公开(公告)号：US20160024251A1

公开(公告)日：2016-01-28

申请号：US14811238

申请日：2015-07-28

申请人： Abraham Joy ,  John Swanson

发明人： Abraham Joy ,  John Swanson

IPC分类号： C08G69/26 ,  C07C237/22 ,  C07D295/16 ,  C08L77/06

CPC分类号： C07D295/16 ,  C07C235/08 ,  C07C235/14 ,  C07C2601/02 ,  C08G63/6856 ,  C08G73/0233

摘要： A thermoresponsive polyester comprising units derived from an amide functional diol compound having a first amide group having a nitrogen atom and a carbonyl group; a second amide group tethered directly or indirectly through an organic group at the carbonyl group of the first amide group; and two organic groups terminated with a hydroxyl group attached to the nitrogen atom of the first amide group. The thermoresponsive polyesters exhibit a lower critical solution temperature at which they undergo a thermally induced reversible hydrophobicity change. This hydrophobicity change may involve the formation of coacervates of the thermoresponsive polyesters which can then coalesce into a precipitated polymer rich phase.

摘要翻译： 包含衍生自具有氮原子和羰基的具有第一酰胺基的酰胺官能二醇化合物的单元的热反应聚酯; 通过第一酰胺基团的羰基上的有机基团直接或间接连接的第二酰胺基团; 并且两个有机基团以与第一酰胺基团的氮原子连接的羟基封端。 热反应聚酯表现出较低的临界溶解温度，在此温度下，它们经历热诱导的可逆疏水性变化。 这种疏水性变化可能涉及热聚合聚酯的凝聚层的形成，其然后可以聚结成沉淀的富聚合物相。

公开(公告)号：US08706257B2

公开(公告)日：2014-04-22

申请号：US13070095

申请日：2011-03-23

申请人： John Swanson

发明人： John Swanson

IPC分类号： A61N1/36

CPC分类号： A61N1/3752 ,  H01R12/77 ,  H01R24/58 ,  H01R2201/12

摘要： In one embodiment, a stimulation system for generating and delivering electrical stimulation pulse to tissue of a patient, comprises: a pulse generator for generating electrical pulses, the pulse generator comprising a housing portion and a header portion with feedthroughs extending from the housing portion into the header portion; and a stimulation lead comprising a flex film component enclosed in a lead body of insulative material, the flex film component including a plurality of electrically isolated conductors extending along a substantial length of the stimulation lead, the stimulation lead further comprising a plurality of electrodes electrically coupled to the conductors, the flex film component comprising a proximal portion that is exposed out of the insulative material of the lead body and includes a plurality of terminal bond bands, the terminal bond bands being electrically coupled to the conductors; and wherein the header portion of the pulse generator comprises a lid component to compress the terminal bond pads of the stimulation lead into electrical contact with conductors of feedthroughs of the pulse generator.

摘要翻译： 在一个实施例中，用于产生并向患者的组织递送电刺激脉冲的刺激系统包括：用于产生电脉冲的脉冲发生器，所述脉冲发生器包括壳体部分和具有从壳体部分延伸到 标题部分 以及刺激引线，其包括封装在绝缘材料的引线本体中的柔性膜部件，所述柔性膜部件包括沿着刺激引线的相当长度延伸的多个电隔离导体，所述刺激引线还包括电耦合的多个电极 所述柔性膜部件包括从所述引线主体的绝缘材料露出的近端部分，并且包括多个端子接合带，所述端子接合带电连接到所述导体; 并且其中所述脉冲发生器的头部部分包括盖部件，以将所述刺激引线的端子接合焊盘压缩成与所述脉冲发生器的馈通导体电接触。

公开(公告)号：US08544170B2

公开(公告)日：2013-10-01

申请号：US13242234

申请日：2011-09-23

申请人： Timothy J. Cox ,  John Erickson ,  Enri Zhulati ,  Terry Daglow ,  John Swanson

发明人： Timothy J. Cox ,  John Erickson ,  Enri Zhulati ,  Terry Daglow ,  John Swanson

