公开(公告)号：US20100266717A1

公开(公告)日：2010-10-21

申请号：US12763892

申请日：2010-04-20

申请人： Ratnakar Asolkar ,  Sarahann Dow ,  Huazhang Huang ,  Marja Koivunen ,  Pamela Marrone ,  Stephanie Shu

发明人： Ratnakar Asolkar ,  Sarahann Dow ,  Huazhang Huang ,  Marja Koivunen ,  Pamela Marrone ,  Stephanie Shu

IPC分类号： A01N63/02 ,  C09D5/16 ,  C07D307/20 ,  C07C59/01 ,  C07D309/12 ,  C07C233/02 ,  C07D207/16 ,  C07D211/60 ,  C07D223/06 ,  A01N43/08 ,  A01N43/16 ,  A01N37/02 ,  A01N37/18 ,  A01N43/36 ,  A01N43/40 ,  A01N43/46 ,  A01P9/00

CPC分类号： A61K35/618 ,  A01N37/02 ,  A01N37/18 ,  A01N37/36 ,  A01N37/46 ,  A01N43/08 ,  A01N43/16 ,  A01N43/36 ,  A01N43/76 ,  A01N49/00 ,  A01N63/02 ,  A61K35/74 ,  C07C59/42 ,  C07C233/06 ,  C07C233/09 ,  C07D207/04 ,  C07D207/06 ,  C07D211/06 ,  C07D211/16 ,  C07D223/04 ,  C07D295/18 ,  C07D307/33 ,  C07D309/30 ,  C09D5/1625

摘要： Compositions and methods for controlling molluscs, members of the Gastropoda and Bivalvia classes which includes but is not limited to lactones, lactams, carbamates, amides, and/or carboxylic acid containing compounds as active ingredients and/or compounds derived from Pseudomonas and/or Erwinia. Also provided are methods and compositions for increasing the efficacy of chemical and biological control for invasive molluscs in open waters, power plants, and drinking water treatment facilities under coldwater conditions.

摘要翻译： 包括但不限于内含物，内酰胺，氨基甲酸酯，酰胺和/或含羧酸的化合物作为活性成分和/或衍生自假单胞菌属和/或欧文氏菌的化合物的组合物和方法，用于控制软体动物，胃食管和百合属成分的成分 。 还提供了用于在冷水条件下提高开放水域，发电厂和饮用水处理设施中侵入性软体动物的化学和生物控制功效的方法和组合物。

公开(公告)号：US20100080880A1

公开(公告)日：2010-04-01

申请号：US12565484

申请日：2009-09-23

申请人： Michael Backes ,  Jan Looft

发明人： Michael Backes ,  Jan Looft

IPC分类号： A23L1/226 ,  C07C271/06 ,  C07C233/02

CPC分类号： C07C233/05 ,  A23G4/06 ,  A23L2/56 ,  A23L23/00 ,  A23L27/202 ,  A23L27/26 ,  A23L27/60 ,  A23L27/63 ,  A23L27/88 ,  A61K8/42 ,  A61K8/44 ,  A61Q11/00

摘要： The present invention concerns geranylamine derivates of oxalic acid, use of the same as flavorings and certain mixtures, compositions, preparations and semi-finished goods containing one or more such compounds.

摘要翻译： 本发明涉及草甘膦酰基胺衍生物，使用其作为调味剂和某些混合物，组合物，制剂和含有一种或多种这样的化合物的半成品。

公开(公告)号：US20100076086A1

公开(公告)日：2010-03-25

申请号：US12522318

申请日：2008-01-31

申请人： Vinayak G. Gore

发明人： Vinayak G. Gore

IPC分类号： A61K31/137 ,  C07C233/02 ,  C07C215/42 ,  A61P25/18 ,  A61P3/04

CPC分类号： C07C231/02 ,  C07C213/02 ,  C07C231/12 ,  C07C2601/14 ,  C07C215/56 ,  C07C217/64 ,  C07C235/34

摘要： The present invention relates to a novel process for the preparation of O-desmethyl venlafaxine (ODV).

