公开(公告)号：US4388165A

公开(公告)日：1983-06-14

申请号：US298343

申请日：1981-08-31

申请人： Kiyozo Koshiishi ,  Noriaki Ono ,  Takashi Kamiyama ,  Yoshimi Kato

发明人： Kiyozo Koshiishi ,  Noriaki Ono ,  Takashi Kamiyama ,  Yoshimi Kato

IPC分类号： G01N27/333 ,  G01N27/30

CPC分类号： G01N27/3335 ,  Y10T428/31663

摘要： A selective ion sensitive electrode is so constructed that an ion exchanger sensitive to a specific ion is formed on a metal electrode, an electric conductive resin electrode or a chlorinated metal electrode to which a signal wire is connected so as to maintain a stable electric connection between the signal wire and the ion exchanger over a long period of time. A layer of a silane coupling agent is used between the electrode member and ion exchanger.

摘要翻译： 选择性离子敏感电极被构造成使得在金属电极，导电树脂电极或连接有信号线的氯化金属电极上形成对特定离子敏感的离子交换剂，以便保持电连接 信号线和离子交换器长时间。 在电极构件和离子交换器之间使用硅烷偶联剂层。

公开(公告)号：US4182668A

公开(公告)日：1980-01-08

申请号：US950295

申请日：1978-10-11

申请人： Kiyozo Koshiishi ,  Takashi Mizusaki

发明人： Kiyozo Koshiishi ,  Takashi Mizusaki

IPC分类号： G01N27/333 ,  G01N27/30

CPC分类号： G01N27/333

摘要： An electrode sensitive to ions in solution comprises an outer tubular body having an opening at its one end, an inner tubular body secured to the other end of the outer tubular body and having an opening at its one end, a tip member threadingly engaged to one end of the outer tubular body and having an aperture at its one end, a first porous membrane provided between the tip member and one end of the outer tubular body to define a first reservoir together with the outer tubular body, a sealing member provided around the periphery of the first porous membrane, a second porous membrane provided at one end of the inner tubular body to define a second reservoir therein, an ion-exchanger liquid accommodated in the first reservoir and in contact with the first porous membrane directly, an internal reference solution accommodated in the second reservoir, and an inner reference electrode connected to a shielded cable extended through the other end of the outer tubular body and dipped in the internal reference solution.The tip member for holding the first porous membrane is formed by a metal tube and at least a portion of the metal tube in contact with a solution to be tested is coated with an insulating film.

摘要翻译： 对溶液中的离子敏感的电极包括在其一端具有开口的外管状体，固定到外管状体的另一端并在其一端具有开口的内管状体， 外管状体的端部并且在其一端具有孔，第一多孔膜设置在末端构件和外管状体的一端之间，以与外管体一起限定第一储存器，密封构件围绕 第一多孔膜的周边，设置在内部管状体的一端以在其中限定第二储存器的第二多孔膜，容纳在第一储存器中并与第一多孔膜直接接触的离子交换液体，内部参考 容纳在第二储存器中的溶液和连接到穿过外管状体的另一端的屏蔽电缆的内参考电极，并浸入 三进制参考解决方案。 用于保持第一多孔膜的尖端构件由金属管形成，并且与待测试溶液接触的金属管的至少一部分涂覆有绝缘膜。

公开(公告)号：US4172777A

公开(公告)日：1979-10-30

申请号：US739052

申请日：1976-11-05

申请人： Tadao Yamamoto ,  Hiroshi Takekawa ,  Taichi Banno ,  Kiyozo Koshiishi

发明人： Tadao Yamamoto ,  Hiroshi Takekawa ,  Taichi Banno ,  Kiyozo Koshiishi

IPC分类号： G01N27/28 ,  G01N27/416 ,  G01N27/46

CPC分类号： G01N27/4166

摘要： In an apparatus for measuring ion activity, a reference electrode and an at least one test electrode project through an opening in a rotating plate while a cup receiver which holds a cup filled with the test solution is lifted from a disengaged position into a position where the cup receiver engages and is rotated by the rotating plate while the electrodes project into the solution. A measuring circuit connected to the electrodes measures the ion activity with the use of a reverse logarithmic amplifier.

