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公开(公告)号：US06900232B2
公开(公告)日：2005-05-31
申请号：US09882186
申请日：2001-06-15
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D213/72
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译： 本发明涉及由式I表示的一类化合物，其中A 1是下式的吡啶基，其任选被一个或多个选自下组的R 0选自 羟基，烷基，烷氧基，烷氧基烷基，硫代烷基，卤代烷基，氰基，氨基烷基氨基，卤素，酰氨基，磺酰胺和-COR; 且R为羟基，烷氧基，烷基或氨基; 和其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α3β3和/或α / 5> 5＆lt; 5＆gt;整联蛋白。
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公开(公告)号：US06531494B1
公开(公告)日：2003-03-11
申请号：US09942214
申请日：2001-08-29
申请人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
发明人： Ish Kumar Khanna , Yi Yu , Balekudru Devadas , Hwang-Fun Lu , Nizal S Chandrakumar , Renee M. Huff , Bipinchandra N. Desai , Srinivasan Raj Nagarajan , Alan F. Gasiecki , Thomas D. Penning , Mark A. Russell , Mark L. Boys , Lori A. Schretzman , Barbara B. Chen , Thomas Rogers , John Adam Wendt , Albert Khilevich , Yaping Wang
IPC分类号： A61K3144
CPC分类号： C07D213/74 , C07D213/73 , C07D401/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译： 本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白的方法。
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公开(公告)号：US6100423A
公开(公告)日：2000-08-08
申请号：US261822
申请日：1999-03-03
申请人： Joe T. Collins , Balekudru Devadas , Hwang-fun Lu , James W. Malecha , Julie Marion Miyashiro , Srinivasan Nagarajan , Joseph Gerace Rico , Thomas E. Rogers
发明人： Joe T. Collins , Balekudru Devadas , Hwang-fun Lu , James W. Malecha , Julie Marion Miyashiro , Srinivasan Nagarajan , Joseph Gerace Rico , Thomas E. Rogers
IPC分类号： C07D239/14 , C07C229/00
CPC分类号： C07D239/14
摘要： The present invention is directed to compounds of the formula ##STR1## where R.sup.1 is BOC or H, R is H or lower alkyl; X and Y are the same or different halo atoms selected from the group consisting of Cl, Br or I and pharmaceutically acceptable salts and isomers thereof.
摘要翻译： 本发明涉及下式的化合物，其中R 1是BOC或H，R是H或低级烷基; X和Y是选自Cl，Br或I的相同或不同的卤原子及其药学上可接受的盐和异构体。
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4.发明授权Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors 失效取代磺酰基烷酰氨基羟乙氨基磺酰胺逆转录病毒蛋白酶抑制剂
公开(公告)号：US5753660A
公开(公告)日：1998-05-19
申请号：US747357
申请日：1996-11-13
申请人： James A. Sikorski , Daniel P. Getman , Gary A. DeCrescenzo , Balekudru Devadas , John N. Freskos , Hwang-Fun Lu , Joseph J. McDonald
发明人： James A. Sikorski , Daniel P. Getman , Gary A. DeCrescenzo , Balekudru Devadas , John N. Freskos , Hwang-Fun Lu , Joseph J. McDonald
IPC分类号： C07D249/18 , A61K31/336 , A61K31/343 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4025 , A61K31/407 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4196 , A61K31/428 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/7024 , A61P31/18 , C07C311/29 , C07C311/41 , C07D235/12 , C07D235/30 , C07D235/32 , C07D277/62 , C07D277/64 , C07D277/82 , C07D303/36 , C07D307/79 , C07D317/62 , C07D319/18 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/056 , C07H13/00 , A61K31/335
CPC分类号： C07D405/12 , C07C311/29 , C07C311/41 , C07D235/30 , C07D235/32 , C07D277/62 , C07D277/82 , C07D307/79 , C07D317/62 , C07D319/18 , C07D407/12 , C07D417/12
摘要： Selected sulfonylalkanoylamino hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
摘要翻译： 选择的磺酰基烷酰基氨基羟乙基氨基磺酰胺化合物作为逆转录病毒蛋白酶抑制剂是有效的，特别是作为HIV蛋白酶的抑制剂。 本发明涉及这种逆转录病毒蛋白酶抑制剂，更具体地涉及所选择的新化合物，用于抑制逆转录病毒蛋白酶如人类免疫缺陷病毒（HIV）蛋白酶的组合物和方法，预防性地预防逆转录病毒感染或逆转录病毒的扩散，以及 治疗逆转录病毒感染。
