公开(公告)号：US20240349001A1

公开(公告)日：2024-10-17

申请号：US18580344

申请日：2022-07-18

申请人： MCMASTER UNIVERSITY

发明人： Navid H. ZANDI ,  Awny M. EL-MOHANDES ,  Rong ZHENG

IPC分类号： H04S7/00 ,  G06N3/0455

CPC分类号： H04S7/303 ,  G06N3/0455 ,  H04S2400/11 ,  H04S2400/15 ,  H04S2420/01 ,  H04S2420/03

摘要： There is provided a system and method for determining individualized head related transfer functions (HRTF) for a user. The method including: receiving measurement data from the user, the measurement data generated by repeatedly emitting an audible reference sound at positions in space around the user and, during each emission, recording sounds received near each ear of the user, the measurement data including, for each emission, the recorded sounds and positional information of the emission; determining the individualized HRTF by updating a decoder of a trained generative artificial neural network model, the decoder receives the measurement data as input, the trained generative artificial neural network model including an encoder and the decoder, the generative artificial neural network model is trained using data gathered from a plurality of test subjects with known spectral representations and directions for associated HRTFs at different positions in space; and outputting the individualized HRTF.

公开(公告)号：US20240331531A1

公开(公告)日：2024-10-03

申请号：US18141334

申请日：2023-04-28

申请人： TOYOTA MOTOR ENGINEERING & MANUFACTURING NORTH AMERICA, INC.

发明人： Yashar Zeiynali Farid ,  Hao Yang ,  Seyhan Ucar ,  Kentaro Oguchi

IPC分类号： G08G1/01

CPC分类号： G08G1/0141 ,  G08G1/0112 ,  G08G1/0129 ,  G08G1/0133

摘要： An example operation includes one or more of receiving traffic data uploaded from vehicles that are currently operating within a geographic area via a computer network, generating a plurality of macroscopic fundamental diagrams (MFDs) for a plurality of sub-areas within the geographic area, respectively, based on the received traffic data, identifying a sub-area among the plurality of sub-areas which is congested based on the plurality of MFDs, and transmitting routing instructions to the vehicles within the geographic area to divert the vehicles away from the sub-area.

公开(公告)号：US20240317660A1

公开(公告)日：2024-09-26

申请号：US18572235

申请日：2022-06-23

申请人： McMaster University

发明人： Jakob Magolan ,  Xiong Zhang ,  Nicholas Jentsch ,  Mathew Piotrowski ,  Meghan Fragis ,  Jarrod Johnson ,  Lauren Irwin

IPC分类号： C07C37/16

CPC分类号： C07C37/16

摘要： The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted.

公开(公告)号：US12078370B2

公开(公告)日：2024-09-03

申请号：US17301907

申请日：2021-04-19

申请人： McMaster University

发明人： James Scott Cotton ,  Kelton Friedrich ,  Vickram Lakhian ,  Saber Mohamed ,  Mohamed Yasser Abdelsalam ,  Jorge Chebeir ,  Jeff Girard

IPC分类号： F24F11/46 ,  F24D11/02 ,  F24F5/00 ,  F24F11/47 ,  F24F11/63 ,  G05B19/042 ,  H02J3/38

CPC分类号： F24F11/46 ,  F24D11/0207 ,  F24F5/0021 ,  F24F11/47 ,  F24F11/63 ,  G05B19/042 ,  F24D2200/11 ,  F24D2200/13 ,  F24D2200/32 ,  F24F2203/02 ,  G05B2219/2614 ,  G05B2219/2639 ,  H02J3/381 ,  H02J2203/20 ,  H02J2310/12 ,  H02J2310/48

摘要： A district energy system includes at least one energy provisioning unit, an energy management controller; a thermal distribution network coupled to the energy provisioning units and to a plurality of coupling interfaces connectable to the associated HVAC system of buildings within a district, and an electrical distribution network coupled to the energy provisioning units and to the coupling interfaces. The coupling interfaces may include both heat pumps and heat exchangers at each building, to provide heating, cooling and enable harvesting of normally wasted thermal energy from the buildings for re-distribution. The controller can manage the selection and number of energy provisioning units (and their operational set points) coupled to the district thermal distribution network and the electrical distribution network to meet the thermal and electrical demands of the district while satisfying other operational goals such as the minimization of greenhouse gas emissions.

公开(公告)号：US20240273386A1

公开(公告)日：2024-08-15

申请号：US18436182

申请日：2024-02-08

申请人： McMaster University

发明人： Mohammadreza Heydarian Firouz Aba ,  Thomas Edward Doyle ,  Reza Samavi

IPC分类号： G06N5/04

CPC分类号： G06N5/04

摘要： A system, method and computer program product for evaluating a multi-label classification machine learning model. A model labelled dataset is received from the model and includes a plurality of data elements each labelled with zero or more model predicted labels of q potential classes. A multi-label confusion matrix is defined to include q+1 rows with q rows for true labels and 1 row for no true label and q+1 columns with q columns for predicted labels and 1 column for no predicted label. The matrix is populated by comparing the model labelled dataset with a true labelled dataset. At least one performance metric is calculated from the populated multi-label confusion matrix.

