公开(公告)号：US20110149292A1

公开(公告)日：2011-06-23

申请号：US12737902

申请日：2009-08-31

Applicant: Michael Himmelhaus

Inventor： Michael Himmelhaus

IPC: G01J3/45 ,  G01B9/02

CPC classification number: G01N21/7746 ,  G01J3/02 ,  G01J3/0205 ,  G01J3/45 ,  G01N21/45 ,  G01N2021/7779

Abstract: A system for analyzing optical cavity modes of at least one microcavity or at least one cluster of microcavities, comprises, an apparatus for sensing a change in the condition of or for analyzing the optical cavity modes by utilizing an optical interference of the optical cavity modes.

Abstract translation: 一种用于分析至少一个微腔或至少一个微腔群的光学腔模的系统，包括：用于通过利用所述光腔模的光学干涉来感测所述光腔模式的状态的变化或用于分析所述光腔模式的装置。

公开(公告)号：US20110058180A1

公开(公告)日：2011-03-10

申请号：US12877888

申请日：2010-09-08

Applicant: Diaa A. Khalil ,  Bassem Mortada ,  Mohamed Nabil ,  Mostafa Medhat ,  Bassam A. Saadany

Inventor： Diaa A. Khalil ,  Bassem Mortada ,  Mohamed Nabil ,  Mostafa Medhat ,  Bassam A. Saadany

IPC: G01B9/02

CPC classification number: G01J3/4532 ,  G01J3/02 ,  G01J3/021 ,  G01J3/45

Abstract: A Micro Electro-Mechanical System (MEMS) spectrometer architecture compensates for verticality and dispersion problems using balancing interfaces. A MEMS spectrometer/interferometer includes a beam splitter formed on a first surface of a first medium at an interface between the first medium and a second medium, a first mirror formed on a second surface of the first medium, a second mirror formed on a third surface of the first medium and balancing interfaces designed to minimize both a difference in tilt angles between the surfaces and a difference in phase errors between beams reflected from the first and second mirrors.

Abstract translation: 微机电系统（MEMS）光谱仪架构使用平衡接口补偿垂直度和色散问题。 MEMS光谱仪/干涉仪包括在第一介质和第二介质之间的界面处形成在第一介质的第一表面上的分束器，形成在第一介质的第二表面上的第一反射镜，形成在第三介质上的第三反射镜 第一介质的表面和平衡界面被设计成最小化表面之间的倾斜角的差异以及从第一和第二反射镜反射的光束之间的相位误差。

公开(公告)号：US07869050B2

公开(公告)日：2011-01-11

申请号：US12540986

申请日：2009-08-13

Applicant: George G. He ,  Diane E. Deterline

Inventor： George G. He ,  Diane E. Deterline

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/0264

Abstract: A method for determining a background noise level includes receiving interferogram data; determining at least one measure of interferogram quality; accumulating said received interferogram data; and generating a background noise level based on said interferogram data and at least one measure of interferogram quality.

Abstract translation: 一种用于确定背景噪声电平的方法包括：接收干涉图数据; 确定干涉图质量的至少一个度量; 累积所述接收的干涉图数据; 以及基于所述干涉图数据和干涉图质量的至少一个度量产生背景噪声电平。

公开(公告)号：US20100315632A1

公开(公告)日：2010-12-16

申请号：US12813262

申请日：2010-06-10

Applicant: James F. Brennan, III

Inventor： James F. Brennan, III

IPC: G01J3/44 ,  G01J3/45

CPC classification number: G01J3/44 ,  A61B5/0066 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0086 ,  A61B5/02007 ,  A61B5/6852 ,  A61B5/6858 ,  G01J3/0205 ,  G01J3/0218 ,  G01J3/45 ,  G01N21/4795 ,  G01N21/65

Abstract: The present invention provides apparatuses and methods for sample analysis, such as tissue analysis, that integrate high wavenumber (HW) Raman spectroscopy for chemical composition analysis and spectral-domain optical coherence tomography (SD-OCT) to provide depth and morphological information. Intravascular catheter embodiments and related vascular diagnostic methods are also provided.

Abstract translation: 本发明提供用于化学成分分析的高波数（HW）拉曼光谱和光谱相干光谱相干断层扫描（SD-OCT）的样品分析等组织分析的装置和方法，以提供深度和形态信息。 还提供了血管内导管实施例和相关的血管诊断方法。

公开(公告)号：US20100290053A1

公开(公告)日：2010-11-18

申请号：US12466161

申请日：2009-05-14

Applicant: Ian S. Robinson

Inventor： Ian S. Robinson

IPC: G01J3/45 ,  G01B9/02

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/0278 ,  G01J3/28 ,  G01J3/4535

Abstract: A sensor and method for remotely determining a presence of a particular substance based on spectral data of the particular substance is disclosed. The sensor includes a sampling module configured to detect radiation from a particular substance using an interferometer, wherein the sampling module includes a control module that is configured to guide and measure spacing of samples taken by the sampling module; a focal plane module configured to detect and convert an interference pattern produced by the interferometer into a series of digital samples; a reference spectra modification module configured to modify reference spectra by modifying according to the measured spacing of samples and an instrument line shape of the sampling module; an estimation module configured to receive the converted series of digital samples and transform the non-uniformly spaced digital samples into frequency space using band centers determined from reference spectra as modified by the instrument line shape of the sampling module; a comparison module configured to compare the transformed digital samples against a database of known chemical signatures; and a determination module configured to determine the presence of the particular substance based on the results of the comparison.

