公开(公告)号：US20150034223A1

公开(公告)日：2015-02-05

申请号：US14364570

申请日：2011-12-16

申请人： Shuichi Kaneko

发明人： Shuichi Kaneko

IPC分类号： B60C11/00

摘要： A tread for a pneumatic tire in which a reinforcing layer is provided on a side wall portion of a ground-contacting element of a tread of a tire, and in a pneumatic tire having such a tread, the reinforcing layer has a mean thickness of less than 0.5 mm, is provided over an area at least equal to 50% of the side wall portion, and has a material modulus at least equal to 200 MPa.

摘要翻译： 一种用于充气轮胎的胎面，其中在轮胎的胎面的接地元件的侧壁部分上设置增强层，并且在具有这种胎面的充气轮胎中，增强层的平均厚度较小 设置在至少等于侧壁部分的50％的面积上，并且具有至少等于200MPa的材料模量。

公开(公告)号：US20130186533A1

公开(公告)日：2013-07-25

申请号：US13819945

申请日：2010-08-31

申请人： Shuichi KANEKO

发明人： Shuichi KANEKO

IPC分类号： B60C11/03

CPC分类号： B60C11/032 ,  B60C11/0302 ,  B60C11/0306 ,  B60C11/1236 ,  B60C11/1281 ,  B60C2011/1213 ,  B60C2011/1254

摘要： To provide a winter-use pneumatic tire with which the performance on ice can be enhanced and tread pattern durability can be enhanced. The tread for a winter-use pneumatic tire according to the present invention has blocks which are aligned in the circumferential direction and in which are formed respectively at least one thin incision which extends substantially parallel to a circumferential direction edge and which has a widened portion at its bottom, and at least one series of small holes comprising at least two small holes which open in a ground contacting surface of the block and extend in the inward radial direction of the tire, and the at least one series of small holes is formed in a neighboring region of the circumferential direction edge, and is formed in an intermediate portion between the circumferential direction edge and the at least one thin incision.

摘要翻译： 提供冬季使用的充气轮胎，可以提高冰上的性能并提高胎面花纹耐久性。 根据本发明的用于冬季使用的充气轮胎的胎面具有在圆周方向上对准的块，并且分别形成有至少一个细切口，该切口基本上平行于圆周方向边缘延伸，并且具有加宽部分 其底部，以及包括至少两个小孔的系列小孔，所述至少两个小孔在所述块的地面接触表面中开口并沿所述轮胎的向内径向延伸，并且所述至少一系列小孔形成在 周向方向边缘的相邻区域，并且形成在圆周方向边缘和至少一个薄切口之间的中间部分中。

公开(公告)号：US08492792B2

公开(公告)日：2013-07-23

申请号：US13233392

申请日：2011-09-15

申请人： Akio Iwabuchi ,  Shuichi Kaneko

发明人： Akio Iwabuchi ,  Shuichi Kaneko

IPC分类号： H01L29/66

CPC分类号： H01L29/7395 ,  H01L29/0653 ,  H01L29/66333

摘要： A manufacturing method of a semiconductor device 10 includes forming a plurality of second conductive second semiconductor regions at specific intervals on one main surface of a first conductive first semiconductor region, the plurality of second conductive second semiconductor regions being opposite to the first conductive first semiconductor region, forming a plurality of the first conductive third semiconductor regions on a main surface of the second semiconductor region, the plurality of the first conductive third regions being separated from each other, forming a plurality of holes at specific intervals on an another main surface which faces the one main surface of the first semiconductor region, the plurality of holes being separated from each other, forming a pair of adjacent second conductive fourth semiconductor regions which are alternately connected at a bottom part of the hole within the first semiconductor region, and burying an electrode within the hole.

