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公开(公告)号：US07582484B2
公开(公告)日：2009-09-01
申请号：US11109526
申请日：2005-04-18
CPC分类号： G01N33/5302 , G01N33/54366 , G01N33/558 , G01N33/92 , G01N2800/044 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design is such that removal of non-HDL lipoproteins from a sample and assay of HDL cholesterol in the sample occur without interruption of the assay. The device also prevents interference by reagents used for the HDL assay with other assays carried out on the same sample.
摘要翻译： 描述了用于测量血液样品中HDL相关胆固醇浓度的测定装置和方法。 测定设计使得样品中的非HDL脂蛋白的去除和样品中的HDL胆固醇的测定不发生中断。 该装置还防止用于HDL测定的试剂与在相同样品上进行的其它测定的干扰。
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公开(公告)号：US07220595B2
公开(公告)日：2007-05-22
申请号：US10456230
申请日：2003-06-06
申请人： Anthony J. Nugent , Leanne M. Cowley , Neal F. Bellet , Jeffrey Shindelman , Michael E. Leos , Thomas E. Worthy , Kimberly Haley
发明人： Anthony J. Nugent , Leanne M. Cowley , Neal F. Bellet , Jeffrey Shindelman , Michael E. Leos , Thomas E. Worthy , Kimberly Haley
IPC分类号： G01N33/558
CPC分类号： B01L9/52 , B01L3/5023 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , B01L2400/0633 , G01N33/5304 , G01N33/54306 , G01N33/54366 , G01N33/54386 , Y10S435/805 , Y10S435/81 , Y10S435/97 , Y10S436/81
摘要： An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement toward and away from a sample transfer position. Sample supplied to a sample well in the cassette body is taken up by a reagent reservoir containing a first reagent composition effective to form a modified sample. The support provides a reagent strip having a transfer zone that is brought into contact with the reservoir, when the support is in the transfer position, a detection zone located downstream of the transfer zone, and a second reagent composition effective to react with the modified sample to form a detectable analyte-dependent product. By controlling movement of the support, volume and rate of sample flow from the reservoir to the strip can be controlled to optimize and/or standardize sample-transfer conditions in the assay.
摘要翻译： 公开了用于检测液体体液样品中的分析物的免疫测定盒，装置和方法。 盒具有安装在主体上的主体和支撑件，用于朝向和远离样品转移位置移动。 在盒体中提供给样品阱的样品被含有有效形成改性样品的第一试剂组合物的试剂容器吸收。 所述支持体提供具有转移区域的试剂条带，所述转移区域在所述载体处于转移位置时与所述储存器接触，位于所述转移区域下游的检测区域和有效与所述修饰样品反应的第二试剂组合物 以形成可检测的分析物依赖性产物。 通过控制载体的移动，可以控制从储存器到条带的样品流量的体积和速率，以在测定中优化和/或标准化样品转移条件。
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公开(公告)号：US07795038B2
公开(公告)日：2010-09-14
申请号：US10410671
申请日：2003-04-08
IPC分类号： G01N33/53
CPC分类号： G01N33/92 , C12Q1/60 , G01N33/558 , G01N2800/044 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design prevents interference by reagents used for such removal with the HDL quantification reaction or with other assays carried out on the same sample. If desired, removal of non-HDL lipoproteins and assay of HDL cholesterol can be carried out without interruption of the assay.
摘要翻译： 描述了用于测量血液样品中HDL相关胆固醇浓度的测定装置和方法。 测定设计可以防止用于这种去除的试剂与HDL定量反应的干扰或与在相同样品上进行的其它测定的干扰。 如果需要，可以在不中断测定的情况下进行非HDL脂蛋白的去除和HDL胆固醇的测定。
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公开(公告)号：US06881581B2
公开(公告)日：2005-04-19
申请号：US10346685
申请日：2003-01-17
IPC分类号： G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/558 , G01N33/92 , G01N33/49
CPC分类号： G01N33/5302 , G01N33/54366 , G01N33/558 , G01N33/92 , G01N2800/044 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： An assay device and method for measuring the concentration of HDL-associated cholesterol in a blood-fluid sample are described. The assay design is such that removal of non-HDL lipoproteins from a sample and assay of HDL cholesterol in the sample occur without interruption of the assay. The device also prevents interference by reagents used for the HDL assay with other assays carried out on the same sample.
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公开(公告)号：US20120309636A1
公开(公告)日：2012-12-06
申请号：US13355458
申请日：2012-01-20
申请人： Ian Gibbons , Anthony J. Nugent , Anthony Delacruz , Daniel Young , Elizabeth Holmes , Andrew Drake , Timothy Michael Kemp , Sunny Balwani , Chinmay Pangarkar
发明人： Ian Gibbons , Anthony J. Nugent , Anthony Delacruz , Daniel Young , Elizabeth Holmes , Andrew Drake , Timothy Michael Kemp , Sunny Balwani , Chinmay Pangarkar
IPC分类号： G06K9/36 , G01N1/10 , B04B5/02 , C12M1/34 , B01D43/00 , C40B30/04 , G01N21/00 , G01N21/59 , B04B15/00
CPC分类号： G01N21/00 , B01L3/0275 , B01L2300/168 , B04B5/0421 , C12Q1/42 , C12Q1/48 , C12Q1/52 , C12Q1/6806 , C12Q1/6809 , C12Q1/689 , C12Q2600/158 , G01N1/4077 , G01N21/0303 , G01N21/51 , G01N21/59 , G01N33/5308 , G01N33/54326 , G01N33/54393 , G01N33/56972 , G01N33/56983 , G01N33/573 , G01N33/74 , G01N33/743 , G01N33/80 , G01N33/82 , G01N33/92 , G01N35/10 , G01N2001/4083 , G01N2035/00495 , G01N2035/1018 , G01N2333/575 , G01N2333/62 , G01N2333/91188 , G01N2333/96463 , G06T3/4084 , G06T7/0002 , G06T7/0012 , G06T2207/30004 , G06T2207/30168 , G16C20/20 , H04N5/23222
摘要： The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.
摘要翻译： 本发明提供了用于点护理和/或分布式测试服务的系统，设备和方法。 本发明的方法和装置旨在自动检测体液中的分析物。 可以对装置的部件进行修改以允许用于各种医疗，实验室和其它应用的所公开的方法更灵活和更健壮的使用。 本发明的系统，装置和方法可以通过改进的样品制备和分析来允许样品的有效使用。
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