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    Method and apparatus for determining terrain surface profiles
    1.
    发明授权
    Method and apparatus for determining terrain surface profiles 失效
    用于确定地形曲面的方法和装置

    公开(公告)号：US5065618A

    公开(公告)日：1991-11-19

    申请号：US613232

    申请日：1990-11-14

    申请人： Hency C. Hodges, Sr. ,  Henry C. Hodges, Jr. ,  Sam C. Ashmore ,  Allan G. Piersol

    发明人： Hency C. Hodges, Sr. ,  Henry C. Hodges, Jr. ,  Sam C. Ashmore ,  Allan G. Piersol

    IPC分类号： G01C7/04

    CPC分类号： G01C7/04

    摘要： A method and apparatus for use in measuring the physical profile of a road surface and a methodology for frequency domain representation of the profile is disclosed. Force transducers and accelerometers are incorporated at each of the four wheels of a vehicle to measure the perturbations of the road surface in a direction normal to the surface over which the vehicle is driven. The disclosed implementation isolates the measurements from the motion of the vehicle body. A shaft encoder is incorporated at each of the front wheels to measure rotation of the wheels allowing the determination of distance traveled. A methodology for analysis of the data is also disclosed which provides vertical displacement data of the wheel/terrain interface while reducing the introduction of errors as the information is processed. Further methodology is used to analyze the data in the frequency domain and provide for the quantification of road/terrain characteristics useful for accelerated life testing of vehicles.

    摘要翻译： 公开了一种用于测量路面的物理特征的方法和装置以及该轮廓的频域表示的方法。 力传感器和加速度计被并入车辆的四个车轮中的每一个，以测量在与车辆驱动的表面正交的方向上的路面的扰动。 所公开的实施方式将测量与车体的运动隔离。 在每个前轮上并入轴编码器，以测量车轮的旋转，从而确定行进的距离。 还公开了分析数据的方法，其提供了轮/地形接口的垂直位移数据，同时在信息被处理时减少了误差的引入。 使用进一步的方法来分析频域中的数据，并提供对车辆加速寿命测试有用的道路/地形特征的量化。

    Method of forming an aerosol for inhalation delivery
    3.
    发明授权
    Method of forming an aerosol for inhalation delivery 有权
    形成用于吸入输送的气溶胶的方法

    公开(公告)号：US08074644B2

    公开(公告)日：2011-12-13

    申请号：US12471070

    申请日：2009-05-22

    申请人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    发明人： Ron L. Hale ,  Craig C. Hodges ,  Peter M. Lloyd ,  Daniel Mufson ,  Daniel D. Rogers ,  Soonho Song ,  Martin J. Wensley ,  Daniel J. Myers ,  Jeffrey A. McKinney ,  Reynaldo J. Quintana ,  Joshua D. Rabinowitz

    IPC分类号： A61L9/04

    CPC分类号： A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

    摘要： The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000° C./s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10μ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

    摘要翻译： 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μ厚的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。

    Source code editor for editing multilanguage documents
    6.
    发明申请
    Source code editor for editing multilanguage documents 有权
    用于编辑多语言文档的源代码编辑器

    公开(公告)号：US20050114769A1

    公开(公告)日：2005-05-26

    申请号：US10723329

    申请日：2003-11-26

    申请人： Mikhail Arkhipov ,  Joshua Kaplan ,  Timothy McBride ,  Li Zhang ,  C. Hodges ,  Elliot Omiya

    发明人： Mikhail Arkhipov ,  Joshua Kaplan ,  Timothy McBride ,  Li Zhang ,  C. Hodges ,  Elliot Omiya

    IPC分类号： G06F15/00 ,  G06Q10/00

    CPC分类号： G06Q10/10

    摘要： A source code editor is used to develop multilanguage documents while providing the advanced editing functionality of secondary editors and without requiring the programmer to explicitly open and interface with the secondary editors. The multilanguage document is presented to the user in a primary application view of the primary editor. Code segments written in different languages are identified and sent to the appropriate secondary editors, which in turn create secondary documents that are transparent to the programmer. As edits are made to the primary application view of the document, the edits are replicated by the secondary editors behind the scene. Functionality that is enabled by the secondary editors, such as syntax coloring, auto-completion, and validation is identified by the primary editor and replicated in the primary application view, so as to appear as if the primary editor is inherently configured with the leveraged functionality of the secondary editors.

    摘要翻译： 源代码编辑器用于开发多语言文档，同时提供辅助编辑器的高级编辑功能，而不需要程序员明确打开并与二级编辑器进行接口。 多语言文档在主编辑器的主应用程序视图中呈现给用户。 用不同语言编写的代码段被识别并发送到相应的辅助编辑器，这些次级编辑器又创建对程序员透明的辅助文档。 当对文档的主应用程序视图进行编辑时，编辑将由场景后面的辅助编辑器复制。 辅助编辑器启用的功能（如语法着色，自动完成和验证）由主编辑器标识并在主应用程序视图中进行复制，以便显示为主编辑器固有地配置了杠杆功能 的二级编辑。

    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
    9.
    发明授权
    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them 失效
    肾素抑制剂，其制备方法，使用方法和含有它们的组合物

    公开(公告)号：US5288851A

    公开(公告)日：1994-02-22

    申请号：US925702

    申请日：1992-08-04

    申请人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    发明人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    IPC分类号： C07K5/02 ,  A61K37/02 ,  C07K5/00

    CPC分类号： C07K5/0227

    摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 制备肽的方法，可用于其制备的新型中间体，含有它们的组合物及其使用方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。

    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them
    10.
    发明授权
    Renin inhibitors, processes for preparing them, methods for using them, and compositions containing them 失效
    肾素抑制剂，其制备方法，使用方法和含有它们的组合物

    公开(公告)号：US5162527A

    公开(公告)日：1992-11-10

    申请号：US676047

    申请日：1991-03-27

    申请人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    发明人： Annette M. Doherty ,  Harriet W. Hamilton ,  John C. Hodges ,  Joseph T. Repine ,  Ila Sircar

    IPC分类号： C07K5/02

    CPC分类号： C07K5/0227

    摘要： The invention concerns novel renin-inhibitory peptides which are useful for treating renin-associated hypertension, congestive heart failure, hyperaldosteronism and diseases caused by retroviruses including HTLV-I and -III. Processes for preparing the peptides, novel intermediates useful in the preparation thereof, compositions containing them, and methods of using them are included. Also included is a diagnostic method which uses the compounds to determine the presence of renin-associated hypertension, congestive heart failure, or hyperaldosteronism.

    摘要翻译： 本发明涉及可用于治疗肾素相关性高血压，充血性心力衰竭，醛固酮增多症和由逆转录病毒（包括HTLV-1和-III）引起的疾病的新型肾素抑制肽。 制备肽的方法，可用于其制备的新型中间体，含有它们的组合物及其使用方法。 还包括使用该化合物来确定肾素相关性高血压，充血性心力衰竭或醛固酮增多症的存在的诊断方法。