公开(公告)号：US07875245B2

公开(公告)日：2011-01-25

申请号：US11156760

申请日：2005-06-20

申请人： John A. Favuzzi ,  Kristopher S. Buchanan ,  Michael T. Barber ,  Loren L. Bland ,  Dawn M. Rohrbacker ,  Robert M. Clark ,  Gordon A. Feingold ,  Benno M. Guggenheimer ,  Marc E. Key ,  Merritt M. Martin, Jr. ,  Robert L. Lathrop ,  Jeffery L. Rau ,  Jonathan R. Sweda ,  Douglas F. Sweet ,  John E. Van Bosch ,  Lars Winther ,  Rosanne Welcher

发明人： John A. Favuzzi ,  Kristopher S. Buchanan ,  Michael T. Barber ,  Loren L. Bland ,  Dawn M. Rohrbacker ,  Robert M. Clark ,  Gordon A. Feingold ,  Benno M. Guggenheimer ,  Marc E. Key ,  Merritt M. Martin, Jr. ,  Robert L. Lathrop ,  Jeffery L. Rau ,  Jonathan R. Sweda ,  Douglas F. Sweet ,  John E. Van Bosch ,  Lars Winther ,  Rosanne Welcher

IPC分类号： B01L3/02

CPC分类号： G01N35/0092 ,  B01L3/508 ,  B01L7/00 ,  B01L9/06 ,  B01L2200/025 ,  B01L2200/16 ,  B01L2300/021 ,  B01L2300/0822 ,  B01L2300/1822 ,  G01N1/312 ,  G01N35/00029 ,  G01N35/00871 ,  G01N35/0095 ,  G01N35/0099 ,  G01N35/1002 ,  G01N35/1004 ,  G01N35/1011 ,  G01N2035/00356 ,  G01N2035/00366 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N2035/00534 ,  G01N2035/00633 ,  G01N2035/00673 ,  G01N2035/00752 ,  G01N2035/00861 ,  G01N2035/00881 ,  G01N2035/102 ,  G01N2035/1058 ,  Y02A90/26 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/12 ,  Y10T436/2575

摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.

摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在 自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。 还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。

公开(公告)号：US08969087B2

公开(公告)日：2015-03-03

申请号：US13605228

申请日：2012-09-06

申请人： Loren L. Bland ,  Marc E. Key ,  Lars Winther ,  David A. Stanforth ,  Martin N. Lindberg

发明人： Loren L. Bland ,  Marc E. Key ,  Lars Winther ,  David A. Stanforth ,  Martin N. Lindberg

IPC分类号： G01N33/00 ,  G01N1/30 ,  B01L3/00 ,  G01N1/31 ,  G01N35/00

CPC分类号： G01N1/30 ,  B01L3/545 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0822 ,  G01N1/312 ,  G01N35/00732 ,  G01N2035/00782 ,  Y10T436/255

摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

摘要翻译： 公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。 还公开了一种装置，包括：非易失性存储器; 该装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。 还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

公开(公告)号：US08283176B2

公开(公告)日：2012-10-09

申请号：US11168987

申请日：2005-06-28

申请人： Loren L. Bland ,  Marc E. Key ,  Lars Winther ,  David A. Stanforth ,  Martin N. Lindberg

发明人： Loren L. Bland ,  Marc E. Key ,  Lars Winther ,  David A. Stanforth ,  Martin N. Lindberg

IPC分类号： G01N33/00

CPC分类号： G01N1/30 ,  B01L3/545 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0822 ,  G01N1/312 ,  G01N35/00732 ,  G01N2035/00782 ,  Y10T436/255

摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

摘要翻译： 公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。 还公开了一种装置，包括：非易失性存储器; 所述装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。 还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

公开(公告)号：US07867443B2

公开(公告)日：2011-01-11

申请号：US11176757

申请日：2005-07-07

申请人： Marc E. Key ,  Scott A. Devore ,  Loren L. Bland ,  Uffe Lovborg

发明人： Marc E. Key ,  Scott A. Devore ,  Loren L. Bland ,  Uffe Lovborg

IPC分类号： G01N21/00

CPC分类号： G01N33/5306 ,  G01N1/30 ,  G01N33/54393 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/2575

摘要： The present invention concerns a method and apparatus for automatic staining or other processing of a biological sample on a slide, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system. Further provided is a method of antigen retrieval, the method comprising contacting, within a heated processing tank of an automated staining apparatus, at least one biological sample with at least one composition for antigen retrieval comprising at least one chelating agent, at least one detergent and at least 50% by volume of at least one liquid that facilitates antigen retrieval.

摘要翻译： 本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂，可能机器人地在载玻片上自动染色或其它处理生物样品的方法和装置，该处理包括预处理步骤 自适应处理控制系统的控制。 进一步提供的是一种抗原回收方法，该方法包括在加热处理罐内自动染色装置的至少一个生物样品与至少一种用于抗原回收的组合物接触，所述组合物用于抗原回收，包括至少一种螯合剂，至少一种洗涤剂和 至少50体积％的至少一种促进抗原回收的液体。

公开(公告)号：US20120330564A1

公开(公告)日：2012-12-27

申请号：US13605228

申请日：2012-09-06

申请人： Loren L. BLAND ,  Marc E. KEY ,  Lars WINTHER ,  David A. STANFORTH ,  Martin N. LINDBERG

发明人： Loren L. BLAND ,  Marc E. KEY ,  Lars WINTHER ,  David A. STANFORTH ,  Martin N. LINDBERG

IPC分类号： G06F19/00

CPC分类号： G01N1/30 ,  B01L3/545 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0822 ,  G01N1/312 ,  G01N35/00732 ,  G01N2035/00782 ,  Y10T436/255

摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.

摘要翻译： 公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。 还公开了一种装置，包括：非易失性存储器; 所述装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。 还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

公开(公告)号：US6161294A

公开(公告)日：2000-12-19

申请号：US46318

申请日：1998-03-23

申请人： Loren L. Bland ,  Walter Naumann ,  Gilbert Short ,  Robert G. Rizos ,  Timothy Cunningham

发明人： Loren L. Bland ,  Walter Naumann ,  Gilbert Short ,  Robert G. Rizos ,  Timothy Cunningham

IPC分类号： G01B7/008 ,  G01B7/012 ,  G01B7/34 ,  G01B3/14 ,  G01B1/00

CPC分类号： G01B7/008 ,  G01B7/012 ,  G01B7/34

摘要： An apparatus and method for surface profile measurements of large samples. The sample is held by a stationary chuck, while a four-axis (X, Y, Z and theta axis) positioning assembly manipulates and positions an overhead scan assembly and measurement stylus to perform the profilometry. To observe the sample surface in the vicinity of the measurement stylus, an illumination and imaging capability is also provided. Backlash and error are reduced in the Z axis assembly through use of cams and cam followers, and in the scan assembly through use of multiple tensioned wires, with low-friction sliding elements. The apparatus reduces vibration and supports heavy (up to 400 kg) samples while allowing accurate profile measurements.

摘要翻译： 用于大样品表面轮廓测量的装置和方法。 样品由固定的卡盘保持，而四轴（X，Y，Z和θ轴）定位组件操纵和定位架空扫描组件和测量笔，以执行轮廓测量。 为了观察测量笔附近的样品表面，还提供照明和成像能力。 通过使用凸轮和凸轮从动件，在Z轴组件中减少了间隙和误差，并且通过使用具有低摩擦滑动元件的多个张紧线在扫描组件中减少了间隙和误差。 该设备减少振动并支持重（最多400 kg）样品，同时允许精确的轮廓测量。