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公开(公告)号：US20120064597A1
公开(公告)日：2012-03-15
申请号：US13099187
申请日：2011-05-02
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US08110392B2
公开(公告)日：2012-02-07
申请号：US12341637
申请日：2008-12-22
申请人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
发明人： C Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R Williford , John Clemmens
IPC分类号： C12M1/36
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译： 公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理而设计的系统中的混合和试剂和样品操作方面的改进。
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公开(公告)号：US09468894B2
公开(公告)日：2016-10-18
申请号：US13099187
申请日：2011-05-02
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US07955836B2
公开(公告)日：2011-06-07
申请号：US12685546
申请日：2010-01-11
IPC分类号： C12M1/36
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US20100167384A1
公开(公告)日：2010-07-01
申请号：US12685546
申请日：2010-01-11
CPC分类号： B01F13/0059 , B01F11/0071 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502761 , B01L2300/0816 , B01L2400/0481 , B01L2400/0655 , C12M23/16 , C12M23/42 , C12M25/16 , C12M29/10 , G01N2035/00544 , G01N2035/00564
摘要： Disclosed herein is a device comprising a pair of bellows pumps configured for efficient mixing at a microfluidic scale. By moving a fluid sample and particles in suspension through an aperture between the paired bellows pump mixing chambers, molecular collisions leading to binding between the particles and ligands in the sample are enhanced. Such devices provide an alternative for mixing that does not use a vent and can be used with a variety of particles in suspension such as magnetic beads to capture or purify useful cells and molecules.
摘要翻译： 本文公开了一种包括一对波纹管泵的装置，其配置为在微流控尺度上有效地混合。 通过将流体样品和悬浮液中的颗粒通过成对的波纹管泵混合室之间的孔移动，导致样品中颗粒和配体之间的结合的分子碰撞得到增强。 这样的装置提供了不使用排气口的混合的替代方案，并且可以与诸如磁珠的悬浮液中的各种颗粒一起使用以捕获或净化有用的细胞和分子。
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公开(公告)号：US20090181411A1
公开(公告)日：2009-07-16
申请号：US12341637
申请日：2008-12-22
申请人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
发明人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译： 公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理设计的系统中的混合和试剂和样品操作方面的改进。
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公开(公告)号：US08772017B2
公开(公告)日：2014-07-08
申请号：US13492612
申请日：2012-06-08
申请人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
发明人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
IPC分类号： C12M1/34
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
摘要翻译： 公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。 这些设备是单进入，卫生和一次性的。 该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板或癌细胞类型的测定板。 还公开了在全自动气动控制装置中使用微流控盒的方法。
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公开(公告)号：US20120164627A1
公开(公告)日：2012-06-28
申请号：US13342859
申请日：2012-01-03
申请人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
发明人： C. Frederick Battrell , John Gerdes , Stephen Mordue , Jason Capodanno , Denise Maxine Hoekstra , John R. Williford , John Clemmens
IPC分类号： G01N33/53 , G01N33/569 , G01N21/75 , B01L3/00 , C12M1/40
CPC分类号： B01L3/50273 , B01F11/0071 , B01F11/0074 , B01F13/0059 , B01L3/502738 , B01L2300/0636 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0867 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/086 , F04B43/043 , F04B43/06 , G01N33/54366 , Y10T436/255
摘要： Microfluidic methods and devices for heterogeneous binding and agglutination assays are disclosed, with improvements relating to mixing and to reagent and sample manipulation in systems designed for safe handling of clinical test samples.
摘要翻译： 公开了用于异质结合和凝集测定的微流体方法和装置，其中涉及在为临床测试样品的安全处理设计的系统中的混合和试剂和样品操作方面的改进。
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公开(公告)号：US20090325276A1
公开(公告)日：2009-12-31
申请号：US12411020
申请日：2009-03-25
申请人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
发明人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
IPC分类号： C12M1/00
CPC分类号： G01N33/5302 , B01F11/0071 , B01F13/0059 , B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , Y02A50/58
摘要： Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
摘要翻译： 提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标进行面板测试。 这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。
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公开(公告)号：US08222023B2
公开(公告)日：2012-07-17
申请号：US12207627
申请日：2008-09-10
申请人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
发明人： C. Frederick Battrell , John Gerdes , John R. Williford , Denise Maxine Hoekstra , Wayne L. Breidford , Stephen Mordue , John Clemmens , Melud Nabavi , Mark Kokoris
IPC分类号： C12M1/34
CPC分类号： C12Q1/6834 , B01F11/0071 , B01F13/0059 , B01L3/5027 , B01L3/502723 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/087 , B01L2300/0887 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , C12Q1/686 , C12Q2563/131 , C12Q2525/197 , C12Q2563/143 , C12Q2565/629
摘要： Integrated microfluidic cartridges for nucleic acid extraction, amplification, and detection from clinical samples are disclosed. The devices are single-entry, sanitary, and disposable. The devices enable simplex or multiplex nucleic acid target detection, as for example: assay panels for multiple infectious agents, or assay panels for cancerous cell types. Methods for use of microfluidic cartridges in a fully automated, pneumatically controlled apparatus are also disclosed.
摘要翻译： 公开了用于从临床样品进行核酸提取，扩增和检测的集成微流控柱。 这些设备是单进入，卫生和一次性的。 该装置能够进行单核或多重核酸靶标检测，例如：用于多种感染剂的测定板或癌细胞类型的测定板。 还公开了在全自动气动控制装置中使用微流控盒的方法。
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