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    Self-cleaning and mixing microfluidic elements
    1.
    发明授权
    Self-cleaning and mixing microfluidic elements 有权
    自清洁和混合微流体元件

    公开(公告)号：US08147775B2

    公开(公告)日：2012-04-03

    申请号：US12552914

    申请日：2009-09-02

    申请人： Sivaramakrishnan Krishnamoorthy ,  Jianiun Feng

    发明人： Sivaramakrishnan Krishnamoorthy ,  Jianiun Feng

    IPC分类号： B01F15/00

    CPC分类号： B08B7/0064 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  Y10S366/04 ,  Y10T137/0329 ,  Y10T137/034 ,  Y10T137/0391

    摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

    摘要翻译： 公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。 该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。 调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。 电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

    Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems
    2.
    发明授权
    Methods and systems employing electrothermally induced flow for mixing and cleaning in microsystems 有权
    在微系统中采用电热诱导流混合和清洗的方法和系统

    公开(公告)号：US07189578B1

    公开(公告)日：2007-03-13

    申请号：US10307907

    申请日：2002-12-02

    申请人： Jianjun Feng ,  Sivaramakrishnan Krishnamoorthy ,  Vinod Bhagwan Makhijani

    发明人： Jianjun Feng ,  Sivaramakrishnan Krishnamoorthy ,  Vinod Bhagwan Makhijani

    IPC分类号： G01N1/00 ,  G01N1/10 ,  G01N35/00 ,  H05F3/00 ,  B01D57/02

    CPC分类号： B08B9/00 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B08B7/0064 ,  F04B19/006 ,  F04B19/24 ,  Y10T29/49 ,  Y10T29/49002 ,  Y10T436/11 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A method and system for controlling flow motion in a channel/cavity in a microfluidic system includes positioning at least one pair of electrodes in and/or proximate to the channel/cavity. A buffer solution is placed in the channel/cavity, the buffer solution having at least one dielectric property that varies in response to changes in temperature of the solution. An AC/DC voltage is applied to the electrodes to generate an electric field in the channel/cavity; the AC voltage having a known magnitude and frequency and the DC voltage having a known magnitude. The magnitude of the AC/DC voltage is adjusted to cause Joule heating of the buffer solution in the channel/cavity. The geometry and position of the electrodes is adjusted to generate a temperature gradient in the buffer solution, thereby causing a non-uniform distribution of the dielectric property within the solution in the channel/cavity. The dielectric non-uniformity produces a body force and flow in the solution. Also, the frequency of the AC voltage is adjusted to generate flow of the buffer solution in the channel/cavity in response to the non-uniform distribution of the dielectric property.

    摘要翻译： 用于控制微流体系统中的通道/空腔中的流动的方法和系统包括将至少一对电极定位在通道/空腔中和/或接近通道/空腔。 将缓冲溶液放置在通道/空腔中，缓冲溶液具有响应于溶液温度变化而变化的至少一种介电特性。 AC / DC电压施加到电极以在通道/空腔中产生电场; AC电压具有已知的幅度和频率，并且DC电压具有已知的幅度。 调整AC / DC电压的大小，使通道/腔中的缓冲溶液焦耳加热。 调节电极的几何形状和位置以在缓冲溶液中产生温度梯度，从而导致溶液中的介电性质在通道/空腔中的不均匀分布。 电介质非均匀性会在溶液中产生体力和流动。 此外，响应于介电性质的不均匀分布，调节AC电压的频率以产生通道/空腔中的缓冲溶液的流动。

    Method and apparatus for separating particles by dielectrophoresis
    3.
    发明申请
    Method and apparatus for separating particles by dielectrophoresis 有权
    通过介电电泳分离颗粒的方法和装置

    公开(公告)号：US20060290745A1

    公开(公告)日：2006-12-28

    申请号：US11167428

    申请日：2005-06-27

    申请人： Jianjun Feng ,  Guiren Wang ,  Sivaramakrishnan Krishnamoorthy ,  Kapil Pant ,  Shivshankar Sundaram

    发明人： Jianjun Feng ,  Guiren Wang ,  Sivaramakrishnan Krishnamoorthy ,  Kapil Pant ,  Shivshankar Sundaram

    IPC分类号： B41J2/05

    CPC分类号： B03C5/005 ,  B03C5/026

    摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.

