NOVEL BIOMARKER FOR LIVER CANCER AND APPLICATIONS FOR SAME
    3.
    发明申请
    NOVEL BIOMARKER FOR LIVER CANCER AND APPLICATIONS FOR SAME 审中-公开
    用于肝癌的新生物标记物及其应用

    公开(公告)号:US20110306513A1

    公开(公告)日:2011-12-15

    申请号:US13139095

    申请日:2009-12-03

    摘要: The present invention relates to the elucidation of a gene that can act as a novel marker for liver cancer diagnosis and to diagnostic and prognostic measurements of liver cancer using the same. More specifically, it relates to a diagnosis kit that enables diagnostic and prognostic measurement of a liver cancer using a preparation that measures expression levels of at least one gene selected from a group of liver cancer diagnosis markers consisting of S100P, NK4, CCL20, CSPG2, PLAU, MMP12, ESM-1, ABHD7, HCAPG, CXCL-3, Col5A2, MAGEA, GSN, CDC2, CST1, MELK, ATAD2, FAP and MSN and/or a method for diagnostic and prognostic measurement of liver cancer using the same. These have been discovered using normal liver tissues and liver cancer tissues collected from the same liver cancer patient of the present invention and represent the markers whose accuracy and reliability have been greatly improved as markers of liver cancer. The markers of the present invention can be used for the accurate diagnosis and prognosis of liver cancer.

    摘要翻译: 本发明涉及可以作为肝癌诊断的新型标志物的基因的阐明,以及使用该基因的肝癌的诊断和预后测定。 更具体地说,本发明涉及能够使用测定从S100P,NK4,CCL20,CSPG2等组成的肝癌诊断标志物组中选出的至少一种基因的表达量的制剂的肝癌的诊断和预后测定的诊断试剂盒, PLAU,MMP12,ESM-1,ABHD7,HCAPG,CXCL-3,Col5A2,MAGEA,GSN,CDC2,CST1,MELK,ATAD2,FAP和MSN和/或使用其进行肝癌的诊断和预后测量的方法。 使用从本发明的同一肝癌患者收集的正常肝组织和肝癌组织已经发现了这些,并且其标志物的准确性和可靠性已经作为肝癌的标志物而大大改善。 本发明的标记物可用于肝癌的准确诊断和预后。

    Apparatus and method for displaying messages in a mobile terminal
    5.
    发明申请
    Apparatus and method for displaying messages in a mobile terminal 有权
    用于在移动终端中显示消息的装置和方法

    公开(公告)号:US20100081463A1

    公开(公告)日:2010-04-01

    申请号:US12587061

    申请日:2009-09-30

    IPC分类号: H04W4/14

    摘要: A mobile terminal includes an apparatus for displaying messages. When a message is transmitted or received, whether the message has a relation with stored messages is determined. When it is determined that the message has a relation with at least one of the stored messages, the message is assigned the same tag as a tag of the at least one message. When a related message view command for one of the message and the at least one message occurs, contents of messages comprising the tag are displayed together.

    摘要翻译: 移动终端包括用于显示消息的装置。 当发送或接收消息时,确定消息是否与存储的消息有关系。 当确定消息与所存储的消息中的至少一个具有关系时,向消息分配与至少一个消息的标签相同的标签。 当发生消息中的一个和至少一个消息的相关消息查看命令时,包括标签的消息的内容一起显示。

    Method for diagnosing liver diseases
    6.
    发明授权
    Method for diagnosing liver diseases 有权
    肝脏疾病诊断方法

    公开(公告)号:US07575938B2

    公开(公告)日:2009-08-18

    申请号:US10540848

    申请日:2003-12-27

    IPC分类号: G01N33/53

    摘要: The present invention relates to a method for diagnosing a liver disease rapidly in an early stage. More particularly, the present invention relates to a monoclonal antibody against asialo α1-acid glycoprotein; a method for diagnosing a liver disease which evaluates asialo α1-acid glycoprotein in a test sample by using said monoclonal antibody; and an diagnostic strip for immunochromatography composed of said monoclonal antibody against asialo α1-acid glycoprotein and Ricinus communis agglutinin (RCA). The diagnostic device of the present invention is convenient to measure the concentration of asialo α1-acid glycoprotein and to diagnose a liver disease rapidly.