摘要翻译： 半导体器件10的制造方法包括在第一导电第一半导体区域的一个主表面上以特定间隔形成多个第二导电第二半导体区域，所述多个第二导电第二半导体区域与第一导电第一半导体区域相对 在所述第二半导体区域的主表面上形成多个所述第一导电第三半导体区域，所述多个所述第一导电第三区域彼此分离，在另一个主表面上以特定间隔形成多个孔，所述另一个主表面 第一半导体区域的一个主表面，多个孔彼此分离，形成一对相邻的第二导电第四半导体区域，其在第一半导体区域内的孔的底部交替连接，并且将 电极内孔。

公开(公告)号：US08207301B2

公开(公告)日：2012-06-26

申请号：US12452216

申请日：2008-06-16

申请人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

发明人： Hirotaka Minagawa ,  Kenji Miyazaki ,  Yo Tabuse ,  Kenichi Kamijo ,  Shuichi Kaneko

IPC分类号： C07K14/435

CPC分类号： C07K14/4748 ,  G01N33/57438

摘要： Provided are: a method of assessing hepatocellular carcinoma by using a protein with a different phosphorylated state in hepatocellular carcinoma cells compared with non-hepatocellular carcinoma cells; and a hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma formed of the protein. The hepatocellular carcinoma protein marker for detecting hepatocellular carcinoma includes tumor rejection antigen gp96 formed of the amino acid represented by SEQ ID NO: 1, and is measured for its phosphorylated state to detect the presence or absence of hepatocellular carcinoma.

摘要翻译： 提供：与非肝细胞癌细胞相比，通过使用肝细胞癌细胞中具有不同磷酸化状态的蛋白质来评估肝细胞癌的方法; 和用于检测由蛋白质形成的肝细胞癌的肝细胞癌蛋白标记物。 用于检测肝细胞癌的肝细胞癌蛋白标志物包括由SEQ ID NO：1表示的氨基酸形成的肿瘤排斥抗原gp96，并测量其磷酸化状态以检测肝细胞癌的存在或不存在。

公开(公告)号：US08039322B2

公开(公告)日：2011-10-18

申请号：US12482060

申请日：2009-06-10

申请人： Akio Iwabuchi ,  Shuichi Kaneko

发明人： Akio Iwabuchi ,  Shuichi Kaneko

IPC分类号： H01L21/332

CPC分类号： H01L29/7395 ,  H01L29/0653 ,  H01L29/66333

摘要： A manufacturing method of a semiconductor device 10 includes forming a plurality of second conductive second semiconductor regions at specific intervals on one main surface of a first conductive first semiconductor region, the plurality of second conductive second semiconductor regions being opposite to the first conductive first semiconductor region, forming a plurality of the first conductive third semiconductor regions on a main surface of the second semiconductor region, the plurality of the first conductive third regions being separated from each other, forming a plurality of holes at specific intervals on an another main surface which faces the one main surface of the first semiconductor region, the plurality of holes being separated from each other, forming a pair of adjacent second conductive fourth semiconductor regions which are alternately connected at a bottom part of the hole within the first semiconductor region, and burying an electrode within the hole.

摘要翻译： 半导体器件10的制造方法包括在第一导电第一半导体区域的一个主表面上以特定间隔形成多个第二导电第二半导体区域，所述多个第二导电第二半导体区域与第一导电第一半导体区域相对 在所述第二半导体区域的主表面上形成多个所述第一导电第三半导体区域，所述多个所述第一导电第三区域彼此分离，在另一个主表面上以特定间隔形成多个孔，所述另一个主表面 第一半导体区域的一个主表面，多个孔彼此分离，形成一对相邻的第二导电第四半导体区域，其在第一半导体区域内的孔的底部交替连接，并且将 电极内孔。

公开(公告)号：US20100230746A1

公开(公告)日：2010-09-16

申请号：US12649953

申请日：2009-12-30

申请人： Hironori AOKI ,  Shuichi Kaneko

发明人： Hironori AOKI ,  Shuichi Kaneko

IPC分类号： H01L29/78 ,  H01L21/336

CPC分类号： H01L29/7813 ,  H01L29/0696 ,  H01L29/0878 ,  H01L29/66734 ,  H01L29/7397

摘要： A semiconductor device includes an epitaxial layer having a first conduction type, a base layer formed adjacent and on the epitaxial layer and having an opposite second conduction type to the first conduction type, a source layer formed selectively on the base layer and having the first conduction type, a trench which passes through the base layer and the source layer and which reaches the epitaxial layer, an insulation film formed along an interior wall of the trench, a control electrode formed within the trench via the insulation film, and a semiconductor region formed along the bottom part of the trench at the epitaxial layer and having the first conduction type.

