of itaconic acid, polymers or copolymers of maleic acid and polymers or copolymers of 3-butene-1,2,3-tricarboxylic acid, or combinations thereof, a second hydrophilic polymer which is capable of interacting with the first polymer to produce, upon drying, a hydrogel of improved water resistance and film forming properties relative to the first polymer alone and water. This material is film forming and substantially transparent but capable of being made opaque.

    摘要翻译： 所公开的本发明是适用于家庭和兽医用途的水凝胶形成伤口敷料或皮肤涂层材料，其基本上完全由伤口相容和皮肤相容的成分组成，并且包含第一亲水性聚合物，其选自丙烯酸的聚合物或共聚物，聚合物 或甲基丙烯酸的共聚物，衣康酸的聚合物或共聚物，马来酸的聚合物或共聚物和3-丁烯-1,2,3-三羧酸的聚合物或共聚物或其组合，能够相互作用的第二亲水聚合物 其中第一聚合物在干燥时产生相对于单独的第一聚合物和水的改善的耐水性和成膜性能的水凝胶。 这种材料是成膜的并且基本上是透明的，但是可以使其变得不透明。