公开(公告)号：US10669350B2

公开(公告)日：2020-06-02

申请号：US15543215

申请日：2016-02-01

申请人： Georg Bauer ,  Manfred Motz

发明人： Georg Bauer ,  Manfred Motz

IPC分类号： C07K16/40 ,  C07K16/30 ,  A61K31/337 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

摘要： The invention relates to single domain VHH fragments which specifically bind to and inhibit superoxide dismutase and/or bind to and inhibit catalase and/or bind to and inhibit superoxide dismutase and catalase, in particular for the use in the therapy of tumor diseases.

公开(公告)号：US20180002445A1

公开(公告)日：2018-01-04

申请号：US15543215

申请日：2016-02-01

申请人： Georg BAUER ,  Manfred MOTZ

发明人： Georg BAUER ,  Manfred MOTZ

IPC分类号： C07K16/40 ,  A61K31/337 ,  A61K39/395 ,  A61K45/06 ,  A61K39/00

摘要： The invention relates to single domain VHH fragments which specifically bind to and inhibit superoxide dismutase and/or bind to and inhibit catalase and/or bind to and inhibit superoxide dismutase and catalase, in particular for the use in the therapy of tumor diseases.

公开(公告)号：US20090098528A1

公开(公告)日：2009-04-16

申请号：US11974030

申请日：2007-10-11

申请人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutscheck

发明人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutscheck

IPC分类号： C12Q1/70

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2770/24222 ,  G01N33/56983 ,  G01N33/5767 ,  Y10S436/82

摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

摘要翻译： 本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽，以及该多肽作为抗原的用途。

公开(公告)号：US20060057563A1

公开(公告)日：2006-03-16

申请号：US11192070

申请日：2005-07-29

申请人： Manfred Motz ,  Georg Bauer ,  Erwin Soutschek

发明人： Manfred Motz ,  Georg Bauer ,  Erwin Soutschek

IPC分类号： C12Q1/70 ,  C07H21/04 ,  C07K14/05

CPC分类号： G01N33/56994

摘要： In the area of virus diagnosis, in particular Epstein-Barr virus (EBV) diagnosis, methods for the detection of EBV and agents suitable for this purpose are provided, including peptides which are derived from p18-VCA and permit discrimination between acute and past EBV infection.

公开(公告)号：US06183755B2

公开(公告)日：2001-02-06

申请号：US09196293

申请日：1998-11-19

申请人： Manfred Motz ,  Erwin Soutscheck ,  Renate Fuchs ,  Bettina Wilske ,  Vera Preac-Mursic

发明人： Manfred Motz ,  Erwin Soutscheck ,  Renate Fuchs ,  Bettina Wilske ,  Vera Preac-Mursic

IPC分类号： A61K3902

CPC分类号： C07K16/1207 ,  A61K38/00 ,  A61K39/00 ,  C07K14/20 ,  G01N33/56911 ,  Y02A50/401 ,  Y02A50/57 ,  Y10S436/804 ,  Y10S530/825

摘要： Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B. burgdorferi gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The Borrelia burgdorferi-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

摘要翻译： 通过遗传操作在微生物中制备了来自博氏疏螺旋体的各种免疫活性蛋白质。 为此，使用合适的筛选方法从布氏疏螺旋体基因库中选择特异性DNA序列，或者通过使用选择的杂交探针的DNA扩增直接制备，并置于诱导型启动子的控制下，例如， lac启动子。 由于对表达的抗原的有效纯化方法的描述，可以以合适的方式提供蛋白质是可能的。 这些蛋白质可用于制备特异性敏感的诊断测定试剂盒。 免疫活性蛋白质的特异性组合使得精确的诊断成为可能。 此外，已经产生了单克隆抗体，并且用作用于在测试样品中或培养后直接检测病原体的试剂。 疏螺旋体异常特异性DNA序列可用于直接检测患者样品中的病原体（例如通过PCR反应）。

公开(公告)号：US6136527A

公开(公告)日：2000-10-24

申请号：US78271

申请日：1993-10-15

申请人： Klaus Fuchs ,  Manfred Motz ,  Michael Roggendorf ,  Erwin Soutschek

发明人： Klaus Fuchs ,  Manfred Motz ,  Michael Roggendorf ,  Erwin Soutschek

IPC分类号： A61K39/29 ,  A61K39/00 ,  A61P31/12 ,  C07H21/04 ,  C07K14/00 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K14/705 ,  C07K19/00 ,  C12N1/21 ,  C12N15/09 ,  C12N15/51 ,  C12P21/02 ,  C12Q1/68 ,  C12R1/19 ,  G01N33/53 ,  G01N33/576

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/24222

摘要： The cloning and sequencing of different polypeptides from the genome of a hepatitis C virus is disclosed. The polypeptides are prepared as non-fusion proteins in good yield. The polypeptide originating from the structure protein (core) is soluble under physiological conditions. Since the polypeptides have no foreign protein portions, they are preferably used in test kits and as vaccine.