IPC分类号： H01R43/00 ,  H05K13/00

CPC分类号： A61N1/05 ,  A61N1/086 ,  Y10T29/4902 ,  Y10T29/49117 ,  Y10T29/49128 ,  Y10T29/49155 ,  Y10T29/49169

摘要： In one embodiment, a percutaneous stimulation lead for applying electrically stimulation pulses to tissue of the patient comprises: a plurality of electrode assemblies electrically coupled to a plurality of terminals through a plurality of conductors of the stimulation lead, wherein each electrode assembly is disposed in an annular manner around the lead body and each electrode assembly comprises (i) an electrode adapted to deliver electrical stimulation to tissue of a patient, (ii) an interior conductive layer, and (iii) a dielectric layer disposed between the electrode and the interior conductive layer; the electrode and interior conductive layer being capacitively coupled, the dielectric layer further comprising an inductor, the inductor being electrically connected to one of the plurality of conductors through the interior conductive layer, and the inductor being electrically coupled to the electrode.

摘要翻译： 在一个实施例中，用于向患者的组织施加电刺激脉冲的经皮刺激引线包括：通过刺激引线的多个导体电耦合到多个端子的多个电极组件，其中每个电极组件设置在 环形方式围绕引线体，并且每个电极组件包括（i）适于将电刺激递送到患者组织的电极，（ii）内部导电层，和（iii）设置在电极和内部导电之间的电介质层 层; 所述电极和内部导电层电容耦合，所述介电层还包括电感器，所述电感器通过所述内部导电层电连接到所述多个导体中的一个，并且所述电感器电耦合到所述电极。

公开(公告)号：US08533944B2

公开(公告)日：2013-09-17

申请号：US12962421

申请日：2010-12-07

申请人： John Swanson

发明人： John Swanson

IPC分类号： H01R43/00

CPC分类号： A61N1/0553

摘要： In one embodiment, a method of fabricating a stimulation lead for stimulation of tissue of a patient, the method comprises: providing a plurality of cables, wherein each of the cables comprises a plurality of wires twisted about a core support and disposed within an outer sheath, wherein each of the plurality of wires comprises a coating of insulative material to electrically isolate each wire from each other wire within the respective cable, each of the plurality of wires being disposed in a single layer circumferentially about a central axis of the respective cable; wrapping the plurality of cables about a central core in a helical manner to form a cable assembly.

摘要翻译： 在一个实施例中，一种制造用于刺激患者组织的刺激引线的方法，所述方法包括：提供多根电缆，其中每根电缆包括围绕芯支撑件扭绞并设置在外护套内的多根电线 其中，所述多根导线中的每一根包括绝缘材料的涂层，以将每根导线与相应的电缆内的每个电线电隔离，所述多个电线中的每一根电线围绕相应的电缆的中心轴线周向地设置在单个层中; 以螺旋方式围绕中心芯缠绕多个电缆以形成电缆组件。

公开(公告)号：US08509918B2

公开(公告)日：2013-08-13

申请号：US13592052

申请日：2012-08-22

申请人： John Swanson ,  Anna Norlin-Weissenrieder

发明人： John Swanson ,  Anna Norlin-Weissenrieder

IPC分类号： A61N1/05

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  Y10T29/49147 ,  Y10T29/49204 ,  Y10T29/49208

摘要： In one embodiment, a method, of fabricating a stimulation lead for stimulating tissue of a patient, comprises: providing a lead body, the lead body comprising a plurality of conductors embedded within insulating material; providing a plurality of terminals; electrically coupling the plurality of terminals with the plurality of conductors; providing a plurality of electrodes, the plurality of electrodes comprising a plurality of substantially continuous longitudinal trenches on a surface of the electrodes, the electrodes comprising areas of reflow material forming microstructures substantially continuously along walls of the longitudinal trenches; and electrically coupling the plurality of electrodes with the plurality of conductors.

