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公开(公告)号:US08389679B2
公开(公告)日:2013-03-05
申请号:US12701443
申请日:2010-02-05
申请人: Randal H. Eckert , Daniel Yarbrough , Wenyuan Shi , Maxwell Anderson , Jian He , Chris Kaplan , Jee-Hyun Sim
发明人: Randal H. Eckert , Daniel Yarbrough , Wenyuan Shi , Maxwell Anderson , Jian He , Chris Kaplan , Jee-Hyun Sim
IPC分类号: A61K39/395
CPC分类号: A01N63/00 , A01N25/10 , C07K2319/01 , C07K2319/55 , A01N35/06 , A01N37/46 , A01N43/24 , A01N43/42 , A01N43/90 , A01N63/02
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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公开(公告)号:US20100316643A1
公开(公告)日:2010-12-16
申请号:US12701443
申请日:2010-02-05
申请人: Randal H. Eckert , Daniel Yarbrough , Wenyuan Shi , Maxwell Anderson , Jian He , Chris Kaplan , Jee-Hyun Sim
发明人: Randal H. Eckert , Daniel Yarbrough , Wenyuan Shi , Maxwell Anderson , Jian He , Chris Kaplan , Jee-Hyun Sim
IPC分类号: A61K39/395 , C07K7/08 , C07K14/00 , C07K19/00 , A61K38/16 , A61K38/10 , C12Q1/04 , A61P31/04 , A61P31/10 , A61P33/02 , A61P31/12
CPC分类号: A01N63/00 , A01N25/10 , C07K2319/01 , C07K2319/55 , A01N35/06 , A01N37/46 , A01N43/24 , A01N43/42 , A01N43/90 , A01N63/02
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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公开(公告)号:US20110039762A1
公开(公告)日:2011-02-17
申请号:US12683327
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
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公开(公告)号:US20100184683A1
公开(公告)日:2010-07-22
申请号:US12683258
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
IPC分类号: A61K38/16 , C07K14/00 , C07K7/08 , C07K7/06 , A61K38/10 , A01N37/18 , A61K38/08 , C07K16/00 , A61P31/04 , A01P1/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
摘要翻译: 本发明提供了新的抗微生物肽及其制剂。 肽和/或制剂有效杀死或抑制各种细菌,酵母和真菌的生长和/或增殖。
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公开(公告)号:US08303962B2
公开(公告)日:2012-11-06
申请号:US12683188
申请日:2010-01-06
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
IPC分类号: A61K38/00 , A61K38/04 , A61K39/00 , A61K39/02 , A61K39/09 , A61K39/38 , C07K4/00 , C07K5/00 , C07K7/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
摘要翻译: 本发明提供了新的抗微生物肽及其制剂。 肽和/或制剂有效杀死或抑制各种细菌,酵母和真菌的生长和/或增殖。
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公开(公告)号:US08754039B2
公开(公告)日:2014-06-17
申请号:US12683160
申请日:2010-01-06
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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公开(公告)号:US20110039761A1
公开(公告)日:2011-02-17
申请号:US12683160
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
摘要翻译: 本发明提供了新颖的靶向抗微生物组合物。 在各种实施方案中,提供了包含与结合细菌菌株或物种的肽靶向部分连接的抗微生物肽的嵌合部分。
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8.
公开(公告)号:US20120003661A1
公开(公告)日:2012-01-05
申请号:US13170045
申请日:2011-06-27
申请人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
发明人: Randal H. Eckert , Chris Kaplan , Jian He , Daniel K. Yarbrough , Maxwell Anderson , Jee-Hyun Sim
IPC分类号: C12Q1/68 , C12M1/34 , C12Q1/66 , C12Q1/40 , C12Q1/32 , G01N27/26 , C12Q1/42 , C12Q1/26 , C12Q1/04 , C12Q1/34 , C12Q1/44 , C12Q1/06 , G01N33/569 , C12Q1/48
摘要: Methods and devices are provided for the rapid and specific detection of target microorganisms, cells, and the like. In one embodiment, the methods involve contacting a target microorganism (e.g., in a sample) with a permeabilization reagent that selectively permeabilizes or lyses the microorganism; contacting the selectively permeabilized microorganism with a detection reagent that is taken into the selectively permeabilized organism or that contacts metabolites or enzymes released by the selectively permeabilized microorganism, where the detection reagent produces a signal in the presence of said metabolites or enzymes; and detecting a signal produced by the detection reagent in the presence of the metabolites or enzymes wherein the strength of the signal indicates the presence and/or amount of the target microorganism in the sample.
摘要翻译: 提供了用于快速和具体检测靶微生物,细胞等的方法和装置。 在一个实施方案中,所述方法包括使靶微生物(例如,样品)与选择性渗透或裂解微生物的透化试剂接触; 使选择性透过的微生物与被选入透化生物体中的检测试剂接触或接触由选择性透化的微生物释放的代谢物或酶,其中所述检测试剂在所述代谢物或酶存在下产生信号; 以及在所述代谢物或酶的存在下检测由所述检测试剂产生的信号,其中所述信号的强度表示样品中目标微生物的存在和/或量。
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公开(公告)号:US20110039763A1
公开(公告)日:2011-02-17
申请号:US12683352
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
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公开(公告)号:US20100184684A1
公开(公告)日:2010-07-22
申请号:US12683286
申请日:2010-01-06
申请人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
发明人: RANDAL H. ECKERT , CHRIS KAPLAN , JIAN HE , DANIEL K. YARBROUGH , MAXWELL ANDERSON , JEE-HYUN SIM
IPC分类号: A61K38/16 , C07K14/00 , C07K7/08 , C07K7/06 , A61K38/10 , A01N37/18 , A61K38/08 , C07K16/00 , A61P31/04 , A61P31/10 , A01P1/00
CPC分类号: A61K47/6911 , A01N37/46 , A61K8/64 , A61K9/0019 , A61K9/0063 , A61K9/06 , A61K38/08 , A61K38/10 , A61K38/16 , A61K41/0009 , A61K41/0057 , A61K41/0071 , A61K47/10 , A61K47/26 , A61K47/34 , A61K47/64 , A61Q11/00 , C07K7/06 , C07K7/08 , C07K14/001 , G01N33/569 , Y02A50/47 , Y02A50/473
摘要: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.
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