摘要翻译： 本发明涉及一种制备O-去甲基文拉法辛（ODV）的新方法。

公开(公告)号：US20090187011A1

公开(公告)日：2009-07-23

申请号：US12308936

申请日：2007-06-29

申请人： Shin-Ichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Jun-ichi Furukawa ,  Yoko Kita ,  Akio Takimoto ,  Mika Nakano

发明人： Shin-Ichiro Nishimura ,  Yasuro Shinohara ,  Yoshiaki Miura ,  Jun-ichi Furukawa ,  Yoko Kita ,  Akio Takimoto ,  Mika Nakano

IPC分类号： C07K1/12 ,  C07C233/02

CPC分类号： C07C309/15 ,  C12P19/00 ,  G01N33/66

摘要： A means for pre-treatment in glycomic analysis of a glycoprotein is provided by the present invention.A salt of the general formula (I): wherein Z, X, R1, R2, M, m and n are the same as described in DESCRIPTION, is useful as a protein solubilizer, and an oligosaccharide is efficiently released from a sample if reductive alkylation and/or digestion by a proteinase are carried out under the presence of the said solubilizer at the first step in the glycomic analysis of glycoprotein derived from a living body.

摘要翻译： 本发明提供了糖蛋白糖基分析中预处理的手段。 通式（I）的盐：其中Z，X，R 1，R 2，M，m和n与描述中所述相同，可用作蛋白质增溶剂，并且如果还原，寡糖有效地从样品中释放 通过蛋白酶的烷基化和/或消化在所述增溶剂的存在下在来自活体的糖蛋白的糖基分析中的第一步进行。

公开(公告)号：US20090137837A1

公开(公告)日：2009-05-28

申请号：US12142450

申请日：2008-06-19

申请人： Oliver Thiel ,  Charles Bernard ,  Robert Larsen ,  Michael John Martinelli ,  Masooma Tamim Raza

发明人： Oliver Thiel ,  Charles Bernard ,  Robert Larsen ,  Michael John Martinelli ,  Masooma Tamim Raza

IPC分类号： C07C271/06 ,  C07C211/27 ,  C07C233/02

CPC分类号： C07C209/70 ,  C07C209/22 ,  C07C211/30

摘要： Methods of preparing cinacalcet, cinacalcet derivatives, and salts thereof is disclosed herein. Also disclosed herein are polymorphs of cinacalcet, compositions of cinacalcet, and methods of treating a subject by administering cinacalcet, wherein cinacalcet is prepared by the disclosed methods.

摘要翻译： 本文公开了西那卡塞，西那卡塞衍生物及其盐的制备方法。 还公开了西那卡塞的多晶型物，西那卡塞的组合物，以及通过施用西那卡塞治疗受试者的方法，其中依撒卡塞通过所公开的方法制备。

公开(公告)号：US20090131675A1

公开(公告)日：2009-05-21

申请号：US11902821

申请日：2007-09-24

申请人： Pehr A.B. Harbury ,  Joshua A. Silverman ,  Warham Lance Martin

发明人： Pehr A.B. Harbury ,  Joshua A. Silverman ,  Warham Lance Martin

IPC分类号： C07D495/04 ,  C07C233/02

CPC分类号： G01N33/6848 ,  C12N15/67 ,  G01N33/6803 ,  G01N33/6818 ,  G01N33/6842

摘要： The invention provides methods and compositions for protein structure analysis, including substrate binding sites, sites of protein-protein interactions, three dimensional structure analysis, and stability, all with single amino acid resolution. In general, the subject methods involve introduction of cysteine residues, which serve as probes for physical analysis, into a protein by translational misincorporation in vivo. In many embodiments, proteins containing misincorporated cysteine residues are reacted with a crosslinking agent that covalently links misincorporated cysteine residues to a proximal amino acid in the folded protein. These methods, termed “MXLINK” methods, may be used for protein tertiary structure analysis. In other embodiments, cysteine-misincorporated proteins are used in protein footprinting methods, termed “MPAX” or “MSX” methods.

