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    PATHWAY ANALYSIS FOR IDENTIFICATION OF DIAGNOSTIC TESTS
    6.
    发明申请
    PATHWAY ANALYSIS FOR IDENTIFICATION OF DIAGNOSTIC TESTS 审中-公开
    路线分析诊断诊断测试

    公开(公告)号：US20150006445A1

    公开(公告)日：2015-01-01

    申请号：US14320214

    申请日：2014-06-30

    申请人： Stephen Charles Benz ,  Shahrooz Rabizadeh ,  Christopher Szeto ,  Paul Weingarten ,  Chunlin Tao

    发明人： Stephen Charles Benz ,  Shahrooz Rabizadeh ,  Christopher Szeto ,  Paul Weingarten ,  Chunlin Tao

    IPC分类号： G06F19/00 ,  G06N5/04 ,  G06N99/00

    CPC分类号： G16H50/20

    摘要： The present inventive subject matter provides apparatus, systems, and methods in which a diagnostic test is identified, where the diagnostic test is for determining whether a particular treatment is effective for a particular patient based on one or more characteristics of a patient's cells. When a treatment is developed with the potential to treat one or more diseases, the drug can have different effects on different cell lines related to the diseases. A machine learning system is programmed to infer a measurable cell characteristic, out of many different measurable cell characteristics, that has a desirable correlation with the sensitivity data of different cell lines to a treatment. The machine learning system is programmed to then determine, based on the correlation, a threshold level of the cell characteristic the patient should exhibit in order to recommend administering the treatment.

    摘要翻译： 本发明的主题提供了其中识别诊断测试的装置，系统和方法，其中诊断测试用于基于患者细胞的一个或多个特征来确定特定治疗是否对特定患者有效。 当开发具有治疗一种或多种疾病潜力的治疗时，该药物可以对与疾病相关的不同细胞系具有不同的作用。 机器学习系统被编程为推断出许多不同可测量的细胞特征中的可测量细胞特征，其与不同细胞系对治疗的敏感性数据具有期望的相关性。 机器学习系统被编程为然后基于相关性来确定患者应该展示的细胞特征的阈值水平以推荐施用治疗。

    Reagents and methods for cancer treatment and prevention
    7.
    发明授权
    Reagents and methods for cancer treatment and prevention 有权
    癌症治疗和预防的试剂和方法

    公开(公告)号：US09107863B2

    公开(公告)日：2015-08-18

    申请号：US11389695

    申请日：2006-03-27

    申请人： Kayvan R. Niazi ,  Shahrooz Rabizadeh ,  Dale E. Bredesen

    发明人： Kayvan R. Niazi ,  Shahrooz Rabizadeh ,  Dale E. Bredesen

    IPC分类号： A61K39/00 ,  A61K31/365

    CPC分类号： G01N33/5023 ,  A61K31/365 ,  A61K39/0011 ,  A61K2039/5154 ,  G01N2333/90241 ,  G01N2500/10

    摘要： The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.

    摘要翻译： 本发明一般涉及癌症的预防和/或治疗，更具体地涉及治疗包括实体瘤及其转移瘤在内的肿瘤，无辐射或标准化学治疗剂。 在一个实施方案中，本发明涉及一种方法，其包括：a）向受试者提供肿瘤细胞，b）从所述受试者中移除所述肿瘤细胞的至少一部分以产生去除的细胞，c）将至少一部分所述去除的细胞 离体使用刺激剂，包括毒胡萝卜素和/或毒胡萝卜素相关化合物，以产生经治疗的肿瘤细胞; 和d）将所述经处理的肿瘤细胞（或其片段）体内引入相同受试者以产生抗癌治疗效果。

    Reagents and methods for cancer treatment and prevention
    9.
    发明授权
    Reagents and methods for cancer treatment and prevention 有权
    癌症治疗和预防的试剂和方法

