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公开(公告)号：US12023169B2
公开(公告)日：2024-07-02
申请号：US14205164
申请日：2014-03-11
发明人： Ivan Osorio
CPC分类号： A61B5/4094 , A61B5/316 , A61B5/1117
摘要： We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
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公开(公告)号：US11672431B2
公开(公告)日：2023-06-13
申请号：US16706688
申请日：2019-12-07
发明人： Ivan Osorio , Alexey Lyubushin , Didier Sornette
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/16 , A61B5/374 , A61B5/024 , A61B5/08 , A61B5/11 , A61B5/24 , A61B5/369 , A61B5/083 , A61B5/145
CPC分类号： A61B5/02055 , A61B5/0205 , A61B5/165 , A61B5/374 , A61B5/4094 , A61B5/4836 , A61B5/726 , A61B5/746 , A61B5/024 , A61B5/0816 , A61B5/0833 , A61B5/1118 , A61B5/14542 , A61B5/16 , A61B5/24 , A61B5/369
摘要： A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
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公开(公告)号：US11633597B2
公开(公告)日：2023-04-25
申请号：US16798370
申请日：2020-02-23
发明人： Ivan Osorio
摘要： Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
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公开(公告)号：US11412995B2
公开(公告)日：2022-08-16
申请号：US16928198
申请日：2020-07-14
发明人： Ivan Osorio
IPC分类号： A61B5/0205 , A61B5/11 , A61N1/36 , A61B5/00 , A61B5/08 , A61B5/021 , A61B5/0245 , A61N1/39 , A61N1/365 , A61B5/16 , G16H50/30 , A61B5/349 , A61F7/00 , A61M5/172 , A61N1/372
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
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公开(公告)号：US11083408B2
公开(公告)日：2021-08-10
申请号：US16452699
申请日：2019-06-26
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61B5/283 , A61B5/316 , A61B5/369 , G16H50/20 , G16H20/40 , G16H20/10 , G16H50/30 , A61M16/10 , A61B5/0205 , A61B5/145 , A61N1/36 , A61B5/026 , A61B5/11 , A61B5/021 , A61B5/024 , A61B5/349 , A61B5/389 , A61B5/08
摘要： A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.
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公开(公告)号：US10959682B2
公开(公告)日：2021-03-30
申请号：US16296601
申请日：2019-03-08
发明人： Ivan Osorio
IPC分类号： A61B5/00 , G16H50/30 , A61F7/00 , A61M5/172 , A61N1/365 , A61N1/36 , A61B5/0205 , A61B5/08 , A61B5/021 , A61B5/11 , A61N1/39 , A61B5/0452 , A61B5/16 , A61B5/0245 , G06F19/00 , A61N1/372
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
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公开(公告)号：US10405792B2
公开(公告)日：2019-09-10
申请号：US15387417
申请日：2016-12-21
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/36 , A61B5/0205 , A61B5/11 , A61B5/0402 , A61B5/08 , A61B5/113 , A61B5/0245 , A61N1/365 , A61B5/021 , A61B5/024 , A61B5/0488 , A61B5/053 , A61B7/04 , A61B8/08 , A61B5/026
摘要： A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.
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公开(公告)号：US10130294B2
公开(公告)日：2018-11-20
申请号：US15246313
申请日：2016-08-24
发明人： Ivan Osorio , Mark G. Frei
IPC分类号： A61B5/00 , A61B5/024 , A61B5/0452 , A61N1/36 , A61B5/0468 , A61B5/04 , A61B5/0456 , A61B5/0245
摘要： Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
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公开(公告)号：US10004446B2
公开(公告)日：2018-06-26
申请号：US14170389
申请日：2014-01-31
发明人： Ivan Osorio
IPC分类号： A61B5/02 , A61B5/00 , A61B5/0205 , A61B5/024
CPC分类号： A61B5/4094 , A61B5/0205 , A61B5/024 , G06F19/00
摘要： We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
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公开(公告)号：US09808207B2
公开(公告)日：2017-11-07
申请号：US15333802
申请日：2016-10-25
发明人： Ivan Osorio
IPC分类号： A61B5/00 , A61N1/365 , A61N1/36 , A61N1/39 , A61B5/16 , A61B5/0452 , A61B5/0205 , A61B5/08 , A61B5/021 , A61B5/0245 , A61B5/11 , G06F19/00 , A61F7/00 , A61M5/172 , A61N1/372
CPC分类号： A61B5/746 , A61B5/0205 , A61B5/02055 , A61B5/021 , A61B5/02455 , A61B5/0452 , A61B5/0826 , A61B5/1118 , A61B5/162 , A61B5/4094 , A61B5/4836 , A61B5/4839 , A61B5/7275 , A61F7/00 , A61M5/1723 , A61M2230/06 , A61M2230/20 , A61M2230/201 , A61M2230/208 , A61M2230/30 , A61M2230/42 , A61M2230/63 , A61N1/36064 , A61N1/36139 , A61N1/36142 , A61N1/36514 , A61N1/36585 , A61N1/37247 , A61N1/37258 , A61N1/3987 , G06F19/00 , G16H50/30
摘要： A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.
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