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    Intraluminal stent assembly and method of deploying the same
    3.
    发明授权
    Intraluminal stent assembly and method of deploying the same 有权
    管腔内支架组装及其部署方法

    公开(公告)号：US07651525B2

    公开(公告)日：2010-01-26

    申请号：US10911931

    申请日：2004-08-05

    申请人： Mark J. Dolan

    发明人： Mark J. Dolan

    IPC分类号： A61F2/06

    CPC分类号： A61F2/958

    摘要： Intraluminal stent assemblies and methods of deploying the same. The assemblies include a catheter including at least one lumen formed therein. At least one inflatable member is disposed on the catheter and in communication with the lumen. The inflatable member includes at least one distal projection and/or at least one retention material. A stent is expandable from a compressed configuration to an expanded configuration. The stent is disposed on the inflatable member in the compressed configuration. A sheath is slidably positioned over the stent wherein the stent expands to the expanded configuration upon retraction of the sheath. The inflatable member is inflated with a fluid flowing through the lumen. The at least one distal projection and/or at least one retention material retain the stent in position on the inflatable member while the stent is being deployed.

    摘要翻译： 管腔内支架组件及其部署方法。 组件包括其中形成有至少一个内腔的导管。 至少一个可充气构件设置在导管上并与内腔连通。 可膨胀构件包括至少一个远端突出部和/或至少一个保持材料。 支架可从压缩构型扩展到扩张构型。 支架以压缩构型设置在可膨胀构件上。 护套可滑动地定位在支架上，其中支架在收缩护套时扩张到扩张构型。 充气构件用流过管腔的流体充气。 当支架被展开时，至少一个远端突出部和/或至少一个保持材料将支架保持在可充气构件上的适当位置。

    Bioactive Agent Delivery Using Liposomes in Conjunction With Stent Deployment
    6.
    发明申请
    Bioactive Agent Delivery Using Liposomes in Conjunction With Stent Deployment 审中-公开
    使用脂质体与支架部署相结合的生物活性剂递送

    公开(公告)号：US20100129414A1

    公开(公告)日：2010-05-27

    申请号：US12276995

    申请日：2008-11-24

    申请人： Mark J. Dolan ,  Dwayne S. Yamasaki

    发明人： Mark J. Dolan ,  Dwayne S. Yamasaki

    IPC分类号： A61F2/04 ,  A61K9/127 ,  A61K39/395 ,  A61K31/7088 ,  A61K31/436 ,  A61K35/00

    CPC分类号： C07K16/44 ,  A61K9/127 ,  A61K31/436 ,  A61K31/7088 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/256 ,  A61L2300/626

    摘要： Described herein are methods for treating aneurysms, vascular occlusions, and vascular lesions. The methods comprise the use of an implantable medical device which includes a bioactive agent substrate associated with its surface. Liposomes are used to encapsulate the bioactive agent and are delivered either systemically or locally to the bloodstream. A means for liberating the bioactive agents from the liposomes is used once an appropriate location is chosen and the liposomes have distributed themselves through the vasculature. Once liberated, the bioactive agent can be sequestered by the bioactive agent substrate associated with the implantable medical device, and slowly released to impart a therapeutic effect on the surrounding tissues.

    摘要翻译： 本文描述了治疗动脉瘤，血管闭塞和血管病变的方法。 所述方法包括使用包括与其表面相关联的生物活性剂底物的可植入医疗装置。 脂质体用于包封生物活性剂，并且全身或局部地递送至血液。 一旦选择适当的位置并且脂质体已经分布在血管系统中，则使用从脂质体中释放生物活性剂的手段。 一旦释放，生物活性剂可以通过与可植入医疗装置相关联的生物活性剂底物螯合，并缓慢释放以赋予周围组织治疗效果。