公开(公告)号：US20180345260A1

公开(公告)日：2018-12-06

申请号：US15778376

申请日：2016-11-21

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Akihito NONOYAMA ,  Kazuki HASHIMOTO ,  Akira SAITO

IPC: B01J31/22 ,  B01J37/04 ,  C07C201/12 ,  C07C205/16 ,  C07C205/54 ,  C07C237/04

CPC classification number: B01J31/22 ,  B01J37/04 ,  B01J2231/341 ,  B01J2531/004 ,  B01J2531/12 ,  B01J2531/38 ,  C07B61/00 ,  C07C201/12 ,  C07C205/16 ,  C07C205/32 ,  C07C205/54 ,  C07C237/04 ,  C07C237/22 ,  C07F7/003

Abstract: A catalyst including: neodymium; sodium; and a ligand, which is a compound expressed by Structural Formula (1) below, wherein the neodymium and the ligand form a complex at a molar ratio of 1:2 (neodymium:ligand):

公开(公告)号：US20150375219A1

公开(公告)日：2015-12-31

申请号：US14767620

申请日：2014-02-07

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Takanori OGAWA

IPC: B01J31/22 ,  C07C201/12

CPC classification number: B01J31/22 ,  B01J21/185 ,  B01J23/10 ,  B01J31/0212 ,  B01J31/0247 ,  B01J31/0252 ,  B01J31/0274 ,  B01J31/0275 ,  B01J31/2226 ,  B01J2231/30 ,  B01J2231/342 ,  B01J2531/0275 ,  B01J2531/12 ,  B01J2531/57 ,  B01J2540/22 ,  C07B2200/07 ,  C07C201/12 ,  C07C205/02 ,  C07C237/22 ,  C07C205/26 ,  C07C205/15 ,  C07C205/31

Abstract: A catalyst, which is obtained by mixing a compound expressed by the following Structural Formula (1), a nitroalkane compound, a neodymium-containing compound, a sodium-containing compound, and a carbon structure:

Abstract translation: 通过将由以下结构式（1）表示的化合物，硝基烷烃化合物，含钕化合物，含钠化合物和碳结构混合得到的催化剂：

公开(公告)号：US20160145278A1

公开(公告)日：2016-05-26

申请号：US14900696

申请日：2013-10-08

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Liang YIN ,  Youmei BAO

IPC: C07F9/40 ,  B01J31/24 ,  C07F9/50

CPC classification number: C07F9/4062 ,  B01J31/24 ,  B01J2231/34 ,  B01J2531/16 ,  C07F9/36 ,  C07F9/4009 ,  C07F9/4015 ,  C07F9/4056 ,  C07F9/5054 ,  C07F9/65683

Abstract: A method for producing a compound represented by General Formula (1), the method including: reacting a compound represented by General Formula (3) and a compound represented by General Formula (4): where R1 and R2 each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R1 and R2 are different groups), R3 represents aromatic group which may have substituent, and R4 represents aliphatic group which may have substituent, or aromatic group which may have substituent, where R1 and R2 each represent aliphatic group which may have substituent, or aromatic group which may have substituent (with the proviso that R1 and R2 are different groups), and R3 represents aromatic group which may have substituent, where R4 represents aliphatic group which may have substituent, or aromatic group which may have substituent.

Abstract translation: 一种制备由通式（1）表示的化合物的方法，所述方法包括：使通式（3）表示的化合物与通式（4）表示的化合物反应：其中R 1和R 2各自表示可具有 取代基或可以具有取代基的芳香族基团（前提条件是R 1和R 2是不同的基团），R 3表示可以具有取代基的芳香族基团，R 4表示可以具有取代基的脂肪族基团，或者可以具有取代基的芳香族基团， R 1和R 2各自表示可以具有取代基的脂肪族基团或可以具有取代基的芳香族基团（前提条件是R 1和R 2是不同的基团），R 3表示可以具有取代基的芳香族基团，其中R 4表示可以具有取代基的脂族基团 取代基或可具有取代基的芳基。

公开(公告)号：US20170283411A1

公开(公告)日：2017-10-05

申请号：US15513635

申请日：2015-09-18

Applicant: MICROBIAL CHEMISTRY RESEARCH FOUNDATION

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI ,  Liang YIN

IPC: C07D471/04 ,  B01J31/24

CPC classification number: C07D471/04 ,  B01J31/22 ,  B01J31/2409 ,  B01J2231/50 ,  B01J2531/16 ,  C07B53/00 ,  C07B57/00 ,  C07B61/00 ,  C07B2200/07 ,  C07C269/06 ,  C07C271/22 ,  C07D213/75

Abstract: A method for producing an optically active α-trifluoromethyl-β-amino acid derivative, the method including: allowing a compound represented by the following General Formula (1) and a compound represented by the following General Formula (2) to react in the presence of a copper-optically active phosphine complex obtained from a copper compound and an optically active phosphine compound, to thereby obtain an optically active α-trifluoromethyl-β-amino acid derivative represented by the following General Formula (3):