    摘要翻译: 本发明涉及一种早期诊断肝病的方法。 更具体地,本发明涉及抗唾液酸α1酸糖蛋白的单克隆抗体; 用于诊断通过使用所述单克隆抗体评估测试样品中的脱唾液酸α1酸糖蛋白的肝病的方法; 和由所述针对唾液酸α1酸糖蛋白和蓖麻凝集素(RCA)的单克隆抗体构成的免疫层析诊断条。 本发明的诊断装置方便测量脱唾液酸α1酸糖蛋白的浓度并迅速诊断肝脏疾病。

    Apparatus and method for displaying messages in a mobile terminal
    9.
    发明授权
    Apparatus and method for displaying messages in a mobile terminal 有权
    用于在移动终端中显示消息的装置和方法

    公开(公告)号:US09537998B2

    公开(公告)日:2017-01-03

    申请号:US12587061

    申请日:2009-09-30

    摘要: A mobile terminal includes an apparatus for displaying messages. When a message is transmitted or received, whether the message has a relation with stored messages is determined. When it is determined that the message has a relation with at least one of the stored messages, the message is assigned the same tag as a tag of the at least one message. When a related message view command for one of the message and the at least one message occurs, contents of messages comprising the tag are displayed together.

    摘要翻译: 移动终端包括用于显示消息的装置。 当发送或接收消息时,确定消息是否与存储的消息有关系。 当确定消息与所存储的消息中的至少一个具有关系时,向消息分配与至少一个消息的标签相同的标签。 当发生消息中的一个和至少一个消息的相关消息查看命令时,包括标签的消息的内容一起显示。

    G protein coupled receptor protein and use thereof
    10.
    发明授权
    G protein coupled receptor protein and use thereof 有权
    G蛋白偶联受体蛋白及其用途

    公开(公告)号:US09034327B2

    公开(公告)日:2015-05-19

    申请号:US13322304

    申请日:2009-09-07

    CPC分类号: C07K14/705 G01N33/5041

    摘要: Disclosed are novel GPCR (G Protein Coupled Receptor) proteins and genes encoding the same. Also provided is the use of the proteins and the genes. Particularly, contemplated are a novel GPCR (G Protein Coupled Receptor) polypeptide, a polynucleotide coding for the same, a recombinant vector carrying the polynucleotide or a fragment thereof, host cells transformed with the vector, a transgenic animal infected with the vector. Also, a composition for detecting a cancer marker, comprising an agent capable of measuring the expression level of mRNA or protein of the GPCR polynucleotide, a kit for the diagnosis of cancer, comprising the composition, and a method for detecting the GPCR polypeptide and a gene encoding the polypeptide are provided. Further, a composition for the treatment and prevention of cancer, comprising an oligonucleotide inhibiting the expression of a gene encoding the GPCR polypeptide or an antibody against the GPCR protein, and a method for screening a modulator of the GPCR protein or a cancer therapeutic agent are provided.

    摘要翻译: 公开了新型GPCR(G蛋白偶联受体)蛋白和编码其的基因。 还提供了蛋白质和基因的使用。 特别地,考虑了新型GPCR(G蛋白偶联受体)多肽,编码它的多核苷酸,携带多核苷酸或其片段的重组载体,用该载体转化的宿主细胞,用载体感染的转基因动物。 另外,含有能够测定GPCR多核苷酸的mRNA或蛋白质的表达量的试剂,癌症诊断用试剂盒,含有该组合物的检测癌标记物的组合物,以及检测GPCR多肽的方法和 提供编码多肽的基因。 此外,用于治疗和预防癌症的组合物包含抑制GPCR多肽或编码GPCR蛋白的抗体表达的寡核苷酸以及筛选GPCR蛋白或癌症治疗剂的调节剂的方法, 提供。