摘要翻译： 在用于测量离子活性的装置中，参考电极和至少一个测试电极通过旋转板中的开口突出，同时将保持装满测试溶液的杯子的杯接收器从脱离位置提升到位置， 杯状接收器接合并且当电极投射到溶液中时由旋转板旋转。 连接到电极的测量电路使用反向对数放大器测量离子活性。

公开(公告)号：US4218746A

公开(公告)日：1980-08-19

申请号：US950294

申请日：1978-10-11

申请人： Kiyozo Koshiishi

发明人： Kiyozo Koshiishi

IPC分类号： G01N27/26 ,  G01D18/00 ,  G01N27/416 ,  G06F15/42 ,  G01N27/46

CPC分类号： G01D18/008 ,  G01N27/4165

摘要： A method for measuring ion concentration of a sample solution by detecting a potential difference generated between an ion electrode and a reference electrode which are dipped in the sample solution, while calibrating or compensating variations in a reference point and a span due to a drift, fluctuations of temperature, humidity, voltage supply source and the like with the aid of at least two standard solutions having known ion concentrations. The method comprisesa step for detecting potential differences E.sub.1 and E.sub.2 corresponding to the known ion concentrations a.sub.1 and a.sub.2 of the first and second standard solutions, respectively;a step for calculating a proportional constant c in accordance with the following equation; ##EQU1## a step for detecting a potential difference E.sub.x corresponding to an unknown ion concentration a.sub.x ;a step for calculating the unknown ion concentration a.sub.x in accordance with an equation of ##EQU2## with the aid of the detected potential value E.sub.1 or E.sub.2, known ion concentration a.sub.1 or a.sub.2 and calculated constant c which have been stored in a memory and the detected potential value E.sub.x. During the measurement the reference point can be simply recalibrated by detecting a potential difference E'.sub.1 or E'.sub.2 of the first or second standard solution and the newly detected potential value E'.sub.1 or E'.sub.2 is used for calculating unknown ion concentrations of subsequent sample solutions.

摘要翻译： 通过检测在浸没在样品溶液中的离子电极和参考电极之间产生的电位差来测量样品溶液的离子浓度的方法，同时校准或补偿由于漂移引起的参考点和跨度的变化，波动 借助于具有已知离子浓度的至少两种标准溶液的温度，湿度，电压源等。 该方法包括分别检测与第一和第二标准溶液的已知离子浓度a1和a2相对应的电位差E1和E2的步骤; 根据下式计算比例常数c的步骤; ＆lt; IMAGE＆gt;用于检测与未知离子浓度ax相对应的电位差Ex的步骤; 借助于检测的电位值E1或E2，已知的离子浓度a1或a2以及已经存储在其中的已知离子浓度a1和a2的计算常数c，根据或等式计算未知离子浓度ax的步骤 记忆和检测到的电位值Ex。 在测量期间，可以通过检测第一或第二标准溶液的电位差E'1或E'2来简单地重新校准参考点，并且新检测的电位值E'1或E'2用于计算未知离子浓度 后续样品溶液。

公开(公告)号：US4070986A

公开(公告)日：1978-01-31

申请号：US614694

申请日：1975-09-18

申请人： Yutaka Kato ,  Teruo Ouchi ,  Kiyozo Koshiishi

发明人： Yutaka Kato ,  Teruo Ouchi ,  Kiyozo Koshiishi

IPC分类号： G01N27/26 ,  G01N27/447 ,  G01N33/48 ,  G01N33/483 ,  B05C1/16

CPC分类号： G01N27/44743

摘要： An apparatus for automatic application of blood serum to a serum bearing film for use in a cataphoretic process includes a serum supply station, a serum application station, a rinsing station and a drip station. The apparatus also comprises a guide along which a serum applicator is sequentially moved through each of these stations, as well as operation controlling microswitches and a cam assembly.

摘要翻译： 将血清自动应用于用于阴道过程的血清载体膜的装置包括血清供应站，血清施用站，漂洗站和滴水站。 该装置还包括一个引导件，血清给药器沿着该引导件依次移动通过这些站中的每一个，以及操作控制微动开关和凸轮组件。

公开(公告)号：US4971445A

公开(公告)日：1990-11-20

申请号：US191606

申请日：1988-05-09

申请人： Eiichi Sato ,  Kiyozo Koshiishi ,  Sadao Shigetomi ,  Syunpei Tanaka ,  Makoto Yoshinaga ,  Terumasa Morita ,  Chikara Nagano ,  Shohei Kobayashi ,  Chiaki Sato ,  Akitoshi Toda ,  Mitunori Kubo ,  Ikuo Tofukuji

