公开(公告)号：US20180312778A1

公开(公告)日：2018-11-01

申请号：US15971626

申请日：2018-05-04

申请人： Lucy M. Campbell ,  A. Keith Campbell

发明人： Lucy M. Campbell ,  A. Keith Campbell

IPC分类号： C11C5/00

摘要： A scented candle is provided. The candle has a body made of a flammable material and a wick. The body of the candle is provided with one or more bores adapted for receiving a respective scent element therein as selected by a user.

公开(公告)号：US20070033664A1

公开(公告)日：2007-02-08

申请号：US11543786

申请日：2006-10-06

申请人： Keith Campbell ,  Ian Wilmut

发明人： Keith Campbell ,  Ian Wilmut

IPC分类号： A01K67/027 ,  C12N5/06

CPC分类号： C12N15/8771 ,  A61K35/54 ,  C12N15/8773

摘要： A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.

公开(公告)号：US20060249818A1

公开(公告)日：2006-11-09

申请号：US11484075

申请日：2006-07-11

申请人： Brian Peterson ,  John Kirner ,  Scott Weigel ,  James MacDougall ,  Lisa Deis ,  Thomas Braymer ,  Keith Campbell ,  Martin Devenney ,  C. Ramberg ,  Konstantinos Chondroudis ,  Keith Cendak

发明人： Brian Peterson ,  John Kirner ,  Scott Weigel ,  James MacDougall ,  Lisa Deis ,  Thomas Braymer ,  Keith Campbell ,  Martin Devenney ,  C. Ramberg ,  Konstantinos Chondroudis ,  Keith Cendak

IPC分类号： H01B1/12 ,  H01B1/00

CPC分类号： H01L21/02126 ,  H01L21/02203 ,  H01L21/02216 ,  H01L21/02282 ,  H01L21/3122 ,  H01L21/31695

摘要： Low dielectric materials and films comprising same have been identified for improved performance when used as performance materials, for example, in interlevel dielectrics integrated circuits as well as methods for making same. In one aspect of the present invention, the performance of the dielectric material may be improved by controlling the weight percentage of ethylene oxide groups in the at least one porogen.

公开(公告)号：US20120177654A1

公开(公告)日：2012-07-12

申请号：US13335974

申请日：2011-12-23

申请人： John Hamilton ,  Gary Peter Anderson ,  Ian Keith Campbell

发明人： John Hamilton ,  Gary Peter Anderson ,  Ian Keith Campbell

IPC分类号： A61K39/395 ,  A61P19/00 ,  A61P11/00 ,  A61P25/00 ,  A61P17/06 ,  A61P1/00 ,  A61K38/02 ,  A61P3/04

CPC分类号： C07K16/2866 ,  A61K38/1793 ,  A61K39/3955 ,  A61K2039/505 ,  A61P29/00 ,  C07K16/241 ,  C07K16/243 ,  C07K2317/73 ,  C07K2317/76 ,  G01N33/5047

摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.

摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

公开(公告)号：US08142777B2

公开(公告)日：2012-03-27

申请号：US11856949

申请日：2007-09-18

申请人： John Hamilton ,  Ian Keith Campbell

发明人： John Hamilton ,  Ian Keith Campbell

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K31/00 ,  A61K38/1793 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/243 ,  C07K2317/73 ,  C07K2317/76 ,  G01N33/5047

摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.

摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

公开(公告)号：US20090137040A1

公开(公告)日：2009-05-28

申请号：US12212557

申请日：2008-09-17

申请人： Jose Cibelli ,  Michael West ,  Keith Campbell

发明人： Jose Cibelli ,  Michael West ,  Keith Campbell

IPC分类号： C12N5/08

CPC分类号： C12N5/16 ,  C12N15/873 ,  C12N15/8776 ,  C12N2517/04 ,  C12N2517/10

摘要： Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. In one embodiment, the invention provides methods for producing activated human embryos by parthenogenesis; in another embodiment, the invention provides methods for producing activated human embryos by somatic cell nuclear transfer whereby the genetic material of a differentiated human donor cell is reprogrammed to form a diploid human pronucleus capable of directing a cell to generate the stem cells from which autologous, isogenic cells for transplantation therapy are derived. The ability to create autologous human embryos represents a critical step towards generating immune-compatible stem cells that can be used to overcome the problem of immune rejection in regenerative medicine. The activated human embryos produced by the present invention also provide model systems for identifying and analyzing the molecular mechanisms of epigenetic imprinting and the genetic regulation of embryogenesis and development.

