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公开(公告)号：US20180141004A1
公开(公告)日：2018-05-24
申请号：US15876891
申请日：2018-01-22
Applicant: Natrix Separations, Inc.
Inventor： Dharmeshkumar M. Kanani , Navneet Sidhu , Bradley A. Kachuik , Charles H. Honeyman
IPC: B01D63/10
CPC classification number: B01D63/10 , B01D2311/2626 , B01D2313/12 , B01D2313/14 , B01D2313/40 , B01D2313/90
Abstract: Described are wrapped fluid treatment elements, comprising: a composite material; an interleaf; and an inner core; wherein the composite material and the interleaf form layers wrapped around the inner core. The composite material and interleaf may be wrapped in a spiral configuration around the inner core. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device or element, thereby adsorbing or absorbing the substance to the composite material contained therein.
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2.发明申请公开(公告)号：US20200047175A1
公开(公告)日：2020-02-13
申请号：US16516500
申请日：2019-07-19
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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3.发明申请公开(公告)号：US20180297023A1
公开(公告)日：2018-10-18
申请号：US15947078
申请日：2018-04-06
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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4.发明申请Chromatography Membranes Formed by Thiol-Ene or Thiol-Yne Click Polymerization Reactions 有权由Thiol-Ene或Thiol-Yne点击聚合反应形成的色谱膜公开(公告)号：US20160243538A1
公开(公告)日：2016-08-25
申请号：US15049625
申请日：2016-02-22
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
Abstract translation: 公开了复合材料及其制备方法。 复合材料包括支撑构件和交联凝胶，其中交联凝胶是由硫醇烯或硫醇 - 聚合和交联合成的聚合物。 交联凝胶可以通过硫醇 - 烯或硫醇 - 接枝反应进行官能化，或者与聚合反应同时进行，或者在两步法中作为第二步。 复合材料可用作色谱分离介质。
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公开(公告)号：US10195567B2
公开(公告)日：2019-02-05
申请号：US15876891
申请日：2018-01-22
Applicant: Natrix Separations, Inc.
Inventor： Dharmeshkumar M. Kanani , Navneet Sidhu , Bradley A. Kachuik , Charles H. Honeyman
Abstract: Described are wrapped fluid treatment elements, comprising: a composite material; an interleaf; and an inner core; wherein the composite material and the interleaf form layers wrapped around the inner core. The composite material and interleaf may be wrapped in a spiral configuration around the inner core. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device or element, thereby adsorbing or absorbing the substance to the composite material contained therein.
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Patent Agency Ranking
公开(公告)号：US20180353939A1
公开(公告)日：2018-12-13
申请号：US16055786
申请日：2018-08-06
Applicant: Natrix Separations Inc.
Inventor： Elena N. Komkova , Charles H. Honeyman
IPC: B01J20/32 , B01J20/291 , B01J43/00 , B01D15/36 , C07K1/16 , B01J20/286 , B01D15/32 , B01J47/12 , B01J41/20 , B01J39/26 , B01D15/38 , B01J20/28
CPC classification number: B01J20/3285 , B01D15/327 , B01D15/36 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/28033 , B01J20/286 , B01J20/291 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/12 , C07K1/165
Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
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公开(公告)号：US20190201851A1
公开(公告)日：2019-07-04
申请号：US16224548
申请日：2018-12-18
Applicant: Natrix Separations Inc.
Inventor： Dharmeshkumar M. Kanani , Navneet Sidhu , Bradley A. Kachuik , Charles H. Honeyman
IPC: B01D63/10
CPC classification number: B01D63/10 , B01D2311/2626 , B01D2313/12 , B01D2313/14 , B01D2313/40 , B01D2313/90
Abstract: Described are wrapped fluid treatment elements, comprising: a composite material; an interleaf; and an inner core; wherein the composite material and the interleaf form layers wrapped around the inner core. The composite material and interleaf may be wrapped in a spiral configuration around the inner core. The invention also relates to a method of separating a substance from a fluid, comprising the step of placing the fluid in contact with an inventive device or element, thereby adsorbing or absorbing the substance to the composite material contained therein.
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公开(公告)号：US09962691B2
公开(公告)日：2018-05-08
申请号：US15049625
申请日：2016-02-22
Applicant: Natrix Separations Inc.
Inventor： Amro Ragheb , Gary Skarja
CPC classification number: B01J39/19 , B01D15/34 , B01J20/267 , B01J20/28033 , B01J20/291 , B01J39/26 , C07K1/18 , C07K1/22
Abstract: Disclosed are composite materials and methods of making them. The composite materials comprise a support member and a cross-linked gel, wherein the cross-linked gel is a polymer synthesized by thiol-ene or thiol-yne polymerization and cross-linking. The cross-linked gel may be functionalized by a thiol-ene or thiol-yne grafting reaction, either simultaneously with the polymerization or as the second step in a two-step procedure. The composite materials are useful as chromatographic separation media.
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公开(公告)号：US20140238935A1
公开(公告)日：2014-08-28
申请号：US14190650
申请日：2014-02-26
Applicant: Natrix Separations Inc.
Inventor： Elena N. Komkova , Charles H. Honeyman
IPC: B01J20/32 , B01J43/00 , B01J20/291 , B01D15/36
CPC classification number: B01J20/3285 , B01D15/327 , B01D15/36 , B01D15/362 , B01D15/363 , B01D15/3847 , B01J20/28033 , B01J20/286 , B01J20/291 , B01J39/26 , B01J41/20 , B01J43/00 , B01J47/12 , C07K1/165
Abstract: Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel. The multi-functional cross-linked gel possesses at least two of the following functions or characteristics: cationic, anionic, hydrophobic, hydrophilic, thiophilic, hydrogen bond donating, hydrogen bond accepting, pi-pi bond donating, pi-pi bond accepting, or metal chelating. The composite materials may be used in the separation or purification of a biological molecule or biological ion.
Abstract translation: 描述了将其用于混合模式层析的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 和多功能交联凝胶。 多功能交联凝胶具有以下功能或特性中的至少两个：阳离子，阴离子，疏水，亲水，亲硫化，给氢氢键，接受氢键，π-π键，π-π键接受或 金属螯合。 复合材料可用于分离或纯化生物分子或生物离子。
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10.发明申请Chromatographic Media for Storage and Delivery of Therapeutic Biologics and Small Molecules 审中-公开用于储存和递送治疗性生物制剂和小分子的色谱介质公开(公告)号：US20130189322A1
公开(公告)日：2013-07-25
申请号：US13744583
申请日：2013-01-18
Applicant: Natrix Separations Inc.
Inventor： Charles H. Honeyman , John A. Chickosky , Molly S. McGlaughlin , Amro Ragheb
IPC: A61K47/48
CPC classification number: A61K9/7007 , G01N33/544
Abstract: Described are composite materials and methods of making and using them for the storage and delivery of unstable drugs or biologics. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; a macroporous cross-linked gel, comprising a plurality of macropores; a therapeutic agent; and a stabilizing agent.
Abstract translation: 描述了制备和使用它们用于储存和递送不稳定药物或生物制剂的复合材料和方法。 在某些实施例中，复合材料包括支撑构件，其包括延伸穿过支撑构件的多个孔; 大孔交联凝胶，其包含多个大孔; 治疗剂; 和稳定剂。
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