公开(公告)号：US10386373B2

公开(公告)日：2019-08-20

申请号：US15991982

申请日：2018-05-29

申请人： SERIMMUNE INC.

发明人： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC分类号： C12N9/10 ,  G01N33/68 ,  A61K38/00 ,  C12Q1/689 ,  G01N33/558 ,  C07K14/195 ,  C07K14/315 ,  C07K14/285 ,  C07K14/435 ,  C07K14/44 ,  C07K14/45 ,  C12N15/10

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20240044911A1

公开(公告)日：2024-02-08

申请号：US18243566

申请日：2023-09-07

申请人： Serimmune Inc.

发明人： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC分类号： G01N33/68 ,  C07K14/285 ,  G01N33/53 ,  C07K14/44 ,  G01N33/569 ,  G01N33/564 ,  C07K14/315 ,  C07K14/195 ,  C07K14/45 ,  C07K14/435

CPC分类号： G01N33/6854 ,  G01N33/6845 ,  C07K14/285 ,  G01N33/53 ,  C07K14/44 ,  G01N33/56988 ,  G01N33/564 ,  G01N33/56944 ,  C07K14/315 ,  C07K14/195 ,  G01N33/56994 ,  G01N33/6842 ,  C07K14/45 ,  G01N33/56905 ,  G01N33/6878 ,  G01N33/56966 ,  C07K14/43554 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/569 ,  G01N2333/18 ,  G01N2333/095 ,  C12Q1/689

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20210230580A1

公开(公告)日：2021-07-29

申请号：US17267004

申请日：2019-08-08

申请人： Serimmune Inc.

发明人： Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert ,  Patrick Sean Daugherty

IPC分类号： C12N15/10

摘要： Disclosed herein are reagents for use in quality control assessment of antibody profiling platforms, such as biopanning and Digital Serology. Also disclosed herein are kits, method of manufacturing, and methods of using the same.

公开(公告)号：US20240192208A1

公开(公告)日：2024-06-13

申请号：US18507763

申请日：2023-11-13

申请人： Serimmune Inc.

发明人： Kathryn Vinaya Louise Kamath

IPC分类号： G01N33/569

CPC分类号： G01N33/56911 ,  G01N2333/20 ,  G01N2469/20

摘要： Disclosed herein are reagents for use in antibody profiling platforms, such as biopanning and Digital Serology, specifically for eptiope motifs directed to Leptospira. Also disclosed herein are kits, method of manufacturing, and methods of using the same.

公开(公告)号：US20230375567A1

公开(公告)日：2023-11-23

申请号：US18122527

申请日：2023-03-16

申请人： Serimmune Inc.

发明人： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC分类号： G01N33/68 ,  C07K14/195 ,  C07K14/315 ,  C07K14/285 ,  C07K14/435 ,  C07K14/44 ,  C07K14/45 ,  G01N33/569 ,  G01N33/53 ,  G01N33/564

CPC分类号： G01N33/6854 ,  C07K14/195 ,  C07K14/315 ,  C07K14/285 ,  C07K14/43554 ,  C07K14/44 ,  C07K14/45 ,  G01N33/6842 ,  G01N33/56911 ,  G01N33/56905 ,  G01N33/56988 ,  G01N33/56994 ,  G01N33/56983 ,  G01N33/53 ,  G01N33/56944 ,  G01N33/564 ,  G01N33/569 ,  G01N33/56966 ,  G01N33/6845 ,  G01N33/6878 ,  C12N15/1037

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20230288421A1

公开(公告)日：2023-09-14

申请号：US18145772

申请日：2022-12-22

申请人： Serimmune Inc.

发明人： Winston A. Haynes ,  Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert ,  Abhilash Dhal ,  John Chul-yong Shon

IPC分类号： G01N33/569 ,  G01N33/543 ,  C07K7/06

CPC分类号： G01N33/56983 ,  G01N33/54386 ,  G01N33/54326 ,  C07K7/06 ,  G01N2469/20 ,  G01N2333/165

摘要： Disclosed herein are reagents for use in antibody profiling platforms, such as biopanning and Digital Serology, specifically for eptiope motifs directed to SARS-CoV-2. Also disclosed herein are kits, method of manufacturing, and methods of using the same.