摘要翻译： 半导体器件包括具有第一导电类型的外延层，与外延层相邻并且在外延层上形成并具有与第一导电类型相反的第二导电类型的基极层，源层选择性地形成在基极层上并具有第一导电 类型，通过基底层和源极层并到达外延层的沟槽，沿着沟槽的内壁形成的绝缘膜，经由绝缘膜形成在沟槽内的控制电极和形成的半导体区域 沿着沟槽的底部在外延层处并具有第一导电类型。

公开(公告)号：US20070020348A1

公开(公告)日：2007-01-25

申请号：US10547548

申请日：2004-03-04

申请人： Satoshi Yoshida ,  Shuichi Kaneko

发明人： Satoshi Yoshida ,  Shuichi Kaneko

IPC分类号： A61K36/54 ,  A61K36/42 ,  A61K36/28

CPC分类号： A61K36/286 ,  A61K36/355 ,  A61K36/42 ,  A61K36/68 ,  A61K2300/00

摘要： By administering a composition comprising pumpkin seed, safflower, plantain and honeysuckle, subjective symptoms (for example, general malaise and abdominal swelling) of a patient with chronic hepatitis C can be eliminated and, moreover, objective symptoms diagnosed by a medical doctor (for example, liver enlargement and palm erythema) can be relieved or eliminated. From 1 to 3 months after the administration of the composition, a significant decrease in hepatitis C virus RNA level is gradually observed. Therefore, the above composition is useful at least as a composition for treating chronic hepatitis C. In particular, it is advantageous in treating a chronic hepatitis C patient showing a high chronic hepatitis C virus RNA level.

摘要翻译： 通过施用包含南瓜籽，红花，车前草和金银花的组合物，可以消除患有慢性丙型肝炎患者的主观症状（例如，一般不适和腹部肿胀），此外，由医生诊断的客观症状（例如， ，肝肿大和棕红斑）可以缓解或消除。 在组合物施用后1至3个月，逐渐观察到丙型肝炎病毒RNA水平的显着降低。 因此，上述组合物至少可用作治疗慢性丙型肝炎的组合物。特别是，治疗显示高的慢性丙型肝炎病毒RNA水平的慢性丙型肝炎患者是有利的。

公开(公告)号：US07056507B2

公开(公告)日：2006-06-06

申请号：US10458297

申请日：2003-06-11

申请人： Eiji Ogino ,  Michio Nomura ,  Takashi Asahi ,  Shuichi Kaneko ,  Akito Sakai

发明人： Eiji Ogino ,  Michio Nomura ,  Takashi Asahi ,  Shuichi Kaneko ,  Akito Sakai

IPC分类号： A61K39/42 ,  C07K1/22 ,  B01D15/08

CPC分类号： A61M1/3633 ,  A61M1/3679 ,  A61M2205/7509 ,  B01J20/262 ,  B01J20/265 ,  B01J20/28078 ,  B01J20/3212 ,  B01J20/3217 ,  B01J20/3219 ,  B01J20/3255 ,  B01J20/3274 ,  B01J2220/58 ,  Y10S530/81

摘要： An adsorbent for removing hepatitis C virus which has the ability to adsorb HCV particles, particularly immune-complex HCV particles, from a patient's body blood safely and with high efficiency and high selectivity for enhancing the efficacy of interferon therapy, an HCV adsorption apparatus including said adsorbent, and a adsorbing method for removing HCV are provided.An adsorbent for removing hepatitis C virus which comprises a compound capable of adsorbing hepatitis C virus as immobilized on a water-insoluble carrier, an adsorption apparatus including said adsorbent, and an adsorbing method for removing HCV.

