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公开(公告)号：US07384970B2
公开(公告)日：2008-06-10
申请号：US10807613
申请日：2004-03-23
申请人： Hong Liu , Phil Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , Phil Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
IPC分类号： A61K31/4045 , C07D209/08
CPC分类号： C07D405/12 , C07C237/22 , C07C237/24 , C07C257/18 , C07C311/19 , C07C311/29 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D209/08 , C07D209/42 , C07D211/60 , C07D213/71 , C07D231/14 , C07D257/04 , C07D261/18 , C07D271/10 , C07D307/20 , C07D307/24 , C07D307/68 , C07D309/08 , C07D311/22 , C07D333/40 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US20080242671A1
公开(公告)日：2008-10-02
申请号：US12055154
申请日：2008-03-25
申请人： Hong Liu , Phillip Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , Phillip Alper , Arnab Chatterjee , David Tully , Badry Bursulaya , David Woodmansee , Robert Epple , Jennifer Leslie Harris , Jun Li
IPC分类号： A61K31/501 , A61K31/165 , C07C233/63 , A61K31/454 , C07D401/12 , C07D209/04 , A61K31/404 , C07D401/14
CPC分类号： C07D405/12 , C07C237/22 , C07C237/24 , C07C257/18 , C07C311/19 , C07C311/29 , C07C2601/14 , C07D207/12 , C07D207/24 , C07D209/08 , C07D209/42 , C07D211/60 , C07D213/71 , C07D231/14 , C07D257/04 , C07D261/18 , C07D271/10 , C07D307/20 , C07D307/24 , C07D307/68 , C07D309/08 , C07D311/22 , C07D333/40 , C07D335/02 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US07109243B2
公开(公告)日：2006-09-19
申请号：US10807612
申请日：2004-03-23
申请人： Hong Liu , David Tully , Robert Epple , Badry Bursulaya , Jennifer Williams , Arnab Chatterjee , Jennifer Leslie Harris , Jun Li
发明人： Hong Liu , David Tully , Robert Epple , Badry Bursulaya , Jennifer Williams , Arnab Chatterjee , Jennifer Leslie Harris , Jun Li
IPC分类号： A01N47/28
CPC分类号： C07D307/68 , C07C237/14 , C07C237/20 , C07C255/57 , C07C275/28 , C07C275/30 , C07C275/42 , C07C2601/14 , C07D213/56 , C07D213/64 , C07D237/24 , C07D239/52 , C07D277/56 , C07D333/38
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供用于选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶（例如cathespin K）的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US20070123523A1
公开(公告)日：2007-05-31
申请号：US11620608
申请日：2007-01-05
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/165 , A61K31/54 , A61K31/497 , A61K31/445
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US07307095B2
公开(公告)日：2007-12-11
申请号：US11620608
申请日：2007-01-05
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/423 , A61K31/403 , A61K31/428
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
摘要翻译： 本发明提供了选择性抑制组织蛋白酶S的化合物，组合物和方法。在优选的方面，组织蛋白酶S在至少一种其它组织蛋白酶同功酶的存在下被选择性地抑制。 本发明还提供了通过选择性抑制组织蛋白酶S来治疗受试者的疾病状态的方法。
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公开(公告)号：US07173051B2
公开(公告)日：2007-02-06
申请号：US10868459
申请日：2004-06-10
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K31/423 , A61K31/403 , A61K31/428 , C07D263/58 , C07D227/04 , C07D417/02 , C07D498/02
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20050049244A1
公开(公告)日：2005-03-03
申请号：US10868459
申请日：2004-06-10
申请人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
发明人： Hong Liu , David Tully , Phillip Alper , Robert Epple , Arnab Chatterjee , Michael Roberts
IPC分类号： A61K20060101 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/47 , A61K31/495 , A61K31/4965 , A61K31/537 , A61K31/54 , C07D277/82 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D327/04 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.
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公开(公告)号：US20150152083A1
公开(公告)日：2015-06-04
申请号：US14405694
申请日：2013-06-05
申请人： Gerald Lelais , Robert Epple , Pierre-Yves Michellys , Badry Bursulaya , Songchun Jiang , Thomas H. Marsilje III , Matthew MCneill
发明人： Gerald Lelais , Robert Epple , Pierre-Yves Michellys , Badry Bursulaya , Songchun Jiang , Thomas H. Marsilje III , Matthew MCneill
IPC分类号： C07D401/12 , A61K31/5377 , A61K45/06 , A61K31/4439 , C07D235/30 , A61K31/4184
CPC分类号： C07D401/12 , A61K31/4184 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D235/30 , Y02A50/411
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
摘要翻译： 本发明提供了可用于调节EGFR活性的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调的EGFR活性相关的病症的方法。
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公开(公告)号：US09440957B2
公开(公告)日：2016-09-13
申请号：US14405773
申请日：2013-06-05
申请人： Gerald Lelais , Robert Epple , Thomas H. Marsilje, III , Pierre-Yves Michellys , Matthew McNeill , Yun Long , Wenshuo Lu , Bei Chen , Badry Bursulaya , Songchun Jiang
发明人： Gerald Lelais , Robert Epple , Thomas H. Marsilje, III , Pierre-Yves Michellys , Matthew McNeill , Yun Long , Wenshuo Lu , Bei Chen , Badry Bursulaya , Songchun Jiang
IPC分类号： A61K31/55 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D411/14 , C07D413/14 , C07D417/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D413/04 , C07D471/04 , C07D513/04
CPC分类号： C07D401/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
摘要翻译： 本发明提供了可用于调节EGFR活性的化合物及其药物组合物，以及使用这些化合物治疗，改善或预防与异常或失调的EGFR活性相关的病症的方法。
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公开(公告)号：US08362050B2
公开(公告)日：2013-01-29
申请号：US12999887
申请日：2009-06-23
申请人： Xiaohui He , Xuefeng Zhu , Kunyong Yang , Robert Epple , Hong Liu
发明人： Xiaohui He , Xuefeng Zhu , Kunyong Yang , Robert Epple , Hong Liu
IPC分类号： A61K31/426 , C07D277/18
CPC分类号： C07D249/06 , C07D271/06 , C07D277/38
摘要： The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with or mediated by G protein-coupled receptors, in particular G protein-coupled receptor 120.
摘要翻译： 本发明提供化合物，包含这些化合物的药物组合物和使用这些化合物治疗或预防与G蛋白偶联受体，特别是G蛋白偶联受体120相关或介导的疾病或病症的方法。
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