公开(公告)号：US20230024898A1

公开(公告)日：2023-01-26

申请号：US17555216

申请日：2021-12-17

申请人： Serimmune Inc.

发明人： John Shon ,  Winston A. Haynes ,  Patrick Sean Daugherty

IPC分类号： G16B30/00 ,  G16B20/30 ,  G16B40/20 ,  G16H70/40

摘要： The present invention provides compositions and methods that can be used to identify an antigen or epitope region of an antigen specific for a disease or other condition. Such methods incorporate k-mer binding statistics to serum antibody from condition and control cohort samples to predict the suitability of antigen sequences identified as relevant to the disease or condition as antigen markers. Also disclosed herein are systems for performing the same.

公开(公告)号：US20210011025A1

公开(公告)日：2021-01-14

申请号：US15775363

申请日：2016-11-14

申请人： SERIMMUNE INC.

发明人： Patrick DAUGHERTY ,  Kathryn KAMATH ,  Jack REIFERT

IPC分类号： G01N33/68 ,  G01N33/569 ,  G01N33/564

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The of an antibody specificity in method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.

公开(公告)号：US20240241131A1

公开(公告)日：2024-07-18

申请号：US18628328

申请日：2024-04-05

申请人： Serimmune Inc.

发明人： John Chul-Yong Shon ,  Minlu Zhang

IPC分类号： G01N33/68 ,  G16H50/20

CPC分类号： G01N33/6854 ,  G16H50/20

摘要： The present invention provides compositions and methods that can be used to identify an antigen or epitope region of an antigen specific for a disease or other condition. Such methods incorporate k-mer binding statistics to serum antibody from condition and control cohort samples to predict the suitability of antigen sequences identified as relevant to the disease or condition as antigen markers. Additionally, statistics can be used for diagnostic and treatment purposes, such as a sum-of-antigenic score statistic. Also disclosed herein are systems for performing the same.

公开(公告)号：US11828762B2

公开(公告)日：2023-11-28

申请号：US17096890

申请日：2020-11-12

申请人： Serimmune Inc.

发明人： Patrick Sean Daugherty ,  Kathryn Vinaya Louise Kamath ,  Jack Ryan Reifert

IPC分类号： G01N33/68 ,  C07K14/195 ,  C07K14/315 ,  C07K14/285 ,  C07K14/435 ,  C07K14/44 ,  C07K14/45 ,  G01N33/569 ,  G01N33/53 ,  G01N33/564 ,  C12N15/10 ,  C12Q1/689

CPC分类号： G01N33/6854 ,  C07K14/195 ,  C07K14/285 ,  C07K14/315 ,  C07K14/43554 ,  C07K14/44 ,  C07K14/45 ,  G01N33/53 ,  G01N33/564 ,  G01N33/569 ,  G01N33/56905 ,  G01N33/56911 ,  G01N33/56944 ,  G01N33/56966 ,  G01N33/56983 ,  G01N33/56988 ,  G01N33/56994 ,  G01N33/6842 ,  G01N33/6845 ,  G01N33/6878 ,  C12N15/1037 ,  C12Q1/689 ,  G01N2333/045 ,  G01N2333/05 ,  G01N2333/095 ,  G01N2333/16 ,  G01N2333/18 ,  G01N2333/20 ,  G01N2333/285 ,  G01N2333/29 ,  G01N2333/315 ,  G01N2333/4353 ,  G01N2570/00 ,  G01N2800/24 ,  G01N2800/26 ,  Y02A50/30

摘要： The present invention provides compositions and methods that can be used to determine a peptide signature for an antibody repertoire in a sample comprising multiple antibodies. The method can be used to characterize a phenotype in a sample, such as providing a diagnosis, prognosis or theranosis of a medical condition.