Abstract translation: 公开了一种用于基于特定物质的光谱数据远程确定特定物质的存在的传感器和方法。 所述传感器包括被配置为使用干涉仪来检测来自特定物质的辐射的采样模块，其中所述采样模块包括控制模块，所述控制模块被配置为引导并测量由所述采样模块采集的采样的间隔; 焦平面模块，其被配置为检测并将由所述干涉仪产生的干涉图案转换成一系列数字样本; 参考光谱修改模块，被配置为通过根据样本的测量间距和采样模块的仪器线形状修改来修改参考光谱; 估计模块，被配置为接收经转换的一系列数字样本，并且使用由采样模块的仪器线形修改的参考光谱确定的频带中心将非均匀间隔的数字样本转换成频率空间; 比较模块，被配置为将经转换的数字样本与已知化学特征数据库进行比较; 以及确定模块，其被配置为基于所述比较的结果来确定所述特定物质的存在。

公开(公告)号：US20100280321A1

公开(公告)日：2010-11-04

申请号：US12661829

申请日：2010-03-24

Applicant: Mark D. Modell

Inventor： Mark D. Modell

IPC: A61B1/06

CPC classification number: G01B9/02097 ,  A61B5/0066 ,  A61B5/6852 ,  G01B9/02091 ,  G01J3/45

Abstract: Light is collected from a sample that is to be imaged, such as tissue or the like, and made to undergo self-interference, e.g., on a detector. An imaging system may include a low coherence light source arranged for illuminating the sample, and an interferometer arranged to receive the light collected from the sample and to pass it to a detector. The interferometer includes a beam divider that directs the radiation collected from the sample along two paths, phase-delaying one beam relative to another and then recombining the beams on a detector. A processor may be coordinated with the phase delay and in some embodiments with spatial scanning or detector array addresses, and operates on the signal from the detector to form a tomographic image of the sample illuminated tissue. By constructing an image based upon interference the interferometric signal from of the split and then recombined radiation collected from the sample signal, rather than interference of a source reference and a return signal, the invention is able to image with light naturally emitted by the sample. , or with wavelength-shifted, delayed or induced light signals of different types, allowing new modalities of diagnostic and other imaging of the sample and its structure. A processor generates one or more images of the structure being viewed, and may create images in registry from different (for example, close but separable) wavelengths. Some systems may operate without an illumination source or may apply other stimuli to evoke emission from the sample.

Abstract translation: 从要成像的样品（例如组织等）收集光，并使其经受自干扰，例如在检测器上。 成像系统可以包括布置成照亮样本的低相干光源和布置成接收从样品收集的光并将其传递到检测器的干涉仪。 该干涉仪包括一个光束分离器，其引导从两个路径收集的样本的辐射，相对于另一个相位延迟一个光束，然后在检测器上重新组合光束。 处理器可以与相位延迟协调，并且在一些实施例中与空间扫描或检测器阵列地址协调，并且对来自检测器的信号进行操作以形成样本照射的组织的断层图像。 通过基于干扰构建来自采样信号收集的分离干扰信号的干涉信号，而不是源参考和返回信号的干扰，本发明能够利用样品自然发射的光进行成像。 ，或具有不同类型的波长偏移，延迟或感应光信号，允许样本的诊断和其他成像的新形式及其结构。 处理器生成正在观看的结构的一个或多个图像，并且可以从不同的（例如，接近但可分离的）波长创建注册表中的图像。 一些系统可以在没有照明源的情况下操作，或者可以应用其他刺激来引起来自样品的发射。

公开(公告)号：US07643952B2

公开(公告)日：2010-01-05

申请号：US11396935

申请日：2006-04-03

Applicant: Aydogan Ozcan ,  Michel J. F. Digonnet ,  Gordon S. Kino

Inventor： Aydogan Ozcan ,  Michel J. F. Digonnet ,  Gordon S. Kino

IPC: G06F17/14 ,  G01N21/00

CPC classification number: G06E3/003 ,  G01J3/45 ,  G01J11/00

Abstract: A method processes an optical image. The method includes providing a measured magnitude of the Fourier transform of a two-dimensional complex transmission function. The method further includes providing an estimated phase term of the Fourier transform of the two-dimensional complex transmission function. The method further includes multiplying the measured magnitude and the estimated phase term to generate an estimated Fourier transform of the two-dimensional complex transmission function. The method further includes calculating an inverse Fourier transform of the estimated Fourier transform, wherein the inverse Fourier transform is a spatial function. The method further includes calculating an estimated two-dimensional complex transmission function by applying at least one constraint to the inverse Fourier transform.