摘要翻译： PCT No.PCT / DE91 / 01020 Sec。 371日期：1993年10月15日 102（e）日期1993年10月15日PCT 1991年12月20日PCT PCT。 出版物WO92 / 11370 日期1992年7月9日公开了来自丙型肝炎病毒基因组的不同多肽的克隆和测序。 多肽以良好的产率制备为非融合蛋白。 来自结构蛋白（核心）的多肽在生理条件下是可溶的。 由于多肽不含外来蛋白质部分，因此优选用于测试试剂盒和疫苗中。

公开(公告)号：US07083792B2

公开(公告)日：2006-08-01

申请号：US10762665

申请日：2004-01-22

申请人： Renate Fuchs ,  Bettina Wilske ,  Vera Preac-Mursic ,  Manfred Motz ,  Erwin Soutscheck

发明人： Renate Fuchs ,  Bettina Wilske ,  Vera Preac-Mursic ,  Manfred Motz ,  Erwin Soutscheck

IPC分类号： A61K39/00 ,  A61K39/02 ,  C07K1/00 ,  C07K14/00

CPC分类号： C07K16/1207 ,  A61K38/00 ,  A61K39/00 ,  C07K14/20 ,  G01N33/56911 ,  Y02A50/401 ,  Y02A50/57 ,  Y10S436/804 ,  Y10S530/825

摘要： Various immunologically active proteins from Borrelia burgdorferi have been prepared by genetic manipulation in microorganisms. To do this, the specific DNA sequences were selected from a B. burgdorferi gene bank using suitable screening methods, or were prepared directly by DNA amplification using selected hybridization probes, and were placed under the control of inducible promoters such as, for example, the lac promoter. It has been possible, owing to description of efficient purification methods for the expressed antigens, to provide the proteins in a suitable way. These proteins can be used to produce specific and sensitive diagnostic assay kits. The specific combination of the immunologically active proteins makes precise diagnosis possible. Furthermore, monoclonal antibodies have been generated and are used as reagents for detecting pathogens directly in test samples or after cultivation. The Borrelia burgdorferi-specific DNA sequences can be employed for direct detection of the pathogen in patients' samples (for example by means of the PCR reaction).

公开(公告)号：US20050095584A1

公开(公告)日：2005-05-05

申请号：US10802891

申请日：2004-03-17

申请人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

发明人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K39/29 ,  A61P1/16 ,  A61P31/12 ,  A61P31/14 ,  C07H21/04 ,  C07K14/02 ,  C07K14/10 ,  C07K14/18 ,  C07K16/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12N15/40 ,  C12N15/51 ,  C12P21/02 ,  C12P21/04 ,  C12R1/19 ,  G01N33/532 ,  G01N33/537 ,  G01N33/569 ,  G01N33/576 ,  G01N33/68 ,  C12Q1/70 ,  C12N15/86 ,  G01N33/48 ,  G01N33/50 ,  G06F19/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2770/24222 ,  G01N33/56983 ,  G01N33/5767 ,  Y10S436/82

摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

摘要翻译： 本发明涉及由免疫学试验中由丙型肝炎病毒的氨基酸1207±10至1488±10和小于20个外来氨基酸组成的多肽和该多肽作为抗原的用途。

公开(公告)号：US06306579B1

公开(公告)日：2001-10-23

申请号：US08892704

申请日：1997-07-15

申请人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

发明人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

IPC分类号： C12Q170

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2770/24222 ,  G01N33/56983 ,  G01N33/5767 ,  Y10S436/82

摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.

摘要翻译： 本发明涉及一种多肽，其由丙型肝炎病毒的氨基酸1207 10至1488 10和少于20个外来氨基酸组成，并且在免疫测试中使用该多肽作为抗原

公开(公告)号：US06270960B1

公开(公告)日：2001-08-07

申请号：US09592197

申请日：2000-06-12

申请人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

发明人： Christoph Seidel ,  Ursula-Henrike Wienhues ,  Urban Schmitt ,  Manfred Motz ,  Michael Wiedmann ,  Barbara Upmeier ,  Erwin Soutschek

IPC分类号： C12Q170

CPC分类号： C07K14/005 ,  A61K38/00 ,  C12N2770/24222 ,  G01N33/56983 ,  G01N33/5767 ,  Y10S436/82

摘要： The present invention concerns a polypeptide which is composed of the amino acids 1207±10 to 1488±10 of a hepatitis C virus and of less than 20 foreign amino acids and the use of this polypeptide as an antigen in an immunological test.