公开(公告)号：US4060598A

公开(公告)日：1977-11-29

申请号：US626513

申请日：1975-10-28

申请人： Gregor Groppenbacher ,  Peter Rieckmann ,  Werner Rothe

发明人： Gregor Groppenbacher ,  Peter Rieckmann ,  Werner Rothe

IPC分类号： A61K9/28 ,  A61K9/32

CPC分类号： A61K9/284 ,  A61K9/2806 ,  A61K9/2893

摘要： Coated tablets are prepared by applying to a core of active material, at least one layer of a coating composition made up of a film forming aqueous synthetic resin dispersion and from 2-50% by weight of a water or alkaline soluble material and thereafter permitting the coating composition layer to dry. The resulting coated tablet has a core surrounded by a continuous porous matrix of synthetic resin formed from the aqueous dispersion which is insoluble in water and insoluble in the gastrointestinal tract. The pores of the continuous resin matrix are filled with a discontinuous particulate material which is water or alkaline soluble. The coated tablet initially is air and moisture tight.

摘要翻译： 通过将活性材料芯，至少一层由成膜水性合成树脂分散体和2-50重量％的水或碱溶性材料组成的涂料组合物制成涂布片，然后允许 涂层组合物层干燥。 所得的包衣片剂具有由不溶于水并且不溶于胃肠道的水性分散体形成的合成树脂的连续多孔基质包围的核心。 连续树脂基体的孔填充有水或碱溶性的不连续的颗粒材料。 包衣片最初是空气和湿气。

公开(公告)号：US4038140A

公开(公告)日：1977-07-26

申请号：US582495

申请日：1975-05-30

申请人： Dieter Jaworek ,  Joseph Maier ,  Michael Nelbock-Hochstetter

发明人： Dieter Jaworek ,  Joseph Maier ,  Michael Nelbock-Hochstetter

IPC分类号： C08F8/00 ,  C08F8/30 ,  C08F251/00 ,  C12N11/10 ,  C12N11/12 ,  C12K1/00 ,  C07G7/02 ,  C08L5/00

CPC分类号： C12N11/10 ,  C08F251/00 ,  C08F8/00 ,  C08F8/30

摘要： Biologically active proteins are bound onto an insoluble carrier by reacting such protein in an aqueous phase with a carrier comprising an activated polysaccharide having a hydrophilic graft co-polmyer grafted thereinto.

公开(公告)号：US4031213A

公开(公告)日：1977-06-21

申请号：US568640

申请日：1975-04-16

申请人： Rolf Kuhn ,  Klaus Hardebeck ,  Helmut Heinemann

发明人： Rolf Kuhn ,  Klaus Hardebeck ,  Helmut Heinemann

IPC分类号： A61K31/565 ,  A61L13/00

CPC分类号： A61K31/565

摘要： Pharmaceutical compositions comprisingA. at least one member of 5-(4-chloro-5-sulfamoyl-2-thenylaminophenyl)-tetrazole and the pharmacologically compatible salts thereof,B. 3-(3-oxo-7.alpha.-acetylthio-17.beta.-hydroxy-4-androsten-17.alpha.-yl)-propionic acid-.gamma.-lactone, andC. a pharmaceutical diluent or carrierPossess outstanding activity for treating hydropic conditions and prevent undesirable increased excretion of potassium without at the same time impairing the desired excretion of water and sodium.

摘要翻译： 包含A.至少一个5-（4-氯-4-磺酰基-2-噻吩-2-基）苯并噻唑的一个成员的药物组合物及其药理学兼容的盐，B. 3-（3-氧代-7α-乙酰基-17β -HYDROXY-4-ANDROSTEN-17α-YL）-PROPIONIC ACID-γ-LACTONE，以及C.一种药物稀释剂或载体，用于治疗水解条件的不可忽视的活性，并且预防不可预期地增加不同时间的硫酸铵，同时不影响预期 水和钠的清除。

公开(公告)号：US3991188A

公开(公告)日：1976-11-09

申请号：US593089

申请日：1975-07-03

申请人： Ansgar Lerch ,  Alfred Popelak ,  Kurt Stach ,  Egon Roesch ,  Klaus Hardebeck

发明人： Ansgar Lerch ,  Alfred Popelak ,  Kurt Stach ,  Egon Roesch ,  Klaus Hardebeck

IPC分类号： A61K31/63 ,  A61K31/625

CPC分类号： A61K31/63 ,  Y10S514/869

摘要： New 3-alkyl-4-sulfamoyl-aniline compounds of the formula ##SPC1##WhereinR.sub.1 is phenyl, furyl or thienyl;R.sub.2 is carboxyl or tetrazolyl-(5)R.sub.4 is a straight-chain or branched alkyl radical of from 2 to 5 carbon atoms; andn is 1 or 2;And the pharmacologically compatible salts thereof; are outstandingly effective saluretic compounds, particularly when administered enterally.

