公开(公告)号：US3927019A

公开(公告)日：1975-12-16

申请号：US26734572

申请日：1972-06-29

申请人： SYNVAR ASS

发明人： BECHER JAN ,  ULLMAN EDWIN F

IPC分类号： G01N31/22 ,  C07D233/22

CPC分类号： G01N31/221 ,  Y10T436/24

摘要： 1-Oxylimidazolinyl compounds bridged to an asymmetric center by a methylene group at the two position of the ring find use in determining acidity or basicity of a medium. One of the groups bonded to the asymmetric carbon atom is capable of gaining or losing a proton which results in a change of asymmetry about the carbon atom. Because the environment of the two protons of the methylene group is different by virtue of the asymmetry of the adjacent carbon atom, changes in asymmetry about the asymmetric carbon atom, change the electron spin resonance spectrum of the compound. The changes in the electron spin resonance spectrum can be related to the acidity or basicity of the medium.

摘要翻译： 通过环的两个位置的亚甲基桥接到不对称中心的1-氧代咪唑啉化合物可用于测定介质的酸度或碱度。 与不对称碳原子键合的基团中的一个能够获得或失去导致碳原子不对称性变化的质子。 由于亚甲基的两个质子的环境由于相邻碳原子的不对称性而不同，所以不对称碳原子的不对称性的变化改变了化合物的电子自旋共振谱。 电子自旋共振谱的变化可能与介质的酸度或碱度有关。

公开(公告)号：US3706537A

公开(公告)日：1972-12-19

申请号：US3706537D

申请日：1971-02-22

申请人： SYNVAR ASS

发明人： BECHER JAN ,  ULLMAN EDWIN F

IPC分类号： C07D213/51 ,  G01N31/22 ,  G01N21/08 ,  G01N33/16

CPC分类号： C07D213/51 ,  G01N31/221 ,  Y10T436/24

摘要： 1-(O-),2-((PYRID-2-YL)-CH(-CH3)-CH2-),3-((-)O-)-2-

IMIDAZOLINIUM

ACIDITY DETERINATIONS ARE MADE FROM VARIATIONS IN ELECTRON SPIN RESONANCE (ESR) SPECTRA WITH COMPOUNDS HAVING AN ASYMMETRIC CENTER BONDED THROUGH A METHYLENE GROUP TO AN ORGANIC FUNCTIONALITY HAVING AN UNPAIRED ELECTRON. ACCURATE DETERMINATION OF ACIDITY CAN BE MADE BY COMPARING THE SPECTRUM OF THE SAMPLE BEING MEASURED TO A STANDARD.

公开(公告)号：US3769210A

公开(公告)日：1973-10-30

申请号：US3769210D

申请日：1970-11-25

申请人： SYNVAR ASS

发明人： OSIECKI J ,  CAIS M ,  GAMBLE F

IPC分类号： C10M103/06 ,  C10M7/02 ,  C10M7/06

CPC分类号： C10M103/06 ,  C10M2201/00 ,  C10M2201/061 ,  C10M2201/062 ,  C10M2201/063 ,  C10M2201/065 ,  C10M2201/08 ,  C10M2201/081 ,  C10M2201/082 ,  C10M2201/084 ,  C10M2201/085 ,  C10M2201/087 ,  C10M2201/16 ,  C10M2201/18 ,  C10N2210/01 ,  C10N2210/02

摘要： NOVEL COMPOSITIONS OF MATTER FORMED OFAMMONIUM AND NON-HEAVY METAL INORGANIC SALT AND HYDROXIDE INTERCALATES AND HEAVY METAL LAYERED CHALCOGENIDES, WHEREIN THE CHALOCOGEN IS SELECTED FROM SULFUR, SELENIUM AND/OR TELLURIUM. THE NOVEL INTERCALATED COMPOUNDS DISPLAY ADVANTAGEOUS CHARACTERISTICS WHEN UTILIZED AS SOLID LUBRICANTS, AND AS X-RAY DIFFRACTION GRATING CRYSTALS. CERTAIN OF THE INTERCALATED TRANSITION METAL CHALCOGENIDES ALSO EXHIBIT UNIQUE SUPERCONDUCTIVITY CHARACTERISTICS.