摘要翻译： 通过治疗性克隆产生的活化的人类胚胎可以产生源自移植治疗的自体细胞的人类全能干细胞和多能干细胞。 本发明提供了用于产生活化的人胚胎的方法，所述活化的人胚胎可用于产生能够产生适合于移植的自体细胞和组织的全能干细胞和多能干细胞。 在一个实施方案中，本发明提供了通过孤雌生殖产生活化的人胚胎的方法; 在另一个实施方案中，本发明提供了通过体细胞核转移产生活化的人胚胎的方法，由此将分化的人供体细胞的遗传物质重新编程以形成能引导细胞产生干细胞的二倍体人原核，其中自体， 衍生出用于移植治疗的同基因细胞。 创建自体人类胚胎的能力代表了产生免疫相容性干细胞的关键步骤，可用于克服再生医学中的免疫排斥问题。 本发明生产的活化人胚胎还提供了用于鉴定和分析表观遗传印记的分子机制和胚胎发生和发育的遗传调控的模型系统。

公开(公告)号：US07455836B2

公开(公告)日：2008-11-25

申请号：US09851230

申请日：2001-05-08

申请人： John Hamilton ,  Gary Peter Anderson ,  Ian Keith Campbell

发明人： John Hamilton ,  Gary Peter Anderson ,  Ian Keith Campbell

IPC分类号： A61K39/40 ,  A61K39/00

CPC分类号： C07K16/2866 ,  A61K31/00 ,  A61K38/1793 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/241 ,  C07K16/243 ,  C07K2317/73 ,  C07K2317/76 ,  G01N33/5047

摘要： The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.

摘要翻译： 本发明一般涉及治疗和预防炎性病症的方法。 本发明部分地基于对炎症，特别是慢性炎症至关重要的单核细胞/巨噬细胞谱系的细胞的鉴定。 根据本发明，提出单核细胞/巨噬细胞型细胞水平的降低和/或由这些细胞，特别是局部的炎症和促炎介质的产生减少在减少炎性病症中是有效的 。 本发明进一步提供可用于筛选单核细胞/巨噬细胞型细胞水平降低和/或减少这些细胞的炎症和促炎介质的产生的动物模型。

公开(公告)号：US20060156424A1

公开(公告)日：2006-07-13

申请号：US11265113

申请日：2005-11-03

申请人： Keith Campbell ,  Ian Wilmut

发明人： Keith Campbell ,  Ian Wilmut

IPC分类号： A01K67/027

CPC分类号： C12N15/8771 ,  A61K35/54 ,  C12N15/8773

摘要： A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in, the production of transgenic animals as well as non-transgenics of high genetic merit.

摘要翻译： 重建动物胚胎的方法涉及将细胞核从静止供体细胞转移到合适的受体细胞中。 供体细胞是静止的，因为它被导致在G1期的生长和分裂周期退出并且在G0状态下停止。 核转移可能通过细胞融合发生。 然后，重构的胚胎可以产生一种或多种动物。 本发明可用于生产转基因动物以及具有高遗传优点的非转基因植物。

公开(公告)号：US06663042B2

公开(公告)日：2003-12-16

申请号：US09974720

申请日：2001-10-09

申请人： Michael John Hatrick ,  Joel David Bennett ,  Finbarr McEvoy ,  Hugh Keith Campbell ,  William Edwin Beattie

发明人： Michael John Hatrick ,  Joel David Bennett ,  Finbarr McEvoy ,  Hugh Keith Campbell ,  William Edwin Beattie

IPC分类号： F02K304

CPC分类号： F02K1/72 ,  B64D33/04 ,  F02K1/566 ,  F02K3/04 ,  F05D2240/14

摘要： A thrust reversing arrangement for an aircraft turbofan propulsive power unit includes a flow redirecting structure which has reverse flow enhancing sub-structures comprising: (i) a cavity which is so dimensioned as to generate a back pressure which supports redirection of flow; (ii) a cascade assembly which provides a flow control slot so dimensioned as to optimize reverse thrust for predetermined fan duct flow conditions; (iii) an obstructing duct wall portion having a leading edge so positioned as to form a leakage slot providing controlled leakage of forward flow; (iv) a box structure, the dimensions of which are such as to optimize back pressure in the cavity; and (v) provision for gaseous fluid under static pressure from the fan duct to load the redirecting structure to the inoperative position.

公开(公告)号：US5683888A

公开(公告)日：1997-11-04

申请号：US270314

申请日：1994-07-05

申请人： Anthony Keith Campbell

发明人： Anthony Keith Campbell

IPC分类号： A61K49/00 ,  C07K14/435 ,  C12N9/02 ,  C12Q1/68 ,  G01N33/542 ,  C12Q1/66 ,  C07H21/04 ,  C07K14/00 ,  C12Q1/00

CPC分类号： C12N9/0069 ,  A61K49/0013 ,  C07K14/43536 ,  C07K14/43595 ,  C12Q1/6897 ,  G01N33/542

摘要： A modified bioluminescent protein responds to different physical, chemical, biochemical or biological conditions to produce light or radiation of altered characteristics when the bioluminescent reaction is initiated. The modified bioluminescent protein may respond to modification thereof, e.g. by covalent modification. The protein may include signal peptides to "target" it. DNA coding for the bioluminescent protein may be altered to include tissue specific promoter or enhancer genes so that the altered DNA acts as reporter gene.

摘要翻译： 当生物发光反应开始时，经修饰的生物发光蛋白质对不同的物理，化学，生物化学或生物学条件作出反应以产生改变的特征的光或辐射。 修饰的生物发光蛋白可以对其修饰作出反应，例如 通过共价修饰。 蛋白质可以包括信号肽“靶”它。 编码生物发光蛋白的DNA可以改变为包括组织特异性启动子或增强子基因，使得改变的DNA作为报告基因。