公开(公告)号：US4685059A

公开(公告)日：1987-08-04

申请号：US636302

申请日：1984-07-31

申请人： Hiroshi Yamamoto

发明人： Hiroshi Yamamoto

IPC分类号： A61B10/00 ,  G01N21/47 ,  G01N21/75 ,  G01N33/487 ,  G06F19/00 ,  G06Q50/00 ,  G06Q50/10 ,  G06Q50/22 ,  G06F15/42 ,  G06G7/60 ,  G01N30/96 ,  G01N21/00

CPC分类号： G01N21/474

摘要： A method for measuring body fluid constituents and storing the test data, which stores the measurement data of body fluid constituents measured by means of a small-size, light-weight, portable analyzing apparatus and a solid reagent, in the memory circuit of the apparatus, and after the required or specified number of measurement data has been stored, delivers the data into an external device. The external action data can also be stored. A method of controlling and processing the test data of body fluid constituents which stores one lot of data groups of each apparatus in an external unit together with the data for identifying the patient and displays the measurements of each patient calculated from one or a plurality of data groups of each analyzing apparatus in digital or analog form.

摘要翻译： 一种用于测量体液成分并存储测试数据的方法，所述测试数据将通过小尺寸，重量轻的便携式分析装置和固体试剂测量的体液成分的测量数据存储在所述装置的存储器电路中 并且在存储了所需或指定数量的测量数据之后，将数据传送到外部设备。 也可以存储外部动作数据。 一种控制和处理体液成分的测试数据的方法，其将每个装置的一批数据组与用于识别患者的数据一起存储在外部单元中，并显示从一个或多个数据计算出的每个患者的测量值 数字或模拟形式的每个分析装置的组。

公开(公告)号：US4398894A

公开(公告)日：1983-08-16

申请号：US271386

申请日：1981-06-08

申请人： Hiroshi Yamamoto

发明人： Hiroshi Yamamoto

IPC分类号： G01N15/00 ,  G01N15/04 ,  G01N15/06 ,  G01N21/82 ,  G01N33/49 ,  G01N33/543 ,  G01N35/08 ,  G01N33/54 ,  G01N21/03 ,  G01N21/85

CPC分类号： G01N21/82 ,  G01N15/04 ,  G01N33/4905 ,  G01N33/54313 ,  G01N35/08 ,  Y10S436/805

摘要： A method and apparatus for quantitatively determining a degree of agglutination of a suspension of particles or the presence of the agglutination thereof is disclosed, wherein a liquid which contains agglutinated clots, otherwise a substance or substances to be about to agglutinate is made to slowly transfer through a small tube, in course of which agglutinated clots and non-agglutinated particles separate from each other in the liquid, when a degree of agglutination of particles and the concentration of the substance to be tested herewith can be determined quantitatively through the detection of difference in the optical properties of both the accumulation layer of agglutinated clots and the suspension layer of non-agglutinated particles, or the change in the optical properties of either of the above two layers, in particular the suspension layer.

摘要翻译： 公开了一种用于定量确定颗粒悬浮液的凝集程度或其凝集物存在的方法和装置，其中包含凝集凝块的液体，否则将要凝集的物质或物质被缓慢转移通过 一个小管，其中凝集的凝块和非凝集的颗粒在液体中彼此分离，当颗粒的凝集程度和待测试的物质的浓度可以通过检测到的差异被定量地确定 凝集凝块的积聚层和非凝集粒子的悬浮层的光学性质，或上述两层中的任一层的光学性质的变化，特别是悬浮液层的光学性质。

公开(公告)号：US4304119A

公开(公告)日：1981-12-08

申请号：US076552

申请日：1979-09-18

申请人： Takatoshi Uchigaki

发明人： Takatoshi Uchigaki

IPC分类号： G01N13/04 ,  A61M1/14 ,  G01N25/04 ,  G01N25/06 ,  G01N33/48 ,  G01N33/483 ,  G01N33/86

CPC分类号： G01N25/04

摘要： A method and device for measuring the osmotic pressure on the basis of an improved supercooling process, whereby and wherein cryohydrate nuclei are made to generate almost spontaneously in a part of a sample liquid by cooling the above part down further to a temperature (to an extra-supercooled state) lower than the temperature of a supercooled state, wherethrough the sample liquid as a whole is induced to freeze statically. Because of a non-necessity of using any stirring rod, it becomes possible to design a small-sized device, to reduce the sample liquid to be used to a possible infinitesimal, and further to perform the continuous measurement with the aid of the adoption of a flow cell.