摘要翻译： 式WHEREIN R1的新的3-烷基-4-氨磺酰基 - 苯胺化合物是苯基，呋喃基或噻吩基; R2是羧基或四唑基 - （5）R4是2至5个碳原子的直链或支链烷基; 和N IS 1 OR 2; 及其药理学兼容性; 具有非常有效的挥发性化合物，特别是在进行管理时尤其如此。

公开(公告)号：US3988208A

公开(公告)日：1976-10-26

申请号：US559273

申请日：1975-03-17

申请人： Wolfgang Werner ,  Peter Vogel ,  Hugo Tiedemann ,  Werner Guthlein

发明人： Wolfgang Werner ,  Peter Vogel ,  Hugo Tiedemann ,  Werner Guthlein

IPC分类号： C07D209/88 ,  C12Q1/28 ,  C12Q1/54 ,  C12K1/04

CPC分类号： C12Q1/54 ,  C07D209/88 ,  C12Q1/28 ,  C12Q2326/00 ,  C12Q2326/14

摘要： Novel 3-aminocarbazole compounds of the formula: ##SPC1##WhereinX is hydrogen or halogen,Y is oxygen or represents two hydrogen atoms; andR.sub.1 and R.sub.2, which can be the same or different, are hydrogen, lower alkyl or hydroxyalkyl or amino; andN is 1 or 2, with the proviso that when n is2, X, Y, R.sub.1 and R.sub.2 cannot all be hydrogen atoms, as well as the salts thereof with inorganic and organic acids; are outstandingly effective indicators for the determination of glucose and provide stable compositions for such glucose determination.

摘要翻译： 新型3-氨基咔唑化合物，具有下式：

公开(公告)号：US3935326A

公开(公告)日：1976-01-27

申请号：US463216

申请日：1974-04-22

申请人： Gregor Groppenbacher ,  Peter Rieckmann ,  Werner Rothe

发明人： Gregor Groppenbacher ,  Peter Rieckmann ,  Werner Rothe

IPC分类号： A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K9/42

CPC分类号： A61K9/284 ,  A61K9/2806 ,  A61K9/2893

摘要： Coated tablets are prepared by applying to a core of active material, at least one layer of a coating composition made up of a film forming aqueous synthetic resin dispersion and from 2-50% by weight of a water or alkaline soluble material and thereafter permitting the coating composition layer to dry. The resulting coated tablet has a core surrounded by a continuous porous matrix of synthetic resin formed from the aqueous dispersion which is insoluble in water and insoluble in the gastrointestinal tract. The pores of the continuous resin matrix are filled with a discontinuous particulate material which is water or alkaline soluble. The coated tablet initially is air and moisture tight.

摘要翻译： 通过将活性材料芯，至少一层由成膜水性合成树脂分散体和2-50重量％的水或碱溶性材料组成的涂料组合物制成涂布片，然后允许 涂层组合物层干燥。 所得的包衣片剂具有由不溶于水并且不溶于胃肠道的水性分散体形成的合成树脂的连续多孔基质包围的核心。 连续树脂基体的孔填充有水或碱溶性的不连续的颗粒材料。 包衣片最初是空气和湿气。

公开(公告)号：US4049702A

公开(公告)日：1977-09-20

申请号：US589653

申请日：1975-06-23

申请人： Erich Bernt ,  Wolfgang Gruber ,  Erich Haid ,  Fritz Stahler ,  August Wilhelm Wahlefeld ,  Gunter Weimann

发明人： Erich Bernt ,  Wolfgang Gruber ,  Erich Haid ,  Fritz Stahler ,  August Wilhelm Wahlefeld ,  Gunter Weimann

IPC分类号： C12Q1/48 ,  C07C143/67

CPC分类号： C12Q1/48

摘要： .gamma.-Glutamyl-4-nitroanilide compounds of the formula ##STR1## wherein R is a .gamma.-glutamyl radical and X is an acid group, and salts of such compounds, are used to determine .gamma.-glutamyl-transpeptidase by contacting a sample suspected of containing .gamma.-glutamyltranspeptidase with said compound and glycylglycine and determining the liberation of the resulting p-nitro-aniline compound as a measure of the .gamma.-glutamyltranspeptidase activity initially present in the sample.