    公开(公告)号：US08895031B2

    公开(公告)日：2014-11-25

    申请号：US12770638

    申请日：2010-04-29

    申请人： Kayvan R. Niazi ,  Shahrooz Rabizadeh ,  Dale E. Bredesen

    发明人： Kayvan R. Niazi ,  Shahrooz Rabizadeh ,  Dale E. Bredesen

    IPC分类号： A61K39/00 ,  A61K31/365

    CPC分类号： G01N33/5023 ,  A61K31/365 ,  A61K39/0011 ,  A61K2039/5154 ,  G01N2333/90241 ,  G01N2500/10

    摘要： The invention generally relates to the prevention and/or treatment of cancer, and, more specifically, to the treatment of tumors, including solid tumors and their metastases, without radiation or standard chemotherapeutic agents. In one embodiment, the invention involves a method comprising: a) providing a subject with tumor cells, b) removing at least a portion of said tumor cells from said subject to create removed cells, c) treating at least a portion of said removed cells ex vivo, using stimulating agents, including thapsigargin and/or thapsigargin-related compounds, so as to create treated tumor cells; and d) introducing said treated tumor cells (or fragments thereof) in vivo into the same subject to generate anticancer therapeutic effects.

    摘要翻译： 本发明一般涉及癌症的预防和/或治疗，更具体地涉及治疗包括实体瘤及其转移瘤在内的肿瘤，无辐射或标准化学治疗剂。 在一个实施方案中，本发明涉及一种方法，其包括：a）向受试者提供肿瘤细胞，b）从所述受试者中除去至少一部分所述肿瘤细胞以产生去除的细胞，c）将至少一部分所述去除的细胞 离体使用刺激剂，包括毒胡萝卜素和/或毒胡萝卜素相关化合物，以产生经治疗的肿瘤细胞; 和d）将所述经处理的肿瘤细胞（或其片段）体内引入相同受试者以产生抗癌治疗效果。

    CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF
    10.
    发明申请
    CYTOTOXIC PEPTIDES AND PEPTIDOMIMETICS BASED THEREON, AND METHODS FOR USE THEREOF 审中-公开
    基于其的细胞毒素和基因组学及其使用方法

    公开(公告)号：US20110104715A1

    公开(公告)日：2011-05-05

    申请号：US12551400

    申请日：2009-08-31

    申请人： Dale E. Bredesen ,  Shahrooz Rabizadeh

    发明人： Dale E. Bredesen ,  Shahrooz Rabizadeh

    IPC分类号： G01N33/68

    CPC分类号： C07K14/4747 ,  A61K38/00 ,  C07K14/4711

    摘要： In accordance with the present invention, it has been discovered that the β-amyloid precursor protein (APP), and two APP-like proteins (APLP1 and APLP2) are proteolytically cleaved by caspases in the C terminus to generate an approximately 31 amino acid peptide. It has been further discovered that the resultant C-terminal peptide is a potent inducer of apoptosis. Both caspase-cleaved APP and activated caspase-9 is present in brains of Alzheimer's disease patients but not in control brains. These findings indicate that caspase cleavage of APP and APP-like proteins leads to the generation of apoptotic peptides, which may contribute to the neuronal death associated with Alzheimer's disease. Accordingly, there are provided compositions and methods for modulating apoptosis.

    摘要翻译： 根据本发明，已经发现，C端的半胱氨酸蛋白酶蛋白水解切割β-淀粉样蛋白前体蛋白（APP）和两种APP样蛋白（APLP1和APLP2），以产生约31个氨基酸 肽。 进一步发现所得的C末端肽是细胞凋亡的有效诱导剂。 半胱氨酸蛋白酶切割的APP和活化的半胱天冬酶-9均存在于阿尔茨海默病患者的脑中，但不存在于对照脑中。 这些发现表明，APP和APP样蛋白的半胱天冬酶切割导致凋亡肽的产生，这可能有助于与阿尔茨海默氏病相关的神经元死亡。 因此，提供了调节凋亡的组合物和方法。