公开(公告)号：US20240272148A1

公开(公告)日：2024-08-15

申请号：US18437875

申请日：2024-02-09

申请人： McMaster University

发明人： Carlos Filipe ,  John D. Brennan ,  Robert Pelton ,  Sana Jahanshahi-Anbuhi ,  Yingfu Li

IPC分类号： G01N33/543 ,  C12Q1/66 ,  C12Q1/686 ,  G01N21/77 ,  G01N21/78 ,  G01N33/548

CPC分类号： G01N33/5436 ,  C12Q1/66 ,  C12Q1/686 ,  G01N21/78 ,  G01N33/548 ,  G01N2021/7786 ,  G01N2333/922

摘要： The present application is directed to methods of performing chemical reactions, including multi-step chemical reactions in which two or more of the reagents in the chemical reaction are incorporated or entrapped in a solid polymeric structure comprising pullulan. In certain embodiments, the chemical reaction or multi-step reaction serves as a sensor. Accordingly the present application is also directed to sensors for performing the methods of the application. In certain embodiments, at least one of the reagents is a biomolecule and the sensor is a biosensor. In certain other embodiments, the solid polymeric structure comprising pullulan and the reagents for performing a chemical reaction form a convenient device for performing a chemical reaction.

公开(公告)号：US20240156972A1

公开(公告)日：2024-05-16

申请号：US18547714

申请日：2022-02-24

申请人： McMaster University

发明人： Anthony RULLO ,  Yonghong WAN ,  Harrison McCann ,  Benjamin LAKE

IPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/54 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005

CPC分类号： A61K47/64 ,  A61K35/763 ,  A61K47/545 ,  A61K47/60 ,  A61P35/00 ,  C07K14/005 ,  C12N2710/16622

摘要： The present disclosure relates generally to the field of cancer immunotherapy. More particularly, the present disclosure provides antibody recruitment molecules, pharmaceutical compositions comprising same and kits comprising same. The present disclosure also provides methods of treating cancer using the antibody recruitment molecules in combination with oncolytic virus therapy, and methods for enhancing the efficacy and/or reducing the toxicity of the oncolytic virus therapy.

公开(公告)号：US20240150269A1

公开(公告)日：2024-05-09

申请号：US18372980

申请日：2023-09-26

申请人： McMaster University

发明人： Jakob Magolan ,  Nicholas Jentsch ,  Xiong Zhang ,  Mathew Piotrowski ,  Patrick Darveau ,  Meghan Fragis ,  Jarrod Johnson ,  Nicole Ritchie ,  Arnav Kaul

IPC分类号： C07C37/14 ,  B01J21/04 ,  C07C41/26 ,  C07C201/12 ,  C07C253/30 ,  C07D209/08 ,  C07D307/80 ,  C07D311/30 ,  C07D311/32 ,  C07J1/00 ,  C07J7/00

CPC分类号： C07C37/14 ,  B01J21/04 ,  C07C41/26 ,  C07C201/12 ,  C07C253/30 ,  C07D209/08 ,  C07D307/80 ,  C07D311/30 ,  C07D311/32 ,  C07J1/0059 ,  C07J7/0005

摘要： The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (1) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected from alumina and aluminum alkoxides and in a non-protic solvent wherein at least one carbon atom ortho to the hydroxy group in the hydroxy aryl compound is unsubstituted. The present application also includes compounds of Formula (1).

公开(公告)号：US11976117B2

公开(公告)日：2024-05-07

申请号：US16826053

申请日：2020-03-20

申请人： McMaster University

发明人： Jonathan Lorne Bramson ,  Christopher W. Helsen ,  Joanne Alicia Hammill ,  Kenneth Anthony Mwawasi

IPC分类号： A61K35/17 ,  C07K14/73 ,  C07K16/28

CPC分类号： C07K16/2803 ,  C07K14/70514 ,  C07K16/2809 ,  C07K2317/622 ,  C07K2319/03

摘要： A trifunctional molecule is provided, comprising (i) a target-specific ligand, (ii) a ligand that binds a protein associated with a TCR complex, and (iii) a T cell receptor signaling domain polypeptide. Variants of the molecule are provided, including variants that exhibit optimized surface expression, transduction efficiency, and effector functionality. Variations include, for example, different ligands that bind CD3 epsilon (e.g., OKT3, L2K, F6A, UCHT1 and humanized UCHT1), different signaling domains, and different linkers between domains.

公开(公告)号：US20240109870A1

公开(公告)日：2024-04-04

申请号：US18383687

申请日：2023-10-25

申请人： McMaster University

发明人： Anthony Rullo ,  Jonathan Bramson ,  Yonghong Wan ,  Benjamin Lake ,  Nickolas Serniuck

IPC分类号： C07D403/12 ,  C07D233/90 ,  C07D493/10

CPC分类号： C07D403/12 ,  C07D233/90 ,  C07D493/10 ,  C07K16/44

摘要： The present application relates to compounds of Formula I comprising an antibody binding domain (ABD) comprising a hapten that binds to an antibody in a subject, the antibody comprising a hapten binding site, an antibody labelling domain (ALD) comprising a functional group that forms a covalent bond with an amino acid in the antibody that is proximal to the hapten binding site and the formation of the covalent bond results in elimination of the ABD and either a target binding domain (TBD) or a detection moiety domain (DMD), each domain being optionally connected with independently selected linkers. The present application also includes methods and uses of the compounds, for example, for immune recognition of target cells by recruited labelled antibodies.


ABD-(L1)n-ALD-(L2)m-R  I