摘要翻译： 一种用于除去丙型肝炎病毒的吸附剂，其具有从患者身体血液中安全地并以高效率和高选择性安全地吸收HCV颗粒，特别是免疫复合物HCV颗粒的能力，以提高干扰素疗法的功效，HCV吸附装置包括所述 吸附剂和用于除去HCV的吸附方法。 一种用于除去丙型肝炎病毒的吸附剂，其包含能够吸附固定在水不溶性载体上的丙型肝炎病毒的化合物，包括所述吸附剂的吸附装置和用于除去HCV的吸附方法。

公开(公告)号：US20150336431A1

公开(公告)日：2015-11-26

申请号：US14655870

申请日：2013-12-27

申请人： Shuichi KANEKO ,  COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN ,  MICHELIN RECHERCHE ET TECHNIQUE S.A.

发明人： Shuichi KANEKO

IPC分类号： B60C11/13 ,  B60C11/04 ,  B60C11/03 ,  B60C5/00

CPC分类号： B60C11/13 ,  B60C5/00 ,  B60C11/0327 ,  B60C11/04 ,  B60C11/11 ,  B60C11/1323 ,  B60C11/1346 ,  B60C11/14 ,  B60C2011/1209

摘要： A pneumatic tire tread in which a reinforcing part is provided on frontal side walls of a block of a tire tread in order to improve the performance on snow and the performance on ice, and a pneumatic tire having such a tread, wherein angles T1 and T2 formed by the upper surface and the two frontal side walls provided with the reinforcing part are both less than 90°.

摘要翻译： 一种充气轮胎胎面，其中增强部分设置在轮胎胎面的块的前侧壁上，以改善雪上的性能和在冰上的性能;以及具有这种胎面的充气轮胎，其中角度T1和T2 由上表面和设置有加强部的两个前侧壁形成均小于90°。

公开(公告)号：US08932990B2

公开(公告)日：2015-01-13

申请号：US13391858

申请日：2010-08-03

申请人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

发明人： Shuichi Kaneko ,  Masao Honda ,  Yoshio Sakai ,  Taro Yamashita

IPC分类号： C40B30/04 ,  C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present invention provides a method and a reagent for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient by analyzing genes with expression levels (in peripheral blood) that vary in association with digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer cases, compared with normal healthy subjects. Specifically, the method for detecting a digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer patient based on expression profiles comprises obtaining the expression profile of at least one gene selected from the group consisting of probes corresponding to genes with expression levels (in peripheral blood) that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, and biliary tract cancer cases, compared with normal healthy subjects. The reagent for detecting digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer contains nucleotides or partial sequences thereof consisting of the nucleotide sequence of at least one gene selected from the group consisting of probes with expression levels that vary in digestive organ cancer, gastric cancer, colorectal cancer, pancreatic cancer, or biliary tract cancer, or nucleotides containing sequences complementary thereto.

摘要翻译： 本发明提供了通过分析与消化器官癌相关的变化的表达水平（外周血）的基因来检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法和试剂， 胃癌，结肠直肠癌，胰腺癌或胆道癌，与正常健康人相比。 具体地，基于表达谱，检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌患者的方法包括获得至少一种基因的表达谱，所述基因选自对应于具有 与正常健康受试者相比，消化器官癌，胃癌，结肠直肠癌，胰腺癌和胆道癌患者的表达水平（外周血）差异不大。 用于检测消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌的试剂含有由至少一种基因的核苷酸序列组成的核苷酸或其部分序列，所述核苷酸序列选自下组的探针：表达水平在 消化器官癌，胃癌，结肠直肠癌，胰腺癌或胆道癌，或含有与其互补的序列的核苷酸。