    摘要翻译： 提供微尺度，介电泳分离颗粒的方法和装置。 颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。 间隙距离和施加电位可用于控制所产生的介电电泳力。 使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。 方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。

    Self-Cleaning and Mixing Microfluidic Elements
    5.
    发明申请
    Self-Cleaning and Mixing Microfluidic Elements 有权
    自清洁和混合微流体元件

    公开(公告)号：US20100008183A1

    公开(公告)日：2010-01-14

    申请号：US12552914

    申请日：2009-09-02

    申请人： Sivaramakrishnan Krishnamoorthy ,  Jianiun Feng

    发明人： Sivaramakrishnan Krishnamoorthy ,  Jianiun Feng

    IPC分类号： B01F15/00 ,  B01F5/06

    CPC分类号： B08B7/0064 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  Y10S366/04 ,  Y10T137/0329 ,  Y10T137/034 ,  Y10T137/0391

    摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

    摘要翻译： 公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。 该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。 调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。 电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

    Self-cleaning and mixing microfluidic elements
    9.
    发明申请
    Self-cleaning and mixing microfluidic elements 有权
    自清洁和混合微流体元件

    公开(公告)号：US20070209940A1

    公开(公告)日：2007-09-13

    申请号：US11516358

    申请日：2006-09-06

    申请人： Sivaramakrishnan Krishnamoorthy ,  Jianjun Feng

    发明人： Sivaramakrishnan Krishnamoorthy ,  Jianjun Feng

    IPC分类号： B01D57/02 ,  B03C5/00

    CPC分类号： B08B7/0064 ,  B01F13/0079 ,  B01F13/0081 ,  B01L3/5027 ,  B01L99/00 ,  B01L2300/1833 ,  B01L2400/0415 ,  B01L2400/0442 ,  B01L2400/0493 ,  B08B9/00 ,  F04B19/006 ,  F04B19/24 ,  Y10S366/04 ,  Y10T137/0329 ,  Y10T137/034 ,  Y10T137/0391

    摘要： Apparatus and methods are disclosed for mixing and self-cleaning elements in microfluidic systems based on electrothermally induced fluid flow. The apparatus and methods provide for the control of fluid flow in and between components in a microfluidic system to cause the removal of unwanted liquids and particulates or mixing of liquids. The geometry and position of electrodes is adjusted to generate a temperature gradient in the liquid, thereby causing a non-uniform distribution of dielectric properties within the liquid. The dielectric non-uniformity produces a body force and flow in the solution, which is controlled by element and electrode geometries, electrode placement, and the frequency and waveform of the applied voltage.

    摘要翻译： 公开了用于基于电热诱导流体流动的微流体系统中的混合和自清洁元件的装置和方法。 该装置和方法提供了在微流体系统中的组件之间和之间的流体流动的控制，以便除去不期望的液体和微粒或混合液体。 调节电极的几何形状和位置，以在液体中产生温度梯度，从而导致液体内介电性质的不均匀分布。 电介质非均匀性在溶液中产生体力和流动，其由元件和电极几何形状，电极布置以及施加电压的频率和波形控制。

    Method and apparatus for separating particles by dielectrophoresis
    10.
    发明授权
    Method and apparatus for separating particles by dielectrophoresis 有权
    通过介电电泳分离颗粒的方法和装置

    公开(公告)号：US07998328B2

    公开(公告)日：2011-08-16

    申请号：US11167428

    申请日：2005-06-27

    申请人： Jianjun Feng ,  Guiren Wang ,  Sivaramakrishnan Krishnamoorthy ,  Kapil Pant ,  Shivshankar Sundaram

    发明人： Jianjun Feng ,  Guiren Wang ,  Sivaramakrishnan Krishnamoorthy ,  Kapil Pant ,  Shivshankar Sundaram

    IPC分类号： B03C5/02

    CPC分类号： B03C5/005 ,  B03C5/026

    摘要： Methods and apparatus for the micro-scale, dielectrophoretic separation of particles are provided. Fluid suspensions of particles are sorted and separated by dielectrophoretic separation chambers that have at least two consecutive, electrically coupled planar electrodes separated by a gap in a fluid flow channel. The gap distance as well as applied potential can be used to control the dielectrophoretic forces generated. Using consecutive, electrically coupled electrodes rather than electrically coupled opposing electrodes facilitates higher flow volumes and rates. The methods and apparatus can be used, for example, to sort living, damaged, diseased, and/or dead cells and functionalized or ligand-bound polymer beads for subsequent identification and/or analysis.

    摘要翻译： 提供微尺度，介电泳分离颗粒的方法和装置。 颗粒的流体悬浮液通过介电泳分离室进行分选和分离，所述介电泳分离室具有至少两个由流体流动通道中的间隙隔开的电耦合平面电极。 间隙距离和施加电位可用于控制所产生的介电电泳力。 使用连续的电耦合电极而不是电耦合的相对电极有助于更高的流量和速率。 方法和装置可以用于例如分类活体，损伤的，患病的和/或死细胞和官能化或配体结合的聚合物珠粒，用于随后的鉴定和/或分析。