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公开(公告)号：US09885017B2
公开(公告)日：2018-02-06
申请号：US14152448
申请日：2014-01-10
IPC分类号： A61K39/395 , A61K39/00 , C07K16/28 , A61P37/04 , C12N5/0784 , A61K39/29 , A61K39/12 , C07K14/005
CPC分类号： C12N5/0639 , A61K39/12 , A61K39/29 , A61K2039/6056 , C07K14/005 , C07K16/2851 , C07K16/2878 , C07K2319/00 , C07K2319/33 , C12N2770/24222 , C12N2770/24234
摘要： Compositions comprising viral antigens and antigenic peptides corresponding to or derived from Hepatitis C virus (HCV) proteins or fragments thereof, fused to heavy and/or light chain of antibodies, or fragments thereof specific for dendritic cells (DCs) are described herein. Included herein are immunostimulatory compositions (HCV vaccines, HCV antigen presenting dendritic cells, etc.) and methods for increasing effectiveness of HCV antigen presentation by an antigen presenting cell, for a treatment, a prophylaxis or a combination thereof against hepatitis C in a human subject, and methods of providing immunostimulation by activation of one or more dendritic cells, methods to treat or prevent hepatitis C.
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公开(公告)号：US09884110B2
公开(公告)日：2018-02-06
申请号：US15264498
申请日：2016-09-13
发明人： William L. Heyward
CPC分类号： A61K39/292 , A61K31/713 , A61K39/12 , A61K39/39 , A61K39/42 , A61K2039/525 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C07K16/08 , C07K16/082 , C12N7/00 , C12N15/113 , C12N15/86 , C12N2730/10134 , C12N2730/10171 , C12N2770/20033
摘要： The present invention relates to immunization of hypo-responsive groups of individuals. In particular, the present invention provides methods and compositions for eliciting a potent immune response to hepatitis B virus in individuals in need thereof.
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公开(公告)号：US09878034B2
公开(公告)日：2018-01-30
申请号：US13499488
申请日：2010-10-01
CPC分类号： A61K39/292 , A61K35/74 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/543 , A61K2039/545 , A61K2039/5555 , A61K2039/55594 , C12N2730/10134 , C12N2760/16134 , A61K2300/00 , A61K35/44
摘要： The invention relates to adjuvanted vaccine formulations, in particular influenza vaccines for intranasal delivery. Provided is an adjuvanted influenza vaccine formulation, comprising (i) peptidoglycan microparticles obtained from a Gram-positive bacterium and (ii) at least one influenza virus antigen or antigenic preparation thereof, which antigen or antigenic preparation is not fused or otherwise covalently attached to a proteinaceous peptidoglycan binding moiety.
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公开(公告)号：US09850468B2
公开(公告)日：2017-12-26
申请号：US14918466
申请日：2015-10-20
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , Royal Cornwall Hospital Trust
发明人： Suzanne U. Emerson , Priyanka Shukla , Hanh T. Nguyen , Robert H. Purcell , Harry R. Dalton , Richard Bendall
IPC分类号： A61K39/29 , A61K39/12 , C07H21/00 , C12N7/00 , C12N15/86 , C12Q1/70 , C07K14/005 , C07K14/47 , A61K39/00
CPC分类号： C12N7/00 , A61K39/00 , C07K14/005 , C07K14/47 , C12N15/86 , C12N2770/28121 , C12N2770/28122 , C12N2770/28134 , C12N2770/28143 , C12N2770/28151 , C12N2770/28152 , C12Q1/707
摘要： The invention relates to the discovery of an HEV strain from a chronically infected patient. The virus grow unusually well in numerous cell cultures. Thus, the invention provides cell cultures, vectors, and vaccine compositions based on the virus.
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公开(公告)号：US09844591B2
公开(公告)日：2017-12-19
申请号：US14701848
申请日：2015-05-01
申请人： BIOMAY AG
发明人： Katarzyna Niespodziana , Margarete Focke-Tejkl , Susanne Vrtala , Srinita Banerjee , Kuan-Wei Chen , Milena Weber , Rudolf Valenta , Katharina Marth
IPC分类号： A61K39/35 , C07K14/415 , A61K39/29 , A61K39/385 , A61K39/36 , C07K14/005 , A61K39/12 , A61K39/00
CPC分类号： A61K39/292 , A61K39/12 , A61K39/36 , A61K39/385 , A61K2039/53 , A61K2039/57 , A61K2039/6075 , A61K2039/64 , A61K2039/645 , C07K14/005 , C07K14/415 , C07K2319/00 , C12N2730/10122 , C12N2730/10134
摘要： The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the N- and C-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.
