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公开(公告)号：US09056291B2
公开(公告)日：2015-06-16
申请号：US13346615
申请日：2012-01-09
CPC分类号： B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , F04B43/02 , F04B43/043 , F04B43/06 , G01N33/54366
摘要： A compact device for operatively coupling a solid planar substrate, for example a glass slide, to a microfluidic circuit and performing a reaction or reactions on organic matter bound to the face of the planar substrate. Typical reactions include binding, staining and/or labeling reactions. In use, a sealed reaction chamber is formed, the chamber enclosing the organic matter and at least a part of the solid substrate. Headspace in the sealed chamber between the solid substrate is generally of microfluidic dimensions, and diaphragm pump members are used to inject, exchange and/or mix the fluids in the chamber.
摘要翻译： 用于将固体平面基底（例如玻璃载玻片）可操作地耦合到微流体电路并且对结合到平面基底的面上的有机物质进行反应或反应的紧凑装置。 典型的反应包括结合，染色和/或标记反应。 在使用中，形成密封的反应室，该室包围有机物和至少一部分固体基质。 在固体基质之间的密封室中的顶部空间通常具有微流体尺寸，并且隔膜泵构件用于在腔室中注入，更换和/或混合流体。
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公开(公告)号：US20120177543A1
公开(公告)日：2012-07-12
申请号：US13346615
申请日：2012-01-09
IPC分类号： B01J8/00
CPC分类号： B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , F04B43/02 , F04B43/043 , F04B43/06 , G01N33/54366
摘要： A compact device for operatively coupling a solid planar substrate, for example a glass slide, to a microfluidic circuit and performing a reaction or reactions on organic matter bound to the face of the planar substrate. Typical reactions include binding, staining and/or labeling reactions. In use, a sealed reaction chamber is formed, the chamber enclosing the organic matter and at least a part of the solid substrate. Headspace in the sealed chamber between the solid substrate is generally of microfluidic dimensions, and diaphragm pump members are used to inject, exchange and/or mix the fluids in the chamber.
摘要翻译： 用于将固体平面基底（例如玻璃载玻片）可操作地耦合到微流体电路并且对结合到平面基底的面上的有机物质进行反应或反应的紧凑装置。 典型的反应包括结合，染色和/或标记反应。 在使用中，形成密封的反应室，该室包围有机物和至少一部分固体基质。 在固体基质之间的密封室中的顶部空间通常具有微流体尺寸，并且隔膜泵构件用于在腔室中注入，更换和/或混合流体。
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3.发明授权Microfluidic apparatus and methods for performing blood typing and crossmatching 有权用于进行血液分型和交配的微流体装置和方法公开(公告)号：US08318439B2
公开(公告)日：2012-11-27
申请号：US12572968
申请日：2009-10-02
申请人： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
发明人： C. Frederick Battrell , Diane Wierzbicki , John Clemmens , Jason Capodanno , John R. Williford , Carolina Elmufdi , Isaac Sprague
IPC分类号： G01N33/53
CPC分类号： G01N33/53 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2300/0627 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/161 , G01N33/5304 , G01N33/80
摘要： Microfluidic cartridges for agglutination reactions are provided. The cartridges include a microfluidic reaction channel with at least two intake channels, one for an antigen-containing fluid and the other for an antibody-containing fluid, conjoined to a reaction channel modified by incorporation of a downstream flow control channel. At low Reynolds Number, the two input streams layer one on top of the other in the reaction channel and form a flowing, unmixed horizontally-stratified laminar fluid diffusion (HLFD) interface for an extended duration of reaction. Surprisingly, the design, surface properties, and flow regime of microfluidic circuits of the present invention potentiate detection of antibody mediated agglutination at the stratified interface. Antigen:antibody reactions involving agglutination potentiated by these devices are useful in blood typing, in crossmatching for blood transfusion, and in immunodiagnostic agglutination assays, for example.
摘要翻译： 提供用于凝集反应的微流控盒。 药筒包括具有至少两个进气通道的微流体反应通道，一个用于含抗原的流体，另一个用于含抗体流体，结合到通过并入下游流动控制通道而修改的反应通道。 在低雷诺数下，两个输入流在反应通道中层叠在另一个之上，并形成流动的，未混合的水平分层的层状流体扩散（HLFD）界面，持续延长的反应时间。 令人惊奇的是，本发明的微流体回路的设计，表面性质和流动状态增强了在分层界面处的抗体介导的凝集的检测。 抗原：涉及通过这些装置增强的凝集的抗体反应可用于血型，输血交配和免疫诊断凝集试验。
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公开(公告)号：US20120064597A1
公开(公告)日：2012-03-15
申请号：US13099187
申请日：2011-05-02
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US08110392B2
公开(公告)日：2012-02-07
申请号：US12341637
申请日：2008-12-22
申请人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
发明人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
IPC分类号： C12M1/36
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译： 公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理而设计的系统中的混合和试剂和样品操作方面的改进。
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公开(公告)号：US09468894B2
公开(公告)日：2016-10-18
申请号：US13099187
申请日：2011-05-02
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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7.发明申请SANITARY SWAB COLLECTION SYSTEM, MICROFLUIDIC ASSAY DEVICE, AND METHODS FOR DIAGNOSTIC ASSAYS 审中-公开卫生衣物收集系统，微流感测定装置及诊断方法公开(公告)号：US20120271127A1
公开(公告)日：2012-10-25
申请号：US13491009
申请日：2012-06-07
CPC分类号： G01N1/02 , A61B10/0045 , A61B10/0096 , B01L3/502715 , B01L3/5029 , B01L7/52 , B01L2200/027 , B01L2200/082 , B01L2200/10 , B01L2300/069 , B01L2300/0854 , B01L2300/087 , B01L2400/0415 , B01L2400/0487 , G01N2001/028
摘要： Biohazard specimen collection containers are provided with an external disposable skin, that is stripped away and discarded after the biohazardous specimen is collected, thus reducing or eliminating objectionable or dangerous residues on the outside surfaces of the container. Further, we teach that the sample collection container with external disposable skin may also serve as an integrated microfluidic biosample processing and analytical device, thereby providing a single entry, disposable assay unit, kit and system for “world-to-result” clinical diagnostic testing. These integrated assay devices are provided with synergic, multiple safe-handling features for protecting healthcare workers who handle them. The modified collection containers and analytical devices find application, for example, in PCR detection of infectious organisms or pathogenic markers collected on a swab.
摘要翻译： 生物危害标本收集容器设置有外部一次性皮肤，其在收集生物危险样本之后被剥离并丢弃，从而减少或消除容器外表面上的令人反感或危险的残留物。 此外，我们教导，具有外部一次性皮肤的样品收集容器也可用作集成的微流体生物样品处理和分析装置，从而为世界到结果临床诊断测试提供单一入口，一次性测定单元，试剂盒和系统。 这些集成测定装置具有协同的多重安全处理功能，用于保护处理它们的医护人员。 经修改的收集容器和分析装置可以应用于例如感染生物的PCR检测或在拭子上收集的病原性标记物。
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公开(公告)号：US07955836B2
公开(公告)日：2011-06-07
申请号：US12685546
申请日：2010-01-11
IPC分类号： C12M1/36
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US20100167384A1
公开(公告)日：2010-07-01
申请号：US12685546
申请日：2010-01-11
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US20090181411A1
公开(公告)日：2009-07-16
申请号：US12341637
申请日：2008-12-22
申请人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
发明人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译： 公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理设计的系统中的混合和试剂和样品操作方面的改进。
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