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公开(公告)号：US09409924B2
公开(公告)日：2016-08-09
申请号：US14129177
申请日：2012-06-27
Applicant: Tong-Shuang Li , Ernest McEachern , David Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold Selnick
Inventor： Tong-Shuang Li , Ernest McEachern , David Vocadlo , Yuanxi Zhou , Yongbao Zhu , Harold Selnick
IPC: C07D513/04 , C07H9/06 , C07H13/04 , C07H13/12 , C07H15/18 , C12Q1/34 , C12Q1/48 , C12Q1/37 , G01N33/50
CPC classification number: C07D513/04 , C07H9/06 , C12Q1/34 , C12Q1/37 , G01N33/5038 , G01N2333/924 , G01N2500/04
Abstract: The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
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公开(公告)号：US09120781B2
公开(公告)日：2015-09-01
申请号：US13697179
申请日：2011-05-10
Applicant: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
Inventor： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu , Kun Liu , Harold G. Selnick
IPC: C07D263/56 , C07D263/58 , C07D277/82 , C07D413/04 , C07D417/04 , C07D277/64 , C07D263/52 , C07D277/60
CPC classification number: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
Abstract: The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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公开(公告)号：US08334310B2
公开(公告)日：2012-12-18
申请号：US12438882
申请日：2007-08-31
Applicant: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
Inventor： David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
IPC: A61K31/429 , C07D513/04
CPC classification number: G01N33/6803 , C07D513/04 , C07D513/14 , C07F9/6561 , C07H9/06
Abstract: The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc
Abstract translation: 本发明提供了用于选择性抑制糖苷酶，化合物前药和包含化合物或药物前体药物的药物组合物的式（I）化合物。本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达有关的疾病和病症的方法， O-GlcNAc的积累或不足
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公开(公告)号：USD573998S1
公开(公告)日：2008-07-29
申请号：US29279722
申请日：2007-05-07
Applicant: Jia-Ming Zhang , Chun-Chi Liang , Jiing-Renn Yu , Dong-Feng Li , Ran-Rong Liu , Lin-Shuang Li
Designer： Jia-Ming Zhang , Chun-Chi Liang , Jiing-Renn Yu , Dong-Feng Li , Ran-Rong Liu , Lin-Shuang Li
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公开(公告)号：US20070049392A1
公开(公告)日：2007-03-01
申请号：US11213856
申请日：2005-08-30
Applicant: Shuang Li
Inventor： Shuang Li
IPC: A63D15/08
CPC classification number: A63D15/086
Abstract: An extendable billiard cue is disclosed to include a shaft, a butt detachably fastened to the shaft, a sleeve, which is embedded in the butt remote from the shaft and has two positioning devices near the two distal ends, a pull bar, and a stem, which has one end fixedly connected to the pull bar and the other end axially movably inserted into the sleeve and fixedly provided with a positioning device selectively engageable to one of the positioning devices of the sleeve to lock the billiard cue in the extended (first length) position or received (second length) position. After disconnection of the shaft from the butt, the detached billiard cue is receivable in a cue bag.