摘要翻译： 一种用于基于改进的过冷却过程来测量渗透压的方法和装置，由此通过将上述部分进一步冷却至一个温度（一个额外的温度），使冷冻水核几乎自发地在一部分样品液体中产生 - 过冷状态）低于过冷状态的温度，通过样品液体作为整体被诱导静止地冷冻。 由于不需要使用任何搅拌棒，因此可以设计小尺寸的装置，以将样品液体减少到可能的无穷小，并且进一步在采用 流动池。

公开(公告)号：US4291981A

公开(公告)日：1981-09-29

申请号：US23407

申请日：1979-03-23

申请人： Masaaki Ohnishi ,  Akio Saito

发明人： Masaaki Ohnishi ,  Akio Saito

IPC分类号： G01N21/01 ,  G01N21/47 ,  G01N21/51 ,  G01N21/15

CPC分类号： G01N21/4785

摘要： A reference scatterer for use in the correction of scattering type photometers having a reference glass scatterer main body with microcrystals therein to split the phase of incident light which is housed within a vessel with a clearance between the two. The clearance is filled with a liquid whose index of refraction substantially matches that of the main body.

摘要翻译： 一种用于校正具有其中具有微晶的参考玻璃散射体主体的散射型光度计的参考散射体，用于分离容纳在容器内的两个间隙之间的入射光的相位。 该间隙填充有折射率基本上与主体的折射率相同的液体。

公开(公告)号：US4931387A

公开(公告)日：1990-06-05

申请号：US714185

申请日：1985-03-20

申请人： Yasuo Yamao ,  Shigeru Fujioka

发明人： Yasuo Yamao ,  Shigeru Fujioka

IPC分类号： C12Q1/00 ,  C12Q1/26 ,  G01N31/22 ,  G01N33/52

CPC分类号： C12Q1/26 ,  G01N33/525 ,  Y10S435/805

摘要： Disclosed is an analysis implement including a support and a reagent layer containing an oxidase applied to the support such that one surface of the reagent layer is exposed to an air atmosphere. A hydrophobic, porous, oxygen permeable layer is positioned between the reagent layer and the support, such that oxygen can permeate to the layer containing oxidase.

摘要翻译： 公开了一种分析工具，其包括载体和试剂层，所述载体和试剂层含有施加到载体的氧化酶，使得试剂层的一个表面暴露于空气气氛。 疏水，多孔，透氧层位于试剂层和载体之间，使得氧气可渗入含有氧化酶的层。

公开(公告)号：US4876204A

公开(公告)日：1989-10-24

申请号：US782356

申请日：1985-10-01

申请人： Kazushige Inoue ,  Hiroshi Yamamoto ,  Hiroshi Hyodo ,  Shinichi Kishimoto

发明人： Kazushige Inoue ,  Hiroshi Yamamoto ,  Hiroshi Hyodo ,  Shinichi Kishimoto

IPC分类号： G01N35/00 ,  G01N35/10

CPC分类号： G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00049 ,  G01N2035/00089 ,  G01N2035/00108 ,  G01N2035/00118 ,  G01N2035/1025 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165

摘要： An autonomous continuous analysis method and apparatus using Dip and Read type analytical implements. A series of operations of taking out analytical implements, dipping them in the sample solution, optical measurement, calculation, and disposal of the used sample solution are performed automatically.The dip stage, in particular, is automated by use of an analytical-implement automatic supply device and an analytical implement automatic handling device which, holding an analytical implement, dips it in the sample solution, and sets it ona reaction turntable. A number of analytical implements are put in a storage section comprising a bottom section provided with an analytical implement groove and at least one inside surface which is parallel with the groove, are taken out one by one by the relative movement of the groove and in normal and reverse direction and by stopping in a specified position after confirming by a detector that an implement has been caught in the groove.

摘要翻译： 一种使用Dip和Read型分析仪器的自主连续分析方法和装置。 自动执行一系列取出分析工具，浸渍在样品溶液中，进行光学测量，计算和处理的操作。 特别地，浸渍阶段通过使用分析工具自动供应装置和分析工具自动处理装置来自动化，其分离工具自动处理装置，其保持分析工具，将其浸入样品溶液中，并将其设置在反应转台上。 许多分析用具被放入存储部分中，该存储部分包括设置有分析用具槽的底部部分和与槽平行的至少一个内表面，通过槽的相对运动逐个取出并且在正常情况下 并且在由检测器确认工具已经被捕获在凹槽中之后停止在指定位置。

公开(公告)号：US4373818A

公开(公告)日：1983-02-15

申请号：US5859

申请日：1979-01-23

申请人： Hiroshi Yamamoto ,  Yoshikazu Furutani

发明人： Hiroshi Yamamoto ,  Yoshikazu Furutani

IPC分类号： G01N21/78 ,  G01N21/47 ,  G01N21/27

CPC分类号： G01N21/4738 ,  G01N2201/065

摘要： A method and apparatus are disclosed for an analyzer which measures concentration of a liquid specimen by monitoring the coloration of test paper which is either dipped into the specimen or is otherwise painted with it. In the method, inner stray rays produced by a light source which do not reach the test paper are experimentally monitored, so that the effect of such inner stray rays upon the accuracy of the test paper analysis is eliminated. Additionally, a method of relating relative reflectivity of the test paper to the concentration of the specimen is disclosed, in which method the calibration curve is modeled as a section of a hyperbola. In the apparatus, a microcomputer performs the evaluation and the detection of the coloration of the test paper and the compensation for various sources of instrumental error takes place electronically.

