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    Method of making and structure of multilayer laue lens for focusing hard x-rays
    1.
    发明授权
    Method of making and structure of multilayer laue lens for focusing hard x-rays 有权
    用于聚焦硬x射线的多层月桂镜片的制作和结构方法

    公开(公告)号：US07440546B2

    公开(公告)日：2008-10-21

    申请号：US11634681

    申请日：2006-12-06

    Applicant: Chian Q. Liu ,  Raymond P. Conley ,  Albert T. Macrander ,  Hyon Chol Kang ,  G. Brian Stephenson ,  Jorg Maser

    Inventor： Chian Q. Liu ,  Raymond P. Conley ,  Albert T. Macrander ,  Hyon Chol Kang ,  G. Brian Stephenson ,  Jorg Maser

    IPC: G21K1/06

    CPC classification number: G21K1/062 ,  B82Y10/00 ,  G21K2201/061 ,  G21K2201/067

    Abstract: A zone plate multilayer structure includes a substrate carrying a plurality of alternating layers respectively formed of tungsten silicide (WSi2) and silicon (Si). The alternating layers are sequentially deposited precisely controlling a thickness of each layer from a minimum thickness of a first deposited layer adjacent the substrate to a maximum thickness of a last deposited layer. The first minimum thickness layer has a selected thickness of less than or equal to 5 nm with the thickness of the alternating layers monotonically increasing to provide a zone plate multilayer structure having a thickness of greater than 12 μm (microns). The x-rays are diffracted in Laue transmission geometry by the specific arrangement of silicon and tungsten silicide.

    Abstract translation: 区域板多层结构包括承载分别由硅化钨（WSi 2 N 2）和硅（Si）形成的多个交替层的基板。 交替层顺序沉积，从邻近衬底的第一沉积层的最小厚度到最后沉积层的最大厚度精确地控制每一层的厚度。 第一最小厚度层具有小于或等于5nm的选定厚度，交替层的厚度单调增加，以提供厚度大于12μm（微米）的区域板多层结构。 X射线通过硅和硅化钨的具体布置在Laue透射几何中衍射。

    Methods and compositions for peptide synthesis
    2.
    发明授权
    Methods and compositions for peptide synthesis 失效
    肽合成的方法和组合物

    公开(公告)号：US6015881A

    公开(公告)日：2000-01-18

    申请号：US71877

    申请日：1998-05-01

    Applicant: Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader ,  Gene Merutka

    Inventor： Myung-Chol Kang ,  Brian Bray ,  Maynard Lichty ,  Catherine Mader ,  Gene Merutka

    IPC: C07K14/16 ,  A61K38/00 ,  C07K5/00

    CPC classification number: C07K14/005 ,  C12N2740/16122

    Abstract: The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.

    Abstract translation: 本发明首先涉及合成肽，特别是T-20（也称为“DP-178”; SEQ ID NO：1）和T-20样肽的方法。 这些方法利用固相和液相合成方法来合成和组合特定肽片段的组合以产生感兴趣的肽。 本发明还涉及在合成目标肽（例如T-20）中充当中间体的单个肽片段。 本发明还涉及可以一起用于产生全长T-20和T-20样肽的这种肽中间体片段的基团。

    ZONE COMPENSATED MULTILAYER LAUE LENS AND APPARATUS AND METHOD OF FABRICATING THE SAME
    4.
    发明申请
    ZONE COMPENSATED MULTILAYER LAUE LENS AND APPARATUS AND METHOD OF FABRICATING THE SAME 有权
    区域补偿多层次透镜及其装置及其制造方法

    公开(公告)号：US20140072106A1

    公开(公告)日：2014-03-13

    申请号：US13515780

    申请日：2010-12-13

    Applicant: Raymond P. Conley ,  Chian Qian Liu ,  Albert T. Macrander ,  Hanfei Yan ,  Jorg Maser ,  Hyon Chol Kang ,  Gregory Brian Stephenson

    Inventor： Raymond P. Conley ,  Chian Qian Liu ,  Albert T. Macrander ,  Hanfei Yan ,  Jorg Maser ,  Hyon Chol Kang ,  Gregory Brian Stephenson