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公开(公告)号：US20170296639A1
公开(公告)日：2017-10-19
申请号：US15312976
申请日：2015-05-20
发明人： Yifan MA , Xiangjun ZHOU , Shang CHEN , Lintao CAI , Ce WANG , Peng LIU
IPC分类号： A61K39/00 , C12N7/00 , A61K39/29 , C12N5/0784
CPC分类号： A61K39/0011 , A61K39/12 , A61K39/292 , A61K2039/5154 , A61K2039/55555 , C12N5/0639 , C12N7/00 , C12N2500/90 , C12N2501/05 , C12N2501/22 , C12N2501/2304 , C12N2730/10134
摘要： The present invention provides a method for preparing dendritic cell loaded with antigen, the method comprising the steps of adding serum-free cell culture medium containing granulocyte-macrophage colony-stimulating factor (GM-CSF) and inter-leukin (IL)-4 into mononuclear cells, culturing in an incubator at 37° C. under 5% carbon dioxide for 5 days, adding target antigen wrapped cationic liposome and culturing for 8-24 hours to obtain target antigen loaded dendritic cell.
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公开(公告)号：US09770503B2
公开(公告)日：2017-09-26
申请号：US14732383
申请日：2015-06-05
申请人： Stephen John Ralph
发明人： Stephen John Ralph
IPC分类号： A61K39/00 , A61K39/395 , C07K1/00 , C07K16/00 , A61K39/29 , A61K31/7016 , A61K31/715 , A61K39/39 , A61K45/06 , G01N33/50 , A61K38/17 , A61K38/19 , A61K38/20 , A61K39/09 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/145 , G01N33/566
CPC分类号： A61K39/292 , A61K31/7016 , A61K31/715 , A61K38/1774 , A61K38/191 , A61K38/193 , A61K38/2066 , A61K39/0011 , A61K39/0016 , A61K39/092 , A61K39/095 , A61K39/102 , A61K39/12 , A61K39/145 , A61K39/29 , A61K39/39 , A61K45/06 , A61K2039/5152 , A61K2039/5154 , A61K2039/5156 , A61K2039/55511 , A61K2039/55583 , A61K2039/70 , G01N33/5047 , G01N33/505 , G01N33/566 , G01N2333/42 , G01N2333/4724 , G01N2500/04 , G01N2500/10 , A61K2300/00
摘要： The present invention discloses immunomodulating compositions. More particularly, the present invention discloses compositions comprising an immune-modulating agent and a lectin-interactive agent, which are useful for stimulating and prolonging host immune cell responses. The compositions of the present invention are particularly useful in the treatment and/or prophylaxis of a range of conditions including pathogenic infections, autoimmune diseases, transplant rejection, graft versus host disease, allergies, inflammatory disease, as well as cancers and tumors.
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公开(公告)号：US09758794B2
公开(公告)日：2017-09-12
申请号：US14267012
申请日：2014-05-01
CPC分类号： C12N15/86 , A61K2039/505 , C07K16/109 , C07K2317/76 , C12N2770/24222 , C12N2770/24233 , C12N2770/24251
摘要： Methods of producing and using Hepatitis C virus (HCV) eE2 polypeptides are described.
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公开(公告)号：US09758489B2
公开(公告)日：2017-09-12
申请号：US14801126
申请日：2015-07-16
发明人： George D. Hartman
IPC分类号： A61K31/55 , A61K31/435 , C07D223/00 , C07D213/00 , C07D243/08 , C07D401/04 , A61K31/551 , C07D471/08 , A61K31/439 , A61K31/5513 , A61K45/06 , C07D487/08 , A61K38/21 , A61K39/29 , C07D401/14
CPC分类号： C07D243/08 , A61K31/439 , A61K31/55 , A61K31/551 , A61K31/5513 , A61K38/21 , A61K39/292 , A61K45/06 , C07D401/04 , C07D401/14 , C07D471/08 , C07D487/08 , A61K2300/00
摘要： Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.
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90.发明申请公开(公告)号：US20170246293A1
公开(公告)日：2017-08-31
申请号：US15315526
申请日：2015-06-01
发明人： Wilhelmus Johannes Theodorus Alexander KREBBER , Johan Herman KESSLER , Cornelis Joseph Maria MELIEF , Kitty Michelle Corinne KWAPPENBERG
IPC分类号： A61K39/29 , C07K14/005
CPC分类号： A61K39/292 , A61K38/00 , A61K39/12 , A61K2039/53 , A61K2039/572 , C07K14/005 , C12N2730/10134
摘要： The present invention relates to the fields of medicine and immunology. In particular, it relates to novel peptides that may be used in the treatment and/or prevention of a Hepatitis B viral infection and/or an Hepatitis B related disease or condition.
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