摘要:
The present invention relates to new compounds that act as inhibitors of metallo-beta-lactamases (MBL). The present invention also relates to pharmaceutical compositions comprising such MBL inhibitors, and uses thereof in the treatment of bacterial infections. More generally, the present invention finds applications in any field wherein bacteria producing MBL must be removed.
摘要:
The present invention features a compound of formula I: or a pharmaceutically acceptable salt thereof, where R1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.
摘要:
The invention relates to compounds that are direct activators of AMPK (AMP-activated protein kinase) and their use in the treatment of disorders regulated by activation of AMPK. For instance, compounds according to the invention are useful for the treatment of diabetes, metabolic syndrome, obesity, inflammation, cancer and cardiovascular diseases.
摘要:
Tire tread (1) comprising a plurality of blocks (6), each block (6) comprising a leading face (61), a trailing face (62) and a contact face (60), the leading face (61) making a mean angle αA greater than 0 degrees, the trailing edge (62) making a mean angle αF greater than 0 degrees, the angle αA of the leading face (61) being greater than the angle αF of the trailing face, each block (6) comprises an incision (7) extending into the thickness of the block, this incision (7) being delimited by opposing faces provided with blocking means (71) for blocking the relative movements of one of the said faces with respect to the other face in at least one direction, this incision (7) dividing the contact face (60) of the block into two parts with substantially equal surface areas, this tread being characterized in that the incision (7) is inclined by a mean angle β, measured with respect to the perpendicular to the contact face (60) in the same direction as the angle αA of the leading face and in that the volume of material contained between the leading face (61) and the incision (7) is less than the volume of material contained between the trailing face (62) and the same incision (7).
摘要:
A composite cord includes a rubber core and a rubber sheath surrounding, at least in part, the rubber core. A formulation of the core is different from that of the sheath. The rubber core includes at least one diene elastomer and more than 30 phr of a filler A. The filler A includes nanoparticles having a weight-average size of less than 500 nm. The rubber sheath includes at least one diene elastomer, from 0 to less than 30 phr of a filler A′, and more than 70 phr of a filler B. The filler A′ includes nanoparticles having a weight-average size of less than 500 nm. The filler B includes microparticles having a weight-median size of greater than 1 μm.
摘要:
A method for addressing a bistable nematic matrix LCD having two stable textures without any applied electric field. Pixel addressing is of the passive multiplex type. The method includes selecting the value of the electrical voltage applied between the substrates so that an average value of the voltage, preferably the average quadratic value, since the initial command for image display up to the time immediately preceding switching, has a predetermined value independent of the information to be displayed, which is the same for all the pixels of the image.
摘要:
The present invention relates to a method of addressing a bistable matrix screen, in which the following two steps are reiterated:A. a disturbance signal is applied to each pixel of a marking area for a time t1, said disturbance signal being higher than a threshold signal such that each pixel of the area leaves its initial stable state, said disturbance signal being lower than a switching signal such that each pixel of the area having one of the stable states as its initial state does not switch into the other stable state, each pixel of the area then being in an intermediate disturbed state that is intermediate between the two stable states, and thenB. no signal is applied to each pixel of the area for a time t2 to allow each pixel of the area to return to its initial stable state.
摘要:
The present invention relates generally to methods and systems for hydrocarbon recovery. More particularly, but not by way of limitation, embodiments of the present invention include methods and systems for enhanced hydrocarbon recovery through secondary recovery operations.
摘要:
The invention includes a prediction method for the screening or diagnosis or therapeutic management or prognosis of prostate cancer, including collecting individual input data and providing predictive information on the risk linked to a type of disease. The input data includes at least one variable or a combination of variables of the genetic type such as the identification of markers of genetic polymorphisms considered as being linked to the development of the disease. The invention also provides an individual prediction device for the screening or diagnosis or therapeutic management or prognosis of prostate cancer including first means for acquiring individual information data by a user, and at least a first software interface on which the said first means operate. The invention additionally includes a computer program product having the method and providing predictive information on risk linked to a disease.
摘要:
Spray device comprising a piezoelectric element, a sonotrode having a base coupled to the piezoelectric element, and a tube extending as far as a horn, a drive circuit for vibrating the piezoelectric element, and a feed device for bringing the product to be sprayed up to the front face of the horn. The sonotrode mainly vibrates in a mode parallel to the tube, the horn being dimensioned so as not to flex along the longitudinal axis, without flexing when the drive circuit vibrates the piezoelectric element. This spray device is applicable in cosmetology and in perfumery.