发明人： Eiichi Sato ,  Kiyozo Koshiishi ,  Sadao Shigetomi ,  Syunpei Tanaka ,  Makoto Yoshinaga ,  Terumasa Morita ,  Chikara Nagano ,  Shohei Kobayashi ,  Chiaki Sato ,  Akitoshi Toda ,  Mitunori Kubo ,  Ikuo Tofukuji

IPC分类号： G01B9/04 ,  G01B11/24

CPC分类号： G01B11/24 ,  G01B9/04

摘要： A fine surface profile meter includes an X-Y stage, supported by a leaf spring, for supporting a sample thereon, a piezoelectric actuator for two-dimensionally scanning the X-Y stage, a positioning table, disposed below the X-Y stage, for positioning the X-Y stage at an arbitrary position, an objective lens disposed above the X-Y stage, an observation optical system for allowing an operator to observe an enlarged sample image, a measurement optical system, an optical axis of which is aligned with an optical path of the objective lens through a beam splitter, the measurement optical system for emitting a laser beam onto the sample through the objective lens and to receive the laser beam reflected by the sample, a calculator circuit for calculating height information of the sample using an output from the measurement optical system and for obtaining a two-dimensional distribution of the height information, a cover for shielding the X-Y stage, the positioning means, the objective lens, the beam splitter, the observation optical system, and the measurement optical system from an outer atmosphere, a detachable measurement unit for integrally holding the objective lens, the beam splitter, and the measurement optical system, a supporting plate supported on the X-Y stage through columns, and an arm, mounted on the supporting plate, for supporting the measurement optical system and the observation optical system.

公开(公告)号：US4222670A

公开(公告)日：1980-09-16

申请号：US921336

申请日：1978-07-03

申请人： Kiyozo Koshiishi

发明人： Kiyozo Koshiishi

IPC分类号： G01N21/15 ,  G01N21/03 ,  G01N21/75 ,  G01N21/77 ,  G01N21/85 ,  G01N27/28 ,  G01N27/38 ,  G01N33/487 ,  G01N33/49 ,  G01N35/08 ,  G01N21/25 ,  G01N1/10 ,  G01N27/26

CPC分类号： G01N21/85 ,  G01N21/03 ,  G01N33/49

摘要： A liquid sample analyzer comprises an open, sample determining channel in the form of a small gap, means for supplying liquid sample to the channel, means for injecting a fluid into the channel to rinse its interior, and means for determining the optical density or the ion concentration of the liquid sample supplied to the channel. In this manner, the concentration of liquid sample such as blood is automatically determined and analyzed.

摘要翻译： 液体样品分析仪包括以小间隙形式的开放样品确定通道，用于向通道供应液体样品的装置，用于将流体注入通道以冲洗其内部的装置，以及用于确定光密度或 提供给通道的液体样品的离子浓度。 以这种方式，自动确定和分析液体样品如血液的浓度。

公开(公告)号：US4204917A

公开(公告)日：1980-05-27

申请号：US970239

申请日：1978-12-18

申请人： Tadao Yamamoto ,  Hiroshi Takekawa ,  Taichi Banno ,  Kiyozo Koshiishi

发明人： Tadao Yamamoto ,  Hiroshi Takekawa ,  Taichi Banno ,  Kiyozo Koshiishi

IPC分类号： G01N27/28 ,  G01N27/416 ,  G01N27/46

CPC分类号： G01N27/4166

摘要： In the disclosed method, ion activity is measured by placing a cup filled with a test solution to be measured on a cup receiver, lifting a cup lifting arm to engage the cup receiver with a rotary plate, rotating the rotary plate to stir the test solution in the cup, measuring a potential difference between a reference electrode and other electrodes after completion of the stirring of the solution, and indicating the ion activity as a function of the potential differences.

