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    Hyperspectral imaging calibration device
    4.
    发明授权
    Hyperspectral imaging calibration device 有权
    高光谱成像校准装置

    公开(公告)号：US06810279B2

    公开(公告)日：2004-10-26

    申请号：US09986105

    申请日：2001-11-07

    Applicant: James R. Mansfield ,  Jenny E. Freeman ,  Michael E. Leventon ,  Michael J. Hopmeier ,  Derek Brand

    Inventor： James R. Mansfield ,  Jenny E. Freeman ,  Michael E. Leventon ,  Michael J. Hopmeier ,  Derek Brand

    IPC: A61B505

    CPC classification number: G01J3/2823 ,  G01J3/28 ,  G01J2003/2866

    Abstract: Hyperspectral imaging calibration devices and methods for their use are described that generate images of three dimensional samples. A calibration device may assume the shape of a desired imaging sample such as a body part and may be sterile prior to placement. The calibration device may include openings or may be modified to expose a region of the sample during use. Spectral images, typically obtained at multiple wavelengths, are made of the calibration device. Algorithms are provided that utilize the spectral images of the calibration device to determine the effects of lighting conditions and sample shape on the sample image to form a calibrated image. Calibrated images produced by these devices and methods can provide information, including clinical data that are less sensitive to lighting and sample shape compared to alternative technologies.

    Abstract translation: 描述了用于生成三维样本图像的高光谱成像校准装置及其使用方法。 校准装置可以呈现期望的成像样品的形状，例如身体部位，并且可以在放置之前是无菌的。 校准装置可以包括开口，或者可以被修改以在使用期间暴露样品的区域。 通常在多个波长下获得的光谱图像由校准装置制成。 提供了利用校准装置的光谱图像来确定照明条件和样品形状对样品图像的影响以形成校准图像的算法。 通过这些设备和方法生成的校准图像可以提供信息，包括与替代技术相比对照明和样品形状不太敏感的临床数据。

    Non-Invasive Tissue Glucose-Level Monitoring
    6.
    发明申请
    Non-Invasive Tissue Glucose-Level Monitoring 审中-公开
    非侵入性组织葡萄糖水平监测

    公开(公告)号：US20120053429A1

    公开(公告)日：2012-03-01

    申请号：US13037348

    申请日：2011-02-28

    Applicant: Pierre Trepagnier ,  Jenny Freeman ,  James Mansfield ,  Derek Brand ,  Michael J. Hopmeier ,  Nikiforos Kollias

    Inventor： Pierre Trepagnier ,  Jenny Freeman ,  James Mansfield ,  Derek Brand ,  Michael J. Hopmeier ,  Nikiforos Kollias

    IPC: A61B5/1455

    CPC classification number: A61B5/1455 ,  A61B5/0071 ,  A61B5/14532

    Abstract: A non-invasive analyte monitoring instrument has a radiation source for directing excitation radiation to a portion of a surface of a tissue wherein said source emits radiation at a plurality of different wavelengths that excites a target in said tissue causing said target to emit radiation such that the radiation received at the surface provides an analyte level indication of the patient. A radiation detector positioned to receive radiation emitted from the surface wherein said radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation. A processing circuit operatively connected to the radiation detector that translates radiation received at the surface to a measurable signal to obtain said analyte level indication, wherein said radiation source comprises a visible light source or an ultraviolet light source and wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD, a flavoprotein, and any combination thereof.

    Abstract translation: 非侵入性分析物监测仪器具有用于将激发辐射引导到组织表面的一部分的辐射源，其中所述源以多个不同波长发射辐射，激发所述组织中的靶，使所述靶发射辐射，使得 在表面处接收的辐射提供了患者的分析物水平指示。 放射线检测器，定位成接收从表面发射的辐射，其中所述辐射检测器被配置成以激发辐射同步扫描由靶发射的辐射。 一种可操作地连接到辐射检测器的处理电路，其将在表面处接收的辐射转换成可测量信号，以获得所述分析物水平指示，其中所述辐射源包括可见光源或紫外光源，并且其中所述靶选自组 由结构基质组织成分，细胞组织成分，线粒体组织成分，胶原交联，胃蛋白酶消化型胶原交联，胶原酶消化型胶原交联，非胃蛋白酶消化型胶原交联，弹性蛋白 交联，含色氨酸的蛋白质，NADH，FAD，黄素蛋白及其任何组合。

    System and method for simulated device training
    8.
    发明授权
    System and method for simulated device training 有权
    模拟设备训练的系统和方法

    公开(公告)号：US06599127B1

    公开(公告)日：2003-07-29

    申请号：US09481682

    申请日：2000-01-12

    Applicant: Michael J. Hopmeier ,  John C. Taffe

    Inventor： Michael J. Hopmeier ,  John C. Taffe

    IPC: G09B1100

    CPC classification number: F41A33/04 ,  F41A33/00 ,  F41H11/12 ,  F42B8/12 ,  F42B33/06 ,  G09B9/003

    Abstract: A system and method for simulated device training is disclosed. According to one embodiment of the present invention, the system includes a simulated device having at least one sensor. A controller is provided, and interfaces with the at least one sensor and with a feedback device. In another embodiment, the method includes the steps of (1) providing a simulated device having at least one sensor; (2) monitoring the simulated device for the presence of a stimulus; and (3) providing feedback in response to a predetermined stimulus.

    Abstract translation: 公开了一种用于模拟设备训练的系统和方法。 根据本发明的一个实施例，该系统包括具有至少一个传感器的模拟装置。 提供控制器，并与至少一个传感器和反馈装置相连接。 在另一个实施例中，该方法包括以下步骤：（1）提供具有至少一个传感器的模拟装置; （2）监测模拟装置是否存在刺激; 和（3）响应于预定的刺激提供反馈。

    Device and method of balloon endoscopy
    9.
    发明授权
    Device and method of balloon endoscopy 有权

    公开(公告)号：US10646109B1

    公开(公告)日：2020-05-12

    申请号：US11184082

    申请日：2005-07-19

    Applicant: Jenny E. Freeman ,  Derek Brand ,  Michael J. Hopmeier

    Inventor： Jenny E. Freeman ,  Derek Brand ,  Michael J. Hopmeier

    IPC: A61B1/00 ,  A61B1/06 ,  A61B1/04

    Abstract: A medical device is provided that comprises: (i) an expandable capsule that can be swallowed by a patient and positioned to a target tissue within the patient, (ii) an endoscope attached to the capsule for obtaining an image of the target tissue at a wavelength of interest, and (iii) a thin tube or wire configured to position the device to the target tissue. The thin tube or wire is expandable. The capsule can be swallowed in stages to position the device at different locations within the gastrointestinal tract. The thin tube or wire can deliver electromagnetic radiation for visualization of the target tissue. The thin tube or wire can provide a passage of a biopsy device for access to the target tissue. In some instances, the capsule comprises a band which rotates around the capsule to clean the capsule. In some instances, the capsule collects multispectral or hyperspectral information.

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