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    Sigma ligands for neuronal regeneration and functional recovery
    1.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 审中-公开
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20110152284A1

    公开(公告)日：2011-06-23

    申请号：US12656182

    申请日：2010-01-20

    申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

    发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

    IPC分类号： A61K31/495 ,  A61K31/438 ,  A61P25/16 ,  A61P25/28

    CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferable AGY-94806, or salts or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, Huntington's disease, or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独或与治​​疗或预防神经变性疾病如由缺血性卒中，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，亨廷顿病或帕金森病引起的疾病的药物组合递送。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用会影响功能恢复。

    Sigma ligands for neuronal regeneration and functional recovery
    3.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 审中-公开
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20060052386A1

    公开(公告)日：2006-03-09

    申请号：US11264957

    申请日：2005-11-01

    申请人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

    发明人： Tadeusz Wieloch ,  Donna Oksenberg ,  Roman Urfer

    IPC分类号： A61K31/495

    CPC分类号： A61K31/495 ,  A61K9/2018 ,  A61K31/485

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptor, wherein the ligand is preferably AGY-94806, or salts, or solvates thereof. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 所述方法和组合物利用了σ受体的配体，其中配体优选为AGY-94806，或其盐或溶剂化物。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

    Sigma ligands for neuronal regeneration and functional recovery
    6.
    发明申请
    Sigma ligands for neuronal regeneration and functional recovery 审中-公开
    Sigma配体用于神经元再生和功能恢复

    公开(公告)号：US20050020483A1

    公开(公告)日：2005-01-27

    申请号：US10868048

    申请日：2004-06-14

    申请人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

    发明人： Donna Oksenberg ,  Mattias Rickhag ,  Mehrdad Shamloo ,  Karoly Nikolich ,  Roman Urfer ,  Tadeusz Wieloch

    IPC分类号： A61K31/00 ,  A61K31/195 ,  A61K31/438 ,  A61K31/473 ,  A61K31/485 ,  A61K31/495 ,  A61K38/17 ,  C07D295/096 ,  G06F21/00 ,  H04L29/06

    CPC分类号： C07D295/096 ,  A61K31/00 ,  A61K31/438 ,  A61K31/495

    摘要： The invention discloses methods and compositions useful for facilitating neuronal regeneration and functional recovery in neurodegenerative diseases. The methods and compositions utilize ligands for the sigma receptors. These molecules can be delivered alone or in combination with agents which treat or prevent neurodegenerative diseases such as those caused by ischemic stroke, diabetic peripheral neuropathy, cancer therapy induced neuropathy, multiple sclerosis, amyotrophic lateral sclerosis, traumatic brain injury, spinal cord injury, Huntington's disease or Parkinson's disease. In other methods, the sigma receptor ligands are administered after stroke to facilitate functional recovery. The administration of the sigma receptor ligands effects faster functional recovery.

    摘要翻译： 本发明公开了用于促进神经退行性疾病中的神经元再生和功能恢复的方法和组合物。 该方法和组合物利用了σ受体的配体。 这些分子可以单独递送或与治疗或预防神经变性疾病如由缺血性卒中，糖尿病性周围神经病变，癌症治疗诱发的神经病变，多发性硬化，肌萎缩性侧索硬化，创伤性脑损伤，脊髓损伤，亨廷顿舞蹈症 疾病或帕金森病。 在其他方法中，σ受体配体在中风后施用以促进功能恢复。 σ受体配体的施用使功能恢复更快。

    Interaction of NMDA receptor with protein tyrosine phosphatase
    10.
    发明申请
    Interaction of NMDA receptor with protein tyrosine phosphatase 审中-公开
    NMDA受体与蛋白酪氨酸磷酸酶的相互作用

    公开(公告)号：US20050266509A1

    公开(公告)日：2005-12-01

    申请号：US10913631

    申请日：2004-08-06

    申请人： Jasna Jerecic ,  Roman Urfer

    发明人： Jasna Jerecic ,  Roman Urfer

    IPC分类号： C12Q1/48 ,  G01N33/53

    CPC分类号： A61K31/00 ,  C12Q1/42 ,  G01N33/9406 ,  G01N2333/70571

    摘要： The present invention relates to the identification of a binding between NMDA receptor (NMDA-R) subunits and the protein tyrosine phosphatase PTPMEG. The present invention provides methods for screening a PTP agonist or antagonist that modulates NMDA-R signaling. The present invention also provides methods and compositions for treatment of disorders mediated by abnormal NMDA-R signaling.

    摘要翻译： 本发明涉及鉴定NMDA受体（NMDA-R）亚基与蛋白酪氨酸磷酸酶PTPMEG之间的结合。 本发明提供了筛选调节NMDA-R信号传导的PTP激动剂或拮抗剂的方法。 本发明还提供了用于治疗由NMDA-R异常信号传导介导的病症的方法和组合物。