摘要翻译： 在所公开的方法中，通过将填充有待测试测试溶液的杯放置在杯接收器上，提升杯提升臂以使杯接收器与旋转板接合来测量离子活性，旋转旋转板以搅拌测试溶液 在杯中，在溶液搅拌完成后测量参考电极和其他电极之间的电位差，并且指示作为电位差的函数的离子活性。

公开(公告)号：US6127681A

公开(公告)日：2000-10-03

申请号：US460076

申请日：1990-02-05

申请人： Chiaki Sato ,  Kiyozo Koshiishi ,  Sadao Shigetomi ,  Shuzo Mishima ,  Tsugiko Takase

发明人： Chiaki Sato ,  Kiyozo Koshiishi ,  Sadao Shigetomi ,  Shuzo Mishima ,  Tsugiko Takase

IPC分类号： A61K31/41 ,  A61K31/433 ,  A61K31/535 ,  A61P25/02 ,  A61P27/02 ,  C07D285/10 ,  C07D417/00 ,  C07D417/12 ,  G01B7/34 ,  G01B21/30 ,  G01N27/00 ,  G01N37/00 ,  G01Q30/02 ,  G01Q60/10 ,  G01Q60/16 ,  G02B21/00 ,  H01L41/09 ,  G12B21/20

CPC分类号： G01Q60/16 ,  B82Y35/00 ,  C07D285/10 ,  C07D417/12 ,  G01Q30/025 ,  G02B21/002 ,  H01L41/092 ,  H02N2/023 ,  H02N2/028 ,  Y10S977/869

摘要： A scanning tunnel microscope is arranged by a combination of an optical microscope and a tunnel scanning unit. The scanning tunnel unit includes a probe held to be spaced apart from a sample placed on a sample table by a predetermined interval in an axial direction, and an actuator for axially moving the sample table and the probe to a tunnel region and relatively and three-dimensionally driving the sample table and the probe. An objective lens and the probe are arranged such that the axis of the probe of the scanning tunnel unit is aligned with an optical axis of the objective lens of the optical microscope. The sample and the probe are axially moved and brought into the tunnel region, and the sample is scanned in its surface direction while the sample and the probe are finely moved in the axial direction and a tunnel current is kept constant, thereby performing an STM observation of an observation surface of the sample. The objective lens of the optical microscope is axially moved to obtain an in-focus state, and the field of the STM observation surface is observed as an optical microscopic image through an eyepiece lens.

摘要翻译： PCT No.PCT / JP88 / 00804 Sec。 371 1990年2月5日第 102（e）日期1990年2月5日PCT提交1988年8月12日PCT公布。 公开号WO89 / 01603 日期1989年2月23日扫描隧道显微镜通过光学显微镜和隧道扫描单元的组合布置。 扫描隧道单元包括：保持与沿轴向方向预定间隔放置在样品台上的样品间隔开的探针;以及用于将样品台和探针轴向移动到隧道区域的致动器， 在尺寸上驱动样品台和探针。 物镜和探针被布置成使得扫描隧道单元的探针的轴线与光学显微镜的物镜的光轴对准。 样品和探针被轴向移动并进入隧道区域，并且在样品和探针沿轴向细微移动并且隧道电流保持恒定的同时沿其表面方向扫描样品，从而进行STM观察 的样品的观察表面。 轴向移动光学显微镜的物镜以获得对焦状态，并且通过目镜透镜观察STM观察表面的场作为光学显微镜图像。

公开(公告)号：US4305802A

公开(公告)日：1981-12-15

申请号：US147708

申请日：1980-05-08

申请人： Kiyozo Koshiishi

发明人： Kiyozo Koshiishi

IPC分类号： G01N27/00 ,  G01N27/414 ,  H01L29/78 ,  G01N27/30

CPC分类号： G01N27/414 ,  G01N33/492

摘要： A compound chemically sensitive element comprises a chemically sensitive assembly which is selectively sensitive to a specific ion or a specific substance in a material to be examined, and a pH sensor having an insulated gate field effect transistor structure, both of which are separately manufactured. The chemically sensitive assembly and the insulated gate of the pH sensor are electrochemically connected together by a conductive resin, thus improving the durability and the selectivity of the element. In this manner, limitations imposed upon the manufacture of MOS pH sensor is removed, permitting a wide variety of chemically sensitive films to be used.

摘要翻译： 复合化学敏感元件包括对待检查材料中的特定离子或特定物质选择性敏感的化学敏感组件和具有绝缘栅场效应晶体管结构的pH传感器，两者均分开制造。 化学敏感组件和pH传感器的绝缘栅通过导电树脂电化学连接在一起，从而提高了元件的耐久性和选择性。 以这种方式，去除了制造MOS pH传感器的限制，允许使用各种各样的化学敏感膜。