公开(公告)号：US3740412A

公开(公告)日：1973-06-19

申请号：US3740412D

申请日：1970-04-08

申请人： SYNVAR ASS

发明人： ULLMAN E ,  OSIECKI J ,  CALL L ,  LEUTE R

IPC分类号： C07D233/06 ,  C07D233/28 ,  C07D233/38 ,  C07D233/42 ,  C07D233/44 ,  C07D233/46 ,  C07D233/48 ,  C07D233/70 ,  C07D233/88 ,  C07D49/30 ,  C07D49/34

CPC分类号： C07D233/46 ,  C07D233/06 ,  C07D233/28 ,  C07D233/38 ,  C07D233/42 ,  C07D233/44 ,  C07D233/48 ,  C07D233/70 ,  C07D233/88 ,  Y10T436/24

摘要： DIHYDROIMIDAAZOLES, TETRAHYDROMINIDAZOLES AND TAUTOMERIC MIXTURES OF DIHYDROIMIDAZOLES AND TETRAHYDROIMIDAZOLES HAVING TERITARY CARBON ATOMS IN THE NUMBER 4 AND NUMBER 5 POSITIONS OF THE HYDROMIDAZOLE RING, AND HAVING ATTACHED AT THE C2 POSITION OF THE IMIDAZOLE RING A RADICAL SELECTED FROM THE GROUP CONSISTING OF -NR1R2, =NR2 --NR2-,--S-, --SR1, AND --OR1, WHEREIN R1 IS HYDROGEN, ALKYL, ARYL, ALKENYL, ALKYNYL, ALKYMYL CYCLOAALKYL AND SUBSTITUTED DERATIVES THEREOF, AND R2 IS HYDROGEN, ALKYL, ARYL ALKENYL, ALKYNYL, CYCLOAKYL,

-CO-R1, -CO-N(-R1)-R2, -COO-R1, -CO-S-R1, -SO2-R1,

-C(-R1)=N-R1, -C(=N-R1)-N(-R1)2, -C(-O-R1)=N-R1,

-C(-S-R1)=N-R1, -COO-CO-N(-C2H5)2

AND SUBSTITUTED DERIVATIVES THEREOF. THERE ARE ONE OR TWO OXIDIZED NITROGEN ATOMS IN THE RING IN THE FORM OF OXIDES OR HYDROXIDES.

公开(公告)号：US3673207A

公开(公告)日：1972-06-27

申请号：US3673207D

申请日：1970-04-17

申请人： SYNVAR ASS

发明人： MCCONNELL HARDEN M ,  ULLMAN EDWIN F

IPC分类号： C07C17/266 ,  C07C59/76 ,  C07D263/04 ,  C07D85/26

CPC分类号： C07D263/04 ,  C07C17/266 ,  C07C59/76 ,  Y10T436/24 ,  C07C21/22

摘要： Novel oxazolidine-3-oxyl compounds, wherein the two-carbon of the oxazolidine is a carbon in the chain of oleic acid, which are useful as spin labels for biological membranes, are prepared by reaction of a 2-amino-2-lower alkyl-alkanol with an oxooleic acid, the resulting product oxidized to the corresponding oxazolidine-3-oxyl.

摘要翻译： 新的恶唑烷-3-氧基化合物，其中，恶唑烷的二碳是油酸链中的碳，其可用作生物膜的自旋标记，是通过2-氨基-2-低级烷基 - 烷醇与氧代烯酸反应，将所得产物氧化成相应的恶唑烷-3-氧基。

公开(公告)号：US3749644A

公开(公告)日：1973-07-31

申请号：US3749644D

申请日：1971-03-03

申请人： SYNVAR ASS

发明人： SCHNEIDER R ,  ULLMAN E

IPC分类号： C12Q1/32 ,  C12Q1/34 ,  C12Q1/42 ,  G01R33/28 ,  G01N31/14

CPC分类号： C12Q1/34 ,  C12Q1/32 ,  C12Q1/42 ,  C12Q2334/00 ,  G01N2333/916 ,  G01R33/281

摘要： COMPOUNDS AND METHOD FOR ASSAYING ENZYMES BY ADDING TO A MEDIUM CONTAINING AN ENZYME A STABLE FREE RADICAL COMPOUND HAVING A STABLE FREE RADICAL FUNCTIONALITY, BONDED DIRECTLY OR INDIRECTLY TO AN ENZYME LABILE FUNCTONALITY, WHICH WHEN SUBJECTED TO AN EMZYNE CATALYZED REACTION CHANGES THE ENVIRONMENT OF THE FREE RADICAL FUNCTIONALITY. BY FOLLOWING THE CHANGE IN THE ELECTRON SPIN RESONANCE (ESR) SPECTRUM AS AFFECTED BY THE CHANGE IN ENVIRONMENT, THE TYPE OF ENZYME AND ACTIVITY OF ENZYME MAY BE DETERMINED.