Abstract translation: 公开了一种可延伸的台球提示，包括一个可拆卸地固定在该轴上的轴，一个套筒，其套在远离轴的臀部中，并且在两个远端附近具有两个定位装置，一个拉杆和一个杆 ，其一端固定地连接到拉杆，另一端轴向可移动地插入到套筒中，并且固定地设置有定位装置，该定位装置可选择地与套筒的定位装置中的一个接合，以将台球提示锁定在延伸的（第一长度） ）位置或接收（第二长度）位置。 在轴与屁股断开之后，脱离的台球提示可以在提示袋中接收。
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Patent Agency Ranking
公开(公告)号：US20050277670A1
公开(公告)日：2005-12-15
申请号：US11012002
申请日：2004-12-13
Applicant: Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
Inventor： Yuanxi Zhou , Gary Bridger , Renato Skerlj , David Bogucki , Wen Yang , Elyse Bourque , Jonathan Langille , Tong-Shuang Li , Markus Metz , Maria Di Fluri , Siqiao Nan
IPC: A61K31/4545 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , C12N20060101 , C07D43/02
CPC classification number: C07D401/14 , C07D401/12 , C07D413/14 , C07D417/14
Abstract: The present invention relates to chemokine receptor binding compounds, pharmaceutical compositions and their use. More specifically, the present invention relates to modulators of chemokine receptor activity, preferably modulators of CCR5. These compounds demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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公开(公告)号：US09254276B2
公开(公告)日：2016-02-09
申请号：US13357916
申请日：2012-01-25
Applicant: Chengwu Li , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
Inventor： Chengwu Li , Naohisa Yoshimi , Xincheng Hu , Shuang Li , Yunhua Gao
IPC: A61K9/127 , A61K31/19 , A61K31/198 , A61K31/203 , A61K31/215 , A61K31/375 , A61K31/704 , A61K8/14 , A61K8/55 , A61K8/60 , A61K8/67 , A61K8/92 , A61P17/00 , A61Q19/00 , A61K8/44 , A61K8/49 , A61K8/86 , A61K9/00 , A61K9/06
CPC classification number: A61K31/19 , A61K8/14 , A61K8/44 , A61K8/4946 , A61K8/4993 , A61K8/602 , A61K8/86 , A61K9/0014 , A61K9/06 , A61K9/1271 , A61K31/198 , A61K31/203 , A61K31/375 , A61K31/704 , A61K2800/10 , A61K2800/56 , A61Q19/00
Abstract: A liposome comprising a phospholipid, a hydrophobic active comprising a carboxylate group, and a component selected from a group consisting of: a hydrophilic adjuvant comprising a positively charged group, a complex of said hydrophobic active with said hydrophilic adjuvant, and combinations thereof. An aqueous liposome dispersion comprising the liposome, and a personal care composition comprising the liposome. A process of preparing the liposome, comprising the steps of: forming a premix by dissolving a phospholipid, a hydrophobic active comprising a carboxylate group in an organic solvent; evaporating off said organic solvent from the premix to form a phospholipid film; and hydrating said lipid film with a hydration medium comprising a hydrophilic adjuvant comprising a positively charged group and homogenize the medium to form an aqueous liposome dispersion.
Abstract translation: 包含磷脂，包含羧酸酯基团的疏水性活性物质和选自以下的组分的脂质体：包含带正电基团的亲水性佐剂，所述疏水性活性物质与所述亲水性佐剂的配合物及其组合。 包含脂质体的脂质体水分散体和包含脂质体的个人护理组合物。 一种制备脂质体的方法，包括以下步骤：通过将磷脂，包含羧酸酯基团的疏水活性物质溶于有机溶剂中形成预混物; 从预混物中蒸发出所述有机溶剂以形成磷脂膜; 以及用包含带正电基团的亲水性佐剂的水合介质水合所述脂质膜，并均质培养基以形成脂质体水分散体。
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公开(公告)号：US08962664B2
公开(公告)日：2015-02-24
申请号：US13591927
申请日：2012-08-22
Applicant: David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
Inventor： David Vocadlo , Ernest McEachern , Keith Stubbs , Tong-Shuang Li , Garrett Whitworth , Julia Heinonen , Matthew Macauley
IPC: A61K31/429 , C07D513/04 , G01N33/68 , C07D513/14 , C07F9/6561 , C07H9/06
CPC classification number: G01N33/6803 , C07D513/04 , C07D513/14 , C07F9/6561 , C07H9/06
Abstract: The invention provides compounds of formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶，化合物前药和包括化合物的化合物或前药的药物组合物的式（I）化合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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公开(公告)号：US20130131044A1
公开(公告)日：2013-05-23
申请号：US13697179
申请日：2011-05-10
Applicant: Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
Inventor： Tong-Shuang Li , Ernest J. Mceachern , David J. Vocadlo , Yuanxi Zhou , Yongbao Zhu
IPC: C07D417/04 , C07D277/60 , C07D413/04 , C07D263/52
CPC classification number: C07D417/04 , C07D263/52 , C07D263/56 , C07D263/58 , C07D277/60 , C07D277/64 , C07D277/82 , C07D413/04
Abstract: The invention provides compounds of Formula (I) for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.
Abstract translation: 本发明提供了用于选择性抑制糖苷酶的化合物（I）的化合物，以及化合物的前药以及包含化合物的化合物或前药的药物组合物。 本发明还提供了治疗与O-GlcNAcase的缺乏或过度表达相关的疾病和障碍的方法，O-GlcNAc的积累或缺乏。
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