摘要:
Provided is a collagen-cellulose material containing, based on a total weight of the collagen-cellulose material: 1.0-9.0 wt. % of a collagen; 0.2-3.0 wt. % of cellulose or a derivative thereof; 0.5-6.5 wt. % of at least one acid selected from an inorganic acid, an organic acid, and mixtures thereof; and water. Also provided is a process for producing the collagen-cellulose material. Also provided is an artificial blood vessel containing the collagen-cellulose material which is in the form of a hollow tube, an artificial tissue containing the collagen-cellulose material which is in the form of a sheet, and an artificial bone containing the collagen-cellulose material which is in the form of a solid. Also provided is a medical device containing the collagen-cellulose material, as well as a process for testing phlebotomical, surgical or orthopedic instrumentation or practicing phlebotomical, surgical or orthopedic procedures using the medical device containing the collagen-cellulose material.
摘要:
Aspects of the invention relate to a device for predicting cutaneous afferent nerve fiber excitation from an electrical potential applied to a cutaneous tissue by an electrode and methods of using the same. In some embodiments, such devices and methods concern the electrical stimulation of nerves in the skin so as to ameliorate pain in a subject. Accordingly, methods making and using cutaneous electrodes are provided.
摘要:
A biomechanical system for testing a coupled joint is provided. The coupled joint has a fixed first end and a moving second end within the testing system. The testing system includes a servo actuation system operatively connected to the moving end. The system is able to impart at least four degrees of freedom to the moving end of the coupled joint. The testing system also includes a first force sensor disposed between the servo actuation system and the moving end of the coupled joint for sensing applied load, and a second force sensor disposed at the fixed end of the coupled joint for sensing transmitted load. The system also includes a controller for selectively directing input signals to the servo actuation system in order to apply selected forces and/or motions to the moving end of the coupled joint. The coupled joint may be a cervical spine specimen.
摘要:
A training model for endoscopic investigation and the treatment of hollow organs. The training model includes a chamber intended for accommodating the hollow organ with a chamber wall, at least one inlet fastened in the chamber wall with a coupling device to which the hollow organ can be coupled for the introduction of an endoscope through the inlet into the hollow organ, a connection in the chamber wall to which can be coupled a suction pump for the generation of a negative pressure in the chamber and a moulding in the chamber comprising a cavity into which the coupling device opens out and which is adapted to an outer contour of the hollow organ and into which the hollow organ can be inserted. The generation of a negative pressure allows the hollow organ to be widened in accordance with natural conditions.
摘要:
Disclosed herein are synthetic anatomical models that are designed to enable simulated use testing by medical device compam'es, medical device designers, individual inventors, or any other entity interested in the performance of medical devices. These models are unique in possessing a level of complexity that allows them to be substituted for either a live animal, an animal cadaver, or a human cadaver in the testing of these devices. These models are further characterized by a similarity of geometry, individual component physical properties, and component-to-component interfacial properties with the appropriate target tissue and anatomy.
摘要:
A test bench assembly (10) for the simulation of cardiac surgery and/or interventional cardiology operations and/or procedures, comprising a passive heart (12), wherein said passive heart (12) is an explanted or artificial or hybrid heart, said passive heart (12) having at least one pair of cardiac chambers (14, 16; 114, 116) comprising an atrial chamber (14; 114) and a ventricular chamber (16; 116); a reservoir (20), adapted to house the working fluid; a pressure generator (22), adapted to provide said passive heart (12) pumping said working fluid with the pumping function, said pressure generator (22) being fluidically connected both to said ventricular chamber (16) of said passive heart (12) and to said reservoir (20) by means of first fluid connection means; a pressure regulation device (24) which provides the working fluid in input to the atrial chamber (14) with the preload pressure, and the working fluid in output from the ventricular chamber (16) with the afterload pressure, said pressure regulation device (24) being fluidically connected both to said atrial chamber (14) of said passive heart (12) and to said ventricular chamber (16) of said passive heart (12) by means of second fluid connection means; wherein said pressure regulation device (24) comprises a single compliant element (26) for each pair of cardiac chambers (14, 16) which provides the working fluid with both the preload and the afterload pressures.
摘要:
The present disclosure relates to a three-dimensional (3D) artificial skin model, and specifically, to a 3D artificial skin model that perfectly mimics the ridge shape of the dermal-epidermal junction, and a method for producing the same. Normal skin tissue has wavy ridges formed at the dermal-epidermal junction (DEJ), but the wavy ridges are known to flatten with aging. The artificial skin model of the present disclosure is a 3D artificial skin model that perfectly mimics the shape of the ridges at the dermal-epidermal junction. Since the artificial skin model mimics the structure and function of normal skin, it is expected to be widely used in the pharmaceutical and cosmetic fields.
摘要:
The presently disclosed subject matter provides a biomimetic lung disease model, and methods of its production and use. In one exemplary embodiment, the biomimetic lung disease model can include a first and second microchannel with a membrane coated with airway epithelial cells disposed between the microchannels and at least one device coupled to the biomimetic model that delivers an agent to at least one microchannel. In certain embodiments, the agent is cigarette smoke.
摘要:
A valve includes a body including an inner bore extending between a first port and a second port, a seat, and one or more restrainers and a disk that is moveable between the seat and the one or more restrainers such that a first pressure that is less than 1 pascal and applied in a first direction causes the disk to move from a first position towards a second position to permit fluid communication between the first port and the second port. A metamaterial scaffold including a structure defining a lumen, at least a portion of an outer or non-lumen surface of the structure is coated with a plurality of biological cells, and wherein the structure is composed of a metamaterial.
摘要:
A test bench assembly (10) for the simulation of cardiac surgery and/or interventional cardiology operations and/or procedures, comprising a passive heart (12), wherein said passive heart (12) is an explanted or artificial or hybrid heart, said passive heart (12) having at least one pair of cardiac chambers (14, 16; 114, 116) comprising an atrial chamber (14; 114) and a ventricular chamber (16; 116); a reservoir (20), adapted to house the working fluid; a pressure generator (22), adapted to provide said passive heart (12) pumping said working fluid with the pumping function, said pressure generator (22) being fluidically connected both to said ventricular chamber (16) of said passive heart (12) and to said reservoir (20) by means of first fluid connection means; a pressure regulation device (24) which provides the working fluid in input to the atrial chamber (14) with the preload pressure, and the working fluid in output from the ventricular chamber (16) with the afterload pressure, said pressure regulation device (24) being fluidically connected both to said atrial chamber (14) of said passive heart (12) and to said ventricular chamber (16) of said passive heart (12) by means of second fluid connection means; wherein said pressure regulation device (24) comprises a single compliant element (26) for each pair of cardiac chambers (14, 16) which provides the working fluid with both the preload and the afterload pressures.