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公开(公告)号：US09962463B2
公开(公告)日：2018-05-08
申请号：US15184228
申请日：2016-06-16
IPC分类号： A61L27/16 , A61L27/44 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/22 , C08J3/28 , C08J3/24 , C08K5/1545
CPC分类号： A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
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公开(公告)号：US08968628B2
公开(公告)日：2015-03-03
申请号：US12987399
申请日：2011-01-10
IPC分类号： B29C35/08 , A61L27/16 , A61L27/50 , B29C43/00 , C08K5/00 , C08K5/1545 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/28 , C08L23/06
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：US08318065B2
公开(公告)日：2012-11-27
申请号：US12904481
申请日：2010-10-14
IPC分类号： C08J3/28
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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4.发明申请High Modulus Crosslinked Polyethylene with Reduced Residual Free Radical Concentration Prepared Below the Melt 审中-公开高模量交联聚乙烯，在熔体下方制备残留的自由基浓度降低公开(公告)号：US20120082860A1
公开(公告)日：2012-04-05
申请号：US13314586
申请日：2011-12-08
IPC分类号： B32B15/08 , C08J3/28 , B32B27/08 , C08F110/02
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译： 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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公开(公告)号：US07906064B2
公开(公告)日：2011-03-15
申请号：US11564594
申请日：2006-11-29
IPC分类号： B29B13/08
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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6.发明授权High modules crosslinked polyethylene with reduced residual free radical concentration prepared below the melt 有权高分子量交联聚乙烯，在熔体下制备残留的自由基浓度降低公开(公告)号：US07507774B2
公开(公告)日：2009-03-24
申请号：US11873853
申请日：2007-10-17
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译： 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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公开(公告)号：US07431874B2
公开(公告)日：2008-10-07
申请号：US10757551
申请日：2004-01-15
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合物材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散和其中使用的材料掺杂含有与维生素E的交联UHMWPE的医疗装置。
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公开(公告)号：US06884264B2
公开(公告)日：2005-04-26
申请号：US10102446
申请日：2002-03-19
CPC分类号： A61B17/8802 , A61B2017/8844 , A61F2/30767 , A61F2/30771 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/389 , A61F2/4607 , A61F2002/30011 , A61F2002/30041 , A61F2002/30112 , A61F2002/30136 , A61F2002/30138 , A61F2002/30172 , A61F2002/30828 , A61F2002/30838 , A61F2002/30848 , A61F2002/30879 , A61F2002/30892 , A61F2002/3611 , A61F2002/3625 , A61F2002/4623 , A61F2002/4631 , A61F2002/4632 , A61F2002/4651 , A61F2002/4654 , A61F2002/4662 , A61F2002/4668 , A61F2002/4672 , A61F2002/4681 , A61F2002/469 , A61F2002/4697 , A61F2230/0004 , A61F2230/0017 , A61F2230/0052 , A61F2250/0023 , A61F2310/00011 , A61F2310/00952 , A61N7/00
摘要： The present invention provides a system and a method for reducing pores, or air pockets, that form at the interface between the material used to attach or adhere the surface of a component, such as a prosthesis, to a site.A preferred embodiment of the invention includes an actuator that controls a coupler which transmits energy to a prosthesis being inserted into a material to reduce porosity at an interface between the prosthesis and the material.The system of the present invention can include an oscillating hand-held device that vibrates the stem component of an orthopedic prosthesis at a particular frequency and amplitude. The device is typically held by the hand of the surgeon, who guides the vibrating prosthesis into the cement-filled medullary cavity.
摘要翻译： 本发明提供一种用于减少在用于将诸如假体的部件的表面附接或粘附到部位的材料之间的界面处形成的孔或气囊的系统和方法。 本发明的优选实施例包括致动器，该致动器控制耦合器，该耦合器将能量传递到被插入到材料中的假体，以减少假体和材料之间的界面处的孔隙率。 本发明的系统可以包括以特定频率和振幅振动矫形假体的茎部分的振动手持装置。 该装置通常由外科医生的手握住，外科医生将该振动假体引导到填充有水泥的髓腔中。
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公开(公告)号：US20180194042A1
公开(公告)日：2018-07-12
申请号：US15914176
申请日：2018-03-07
IPC分类号： B29C35/08 , C08L23/06 , A61L27/16 , A61L31/14 , A61L31/04 , A61L29/14 , A61L29/04 , A61L27/50 , C08K5/1545 , C08K5/00 , B29C43/00 , C08J3/28
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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公开(公告)号：US09441081B2
公开(公告)日：2016-09-13
申请号：US12041249
申请日：2008-03-03
IPC分类号： A61L27/16 , A61L27/44 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08K5/00 , C08K3/00 , C08L23/06 , C08J3/28 , C08J3/22
CPC分类号： A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
摘要翻译： 本发明涉及制备交联的，氧化稳定的和高度结晶的聚合物材料的方法。 本发明还提供了处理照射交联的含抗氧化剂的聚合物和与其一起使用的材料的方法。
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