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![Pyrazolo[4,3-D]Pyrimidines](/abs-image/US/2008/11/27/US20080293697A1/abs.jpg.150x150.jpg)
公开(公告)号：US20080293697A1
公开(公告)日：2008-11-27
申请号：US10599702
申请日：2005-03-30
申请人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Dafydd Rhys Owen , Michael John Palmer , Carol Ann Winslow , Hwang Fun Lu , Thomas Edward Rogers
发明人： Andrew Simon Bell , David Graham Brown , David Nathan Abraham Fox , Ian Roger Marsh , Andrew Ian Morrell , Dafydd Rhys Owen , Michael John Palmer , Carol Ann Winslow , Hwang Fun Lu , Thomas Edward Rogers
IPC分类号： C07D487/04 , A61K31/519 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P9/00
CPC分类号： C07D487/04
摘要： This invention relates to compounds of formula (I).
摘要翻译： 本发明涉及式（I）化合物。
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6.发明授权Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效杂环取代的异羟肟酸衍生物作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06875785B2
公开(公告)日：2005-04-05
申请号：US10254701
申请日：2002-09-25
申请人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J. Talley , James A. Sikorski , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： A61P29/00 , C07D231/12 , C07D263/32 , A61K31/421 , C07D413/00
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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7.发明申请公开(公告)号：US20050043344A1
公开(公告)日：2005-02-24
申请号：US10743354
申请日：2003-12-22
申请人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
发明人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
IPC分类号： A61K31/4245 , A61K31/4745 , A61P19/02 , A61P19/10 , A61P27/00 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译： 本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白而不显着抑制αVβ6整联蛋白的方法。
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公开(公告)号：US06833366B1
公开(公告)日：2004-12-21
申请号：US10657932
申请日：2003-09-09
申请人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
发明人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
IPC分类号： A61K3133
CPC分类号： C07D213/74 , C07D239/14 , C07D401/12
摘要： The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
摘要翻译： 本发明涉及一类由式1表示的化合物或其药学上可接受的盐，包含式1的化合物的药物组合物，以及选择性抑制或拮抗阿尔法博三唑和/或阿尔法肽5整联蛋白的方法。
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9.发明授权Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors 失效取代的磺酰基苯基杂环作为环加氧酶-2和5-脂氧合酶抑制剂公开(公告)号：US06998415B2
公开(公告)日：2006-02-14
申请号：US10757606
申请日：2004-01-12
申请人： John J. Talley , James A. Sikorski , Balekudru Devadas , Matthew J. Graneto , Jeffery S. Carter , Bryan H. Norman , Kathy L. Rogers, legal representative , Hwang-Fun Lu , David L. Brown
IPC分类号： A61K31/415 , C07D23/00 , A61P29/00
CPC分类号： A61K31/44 , A61K31/15 , A61K31/277 , A61K31/4015
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
摘要翻译： 本发明涉及抗炎药物领域，具体涉及用于治疗由环氧合酶-2或5-脂氧合酶如炎症介导的病症的化合物，组合物和方法。
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10.发明授权公开(公告)号：US06512121B2
公开(公告)日：2003-01-28
申请号：US09878452
申请日：2001-06-11
申请人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
发明人： John J Talley , James A Sikorski , Matthew J Graneto , Jeffrey S Carter , Bryan H Norman , Balekudru Devadas , Hwang-Fun Lu
IPC分类号： C07D26332
CPC分类号： C07D231/12 , C07D263/32
摘要： This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation.
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