利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

15 条记录 (耗时 0.022 秒)

    MEDICAL DEVICES FOR DELIVERING FLUIDS DURING SURGERY AND METHODS FOR THEIR USE
    4.
    发明申请
    MEDICAL DEVICES FOR DELIVERING FLUIDS DURING SURGERY AND METHODS FOR THEIR USE 审中-公开

    公开(公告)号：US20170143321A1

    公开(公告)日：2017-05-25

    申请号：US15422114

    申请日：2017-02-01

    申请人： Mallinckrodt Pharma IP Trading D.A.C.

    发明人： William Allan Alexander ,  Paul D. Bishop ,  Steve R. Carter ,  Alisa M. Littau

    IPC分类号： A61B17/00

    摘要： Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion. There are also provided methods of use for the attached tip and pledget, including debridement, tissue translocation, delivery of fluid substances, absorption of fluid substances and combinations thereof. In a particular embodiment, the applicator places a thrombin solution into the attached pledget for delivery of an active hemostatic agent to a tissue site.

    POWDER FORMULATION
    5.
    发明申请
    POWDER FORMULATION 审中-公开

    公开(公告)号：US20190269764A1

    公开(公告)日：2019-09-05

    申请号：US16408678

    申请日：2019-05-10

    申请人： Mallinckrodt Pharma IP Trading D.A.C.

    发明人： Laurens Adrianus Hendricus van Pinxteren ,  Glen Martyn ,  Nicola Kim Whitfield

    IPC分类号： A61K38/48 ,  A61K9/50 ,  A61K9/00 ,  A61K9/16 ,  A61L26/00 ,  C12N9/74 ,  A61K9/14 ,  A61K38/36 ,  C07K14/75

    摘要： The invention relates to sterile powder compositions suitable for medical use comprising thrombin and fibrinogen, and to methods for producing the same, wherein the thrombin powder is produced from a liquid feedstock, wherein the feedstock comprises a solution or a suspension of thrombin, preferably a solution, wherein the powder is produced by removal of liquid by a process selected from aseptic spray drying or aseptic fluid bed drying, and wherein the powder resulting from removal of liquid from the feedstock exhibits at least 80% of the thrombin potency or activity of the liquid feedstock, and wherein the fibrinogen powder is produced by removal of liquid from a feedstock, wherein the feedstock comprises a solution or a suspension of fibrinogen, preferably a solution, by aseptic spray drying or aseptic fluid bed drying, and wherein said composition is packaged as a sterile final pharmaceutical product for medical use.

    BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME
    7.
    发明申请
    BIOCOMPATIBLE PHASE INVERTIBLE PROTEINACEOUS COMPOSITIONS AND METHODS FOR MAKING AND USING THE SAME 审中-公开
    生物相容性反相蛋白质组合物及其制备和使用方法

    公开(公告)号：US20160346425A1

    公开(公告)日：2016-12-01

    申请号：US15233297

    申请日：2016-08-10

    申请人： Mallinckrodt Pharma IP Trading D.A.C.

    发明人： Ian J. Handley ,  Joanna Wong

    IPC分类号： A61L24/04 ,  C08J3/18 ,  C08J3/24 ,  C08L89/00 ,  A61L24/00 ,  C08J3/075

    CPC分类号： A61L24/043 ,  A61L24/0031 ,  C08J3/075 ,  C08J3/18 ,  C08J3/24 ,  C08J2389/00 ,  C08J2405/08 ,  C08J2479/02 ,  C08K5/0025 ,  C08K5/07 ,  C08L5/08 ,  C08L79/02 ,  C08L89/00 ,  C08L2203/02 ,  C08L2205/03 ,  C08L2205/05

    摘要： Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.

    摘要翻译： 提供生物相容相可逆蛋白质组合物及其制备和使用方法。 通过组合交联剂和蛋白质底物制备目标相可逆组合物。 蛋白质底物包括一种或多种蛋白质和多胺，其中多胺和蛋白质底物以协同增粘的量存在，并且还可以包括以下中的一种或多种：碳水化合物，增粘剂，增塑剂或其它改性剂 。 在某些实施方案中，交联剂是经热处理的二醛，例如经热处理的戊二醛。 还提供了用于制备主题组合物的试剂盒。 主题组合物，试剂盒和系统可用于各种不同的应用。