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公开(公告)号：US06953663B1
公开(公告)日：2005-10-11
申请号：US10607829
申请日：2003-06-27
CPC分类号： C07H21/04 , B01J2219/00432 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6827 , C12Q1/6874 , C40B40/06 , C40B60/14 , G06F19/20 , G06F19/22 , Y10T436/143333 , C12Q2565/501 , C12Q2525/179 , C12Q2525/204 , C12Q2525/185 , C12Q2535/131
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, e.g., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits.
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常被布置在检测块中，每个区块能够区分给定标记（例如杂合子或两个纯合子中的任一个）的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析。
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2.发明申请Capturing sequences adjacent to type-IIS restriction sites for genomic library mapping 有权捕获与基因组文库映射的类型-Ill限制位点相邻的序列公开(公告)号：US20050026212A1
公开(公告)日：2005-02-03
申请号：US10942479
申请日：2004-09-16
CPC分类号： C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/501 , C12Q2600/156 , C12Q2525/191 , C12Q2521/313 , C12Q2525/179 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143 , C12Q2525/131
摘要： The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic mapping, screening and manipulation.
摘要翻译： 本发明涉及使用II型限制性内切核酸酶对多核苷酸序列中的遗传标记进行测序和鉴定的新方法。 本文描述的方法导致“捕获”和确定与II型限制性位点相邻的特定寡核苷酸序列。 所得序列可用作用于遗传图谱，筛选和操纵的有效标记。
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公开(公告)号：US06586186B2
公开(公告)日：2003-07-01
申请号：US09939119
申请日：2001-08-24
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , B01J19/0046 , B01J2219/00529 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00695 , B01J2219/00722 , C07H21/04 , C12Q1/6837 , C40B40/06
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, e.g., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits.
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公开(公告)号：US20080044920A1
公开(公告)日：2008-02-21
申请号：US11675980
申请日：2007-02-16
CPC分类号： C07H21/04 , B01J2219/00432 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6827 , C12Q1/6874 , C40B40/06 , C40B60/14 , G06F19/20 , G06F19/22 , Y10T436/143333 , C12Q2565/501 , C12Q2525/179 , C12Q2525/204 , C12Q2525/185 , C12Q2535/131
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, i.e., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常被布置在检测块中，每个区块能够区分给定标记，即杂合子或两个纯合子中的任一个的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析
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公开(公告)号：US20050208570A1
公开(公告)日：2005-09-22
申请号：US11125588
申请日：2005-05-09
CPC分类号： C07H21/04 , C07H21/02 , C12Q1/6827 , C12Q1/6895 , C12Q2600/158
摘要： The invention provides oligonucleotides and their complements that can be used as allele-specific probes or primers for sequencing, oligonucleotide probe hybridization, and allele-specific amplification. Such oligonucleotides can be used, for example, to facilitate genetic distinction between individual plants in plant populations.
摘要翻译： 本发明提供可用作等位基因特异性探针或引物用于测序，寡核苷酸探针杂交和等位基因特异性扩增的寡核苷酸及其互补序列。 这样的寡核苷酸可用于例如促进植物种群中各植物之间的遗传区别。
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6.发明申请Capturing sequences adjacent to type-IIS restriction sites for genomic library mapping 审中-公开捕获与基因组文库映射的类型-Ill限制位点相邻的序列公开(公告)号：US20060223097A1
公开(公告)日：2006-10-05
申请号：US11390803
申请日：2006-06-12
CPC分类号： C12Q1/683 , C12Q1/6806 , C12Q1/6809 , C12Q1/6827 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/501 , C12Q2600/156 , C12Q2525/191 , C12Q2521/313 , C12Q2525/179 , C12Q2525/161 , C12Q2525/155 , C12Q2525/143 , C12Q2525/131
摘要： The present invention relates to novel methods for sequencing and mapping genetic markers in polynucleotide sequences using Type-IIs restriction endonucleases. The methods herein described result in the “capturing” and determination of specific oligonucleotide sequences located adjacent to Type-IIs restriction sites. The resulting sequences are useful as effective markers for use in genetic napping, screening and manipulation.
摘要翻译： 本发明涉及使用II型限制性内切核酸酶对多核苷酸序列中的遗传标记进行测序和鉴定的新方法。 本文描述的方法导致“捕获”和确定与II型限制性位点相邻的特异性寡核苷酸序列。 所得序列可用作用于遗传睡眠，筛选和操作的有效标记物。
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公开(公告)号：US20060110752A1
公开(公告)日：2006-05-25
申请号：US11247053
申请日：2005-10-11
IPC分类号： C12Q1/68
CPC分类号： C07H21/04 , B01J2219/00432 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6827 , C12Q1/6874 , C40B40/06 , C40B60/14 , G16B25/00 , G16B30/00 , Y10T436/143333 , C12Q2565/501 , C12Q2525/179 , C12Q2525/204 , C12Q2525/185 , C12Q2535/131
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, e g, the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常设置在检测块中，每个区段能够区分给定标记（例如杂合子或两个纯合子中的任一个）的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析
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公开(公告)号：US20120258879A1
公开(公告)日：2012-10-11
申请号：US13297072
申请日：2011-11-15
CPC分类号： C07H21/04 , B01J2219/00432 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6827 , C12Q1/6874 , C40B40/06 , C40B60/14 , G16B25/00 , G16B30/00 , Y10T436/143333 , C12Q2565/501 , C12Q2525/179 , C12Q2525/204 , C12Q2525/185 , C12Q2535/131
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, i.e., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常被布置在检测块中，每个区块能够区分给定标记，即杂合子或两个纯合子中的任一个的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析
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公开(公告)号：US20100286924A1
公开(公告)日：2010-11-11
申请号：US12692729
申请日：2010-01-25
IPC分类号： G06F19/00
CPC分类号： C07H21/04 , B01J2219/00432 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6827 , C12Q1/6874 , C40B40/06 , C40B60/14 , G06F19/20 , G06F19/22 , Y10T436/143333 , C12Q2565/501 , C12Q2525/179 , C12Q2525/204 , C12Q2525/185 , C12Q2535/131
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, i.e., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常被布置在检测块中，每个区块能够区分给定标记，即杂合子或两个纯合子中的任一个的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析
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公开(公告)号：US06300063B1
公开(公告)日：2001-10-09
申请号：US08853370
申请日：1997-05-08
IPC分类号： C12Q168
CPC分类号： C12Q1/6827 , B01J19/0046 , B01J2219/00529 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00695 , B01J2219/00722 , C07H21/04 , C12Q1/6837 , C40B40/06
摘要： The present invention generally provides a rapid efficient method for analyzing polymorphic or biallelic markers, and arrays for carrying out these analyses. In general, the methods of the present invention employ arrays of oligonucleotide probes that are complementary to target nucleic acids which correspond to the marker sequences of an individual. The probes are typically arranged in detection blocks, each block being capable of discriminating the three genotypes for a given marker, e.g., the heterozygote or either of the two homozygotes. The method allows for rapid, automatable analysis of genetic linkage to even complex polygenic traits.
摘要翻译： 本发明通常提供用于分析多态性或双重标记的快速有效的方法和用于进行这些分析的阵列。 通常，本发明的方法使用与对应于个体的标记序列的靶核酸互补的寡核苷酸探针阵列。 探针通常被布置在检测块中，每个区块能够区分给定标记（例如杂合子或两个纯合子中的任一个）的三种基因型。 该方法允许对甚至复杂的多基因性状的遗传连锁的快速，自动化分析。
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