摘要翻译： 其中R是γ-谷氨酰基，X是酸基的γ-谷氨酰基-4-硝基苯胺化合物和这些化合物的盐被用于通过使怀疑有γ-谷氨酰转肽酶的样品接触来测定γ-谷氨酰转肽酶 含有γ-谷氨酰基转肽酶与所述化合物和甘氨酰甘氨酸，并确定所得对硝基苯胺化合物的释放作为样品中最初存在的γ-谷氨酰转肽酶活性的量度。

公开(公告)号：US4033967A

公开(公告)日：1977-07-05

申请号：US515790

申请日：1974-10-17

申请人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

发明人： Alfred Rhomberg ,  Herbert Berger ,  Kurt Stach, deceased ,  Werner Plattner, administrator ,  Wolfgang Vomel ,  Winfriede Sauer

IPC分类号： C07D215/20 ,  A61K31/473 ,  C07D215/06 ,  C07D215/233 ,  C07D221/16 ,  C07D215/56

CPC分类号： C07D221/16

摘要： New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,X is hydrogen or alkyl, andY is halogen, azido, alkylthio, alkyl-sulfonyl, or nitrile or unsubstituted or substituted (e.g., alkyl mono or di-substituted) amino;And the pharmacologically compatible salts thereof; are outstandingly effective as bacteriostats in mammals.

摘要翻译： 其中R是饱和或不饱和脂族烃基，例如烷基和链烯基，X是氢或烷基，Y是卤素，叠氮基，烷硫基，烷基磺酰基或腈或未取代的新的环戊烯 - 喹诺酮衍生物 或取代的（例如烷基单或二取代的）氨基; 及其药理学兼容性; 作为母体中的细菌具有非常有效的作用。

公开(公告)号：US4019961A

公开(公告)日：1977-04-26

申请号：US556961

申请日：1975-03-10

申请人： Sigmar Klose ,  August Wilhelm Wahlefeld ,  Alexander Hagen

发明人： Sigmar Klose ,  August Wilhelm Wahlefeld ,  Alexander Hagen

IPC分类号： C12Q1/32 ,  C12Q1/44 ,  C12Q1/48 ,  C12Q1/54 ,  C12Q1/61 ,  G01N31/14

CPC分类号： C12Q1/61 ,  C12Q1/32 ,  C12Q1/44 ,  C12Q1/48 ,  G01N2333/904 ,  G01N2333/9121 ,  G01N2333/918

摘要： An analytical process for enzymatic determination of a substrate in biological fluids. The fluid sample is reacted first in the absence of the specific kinase but in the presence of an NADH -- regenerating enzymatic system with the reagents needed for the reaction sequence; then the enzymes are separated from the reaction solution, and thereafter the necessary enzymes are added to the filtrate and NADH consumption is measured.The method is very accurate, economical in requiring less enzymes and only one measurement is necessary.

摘要翻译： 用于生物流体中底物的酶测定的分析方法。 流体样品首先在不存在特异性激酶的情况下反应，但在具有反应顺序所需试剂的NADH再生酶系统的存在下反应; 然后将酶与反应溶液分离，然后将必需的酶加入到滤液中，并测量NADH消耗。

公开(公告)号：US3998810A

公开(公告)日：1976-12-21

申请号：US487423

申请日：1974-07-10

申请人： Fritz Wiedemann ,  Max Thiel ,  Kurt Stach ,  Karl Dietmann ,  Gisbert Sponer

发明人： Fritz Wiedemann ,  Max Thiel ,  Kurt Stach ,  Karl Dietmann ,  Gisbert Sponer

IPC分类号： A61K31/135 ,  A61K31/00 ,  A61K31/395 ,  A61K31/54 ,  A61K31/5415 ,  A61P9/00 ,  C07C67/00 ,  C07C213/00 ,  C07C217/30 ,  C07D209/82 ,  C07D209/86 ,  C07D223/24 ,  C07D223/28 ,  C07D279/24 ,  C07D279/28

CPC分类号： C07D209/86

摘要： New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.