公开(公告)号：US3688109A

公开(公告)日：1972-08-29

申请号：US3688109D

申请日：1970-07-14

申请人： SYNVAR ASS

发明人： GAMBLE FRED R

IPC分类号： G21K1/06 ,  G01N23/20

CPC分类号： G21K1/06 ,  G21K2201/062 ,  G21K2201/067

摘要： The use of structurally layered heavy metal chalcogenides as diffraction grating crystals in X-ray optical assemblies such as X-ray fluorescence spectroscopy, the chalcogen being selected from sulfur, selenium and tellurium, or mixtures thereof. Chalcogenides intercalated with inorganic and organic materials are contemplated.

摘要翻译： 在X射线光学组件如X射线荧光光谱法中，使用结构分层的重金属硫族化物作为衍射光栅晶体，硫族元素选自硫，硒和碲，或其混合物。 考虑用无机和有机材料插入的硫族化合物。

公开(公告)号：US3668214A

公开(公告)日：1972-06-06

申请号：US3668214D

申请日：1970-04-17

申请人： SYNVAR ASS

发明人： MCCONNELL HARDEN M ,  ULLMAN EDWIN F

IPC分类号： C07C59/76 ,  C07D263/04 ,  C07D85/26

CPC分类号： C07D263/04 ,  C07C59/76 ,  Y10T436/24

摘要： Novel oxazolidine-3-oxyl compounds, wherein the two carbon of the oxazolidine ring is a carbon in the chain of palmitoleic acid, e.g. cis-2-(11-carboxy-3-undecenyl)-2-propyl-4,4diethyloxazolidine-3-oxyl, which are useful as spin labels for biological membranes, are prepared by reaction of a 2-amino-2lower alkyl-alkanol with an oxopalmitoleic acid, the resulting product oxidized to the corresponding oxazolidine-3-oxyl.

摘要翻译： 新的恶唑烷-3-氧基化合物，其中恶唑烷环的两个碳是棕榈油酸链中的碳，例如， 可用作生物膜的自旋标记的顺式-2-（11-羧基-3-十一烯基）-2-丙基-4,4-二乙基恶唑烷-3-氧基通过2-氨基-2- 低级烷基 - 链烷醇与氧代苹果酸，将所得产物氧化成相应的恶唑烷-3-氧基。

公开(公告)号：US3489522A

公开(公告)日：1970-01-13

申请号：US3489522D

申请日：1965-10-15

申请人： SYNVAR ASS

发明人： MCCONNELL HARDEN M

IPC分类号： B23H3/08 ,  C12Q1/68 ,  G01N33/58 ,  G01N33/16 ,  C12K1/04 ,  G21H5/00

CPC分类号： G01N33/58 ,  B23H3/08 ,  C12Q1/68 ,  Y10S530/806 ,  Y10T436/143333 ,  Y10T436/24

公开(公告)号：US3873564A

公开(公告)日：1975-03-25

申请号：US28716872

申请日：1972-09-07

申请人： SYNVAR ASS

发明人： SCHNEIDER RICHARD S ,  ULLMAN EDWIN F

IPC分类号： C07C45/67 ,  C07C51/29 ,  C07C65/30 ,  C07D213/51 ,  C07D213/55 ,  C07F9/6506 ,  C08B33/00 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/42 ,  G01R33/28 ,  C07D49/34

CPC分类号： G01R33/281 ,  C07C45/673 ,  C07C51/29 ,  C07C65/30 ,  C07D213/51 ,  C07D213/55 ,  C07F9/6506 ,  C08B33/00 ,  C12Q1/00 ,  C12Q1/34 ,  C12Q1/42 ,  C12Q2334/00 ,  G01N2333/916 ,  Y10T436/24 ,  C07C49/747

摘要： Compounds and method for assaying enzymes by adding to a medium containing an enzyme a stable free radical compound having a stable free radical functionality, bonded directly or indirectly to an enzyme labile functionality, which when subjected to an enzyme catalyzed reaction changes the environment of the free radical functionality. By following the change in the electron spin resonance (ESR) spectrum as affected by the change in environment, the type of enzyme and activity of enzyme may be determined. The compounds which find use in this invention are normally stable nitroxide radicals. Particularly, nitronyl nitroxides, with the nitrogens in an imidazoline ring are employed, having a methylene group joining the 2 position of the imidazoline ring with an asymmetric carbon atom. One of the groups bonded to the asymmetric carbon atoms has an enzyme labile functionality. Other compounds include two cyclic nitroxide containing rings joined by a chain having an enzyme labile functionality.

摘要翻译： 通过向含有酶的培养基中添加具有稳定的自由基官能团的稳定的自由基化合物，直接或间接地结合于酶不稳定官能团的酶来测定酶的化合物和方法，其在进行酶催化反应时改变游离的环境 激进的功能。 通过遵循由环境变化影响的电子自旋共振（ESR）光谱的变化，可以确定酶的类型和酶的活性。