摘要翻译： 在一个实施例中，制造用于刺激患者组织的刺激引线的方法包括：提供引线体，所述引线主体包括嵌入在绝缘材料内的多个导体; 提供多个终端; 将所述多个端子与所述多个导体电耦合; 提供多个电极，所述多个电极在电极的表面上包括多个基本上连续的纵向沟槽，所述电极包括基本上沿着纵向沟槽的壁连续地形成微结构的区域的回流材料; 并且将所述多个电极与所述多个导体电耦合。

公开(公告)号：US20130123891A1

公开(公告)日：2013-05-16

申请号：US13607280

申请日：2012-09-07

申请人： John Swanson

发明人： John Swanson

IPC分类号： A61N1/04 ,  H05K3/12 ,  H05K3/02 ,  H05K3/00 ,  H05K3/06

CPC分类号： A61N1/04 ,  A61N1/05 ,  H01R12/778 ,  H01R2201/12 ,  H05K1/028 ,  H05K1/118 ,  H05K3/00 ,  H05K3/027 ,  H05K3/06 ,  H05K3/12 ,  H05K2201/10356 ,  Y10T29/49124 ,  Y10T29/49155 ,  Y10T29/49156

摘要： In one embodiment, a method of fabricating a lead comprises: providing a lead body comprising a plurality of conductive wires; providing a flex film connector structure, the flex film connector structure comprising a plurality of conductive pads on a first portion of the flex film connector structure, a plurality of contacts on a second portion of the flex film connectors, and a plurality of traces electrically connecting the plurality of conductive pads with the plurality of contacts; placing the first portion of the flex film connector adjacent to a cross-section of one end of the lead body; electrically coupling the plurality of conductive pads of the flex film connector structure to the plurality of conductive wires at the one end of the lead body; and wrapping the second portion of the flex film connector structure about the lead body to form a plurality of electrical contacts.

摘要翻译： 在一个实施例中，制造引线的方法包括：提供包括多根导线的引线本体; 提供柔性膜连接器结构，柔性膜连接器结构包括在柔性膜连接器结构的第一部分上的多个导电焊盘，柔性膜连接器的第二部分上的多个触点，以及电连接 所述多个导电焊盘具有所述多个触点; 将柔性膜连接器的第一部分放置在铅体的一端的横截面附近; 将柔性膜连接器结构的多个导电焊盘电连接到引线体的一端处的多个导电线; 并且围绕引线本体缠绕柔性膜连接器结构的第二部分以形成多个电触点。

公开(公告)号：US08179412B2

公开(公告)日：2012-05-15

申请号：US12543530

申请日：2009-08-19

申请人： John Swanson

发明人： John Swanson

IPC分类号： B41J2/435

CPC分类号： G06K15/107 ,  G06K2215/111

摘要： A method for reducing visible artifacts among image pixels formed on recording media by a plurality of individually addressable recording channels includes operating the recording channels to form a plurality of image pixel arrangements, wherein each image pixel arrangement comprises a plurality of image pixel columns extending along a first direction. The image pixels columns in each image pixel arrangement are arranged along a second direction that intersects the first direction. The recording channels form a first image pixel arrangement on the recording media and overlap a first image pixel column with a second image pixel column by an amount along the second direction that is determined based at least on a misalignment along the first direction between two of the image pixel arrangements.

摘要翻译： 一种用于通过多个可单独寻址的记录通道来减少在记录介质上形成的图像像素之间的可见伪像的方法包括操作记录通道以形成多个图像像素布置，其中每个图像像素排列包括沿着 第一个方向 每个图像像素布置中的图像像素列沿着与第一方向相交的第二方向布置。 记录通道在记录介质上形成第一图像像素布置，并且将第一图像像素列与第二图像像素列重叠，沿着第二方向的量至少基于沿着第一方向的两个 图像像素排列。

公开(公告)号：US20120110846A1

公开(公告)日：2012-05-10

申请号：US13352785

申请日：2012-01-18

申请人： Brian Franz ,  John Swanson ,  Jerome Boogaard ,  Terry D. Daglow ,  Tom Sosebee ,  Stephen L. Goldman ,  Rajasree Sarah Das ,  Michael DiGiancomo

发明人： Brian Franz ,  John Swanson ,  Jerome Boogaard ,  Terry D. Daglow ,  Tom Sosebee ,  Stephen L. Goldman ,  Rajasree Sarah Das ,  Michael DiGiancomo

IPC分类号： H01R43/20

CPC分类号： A61N1/0551 ,  A61N1/0504 ,  A61N1/0558 ,  Y10T29/49208

摘要： In one embodiment, a neurostimulation lead for stimulating neural tissue of a patient, comprises: a lead body of insulative material; a plurality of electrodes; a plurality of terminals; a plurality of conductors, wherein the plurality of electrodes are electrically coupled to the plurality of terminals through the plurality of conductors; wherein the plurality of conductors are disposed in a helical manner in a repeating pattern of groups of conductors separated by gaps along a substantial length of the lead body, each gap being larger than an inter-conductor pitch within the groups of conductors; wherein the insulative material is a compliant material permitting elongation of the lead at low stretching forces and the insulative material of the lead body is fused through a substantial volume of the lead body and along a substantial length of the lead body.