公开(公告)号：US20150183807A1

公开(公告)日：2015-07-02

申请号：US14658297

申请日：2015-03-16

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI

IPC: C07F7/08 ,  C07D307/33 ,  C07F7/18 ,  C07D405/12 ,  C07D215/227

CPC classification number: C07F7/0812 ,  B01J31/24 ,  C07B53/00 ,  C07C323/12 ,  C07C323/16 ,  C07C381/12 ,  C07D215/227 ,  C07D301/02 ,  C07D303/22 ,  C07D307/33 ,  C07D309/30 ,  C07D405/12 ,  C07F7/12 ,  C07F7/1804 ,  C07F9/5059 ,  C07F9/65616 ,  Y02P20/55

Abstract: A compound represented by the following General Formula (1): where R1 represents a protective group for a hydroxyl group or a hydrogen atom, and R2 represents a methyl group or an ethyl group.

Abstract translation: 由以下通式（1）表示的化合物：其中R1表示羟基或氢原子的保护基，R2表示甲基或乙基。

公开(公告)号：US20140296539A1

公开(公告)日：2014-10-02

申请号：US14301562

申请日：2014-06-11

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI

IPC: C07F9/6561 ,  C07F7/12 ,  C07F9/50 ,  C07D307/33 ,  C07C323/16

CPC classification number: C07F7/0812 ,  B01J31/24 ,  C07B53/00 ,  C07C323/12 ,  C07C323/16 ,  C07C381/12 ,  C07D215/227 ,  C07D301/02 ,  C07D303/22 ,  C07D307/33 ,  C07D309/30 ,  C07D405/12 ,  C07F7/12 ,  C07F7/1804 ,  C07F9/5059 ,  C07F9/65616 ,  Y02P20/55

Abstract: A compound represented by the following General Formula (1): where R1 represents a protective group for a hydroxyl group or a hydrogen atom, and R2 represents a methyl group or an ethyl group.

Abstract translation: 由以下通式（1）表示的化合物：其中R1表示羟基或氢原子的保护基，R2表示甲基或乙基。

公开(公告)号：US20140046087A1

公开(公告)日：2014-02-13

申请号：US14017574

申请日：2013-09-04

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Kenzo YAMATSUGU

IPC: C07C229/48 ,  C07C229/34 ,  C07C229/60 ,  C07C229/30

CPC classification number: C07C229/48 ,  C07B53/00 ,  C07C229/30 ,  C07C229/34 ,  C07C229/60 ,  C07C269/06 ,  C07C271/24 ,  C07C2601/16 ,  Y02P20/55

Abstract: A compound represented by the following general formula (1), and a method for producing the compound represented by the general formula (1), the method comprising: reacting together a compound represented by the following general formula (2), a compound represented by the following general formula (3), and a compound represented by the following general formula (4): wherein R1 represents any of a protective group of a carboxyl group, and a hydrogen atom, R2 and R3 each independently represent any of a protective group of an amino group, and a hydrogen atom, and R4 represents any of a protective group of a carboxyl group, and a hydrogen atom.

Abstract translation: 由以下通式（1）表示的化合物和由通式（1）表示的化合物的制备方法，该方法包括：使由以下通式（2）表示的化合物，由 下述通式（3）表示的化合物和下述通式（4）表示的化合物：其中，R1表示羧基的保护基，氢原子，R2和R3各自独立地表示保护基 的氨基和氢原子，R 4表示羧基的保护基和氢原子中的任一个。

公开(公告)号：US20130338375A1

公开(公告)日：2013-12-19

申请号：US13971186

申请日：2013-08-20

Applicant: Microbial Chemistry Research Foundation

Inventor： Masakatsu SHIBASAKI ,  Naoya KUMAGAI

IPC: C07C327/42 ,  C07D207/337

CPC classification number: C07C327/42 ,  C07B53/00 ,  C07D207/337 ,  C07D207/34 ,  C07F7/1804 ,  Y02P20/55

Abstract: A thioamide compound represented by the following general formula (1); wherein, in the general formula (1), R1 represents one of —OR11 and —NR12R13; R2 and R3 each independently represent one of a protecting group of an amide group and a hydrogen atom; the R11 represents one of a protecting group of a hydroxyl group and a hydrogen atom; and the R12 and R13 each independently represent one of a protecting group of an amino group and a hydrogen atom, where the R12 and R13 may together form a protecting group having a cyclic structure.

Abstract translation: 由以下通式（1）表示的硫代酰胺化合物; 其中，在通式（1）中，R 1表示-OR 11和-NR 12 R 13之一; R2和R3各自独立地表示酰胺基和氢原子的保护基之一; R 11表示羟基和氢原子的保护基之一; R 12和R 13各自独立地表示氨基和氢原子的保护基中的一个，其中R 12和R 13可以一起形成具有环状结构的保护基。