摘要翻译： 本发明提供了用于蛋白质结构分析的方法和组合物，包括底物结合位点，蛋白质 - 蛋白质相互作用的位点，三维结构分析和稳定性，全部具有单一氨基酸分辨率。 通常，本发明方法涉及通过体内平移错配引入作为物理分析探针的半胱氨酸残基的蛋白质。 在许多实施方案中，含有错配的半胱氨酸残基的蛋白质与交联剂反应，所述交联剂将错配的半胱氨酸残基共价连接到折叠的蛋白质中的近端氨基酸。 这些方法称为“MXLINK”方法，可用于蛋白质三级结构分析。 在其他实施方案中，将半胱氨酸错配的蛋白质用于称为“MPAX”或“MSX”方法的蛋白质足迹方法中。

公开(公告)号：US20080268073A1

公开(公告)日：2008-10-30

申请号：US12147798

申请日：2008-06-27

申请人： Mutsumi SANO ,  Hiroyuki Izu ,  Mitsuo Imamura ,  Motoko Okamoto ,  Toyohisa Kurita ,  Ikunoshin Kato

发明人： Mutsumi SANO ,  Hiroyuki Izu ,  Mitsuo Imamura ,  Motoko Okamoto ,  Toyohisa Kurita ,  Ikunoshin Kato

IPC分类号： A61K36/00 ,  C07C233/02 ,  C12N9/99

CPC分类号： A61K31/201 ,  A23L33/105 ,  A61K8/97 ,  A61K36/03 ,  A61K36/16 ,  A61K36/28 ,  A61K36/282 ,  A61K36/42 ,  A61K36/61 ,  A61K36/75 ,  A61K2800/782 ,  A61Q19/02 ,  C07C59/42

摘要： The present invention provides a ceramidase activity inhibitor which inhibits ceramidase activity, specifically neutral/alkaline ceramidase activity, characterized in that the inhibitor comprises, as an active ingredient, a processed product derived from at least one plant selected from the group consisting of plants belonging to Ginkgoaceae, plants belonging to Cucurbitaceae, plants belonging to Rutaceae, plants belonging to Laminariaceae, plants belonging to Myrtaceae and plants belonging to Compositae, and a medicament, a quasi-drug, cosmetics and a food, each comprising the inhibitor.

摘要翻译： 本发明提供了抑制神经酰胺酶活性，特别是中性/碱性神经酰胺糖酶活性的神经酰胺酶活性抑制剂，其特征在于，所述抑制剂包含作为活性成分的来自至少一种选自属于 银杏科，属于葫芦科的植物，属于芸香科的植物，属于ari科的植物，属于桃金娘科的植物和属于菊科的植物，以及各自包含抑制剂的药物，准药物，化妆品和食品。

公开(公告)号：US20080200525A1

公开(公告)日：2008-08-21

申请号：US12098594

申请日：2008-04-07

申请人： Werner Zambach ,  Roger Graham Hall ,  Peter Renold ,  Stephan Trah

发明人： Werner Zambach ,  Roger Graham Hall ,  Peter Renold ,  Stephan Trah

IPC分类号： A01N43/40 ,  C07C233/02 ,  C07C259/00 ,  A01N37/18 ,  A01N33/24 ,  A01N43/80 ,  C07D261/02 ,  A01P17/00 ,  C07D211/82

CPC分类号： C07D333/58 ,  A01N33/24 ,  A01N35/10 ,  A01N37/52 ,  A01N41/06 ,  A01N43/10 ,  A01N43/40 ,  A01N43/78 ,  A01N43/80 ,  C07C49/753 ,  C07C49/755 ,  C07C49/84 ,  C07C235/84 ,  C07C251/44 ,  C07C251/48 ,  C07C251/54 ,  C07C251/58 ,  C07C311/04 ,  C07C311/05 ,  C07C311/09 ,  C07C323/47 ,  C07D213/50 ,  C07D213/53 ,  C07D213/61 ,  C07D213/64 ,  C07D261/08 ,  C07D277/24 ,  C07D277/28 ,  C07D307/52 ,  C07D307/81 ,  C07D333/22