摘要翻译： 公开了一种用于分析仪的方法和装置，该分析器通过监测浸入试样中或以其它方式涂漆的试纸的着色来测量液体试样的浓度。 在该方法中，通过实验来监测不到达试纸的光源产生的内部杂散光线，从而消除了这种内部杂散光线对测试纸分析精度的影响。 另外，公开了将试纸的相对反射率与试样的浓度相关联的方法，其中校准曲线被建模为双曲线的一部分。 在该装置中，微型计算机执行评估和检测试纸的着色，并且以电子方式进行各种工具误差源的补偿。

公开(公告)号：US4353984A

公开(公告)日：1982-10-12

申请号：US205367

申请日：1980-09-02

申请人： Shigeki Yamada ,  Takao Yamamoto

发明人： Shigeki Yamada ,  Takao Yamamoto

IPC分类号： G01N33/66 ,  C12Q1/26 ,  C12Q1/54 ,  G01N33/52

CPC分类号： C12Q1/54 ,  Y10S435/805 ,  Y10T436/144444 ,  Y10T436/203332

摘要： A composition and test piece or dipstick for measuring the glucose concentration in body fluids such as urine, spinal fluid and blood. The composition includes a glucose oxidase, a peroxidase a N,N'-tetramethyldiaminophenylmethane and guaiac.

摘要翻译： PCT No.PCT / JP80 / 00004 Sec。 371日期1980年9月2日 102（e）日期1980年8月28日PCT提交1980年1月4日PCT公布。 出版物WO80 / 01389 日期1980年7月10日。用于测量体液如尿液，脊髓液和血液中的葡萄糖浓度的组合物和试片或量油尺。 组合物包括葡萄糖氧化酶，过氧化物酶，N，N'-四甲基二氨基苯基甲烷和愈创木瓜。

公开(公告)号：US5474677A

公开(公告)日：1995-12-12

申请号：US340795

申请日：1994-11-15

申请人： Michio Naka

发明人： Michio Naka

IPC分类号： G01N30/24 ,  G01N33/72 ,  B01D15/08 ,  B01D15/00 ,  G01N30/04

CPC分类号： G01N33/723 ,  G01N30/24

摘要： A number of blood samples collected in sample vessels are allowed to stand by as whole blood or blood cell layer, the sample vessels are sent into sampling part in order, the blood sample suctioned from the sampling nozzle is diluted by mixing with hemolyzing liquid containing labile HbA.sub.1c removing reagent, a part of the mixture is led to a sample-loop of sample injection valve and injected into the column of high pressure liquid chromatograph at a specified time after mixing start, hemoglobin fractions are measured in the state of removal or lowering of labile HbA.sub.1c, and the rate of stable glycohemoglobin is determined from thus obtained chromatogram.

摘要翻译： 将样品容器中收集的多个血液样品作为全血或血细胞层静置，将样品容器依次送入取样部分，从采样喷嘴抽吸的血液样品通过与含有不稳定性的溶血液混合而稀释 HbA1c去除试剂，将一部分混合物引入样品注射阀的样品回路，并在混合开始后的指定时间内注入高压液相色谱柱，在除去或降低的状态下测量血红蛋白级分 由此得到的色谱图确定稳定的糖血红蛋白的比例。

公开(公告)号：US5425374A

公开(公告)日：1995-06-20

申请号：US70984

申请日：1993-06-03

申请人： Hideo Ueda ,  Mitsuo Hiromoto

发明人： Hideo Ueda ,  Mitsuo Hiromoto

IPC分类号： A61B5/083 ,  G01N33/497 ,  A61B5/00

CPC分类号： G01N33/497 ,  A61B5/0836

摘要： A portable type clinical examination device using expiratory air of a patient as a sample and measuring with high accuracy and rapidity concentration of trace amounts of aimed gas components contained in the expiratory air. The clinical examination device feeds an expiratory air sample provided by a patient, fed through an expiratory air sucking portion and separated in a column to a detector which detects trace amounts of aimed gas components contained in the expiratory air sample by ionizing the aimed gas components through application of ultraviolet or radiation, so that output signals from the detector are processed and concentration of the aimed gas components is computed by use of a previously memorized working curve to provide a clinical examination data which is output on a recording device or the like.

摘要翻译： 一种便携式临床检查装置，使用患者的呼气作为样品，并以高精度和快速浓度测量呼气中所含的痕量目标气体成分。 临床检查装置供给由患者提供的呼气空气样本，通过呼气空气吸入部分供给，并在柱中分离成检测器，检测器通过将目标气体成分通过电离目标气体成分 施加紫外线或辐射，使得来自检测器的输出信号被处理，并且通过使用先前存储的工作曲线来计算目标气体成分的浓度，以提供在记录装置等上输出的临床检查数据。