    IPC: G21K1/06

    CPC classification number: G21K1/062 ,  B82Y10/00 ,  G21K2201/067 ,  Y10T156/10

    Abstract: A multilayer Laue Lens includes a compensation layer formed in between a first multilayer section and a second multilayer section. Each of the first and second multilayer sections includes a plurality of alternating layers made of a pair of different materials. Also, the thickness of layers of the first multilayer section is monotonically increased so that a layer adjacent the substrate has a minimum thickness, and the thickness of layers of the second multilayer section is monotonically decreased so that a layer adjacent the compensation layer has a maximum thickness. In particular, the compensation layer of the multilayer Laue lens has an in-plane thickness gradient laterally offset by 90° as compared to other layers in the first and second multilayer sections, thereby eliminating the strict requirement of the placement error.

    Abstract translation: 多层透镜包括形成在第一多层部分和第二多层部分之间的补偿层。 第一和第二多层部分中的每一个包括由一对不同材料制成的多个交替层。 此外，第一多层部分的层的厚度单调增加，使得与基板相邻的层具有最小厚度，并且第二多层部分的层的厚度单调减小，使得邻近补偿层的层具有最大值 厚度。 特别地，与第一和第二多层部分中的其它层相比，多层Laue透镜的补偿层具有横向偏移90°的面内厚度梯度，从而消除了放置误差的严格要求。

    Competitive immunoassay
    10.
    发明申请
    Competitive immunoassay 有权
    竞争性免疫测定

    公开(公告)号：US20060160068A1

    公开(公告)日：2006-07-20

    申请号：US10943463

    申请日：2004-09-17

    Applicant: Joseph Beechem ,  Kyle Gee ,  David Hagen ,  Iain Johnson ,  Hee-Chol Kang ,  Christina Pastula

    Inventor： Joseph Beechem ,  Kyle Gee ,  David Hagen ,  Iain Johnson ,  Hee-Chol Kang ,  Christina Pastula

    IPC: C12Q1/70 ,  C12Q1/68 ,  C07K16/46 ,  C07F5/02 ,  C07D311/88

    CPC classification number: G01N33/542 ,  C07F9/12 ,  C07F9/65318 ,  C07F9/65522 ,  C07F9/6596 ,  C07K16/46 ,  Y10S435/968 ,  Y10S436/80 ,  Y10S530/807 ,  Y10T436/13

    Abstract: The present invention provides ligand-detection reagents, ligand analogs and methods for determining the presence of a ligand in a sample. The ligand-detection reagent comprises a ligand-binding antibody and a ligand analog to form an antibody-ligand analog complex wherein the ligand analog is covalently bonded to a reporter molecule. This complex may additionally comprise a labeling protein non-covalently bonded to the antibody to form a ternary complex wherein the labeling protein comprises a monovalent antibody fragment or a non-antibody protein that is covalently bonded to a label moiety. The reporter molecule is either quenched by the ligand-binding antibody or by the label moiety of the labeling protein, depending on the reporter molecule and the ligand-binding antibody, wherein the amount of quenching is directly related to the amount of ligand present in the sample. Alternatively, the ligand analog is fluorogenic wherein the ligand analog is essentially non-fluorescent in solution but when bound by the ligand-binding antibody the detectable signal increases. In this instance a decrease in signal, as opposed to the relieving of quenching, is measured for the presence of a target ligand.

    Abstract translation: 本发明提供配体检测试剂，配体类似物和用于测定样品中配体存在的方法。 配体检测试剂包含配体结合抗体和配体类似物以形成抗体 - 配体类似物复合物，其中配体类似物共价键合到报告分子。 该复合物还可以包含与抗体非共价键合以形成三元复合物的标记蛋白质，其中标记蛋白质包含共价键合到标记部分的单价抗体片段或非抗体蛋白质。 取决于报道分子和配体结合抗体，报告分子被配体结合抗体或标记蛋白的标记部分淬灭，其中淬灭量与存在于 样品。 或者，配体类似物是荧光的，其中配体类似物在溶液中基本上是非荧光的，但当被配体结合抗体结合时，可检测信号增加。 在这种情况下，与目标配体的存在相比，测量了与消除淬灭相反的信号降低。

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