摘要： Compounds of formula wherein A0, A1 and A2 are each independently of the others a bond or a C1-C6alkylene bridge; A3 is a C1-C6alkylene bridge which is unsubstituted or substituted by from one to six identical or different substituents selected from halogen and C3-C8cycloalkyl; Y is, for example, O, S, SO or SO2; M is O or NOR6, X1 and X2 are each independently of the other fluorine, chlorine or bromine; R1, R2 and R3 are, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkylcarbonyl, C2-C6alkenyl, C2-C6haloalkenyl or C2-C6alkynyl; Q is, for example, O, S, SO or SO2; W is, for example, O, S, SO, SO2, —C(═O)—O— or —O—C(═O)—; T is, for example, a bond, O, S, SO, SO2, —C(═O)—O— or —O—C(═O)—; D is CH or N; R4 is, for example, H, halogen, OH, SH, CN, nitro, C1-C6alkyl or C1-C6haloalkyl; R5 is, for example, C1-C12alkyl, C3-C8cycloalkyl or —N(R7)2; R7 is H, C1-C6alkyl, C1-C3haloalkyl, C1-C6alkylcarbonyl, C1-C3haloalkylcarbonyl, C1-C6alkoxycarbonyl, C3-C8cycloalkyl, C3-C8 cycloalkylcarbonyl or formyl; k is 0, 1, 2, 3 or 4; m is 1 or 2; and q is 0, 1 or 2; and, where applicable, their possible E/Z isomers, E/Z isomeric mixtures and/or tautomers, in each case in free form or in salt form, a process for the preparation of those compounds and their use, pesticidal compositions in which the active ingredient has been selected from those compounds and agrochemically acceptable salts thereof, and a process for the preparation of those compositions and their use, to plant propagation material treated with those compositions, and a method of controlling pests.

公开(公告)号：US20080097127A1

公开(公告)日：2008-04-24

申请号：US12000587

申请日：2007-12-14

申请人： Gabriele Razzetti ,  Simone Mantegazza ,  Roberto Rossi ,  Pietro Allegrini

发明人： Gabriele Razzetti ,  Simone Mantegazza ,  Roberto Rossi ,  Pietro Allegrini

IPC分类号： C07C233/02 ,  C07C211/27

CPC分类号： C07C215/54 ,  C07C69/736 ,  C07C217/18 ,  C07C233/18

摘要： A novel process for the preparation of tolterodine, i.e. (R)—N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine, in the racemic form, as well as intermediates useful for its preparation.

摘要翻译： 用于制备托特罗定（即（R）-N，N-二异丙基-3-（2-羟基-5-甲基苯基）-3-苯基丙胺）的外消旋形式的新方法，以及可用于其制备的中间体。

公开(公告)号：US20080039655A1

公开(公告)日：2008-02-14

申请号：US11842918

申请日：2007-08-21

申请人： In Baik ,  In Cho ,  Gyeong Ghi ,  Dong Han

发明人： In Baik ,  In Cho ,  Gyeong Ghi ,  Dong Han

IPC分类号： C07C233/02

CPC分类号： C11D1/75

摘要： An amine oxide type surfactant, which has excellent compatibility with an anionic or non-ionic surfactant having excellent detergency and shows excellent detergency and softening effect, is represented by the following formula 1: wherein R1 and R2 are the same or different, and each independently represents a C8˜C22 linear or branched alkyl or alkenyl group; A represents a C1˜C4 alkyl, alkenyl or hydroxyalkyl group; X represents OH, a C1˜C4 alkyl, hydroxyalkyl, (CH2CH2O)nH, (CHCH3CH2O)nH or a combination of (CH2CH2O)nH and (CHCH3CH2O)nH; and n is a number of 1˜30.

摘要翻译： 与具有优异的去污力和显示出优异的去污力和软化效果的阴离子或非离子表面活性剂具有优异的相容性的氧化胺型表面活性剂由下式1表示：其中R 1和R 2， SUB> 2相同或不同，并且各自独立地表示C 12 -C 22直链或支链烷基或烯基; A表示C 1 -C 4烷基，烯基或羟烷基; X表示OH，C 1 -C 4烷基，羟烷基，（CH 2 CH 2 CH 2） H，（CHCH 3 CH 2 O）n H或H（CH 2）2的组合， H和（CHCH 3 CH 2 CH 2）n H（CH 2 CH 2 CH 2） H; n为1〜30的数。