摘要翻译： 在一个实施方案中，用于刺激患者的神经组织的神经刺激引线包括：绝缘材料的引线体; 多个电极; 多个终端; 多个导体，其中所述多个电极通过所述多个导体电耦合到所述多个端子; 其中所述多个导体以螺旋形的方式设置在沿着所述引线体的相当长度的间隙分开的导体组的重复图案中，每个间隙大于所述导体组内的导体间间距; 其中所述绝缘材料是允许所述引线在低拉伸力下伸长的顺应性材料，并且所述引线体的绝缘材料通过所述引线体的大体积并且沿所述引线体的大体长度熔合。

公开(公告)号：US20120071951A1

公开(公告)日：2012-03-22

申请号：US13070095

申请日：2011-03-23

申请人： John Swanson

发明人： John Swanson

IPC分类号： A61N1/36

CPC分类号： A61N1/3752 ,  H01R12/77 ,  H01R24/58 ,  H01R2201/12

摘要： In one embodiment, a stimulation system for generating and delivering electrical stimulation pulse to tissue of a patient, comprises: a pulse generator for generating electrical pulses, the pulse generator comprising a housing portion and a header portion with feedthroughs extending from the housing portion into the header portion; and a stimulation lead comprising a flex film component enclosed in a lead body of insulative material, the flex film component including a plurality of electrically isolated conductors extending along a substantial length of the stimulation lead, the stimulation lead further comprising a plurality of electrodes electrically coupled to the conductors, the flex film component comprising a proximal portion that is exposed out of the insulative material of the lead body and includes a plurality of terminal bond bands, the terminal bond bands being electrically coupled to the conductors; and wherein the header portion of the pulse generator comprises a lid component to compress the terminal bond pads of the stimulation lead into electrical contact with conductors of feedthroughs of the pulse generator.

摘要翻译： 在一个实施例中，用于产生并向患者的组织递送电刺激脉冲的刺激系统包括：用于产生电脉冲的脉冲发生器，所述脉冲发生器包括壳体部分和具有从壳体部分延伸到 标题部分 以及刺激引线，其包括封装在绝缘材料的引线本体中的柔性膜部件，所述柔性膜部件包括沿着刺激引线的相当长度延伸的多个电隔离导体，所述刺激引线还包括电耦合的多个电极 所述柔性膜部件包括从所述引线主体的绝缘材料露出的近端部分，并且包括多个端子接合带，所述端子接合带电连接到所述导体; 并且其中所述脉冲发生器的头部部分包括盖部件，以将所述刺激引线的端子接合焊盘压缩成与所述脉冲发生器的馈通导体电接触。

公开(公告)号：US20110137382A1

公开(公告)日：2011-06-09

申请号：US12962421

申请日：2010-12-07

申请人： John Swanson

发明人： John Swanson

IPC分类号： A61N1/36 ,  H01R43/20

CPC分类号： A61N1/0553

摘要： In one embodiment, a method of fabricating a stimulation lead for stimulation of tissue of a patient, the method comprises: providing a plurality of cables, wherein each of the cables comprises a plurality of wires twisted about a core support and disposed within an outer sheath, wherein each of the plurality of wires comprises a coating of insulative material to electrically isolate each wire from each other wire within the respective cable, each of the plurality of wires being disposed in a single layer circumferentially about a central axis of the respective cable; wrapping the plurality of cables about a central core in a helical manner to form a cable assembly.

摘要翻译： 在一个实施例中，一种制造用于刺激患者组织的刺激引线的方法，所述方法包括：提供多根电缆，其中每根电缆包括围绕芯支撑件扭绞并设置在外护套内的多根电线 其中，所述多根导线中的每一根包括绝缘材料的涂层，以将每根导线与相应的电缆内的每个电线电隔离，所述多个电线中的每一根电线围绕相应的电缆的中心轴线周向地设置在单个层中; 以螺旋方式围绕中心芯缠绕多个电缆以形成电缆组件。