Abstract translation: 一种处理光学图像的方法。 该方法包括提供二维复数传输函数的傅立叶变换的测量幅度。 该方法还包括提供二维复数传输函数的傅立叶变换的估计相位项。 该方法还包括将测量的幅度和估计的相位项相乘以产生二维复数传输函数的估计傅里叶变换。 该方法还包括计算傅立叶逆变换的傅立叶逆变换，其中逆傅里叶变换是空间函数。 该方法还包括通过对傅里叶逆变换应用至少一个约束来计算估计的二维复传输函数。

公开(公告)号：US20090286172A1

公开(公告)日：2009-11-19

申请号：US12465567

申请日：2009-05-13

Applicant: Koichi Sentoku ,  Takahiro Matsumoto ,  Satoru Oishi ,  Hideki Ina

Inventor： Koichi Sentoku ,  Takahiro Matsumoto ,  Satoru Oishi ,  Hideki Ina

IPC: G03F7/20 ,  G01B11/24 ,  G03B27/54

CPC classification number: G03B27/54 ,  G01B11/24 ,  G01J3/45 ,  G01J2003/1213 ,  G01J2003/1226 ,  G03F9/7003 ,  G03F9/7015 ,  G03F9/7026 ,  G03F9/7088

Abstract: A surface shape measurement apparatus is configured to measure a surface shape of an object to be measured, and includes a beam splitter configured to split white light from a light source into two light beams, a pair of prisms each configured to increase an incident angle of each light beam that has been split by the beam splitter and directed to the object or a reference surface, each prism having an antireflection part that is formed at a period of a wavelength of the white light or smaller and has a moth-eye shape, a superimposition unit configured to superimpose object light from the object with reference light from the reference surface and has passed the second prism, and to generate white interference light, and a Lyot filter configured to discretely separate the white interference light for each of a plurality of wavelengths.

Abstract translation: 表面形状测量装置被配置为测量待测物体的表面形状，并且包括：分束器，被配置为将来自光源的白光分成两束光束;一对棱镜，每个棱镜被配置为增加入射角 已经被分束器分离并被引导到物体或参考表面的每个光束，每个棱镜具有在白色光的波长或更小的周期形成并具有蛾眼形状的抗反射部分， 叠加单元，被配置为用来自所述参考表面的参考光叠加来自所述物体的物体光并且已经通过所述第二棱镜，并且产生白色干涉光;以及Lyot滤波器，其被配置为离散地分离所述白色干涉光， 波长。

公开(公告)号：US20090206263A1

公开(公告)日：2009-08-20

申请号：US12322662

申请日：2009-02-05

Applicant: Anis Rahman

Inventor： Anis Rahman

IPC: G01N21/35

CPC classification number: G01J3/45 ,  G01J3/02 ,  G01J3/0232 ,  G01J3/26 ,  G01J3/42 ,  G01N21/3586 ,  G01N21/9027 ,  G02F1/353 ,  G02F1/3558 ,  G02F2203/13

Abstract: A terahertz spectrometer having a wider range of terahertz radiation source, high temporal resolution of scanning (

Abstract translation: 具有更宽范围的太赫兹辐射源的太赫兹光谱仪，在更宽的扫描范围（高达〜100微秒）下具有高扫描时间分辨率（<0.0.099mum或〜0.3皮秒）。 还公开了光谱仪在生物医学，生物学，药学和安全领域中的示例性应用。

公开(公告)号：US07480058B2

公开(公告)日：2009-01-20

申请号：US11656222

申请日：2007-01-19

Applicant: Yonghua Zhao ,  Jay Wei

Inventor： Yonghua Zhao ,  Jay Wei

IPC: G01B9/02

CPC classification number: G01B9/02044 ,  G01B9/02068 ,  G01B9/02087 ,  G01B9/02091 ,  G01J3/02 ,  G01J3/0289 ,  G01J3/45 ,  G01J3/4537

Abstract: A Fourier-domain optical coherence tomography (OCT) imager is presented. An OCT imager according to the present invention can have an auto-alignment process. The auto-alignment process automatically adjusts at least one optical component of a spectrometer of the imager so that the spectrometer is aligned during an imaging session. In addition to the auto-alignment process, OCT spectra are normalized for background spectra and for noise characteristics in order to provide a more accurate and clear OCT image.

Abstract translation: 提出了傅里叶域光学相干断层扫描（OCT）成像仪。 根据本发明的OCT成像器可以具有自动对准过程。 自动对准过程自动调整成像仪的光谱仪的至少一个光学组件，使得光谱仪在成像会话期间对准。 除了自动对准过程之外，为了提供更精确和更清晰的OCT图像，将OCT光谱归一化用于背景光谱和噪声特性。